SigmaGraft

What SigmaGraft does

SigmaGraft Biomaterials, Inc. is a privately held U.S. manufacturer of dental and orthopedic biomaterials, founded in 2010 and operating from Brea, California (corporate headquarters at 450 Apollo St Ste B) and Fullerton, California (manufacturing facility at 575 Sally Place). The company designs, produces, and distributes bone graft substitutes, resorbable collagen membranes, synthetic bioceramics, wound dressings, and sutures used in guided bone regeneration (GBR), guided tissue regeneration (GTR), dental implantology, periodontal surgery, spinal fusion, and orthopedic trauma. Its portfolio spans allograft (SigmaOss), xenograft (InterOss), bone-collagen composites (InterOss Collagen), biphasic and tricalcium phosphate ceramics (BoneSigma BCP/TCP), resorbable collagen membranes (InterCollagen Guide), DBM products (AlloGen), active bone graft substitutes for spine (ExcellBone Active), sports medicine/trauma grafts (MaximOss), and wound dressings (SigmaPlug, SigmaTape).

Underlying technology centers on biomaterial scaffolds with controlled porous architecture (e.g., InterOss macropores of 40–60 μm and micro-channels ≤1.5 μm) designed to mimic natural trabecular bone and support osteoconduction. Manufacturing is vertically integrated in ISO Class 7 cleanroom environments under ISO 13485 certification, enabling both proprietary product lines and contract manufacturing services for other medical device companies.

SigmaGraft monetizes through one-time product sales across three channels: a direct e-commerce storefront (shop.sigmagraft.com), a dedicated customer service sales team, and a global distribution network serving more than 60 countries. The company also offers contract manufacturing for third-party dental, spine, and orthopedic device companies. Customer education and clinical faculty relationships (e.g., SigmaGraft Bone & Tissue Regeneration CE course, VISTA Institute programs) function as a marketing and brand-building layer rather than a direct revenue stream. Pricing is quote-based and not publicly disclosed; no revenue figures, funding rounds, or ownership disclosures are available in the source data, indicating an independent, likely founder-controlled private company.

Name

SigmaGraft

Legal name

SigmaGraft Biomaterials, Inc.

Website

https://sigmagraft.com

Company type

Private

Founded year

2010

Operating status

Operating

Headcount range

11–50 employees

Short description

SigmaGraft Biomaterials is a privately held U.S. manufacturer of dental and orthopedic biomaterials — bone grafts, resorbable membranes, synthetic bioceramics, and wound dressings — sold in more than 60 countries to clinicians through distribution, e-commerce, and contract manufacturing.

Ownership category

akta.pro rank

Product category

Medical Device Biomaterials

NAICS

Surgical Appliance and Supplies Manufacturing (339113), Dental Equipment and Supplies Manufacturing (339114), Biological Product (except Diagnostic) Manufacturing (325414), Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers (42345)

SIC

Orthopedic, Prosthetic & Surgical Appliances & Supplies (3842), Biological Products, (No Disgnostic Substances) (2836), Wholesale-Medical, Dental & Hospital Equipment & Supplies (5047)

akta.pro primary industry

Bone Graft Substitutes & Orthobiologics (Synthetic/Allograft/DBM) (HLAHAEAG)

akta.pro secondary industries

Cartilage, Bone & Musculoskeletal Regeneration (HLAAAGAH), Tissue-Engineered Constructs & Scaffolds (natural/synthetic biomaterials) (HLAAAGAB), Skin Substitutes & Biologic/Regenerative Wound Therapies (Matrices, Grafts) (HLAHALAE), Implant Prosthetics & Abutment Fabrication (HLABAJAC)

Keywords

• Bone graft substitutes
• Dental biomaterials
• Orthopedic regenerative products
• Resorbable collagen membranes
• Synthetic bioceramics

Headquarters

HQ city

Fullerton

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Personnel, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. Biomaterial Products: Sale of bone graft substitutes, collagen membranes, wound dressings, and related medical devices for dental and orthopedic applications. Products are sold directly through e-commerce and distribution network.

Pricing tiers

Go-to-market motion1 record

Distribution channels4 records

Marketing channels5 records

Core offering

SigmaGraft manufactures and sells biomaterial products for bone and tissue regeneration, including allograft and xenograft bone substitutes, bone-collagen composites, synthetic biphasic and tricalcium phosphate bioceramics, resorbable collagen membranes, wound dressings, and surgical sutures. These products are used by dental professionals and orthopedic surgeons for guided bone regeneration, ridge preservation, dental implant placement, sinus augmentation, periodontal defect treatment, spinal fusion, trauma surgery, and sports medicine. The company also offers contract manufacturing services to other medical device companies using its ISO Class 7 facilities.

Product overview

SigmaGraft Biomaterials is a manufacturer of biomaterials for dental and orthopedic surgeries specializing in bone and tissue regeneration products. The product portfolio includes allograft bone substitutes (SigmaOss™), xenograft bone grafts (InterOss®), bone-collagen composites, biphasic and tricalcium phosphate ceramics (BoneSigma™), resorbable collagen membranes (InterCollagen® Guide), wound dressings (SigmaPlug™, SigmaTape™), demineralized bone matrix (AlloGen™ DBM), and sutures. The company operates in dental (bone grafting, tissue regeneration, wound care) and orthopedic (spine, sports medicine/trauma) segments, selling products in over 60 countries worldwide.

Differentiator

Problem solved

Functional benefit

Brands

• InterOss: Anorganic cancellous bone graft granules derived from bovine source, featuring naturally interconnected porous architecture for osteoconductive scaffold in guided bone regeneration.
• InterOss Collagen
• InterCollagen Guide
• SigmaOss
• BoneSigma
• AlloGen
• ExcellBone Active
• SigmaPlug
• SigmaTape

Products and services

• SigmaOss™

Quantifiable outcome

• Products registered and sold in more than 60 countries worldwide

Named customers8 records

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

Three partnerships are on record, tiered core and minor.

• Leading Universities (Research Collaborations)coreStrategic or Co-development PartnerSigmaGraft has established close partnerships with several leading universities for research and development. These collaborations provide access to cutting-edge research and technology, allowing the company to work alongside leading minds in the biomaterials field. Research has been published in several renowned, prestigious journals.
• VISTA InstitutecoreStrategic or Co-development PartnerSigmaGraft partners with VISTA Institute for dental education programs. Joint program on Management of Implant Functional and Esthetic Complications scheduled for July 11-12, 2026 in Woodland Hills, CA, featuring multiple clinicians and offering 16 CE units.
• EAO (European Association for Osseointegration)minorGTM or Marketing PartnerSigmaGraft Industry Forums at EAO Congress 2026 in Lisbon, Portugal featuring Dr. Hom-Lay Wang discussing advancements in bone regeneration and implant therapy.

Scale indicators3 records

Recent moves5 records

Expansion highlights5 records

Broad incumbents

• Stryker: Stryker's orthobiologics portfolio includes Vitoss synthetic bone graft, OP-1 putty, and various allograft products. Comparable as a broad incumbent selling bone graft substitutes into orthopedic, spine, and trauma channels overlapping with SigmaGraft's orthopedic segment.
• Medtronic (Spine & Biologics): Through its Spine & Biologics division, Medtronic offers Infuse (rhBMP-2), Grafton DBM, and Mastergraft synthetic bone grafts. Directly comparable in orthopedic spine and trauma bone graft substitutes where SigmaGraft's AlloGen DBM and BoneSigma TCP compete.
• Zimmer Biomet: Major orthopedic and dental medical device company offering RegenerOss bone graft substitutes and dental implant solutions. Comparable because it sells allograft, xenograft, and synthetic bone grafts into the same dental and orthopedic surgical call points.
• Dentsply Sirona: Global dental equipment and consumables leader with bone graft substitute offerings (e.g., Symbios) and the largest installed base in dental practices. Comparable as a broad incumbent in the dental regenerative materials space.

Direct peers

• NovaBone Products: Specialist manufacturer of synthetic bioactive glass and calcium phosphate bone graft substitutes (NovaBone IRM, NovaBone Morsels). Direct peer for SigmaGraft's BoneSigma BCP/TCP ceramic lines in dental and orthopedic bone regeneration.
• Geistlich Pharma: The global leader in dental bone regeneration (Bio-Oss xenograft, Bio-Gide membrane). Direct peer with overlapping product portfolio in dental bone graft substitutes and resorbable collagen membranes serving periodontists, oral surgeons, and implantologists worldwide.
• Biomatlante: French specialist in synthetic bone graft substitutes (MBCP biphasic calcium phosphate). Direct peer for SigmaGraft's bioceramic bone substitutes with comparable technology positioning in dental and orthopedic bone regeneration.
• BioHorizons (Henry Schein): Dental implant company with a regeneration portfolio including MinerOss xenograft and allograft bone substitutes plus resorbable membranes. Direct peer in dental bone grafting and tissue regeneration products sold through the same implantology channel.
• ACE Surgical Supply: US-based dental surgical supply company offering bone graft materials, membranes, and regenerative products to periodontists and oral surgeons. Comparable mid-size peer with overlapping dental bone graft and tissue regeneration catalog.

Emerging players

• Collagen Matrix / Collagen Solutions: Specialist manufacturer of collagen-based medical devices including dental membranes and bone graft substitutes. Comparable as a focused player in the collagen/membrane niche where SigmaGraft's InterCollagen Guide competes.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

• YouTubeyoutube.com/@sigmagraft
• Facebookfacebook.com/sigmagraft
• LinkedInlinkedin.com/company/sigmagraft
• Instagraminstagram.com/sigmagraft
• Xx.com/sigmagraft

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about SigmaGraft