What Analytical Scientific Instruments does

Analytical Scientific Instruments (ASI), legally registered as Analytical Scientific Instruments US, Inc., is a privately held US manufacturer of high-specification HPLC (High-Performance Liquid Chromatography) and UHPLC (Ultra High Performance Liquid Chromatography) replacement parts and fluidics components. The company designs and manufactures flow splitters, static and dynamic mixers, solvent delivery pumps (isocratic, gradient, metering, syringe, prep, and pilot scale), pulse dampers, precolumn and in-line filters, check valves, guard column hardware, post-column reactor modules, and biolistic supplies from its Richmond, California facility. Products are engineered for demanding analytical through preparative flow ranges, with technical specifications including pump accuracy of ±1% or 1-2 µL/min, pressures up to 15,000 PSI for UPLC applications, and biocompatible PEEK variants for metal-free fluid paths.

ASI's product portfolio is designed for compatibility with HPLC instruments from 30+ major manufacturers including Agilent, Waters, Shimadzu, ThermoFisher, Beckman, Hitachi, Jasco, Varian, and Perkin-Elmer. The company generates revenue through direct e-commerce sales of replacement components and complete fluidics subsystems, with individual parts priced from $26 (replacement filter disks) to $135 (precolumn filter assemblies) and complete pump systems sold on a quote basis. Customers include bench scientists and researchers needing to maintain equipment uptime, third-party HPLC service repair companies, and HPLC OEMs seeking outsourced component manufacturing.

The company operates as a direct-to-consumer B2B supplier, with orders placed through the ASI website, by phone (1-800-344-4340), or email. Marketing relies on organic SEO-driven discovery of the structured online catalog, with no disclosed distributor network, third-party sales channels, or external funding. The company is privately held with no disclosed parent company, subsidiaries, or external investment, suggesting founder or family ownership. No management team, patents, awards, or regulatory actions are disclosed in available data.

Name

Analytical Scientific Instruments

Legal name

Analytical Scientific Instruments US, Inc.

Website

https://hplc-asi.com

Company type

Private

Operating status

Operating

Headcount range

11–50 employees

Short description

Analytical Scientific Instruments (ASI) is a privately held US manufacturer of high-specification HPLC and UHPLC fluidics replacement parts, including flow splitters, mixers, pumps, and filters, sold direct via e-commerce to scientists, service repair companies, and HPLC OEMs.

Ownership category

akta.pro rank

Product category

Laboratory Chromatography Components

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Analytical Instruments (3826)

akta.pro primary industry

Analytical Instruments & Chromatography Systems (HLAGAIAA)

Keywords

• HPLC replacement parts
• Chromatography fluidics components
• UHPLC solvent pumps
• Laboratory instrument filters
• HPLC check valves

Headquarters

HQ city

Richmond

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Personnel, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. HPLC/UHPLC Component Sales: ASI generates revenue through the direct sale of HPLC replacement parts and complete fluidics systems. Products include flow splitters, mixers, pumps, filters, check valves, pulse dampers, and related accessories. The company sells to scientists, service repair companies, and HPLC OEMs through an e-commerce platform with phone and email support. Individual components range from replacement frits ($26-$140) to complete pump systems (contact for pricing).

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels4 records

Core offering

Analytical Scientific Instruments designs, manufactures, and sells high-specification HPLC and UHPLC replacement parts and complete fluidics systems. The catalog includes flow splitters, static and dynamic mixers, solvent delivery pumps, precolumn and in-line filters, pulse dampers, check valves, guard column hardware, and post-column reactor modules. Products are made in the USA at the Richmond, California facility and are designed for compatibility with HPLC instruments from 30+ manufacturers.

Product overview

Analytical Scientific Instruments (ASI) is a manufacturer of high-specification HPLC and UHPLC replacement parts and components. The product portfolio centers on chromatography fluidics components including Flow Splitters (Fixed, Adjustable, Automated, Makeup-Flow types), Mixers (Static and Dynamic variants including Standard HPLC, Ultra HPLC, High Temperature, and Biocompatible PEEK), Pumps (Syringe Pumps, HPLC/UHPLC Pumps including Metering Pump 561, Isocratic Model 541, Model 540G Gradient Systems, High Temperature Metering Pumps, Star Prep and Pilot Pumps), Filters (UltraShield, ColumnShield, In-line, Direct Connect, High Capacity, and Solvent Filters in various materials including SST and Titanium), and ancillary components (Pulse Dampers, Check Valves, Guard Column Hardware, Post-Column Reactors, Biolistic Supplies, Fittings, and Metering Valves). ASI also offers extensive pump replacement parts compatible with instruments from Agilent, Waters, Shimadzu, ThermoFisher, Dionex, Beckman, Hitachi, and other major HPLC manufacturers. The company serves scientists, service repair companies, and HPLC OEMs with products designed for demanding analytical applications.

Differentiator

Problem solved

Functional benefit

Products and services

• Flow Splitters Fixed, Adjustable, Automated, and Makeup-Flow Splitters for LC/MS applications, including post-column and pre-column configurations for analytical, semi-preparative, and preparative flows. Used by scientists and service companies performing mass-directed fraction collection and LC/MS workflows.
• Static and Dynamic Mixers Static and dynamic mixers including Standard HPLC, Ultra HPLC, High Temperature, and Biocompatible PEEK variants designed to reduce delay volume and baseline noise. Used in HPLC and UHPLC solvent delivery and gradient systems.
• Syringe Pumps Infusion Syringe Pump and High Pressure 576 Syringe Pumps with integral drive/controller for fluidics experiments. Custom OEM design available. Used by researchers and OEMs requiring precise low-volume fluid delivery.
• HPLC & UHPLC Solvent Delivery Pumps Solvent delivery systems including Metering Pump 561, Isocratic Model 541, and Model 540G Gradient Systems with stainless steel, titanium, and biocompatible PEEK head options. Used for gradient and isocratic HPLC/UHPLC solvent delivery in research and production labs.
• High Temperature Metering Pumps Model 541 and Model 551 High Temperature Metering Pumps designed for elevated temperature HPLC applications. Used in laboratories requiring heated solvent delivery for high-temperature chromatography.
• 545 Star Prep Pumps Star Prep Pumps with flow rates of 150 mL/min, 250 mL/min, 500 mL/min, and 1,500 mL/min for preparative chromatography. Used in scale-up and preparative purification workflows.
• 546 Star Pilot Pumps Pilot-scale chromatography pumps for larger throughput applications. Used in pilot-scale purification and process chromatography.
• UltraShield HPLC/UHPLC Precolumn Filters UHPLC Direct-connect pre-column filters with 0.5 and 2 micron frit options for column protection. Used by laboratories to protect UHPLC columns from particulate contamination.
• ColumnShield HPLC FingerTight Precolumn Filters FingerTight precolumn filters for easy installation and column protection. Used by laboratories needing tool-free filter replacement.
• In-line HPLC/UHPLC Precolumn Filters Precolumn filters available in 0.2, 0.5, 2, and 5 micron porosity options for column protection. Used to extend HPLC column lifetime in routine analytical workflows.
• Direct Connect HPLC/UHPLC Precolumn Filters Direct connect precolumn filters for UHPLC applications with multiple frit sizes. Used to protect UHPLC columns in high-pressure analytical systems.
• High Capacity In-Line Filters High capacity filters rated to 6,000 PSI (standard) or 15,000 PSI (UHPLC) with 2.2 cm² filter area. Used for high-throughput and high-pressure chromatography filtration.
• In-Line Filters Compact in-line filters with minimal system volume, available in 0.2 to 20 micron porosity. Used for low-dead-volume inline filtration in HPLC systems.
• Solvent Filters Pump intake solvent filters including 10 and 20 micron options, with biocompatible PTFE and PEEK mesh variants. Used to protect HPLC pumps from solvent particulates.
• Pulse Dampers Rupture-proof diaphragm dampers for HPLC/UHPLC including Standard HPLC, UHPLC, and Biocompatible options; custom design available for OEM applications. Used to reduce pump pulsation in HPLC solvent delivery systems.
• In-line Check Valves Slim-Line and standard ball cartridge check valves for HPLC/UHPLC applications, including high temperature and SFC variants. Used to ensure unidirectional solvent flow in HPLC pumps.
• Direct Connect Guard Column Hardware Guard column hardware in 5mm, 7mm, 10mm, and 20mm lengths for HPLC/UHPLC. Used to hold guard columns that protect analytical columns from contamination.
• Post-Column Reactor Modules Reactor modules available in Stainless Steel or Biocompatible PEEK for post-column derivatization. Used in post-column reaction detection workflows.
• Biolistic Supplies Gene gun/supply products including Carrier Discs, Rupture Discs, Stopping Screens, Gold Particles, and Tungsten Particles. Used by life-science researchers for biolistic particle delivery.
• Fittings & Unions HPLC fittings and union connectors for system plumbing. Used to connect HPLC fluid paths and components.
• Metering Valves Precision metering valves for flow control applications. Used in HPLC and fluidics systems requiring precise flow adjustment.
• Pump Replacement Parts Replacement parts and check valves for pumps from major manufacturers including Agilent, Waters, Shimadzu, ThermoFisher, Dionex, Beckman, and many others. Used by service companies and laboratories to repair third-party HPLC pumps.
• Check Valves for OEM OEM check valves for original equipment manufacturers. Used by HPLC instrument OEMs integrating ASI check valves into their products.

Quantifiable outcome

• Pump accuracy of ±1% or 1-2 µL/min depending on model
• +3 more outcomes

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Scale indicators2 records

Recent moves3 records

Expansion highlights3 records

Direct peers

• Optimize Technologies: Optimize Technologies manufactures HPLC and UHPLC replacement components including filters, fittings, and solvent management products. It is the closest direct competitor to ASI in the aftermarket HPLC fluidics space, serving the same scientist and service-repair segments with compatible parts for major OEM instruments.
• VICI Valco Instruments: VICI Valco Instruments produces precision fluidics components for HPLC and GC including valves, fittings, and pulse dampers. It directly overlaps with ASI's check valves, fittings, and pulse damper product lines and serves a similar analytical chemistry customer base.
• IDEX Health & Science: IDEX Health & Science (including the legacy Upchurch Scientific and Rheodyne brands) manufactures HPLC fluidics components such as check valves, fittings, and pump heads. It is a direct competitor in the OEM and aftermarket HPLC fluidics market and operates at considerably larger scale than ASI.
• Trajan Scientific and Medical: Trajan (formerly SGE Analytical Science) manufactures HPLC and GC consumables including syringe filters, fittings, and columns. It overlaps with ASI's fittings, filters, and consumable accessories and targets the same analytical laboratory customers.
• Restek Corporation: Restek manufactures HPLC columns, accessories, and consumables for analytical chemistry laboratories. It is a relevant peer in the broader HPLC consumables ecosystem that ASI serves, though Restek is significantly larger and more diversified into columns and standards.
• Phenomenex: Phenomenex (a Danaher operating company) manufactures HPLC columns, guards, and consumables used in analytical chemistry laboratories. It is comparable to ASI as a supplier to the same HPLC-using customer base, with stronger focus on column hardware and consumables versus ASI's fluidics focus.

Broad incumbents

• Agilent Technologies: Agilent is a leading manufacturer of HPLC and UHPLC instrument systems and operates a large captive parts and consumables business. It is a broad incumbent whose OEM parts channel directly competes with ASI's compatible aftermarket components for Agilent instruments.
• Waters Corporation: Waters is a major HPLC and UHPLC instrument manufacturer with a strong captive parts and consumables business. It is a broad incumbent relevant to ASI as both a competitor in replacement parts and a partner as an OEM customer for fluidics components.
• Shimadzu Scientific Instruments: Shimadzu manufactures HPLC systems and instruments with a broad captive parts channel. It competes with ASI on aftermarket parts for Shimadzu instruments and is also a potential OEM customer for ASI fluidics components.
• Thermo Fisher Scientific: Thermo Fisher manufactures HPLC and Dionex chromatography systems along with associated consumables. It is a broad incumbent whose parts business overlaps with ASI and whose instruments represent one of ASI's largest compatibility targets.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/analytical-scientific-instruments-us-inc.

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Analytical Scientific Instruments