What Biolytic Lab Performance does

Biolytic Lab Performance, Inc. is a privately held US manufacturer founded in 1993 and headquartered in Fremont, California, that designs, builds, and services DNA, RNA, and peptide oligonucleotide synthesizers sold under the Dr. Oligo brand. The product line uses solid-phase phosphoramidite synthesis chemistry with positive-pressure (inert-gas) reagent delivery rather than vacuum pumps, spanning low-throughput (Dr. Oligo 12, 12 oligos/run) to ultra-high-throughput (Dr. Oligo 768XLc, 768 oligos/run) instruments, with synthesis scales from 2 nmol to 100 nmol and support for DNA, RNA, LNA, 2'-modified RNA, and mixed backbones. The portfolio also includes the Dr. Oligo Processor for automated post-synthesis OPC-cartridge purification, a Heated Pressure Chamber for cleave-and-deprotect, a full line of synthesis consumables, parts and upgrades, certified pre-owned refurbished units, and supporting services (PTS/PLT service plans, end-to-end training, and IQ/OQ/PM hardware qualifications). All instruments are designed and manufactured at the Fremont facility, are labeled Research Use Only, and carry CE, UL 60950-1 (XLc), KC (Processor), and ASME BPVC Section VIII (Heated Pressure Chamber) certifications, with the quality system aligned to ISO 9001:2015 best practices and attestation to the U.S. Framework for Nucleic Acid Synthesis Screening.

The company monetizes primarily through one-time hardware sales of configurable synthesizers (quote-based pricing with academic discounts), recurring consumables, replacement parts, and subscription-style annual service plans estimated at 6–12% of instrument list price. Go-to-market is sales-led: a direct sales team serves US customers while international sales run through a global distributor network accessed via a formal distributor portal. Customer concentration is diversified across elite academic research institutions (MIT, Yale, Stanford, UC Irvine, UMass Chan, Northwestern), pharmaceutical and biopharmaceutical firms (Ionis, Janssen Pharmaceutica, Agilent Research Laboratories), government institutions, startups, and oligo synthesis service companies, with the Dr. Oligo name appearing across peer-reviewed publications that document real-world use. Biolytic holds four granted US patents covering synthesis reaction control, bidirectional flow, tubing architecture, and automated solid-phase extraction, and operates the registered trademarks Biolytic, Dr. Oligo, Dr. Oligo by Biolytic, Controlled Flow, and VVV. The company is led by CEO James Demmitt and operates without disclosed venture capital, M&A activity, or external funding rounds.

Name

Biolytic Lab Performance

Legal name

Biolytic Lab Performance, Inc.

Website

https://biolytic.com

Company type

Private

Founded year

1993

Operating status

Operating

Headcount range

11–50 employees

Short description

Biolytic Lab Performance is a privately held Fremont, California manufacturer of Dr. Oligo DNA, RNA, and peptide oligonucleotide synthesizers and post-synthesis processing instruments, serving pharmaceutical, biopharmaceutical, academic, government, and CDMO customers worldwide via direct US sales and an international distributor network.

Ownership category

akta.pro rank

Product category

Oligonucleotide Synthesizers

NAICS

Analytical Laboratory Instrument Manufacturing (334516), Electronic and Precision Equipment Repair and Maintenance (811210)

SIC

Laboratory Analytical Instruments (3826), Laboratory Apparatus & Furniture (3821)

akta.pro primary industry

Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF)

akta.pro secondary industries

RNA Manufacturing & CMC (oligo synthesis, IVT, purification, formulation, QC) (HLAAADAF), mRNA & Nucleic Acid Manufacturing Services (mRNA/saRNA/Plasmid DNA) (HLAGAGAC)

Keywords

• DNA oligonucleotide synthesizers
• RNA synthesis instruments
• Peptide synthesis equipment
• Oligo synthesis consumables
• Laboratory instrument manufacturing

Headquarters

HQ city

Fremont

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Oligonucleotide Synthesizer Sales: Sale of DNA/RNA/peptide oligonucleotide synthesizers including Dr. Oligo 12, 48, 192XLc, and 768XLc instruments. Instruments are highly customizable with prices varying based on configuration. Direct sales for domestic customers.
2. Synthesis Consumables: Sale of synthesis consumables including columns, plates, molecular traps, filters, and reagents. Quality-tested consumables for oligo synthesis.
3. Parts and Upgrades: Replacement parts, valve assemblies, tubing, fittings, and instrument upgrades. Parts catalog available online with pricing for logged-in users. Average annual maintenance cost estimated at 6-12% of instrument list price.
4. Service Plans: Instrument service plans including PTS (Parts and Technical Support), PLT (Parts Labor and Travel) warranty. New instruments include 12-month PTS warranty. IQ/OQ/PM qualification services available.
5. Certified Pre-Owned Equipment: Sale of refurbished Dr. Oligo synthesizers and accessories at reduced cost. Each instrument undergoes rigorous testing and reconditioning.

Pricing tiers

Go-to-market motion1 record

Distribution channels4 records

Marketing channels6 records

Core offering

Biolytic Lab Performance designs, manufactures, and services DNA, RNA, and peptide oligonucleotide synthesizers under the Dr. Oligo brand, with throughput ranging from 12 to 768 oligos per run. The company offers an end-to-end synthesis workflow including synthesizers, post-synthesis processors, synthesis consumables, replacement parts, and instrument service plans, all built in Fremont, California.

Product overview

Biolytic Lab Performance, Inc. offers a comprehensive portfolio of oligonucleotide synthesis instruments and services centered around the Dr. Oligo line of DNA/RNA synthesizers. The product range spans from low-throughput (Dr. Oligo 12, synthesizing 12 oligos per run) to ultra-high-throughput systems (Dr. Oligo 768XLc, synthesizing 768 oligos per run), complemented by the Dr. Oligo Processor for automated post-synthesis purification. The portfolio includes synthesis consumables (columns, plates, molecular traps), parts and upgrades for instrument maintenance, and support services including instrument service plans, training, and hardware qualifications (IQ/OQ/PM). Certified Pre-Owned instruments provide a cost-effective entry option. All instruments are manufactured in Fremont, California and support DNA, RNA, LNA, and various modified oligonucleotide synthesis.

Differentiator

Problem solved

Functional benefit

Brands

• Dr. Oligo: Product line of DNA/RNA oligonucleotide synthesizers and related instruments. Includes Dr. Oligo 12, Dr. Oligo 48, Dr. Oligo 192XLc, Dr. Oligo 768XLc, and Dr. Oligo Processor for automated downstream processing and purification.

Products and services

• Dr. Oligo 12 Low throughput DNA/RNA oligonucleotide synthesizer synthesizing 12 oligos per run at 5 nmol to 5 umol scale; supports DNA, RNA, LNA, 2'-Modified RNA, and mixed backbone synthesis with up to 42 reagents. Targeted at laboratories requiring entry-level or low-volume synthesis.
• Dr. Oligo 48 Medium throughput DNA/RNA oligonucleotide synthesizer synthesizing up to 48 oligos per run with up to 42 reagents; supports DNA, RNA, LNA, 2'-Modified RNA, and mixed backbone synthesis. Designed for laboratories requiring moderate synthesis capacity.
• Dr. Oligo 192XLc High throughput DNA/RNA oligonucleotide synthesizer synthesizing 192 oligos per run with up to 49 reagents; features an up/down flow system for enhanced synthesis efficiency. Supports DNA, RNA, LNA, 2'-Modified RNA, and mixed backbone synthesis at 5 nmol to 5 umol scale.
• Dr. Oligo 768XLc Ultra-high throughput DNA/RNA oligonucleotide synthesizer synthesizing 768 oligos per run with 25 reagents; supports synthesis scales from 2 nmol to 100 nmol and a broad range of chemistries including DNA, RNA, LNA, 2'-Modified RNA, and mixed backbones.
• Dr. Oligo Processor Automated post-synthesis instrument for desalting and oligonucleotide purification via OPC cartridges; fully automated operation with up to 96 oligos purified per run and dispensing of up to 8 reagents in 96-well plate format; can also perform solid phase extraction from solid supports. Compatible with OPC cartridges from Glen Research, Biosearch, Phusa Chem, and Varian.
• Heated Pressure Chamber Accessory for single operation cleave and deprotect that applies heat and pressure in an accurate and controlled manner; available in 1 gallon size with 120 VAC and 130 psi capacity, with pressure vessel certified to ASME BPVC Section VIII, Division 1 - UM.
• Synthesis Consumables Quality-tested synthesis consumables including columns, plates, molecular traps, filters, and other reagents used during oligonucleotide synthesis to ensure consistent oligo output.
• Parts & Upgrades Replacement parts and upgrade kits for Dr. Oligo synthesizers and other laboratory equipment, including valves, manifolds, tubing, seals, gaskets, fittings, sensors, and electronic components.
• Instrument Service Plans Comprehensive instrument service packages including Parts and Technical Support (PTS) and Parts, Labor and Travel (PLT) warranties, preventative maintenance, and repair services. New instruments include a 12-month PTS warranty, with rebuilt instruments covered by a 90-day warranty.
• End-to-End Oligo Synthesis Training Training services covering complete oligo synthesis workflows, chemistry processes, and post-synthesis operations for laboratory staff.
• Instrument Hardware Qualifications (IQ/OQ/PM) Installation Qualification (IQ), Operational Qualification (OQ), and Preventative Maintenance (PM) services designed to support regulatory compliance and laboratory readiness for regulated environments.
• Certified Pre-Owned Instruments Rigorously tested, inspected, and reconditioned pre-owned Dr. Oligo synthesizers and accessories offering the same precision, reliability, and efficiency as new instruments at a lower cost.

Quantifiable outcome

• Synthesis throughput ranging from 12 to 768 oligos per run depending on instrument model
• +1 more outcomes

Named customers9 records

Segments5 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

Feature6 records

Partnerships

Two partnerships are on record, tiered core and minor.

• International DistributorscoreChannel Partner/ Reseller/ DistributorGlobal network of distributors for international sales. Distributors sell and support Biolytic products in regions outside the US. Contact [email protected] to apply for distributorship.
• FedExminorOthersPrimary shipping carrier for small to medium packages (FedEx Express, Ground, Home Delivery) and large packages/instruments (FedEx Freight).

Scale indicators3 records

Recent moves6 records

Expansion highlights6 records

Market position

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/biolytic
• YouTubeyoutube.com/c/biolytic
• Facebookfacebook.com/Biolytic
• LinkedInlinkedin.com/company/biolytic
• Instagraminstagram.com/biolytic_

Compliance8 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Biolytic Lab Performance