What rPeptide does

rPeptide is a privately held biotechnology supplier founded in 1999 and headquartered in Watkinsville, Georgia. The company specializes in the recombinant production of hard-to-express peptides and proteins for neurodegenerative disease research, with a primary focus on Alzheimer's, Parkinson's, and related disorder applications. Its core product portfolio comprises preformed fibrils (Beta-Amyloid, Alpha-Synuclein, Tau-441 and a multi-protein ABT Complex), research antibodies, recombinant peptides and proteins (including Apolipoprotein E isoforms, Calmodulin, Tubulin), research kits, small molecule compounds, and SARS-CoV-2 research tools.

The company's underlying technology platform centers on E. coli-based recombinant protein expression combined with proprietary fibrillization methods validated through transmission electron microscopy and thioflavin fluorescence assays. It offers uniform C13 and N15 isotope labeling for NMR structural studies, FITC fluorescent labeling via lysine residues, and a rigorous batch-to-batch consistency standard. Product purity thresholds are documented at >97% (Beta-Amyloid PFFs), >95% (Alpha-Synuclein PFFs), and >90% (Tau-441 PFFs) by SDS-PAGE or mass spectrometry. Beyond catalog sales, rPeptide operates custom synthesis and bulk production services for molecular biology, protein expression, and purification projects.

Commercially, rPeptide runs a direct-to-consumer e-commerce model through rpeptide.com, supplemented by an international distributor network and a content-marketing engine built around a curated peer-reviewed publications/citations database. The customer base consists of academic and industry research laboratories worldwide, with product prices ranging from approximately $57 to over $4,800 per unit. Revenue streams are predominantly one-time reagent sales alongside contract custom synthesis work. The firm operates as a Georgia LLC with no disclosed institutional investors, parent company, or acquisition activity.

Name

rPeptide

Legal name

rPeptide, LLC

Website

https://rpeptide.com

Company type

Private

Founded year

1999

Operating status

Operating

Headcount range

11–50 employees

Short description

rPeptide is a Georgia-based biotechnology supplier founded in 1999 that provides recombinant peptides, proteins, preformed fibrils, antibodies, and custom synthesis services for Alzheimer's, Parkinson's, and neurodegenerative disease research laboratories worldwide via direct e-commerce and distributors.

Ownership category

akta.pro rank

Product category

Biotechnology Research Reagents

NAICS

Biological Product (except Diagnostic) Manufacturing (325414), Research and Development in Biotechnology (except Nanobiotechnology) (541714)

SIC

Biological Products, (No Disgnostic Substances) (2836), Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Reagents, Chemicals & Assay Kits (Buffers, Antibodies, ELISA, Enzymes) (HLAGAIAI)

akta.pro secondary industry

Protein Engineering & Directed Evolution Platforms (enzyme/therapeutic protein optimization) (HLAAAIAC)

Keywords

• Recombinant protein reagents
• Preformed fibrils
• Neurodegenerative disease research
• Research grade peptides
• Isotope labeled proteins

Headquarters

HQ city

Bogart

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Supply Chain, Operations, Personnel, Marketing or Sales, Infrastructure

Revenue model

1. Research Reagent Sales: One-time product sales of recombinant peptides, proteins, antibodies, preformed fibrils, and kits to academic and industry research laboratories. Products are sold in various sizes with tiered pricing based on quantity.
2. Custom Services: Contract services including custom peptide and protein synthesis, molecular biology, protein expression and purification, and bulk production requests.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels4 records

Core offering

rPeptide manufactures and sells research-grade recombinant peptides, proteins, preformed fibrils, antibodies, kits, and SARS-CoV-2 reagents, primarily for Alzheimer's, Parkinson's, and broader neurodegenerative disease research. The firm also offers contract services for custom peptide/protein synthesis, recombinant expression and purification, bulk production, and uniform C13 and N15 isotope labeling. Products are sold direct through rpeptide.com and via international distributors to academic and industry laboratories worldwide.

Product overview

rPeptide is a USA-based recombinant peptide and protein company specializing in hard-to-express protein synthesis for Alzheimer's, Parkinson's, and neurodegenerative disease research. The product portfolio centers on research-grade recombinant reagents including: Preformed Fibrils (PFFs) such as Beta-Amyloid (1-42), Alpha-Synuclein, and Tau-441 PFFs, plus the ABT Fibril Complex combining all three; Antibodies including Beta-Amyloid (7E7, 6C2), Tau (1A6, 4G11), and Alpha-Synuclein (5G4, 10D2, 10C3, Pab 63) antibodies; Kits including Tau Starter Kit, Beta-Amyloid Starter Kits (with multiple counter-ions), Aggregation Kits, and Antibody & Peptide combination kits; Proteins including Synucleins (Alpha, Beta), Apolipoproteins (ApoE2, E3, E4, ApoA-1, Apo-D, Apo-SAA), Calmodulin, Tubulin, and Myeloperoxidase; Coronavirus Research Tools including SARS-CoV-2 Spike Proteins (various forms), Nucleoprotein, proteases (3C-like Proteinase, Papain-Like Protease), ACE2, and small molecule inhibitors; and small molecule compounds for research. Services include Custom Peptides & Proteins (with C13/N15 isotope labeling), Lab Services, and Bulk Production. The company emphasizes batch-to-batch consistency, purity, and dependable long-term supply for academic and industry laboratories.

Differentiator

Problem solved

Functional benefit

Products and services

• Beta-Amyloid (1-42) Preformed Fibrils Recombinant human Beta-Amyloid (1-42) expressed in E. coli and assembled into preformed fibrils (>97% purity by mass spec), sold frozen at 4 mg/mL for aggregation studies, seeding experiments, fibril stability work, and preformed fibril injection studies in Alzheimer's disease research.
• Alpha-Synuclein Preformed Fibrils Recombinant human Alpha-Synuclein expressed in E. coli and formed into preformed fibrils (>95% purity by SDS-PAGE), sold frozen at 10 mg/mL for Parkinson's Disease, Lewy Body Dementia, and other synucleinopathy research applications including aggregation studies and seeding experiments.
• Tau-441 Preformed Fibrils Recombinant human full-length Tau-441 (2N4R isoform) expressed in E. coli and assembled into preformed fibrils (>90% purity by SDS-PAGE), sold frozen at 2 mg/mL as a neurofibrillary tangle model for Alzheimer's disease research.
• ABT Fibril Complex (Alpha-Synuclein + Beta-Amyloid 1-42 + Tau-441) Pre-formed complex combining Alpha-Synuclein, Beta-Amyloid (1-42), and Tau-441 fibrils as a model for pathogenic amyloid plaques and Tau NFTs in Alzheimer's Disease research, sold in volume tiers up to $4,800.
• FITC Tau-441 Preformed Fibrils FITC-labeled recombinant human Tau-441 covalently tagged with fluorescein isothiocyanate and then formed into fibrils, intended as fluorescent controls in aggregation kinetics, fibril morphology, seeding experiments, and in vivo imaging studies.
• FITC Alpha-Synuclein Preformed Fibrils FITC-labeled recombinant human Alpha-Synuclein covalently labeled with fluorescein isothiocyanate and formed into fibrils, sold in 200 mM Tris / 250 mM NaCl (pH 7.4) for aggregation kinetics, fibril morphology, and seeding experiments.
• FITC Beta-Amyloid (1-42) Preformed Fibrils FITC-labeled recombinant human Beta-Amyloid (1-42) covalently labeled with fluorescein isothiocyanate and assembled into fibrils, designed as fluorescent controls for aggregation kinetics, fibril morphology, seeding experiments, and in vivo imaging.
• Alpha-Synuclein 98AA Preformed Fibrils Alpha-Synuclein 98AA splicing variant (lacking exons 3 and 5) recombinantly expressed in E. coli and formed into fibrils, sold in 200 mM Tris / 250 mM NaCl (pH 7.4) with >95% purity for synucleinopathy research.
• Anti-Human Alpha-Synuclein 5G4, Monoclonal Antibody Mouse monoclonal antibody specific for human Alpha-Synuclein, validated for ELISA, Western blot, and immunohistochemistry, sold in size tiers from 100 µg to 1.0 mg.
• Anti-Human Alpha-Synuclein 10D2, Monoclonal Antibody Mouse IgG monoclonal antibody specific for human Alpha-Synuclein, validated for ELISA, Western blot, and immunohistochemistry applications.
• Anti-Human Alpha-Synuclein 10C3, Monoclonal Antibody Mouse monoclonal antibody specific for human Alpha-Synuclein, validated for ELISA, Western blot, and immunohistochemistry applications.
• Anti-Human Alpha-Synuclein Pab 63, Polyclonal Antibody Rabbit polyclonal antibody purified from rabbit antiserum and tested against human Alpha-Synuclein, validated in ELISA, Western blot, and immunohistochemistry applications.
• Beta-Amyloid 7E7 Antibody & BA(1-42) Kit Kit containing Beta-Amyloid 7E7 monoclonal antibody (BA-1001, which binds Beta-Amyloid 1-42 and 1-40) and Beta-Amyloid (1-42) NH4OH reagent, priced $200 to $1,685 across size options for Alzheimer's research.
• Beta-Amyloid 6C2 Antibody & BA(1-42) Kit Kit combining Beta-Amyloid 6C2 monoclonal antibody (BA-2001, which binds Beta-Amyloid 1-42 and 1-40) with Beta-Amyloid (1-42) NH4OH reagent for Alzheimer's research applications.
• Tau 1A6 Antibody Kit Kit containing the rPeptide-exclusive Tau-1A6 (TA-1001) mouse monoclonal antibody that binds all six Tau isoforms, intended for isoform identification, qualitative analysis, and expression level monitoring.
• Tau 4G11 Antibody Kit Kit containing the Tau-4G11 (TA-1001) mouse monoclonal antibody that binds four of the six Tau isoforms (Tau-381, Tau-410, Tau-412, and Tau-441).
• Tau Starter Kit (all six Tau isoforms) All-in-one starter kit containing all six recombinant Tau isoforms (Tau-441, Tau-412, Tau-410, Tau-381, Tau-352, plus one additional isoform) expressed in E. coli for Tau isoform comparison and expression studies.
• Beta-Amyloid (1-42) Starter Kit Starter kit of recombinant Beta-Amyloid (1-42) provided in each available counter-ion (TFA, HFIP, HCl, NaOH, and NH4OH), priced $730 to $1,275 for side-by-side aggregation experiments.
• Beta-Amyloid (1-40) Starter Kit Starter kit of recombinant Beta-Amyloid (1-40) supplied in each counter-ion formulation (TFA, HFIP, HCl, NaOH, and NH4OH) for aggregation and counter-ion comparison studies.
• Beta-Amyloid (1-42) Aggregation Kit Aggregation kit including Beta-Amyloid (1-42) in NH4OH counter-ion plus reagents to initiate and detect aggregation through thioflavin fluorescence assay, used for aggregation kinetics, aggregate stability studies, and therapeutic models.
• Beta-Amyloid (1-40) Aggregation Kit Aggregation kit including Beta-Amyloid (1-40) in NH4OH counter-ion plus reagents to initiate and detect aggregation through thioflavin fluorescence assay, used for aggregation kinetics and stability studies.
• N15 Beta-Amyloid (1-42), Uniformly Labeled N15 isotopically labeled recombinant Beta-Amyloid (1-42) expressed in E. coli using N15 as nitrogen source, supplied for NMR structural studies, molecular weight standards, and biomarker research.
• Alpha-Synuclein (1-140) Recombinant human Alpha-Synuclein (1-140) expressed in E. coli at >95% purity (by SDS-PAGE and mass spec), supplied in 20 mM Tris / 100 mM NaCl (pH 7.4) for aggregation studies and seeding experiments.
• Beta-Synuclein Recombinant human Beta-Synuclein expressed in E. coli, supplied in 20 mM Tris / 100 mM NaCl (pH 7.4) for aggregation studies and seeding experiments.
• ApoE3, Human Recombinant Recombinant human Apolipoprotein E3, a 34.3 kDa protein of 300 amino acids used in Alzheimer's disease research and studies of lipid metabolism.
• ApoE4, Human Recombinant Recombinant human Apolipoprotein E4, a 34.4 kDa protein of 300 amino acids; heterozygous carriers of the ApoE4 allele have increased risk of late-onset Alzheimer's disease.
• ApoE2, Human Recombinant Recombinant human Apolipoprotein E2; ApoE2 exhibits the lowest receptor binding affinity of the three major ApoE isoforms, useful for comparative apolipoprotein studies.
• ApoA-1, Human Recombinant Recombinant human Apolipoprotein A-I, a 28.2 kDa protein of 244 amino acids that is the predominant constituent of nascent high-density lipoprotein (HDL) particles.
• Tubulin, Porcine Native Tubulin purified from porcine brain tissue and supplied as the alpha/beta subunit dimer (1.0 mg size, $115) for assembly into protofilaments and microtubules for cytoskeletal research.
• Myeloperoxidase, Human Neutrophil Human neutrophil Myeloperoxidase, lyophilized from 50 mM sodium acetate (pH 6.0), supplied at 100 µg ($328) for studies linking inflammation and Parkinson's disease.
• Human Calmodulin 1 Recombinant human Calmodulin 1 expressed in E. coli, supplied as a ubiquitous calcium-binding protein that acts as a calcium sensor within cell signaling pathways.
• Calmodulin, Bovine Brain Calmodulin purified from bovine brain, supplied as a ubiquitous calcium-binding protein that mediates inflammation, metabolism, apoptosis, muscle contraction, and immune response processes.
• Calmodulin (CALM1) Human ELISA Kit Sandwich ELISA kit for the quantitative measurement of human Calmodulin in serum, plasma, and cell culture supernatants.
• SARS-CoV-2 Spike Protein (full-length) Full-length SARS-CoV-2 Spike Protein, a type I transmembrane glycoprotein containing S1 and S2 subunits that mediates viral entry via ACE2 binding, supplied for coronavirus research and ACE2 interaction studies.
• SARS-CoV-2 Spike Protein (Receptor Binding Domain) SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) supplied for coronavirus research, including ACE2 binding assays, neutralization studies, and viral entry experiments.
• SARS-CoV-2 Nucleoprotein SARS-CoV-2 Nucleoprotein that packages the positive-strand viral genome RNA into a helical ribonucleocapsid (RNP), supplied as a liquid for diagnostic and coronavirus biology research.
• Angiotensin-Converting Enzyme 2 (ACE2), Human Recombinant Recombinant human Angiotensin-Converting Enzyme 2 (ACE2) expressed in HEK 293 cells and supplied as liquid; ACE2 is the cellular contact point for many coronaviruses including SARS-CoV-2 and plays a role in blood pressure regulation.
• I-BET762 (BET Bromodomain Inhibitor) Potent inhibitor of the BET family of bromodomains that suppresses key inflammatory genes, releases proinflammatory cytokines, prevents acute inflammation, and downregulates Myc transcription; supplied as 5.0 mg or 25.0 mg ($95–$352).
• JQ1 (BRD3/BRD4 Inhibitor) Small-molecule inhibitor of Bromodomain and extraterminal family proteins BRD3 and BRD4, used in cancer studies, therapeutic design, and drug design applications.
• Bromosporine (pan-Bromodomain Inhibitor) Potent pan-Bromodomain (BRD) inhibitor that reactivates HIV-1 replication in latency models, inhibits myogenic differentiation, and synergizes with 5-fluorouracil in cancer studies.
• Camostat Mesylate (TMPRSS2 Inhibitor) Serine protease inhibitor that reduces infection of Calu-3 lung cells by SARS-CoV-2 via inhibition of TMPRSS2, the protease required for viral spike protein priming.
• Metformin (AMPK Activator) Clinically used antidiabetic agent that inhibits hepatic gluconeogenesis via the AMPK pathway and has been reported as neuroprotective, lowering alpha-synuclein phosphorylation in Parkinson's disease MPTP mouse models.
• Entacapone (COMT Inhibitor) Potent catechol O-methyltransferase (COMT) inhibitor used as L-DOPA adjunct therapy for Parkinson's disease and reported to inhibit alpha-synuclein aggregation in vitro.
• Custom Peptides & Proteins Contract Services Contract services for custom peptide and protein synthesis, including molecular biology, recombinant protein expression and purification, and uniform C13 and N15 isotope labeling of peptides and proteins for NMR and related structural studies.
• Lab Services (Custom Projects) Custom laboratory services for client research projects including bespoke protein synthesis, characterization, and related reagent preparation outside the standard catalog.
• Bulk Production Requests Bulk manufacturing services for large-scale peptide and protein production, accessed through the dedicated Bulk Quote service page for industrial, screening, or large-cohort use cases.

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Scale indicators2 records

Recent moves5 records

Expansion highlights5 records

Direct peers

• StressMarq Biosciences: Specializes in preformed fibrils (alpha-synuclein, tau, beta-amyloid) and antibodies for neurodegenerative disease research, directly competing with rPeptide in the same fibril and antibody product categories serving the same academic and pharma customers.
• GenScript: Global contract research organization offering custom peptide and recombinant protein synthesis services, including isotope labeling and hard-to-express proteins, competing head-to-head with rPeptide's Custom Peptides & Proteins and bulk production services.
• Anaspec (Kaneka): Custom peptide synthesis specialist with a research reagent catalog spanning neuroscience, including amyloid and tau peptides; targets the same academic/biopharma buyer and competes on custom synthesis, purity, and catalog depth for neurodegenerative research.
• Tocris Bioscience (Bio-Techne): Specialty supplier of small-molecule compounds and tool reagents for life science research with strong neuroscience and pharmacology coverage; competes with rPeptide's Neurodegenerative Related Compounds line for the same investigator budget.

Broad incumbents

• PeproTech (Thermo Fisher Scientific): Established manufacturer of recombinant proteins and cytokines with extensive catalog for life science research; now part of Thermo Fisher, providing broader reagent breadth but competing with rPeptide's recombinant protein and custom expression offering at scale.
• Abcam (Danaher): Leading research antibody supplier (with related recombinant proteins and kits) now within Danaher Life Sciences; overlaps with rPeptide on neurodegenerative antibodies (beta-amyloid, tau, synuclein) and competes for the same academic/pharma lab budget.
• Cell Signaling Technology (CST): Large research antibody and reagent manufacturer with strong presence in neuroscience and signaling pathway products; overlapping customer base in pharma and academia, and competes with rPeptide in the antibody and kit portion of the catalog.
• Santa Cruz Biotechnology: Established broad-line supplier of research antibodies, proteins, and small molecules, including neuroscience targets; competes with rPeptide on antibody and catalog reagent pricing and breadth in academic accounts.

Emerging players

• Synaptic Systems: Niche neuroscience-focused antibody company with deep coverage of synaptic and neurodegenerative markers (including alpha-synuclein, tau); adjacent competitor in the same academic neuroscience purchasing workflows.
• Cayman Chemical: Research-focused biochemical supplier offering inhibitors, antibodies, proteins, and assay kits with neuroscience and pharmacology content; competes with rPeptide's research compound and custom offerings for the same biotech/pharma research budgets.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat3 records

Key risks7 records

Key highlights7 records

Customer concentration

• Xx.com/rPeptideLLC
• LinkedInlinkedin.com/company/rpeptide

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about rPeptide