What KaryoLogic does

KaryoLogic Inc. is a specialty cytogenetics laboratory founded in 2008 in Durham, North Carolina (Research Triangle Park) by cytogeneticist Elizabeth Gonzalez, and acquired in April 2025 by Clean Cells, part of the Clean Biologics group, where it now operates as a US-based subsidiary. The company provides chromosome analysis and biosafety testing services to academic research institutions, government laboratories, and biopharmaceutical and cell therapy developers working with human pluripotent stem cells, other human cells, and a range of non-human species (mouse, rat, pig, dog, cat, Chinese hamster, sheep, chicken).

Its core technical offering is G-band karyotyping — brief cell culture, metaphase arrest, fixation, banded slide preparation, and microscope-based analysis of 20 metaphase spreads per sample — offered in Standard and Complex tiers, with the latter including two representative images and a per-chromosome Excel table. The differentiator is the Duo iCS-Karyo package, which combines G-band karyotyping with a 24-probe digital PCR assay (run in partnership with Stem Genomics) covering the most common abnormalities in hPSCs, including the chromosome 20q11.21 amplification that is too small to detect by G-band alone. Adjacent services include Fluorescence In Situ Hybridization (FISH), non-human species karyotyping, and — launched in 2025 — microbiology and viral safety testing (sterility, mycoplasma detection by qPCR covering 120+ strains, and HIV/HTLV/HBV/HCV qPCR screening). Work is performed in a GLP-compliant environment for RUO workflows; GMP-grade release testing and advanced assays (retrovirus, RCAAV, RCL, TEM) are routed through Clean Cells France.

The business model is B2B professional services: quote-based unit pricing per sample, with academic, non-profit, government, and volume discounts, plus fees for rush turnaround, additional images, additional spreads, cryopreserved-sample handling, and add-on digital PCR. Customer acquisition is direct and unscaled — website quote request, order form, email, and free local courier pickup across Durham, Wake, and Orange County NC, with overnight shipping for global clients. With 1-10 employees, no disclosed revenue, and no funding rounds on record, KaryoLogic is a niche specialist lab whose growth and reach now depend on integration into the Clean Biologics platform.

Name

KaryoLogic

Legal name

KaryoLogic Inc.

Website

https://karyologic.com

Company type

Private

Founded year

2008

Operating status

Operating

Headcount range

1–10 employees

Short description

KaryoLogic is a Durham, NC specialty cytogenetics lab offering G-band karyotyping, FISH, digital PCR (Duo iCS-Karyo with Stem Genomics), and biosafety testing for academic, government, and cell therapy clients; acquired by Clean Cells in April 2025.

Ownership category

akta.pro rank

Product category

Cytogenetic Testing Services

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714), Medical and Diagnostic Laboratories (6215), Scientific Research and Development Services (5417)

SIC

Services-Testing Laboratories (8734), Services-Commercial Physical & Biological Research (8731), Services-Medical Laboratories (8071)

akta.pro primary industry

Molecular & Genetic Testing (PCR/NGS/qPCR) (HLAGADAF)

akta.pro secondary industries

Molecular Diagnostics (PCR/qPCR, NGS-based assays) (HLAAALAA), Genetic, Cytogenetic & Prenatal Screening IVD (HLAHAAAI)

Keywords

• Cytogenetic testing services
• Chromosome karyotyping
• Stem cell analysis
• Microbial safety testing
• Genetic integrity verification

Headquarters

HQ city

Durham

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Marketing or Sales

Revenue model

1. Cytogenetic Testing Services: Laboratory testing services for chromosome karyotyping, digital PCR, FISH, and safety testing. Services include base analysis with additional fees for rush turnaround, extra images, additional spreads, cryopreserved sample processing, and add-on digital PCR assays. Pricing is quote-based with discounts for academic, non-profit, and government labs, plus volume discounts.
2. Sample Analysis Add-ons: Additional fees for cryopreserved sample processing (with longer turnaround), rush service, additional images, additional metaphase spreads analyzed, and digital PCR assay add-on to standard karyotyping.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels1 record

Core offering

KaryoLogic is a contract cytogenetics laboratory that performs G-band chromosome karyotyping (Standard and Complex analyses of 20 metaphase spreads), Fluorescence In Situ Hybridization (FISH), and digital PCR assays on human and non-human cell samples submitted by research institutions, biopharmaceutical companies, and cell therapy developers. The firm also provides biosafety testing including sterility, mycoplasma detection (120+ strains by qPCR), and human virus screening (HIV, HTLV, HBV, HCV), and operates in a GLP-compliant laboratory in Durham, NC.

Product overview

KaryoLogic offers a portfolio of laboratory testing services focused on cytogenetic analysis and biosafety testing. The core offerings include G-band chromosome karyotyping services (Standard and Complex) across human stem cells, human non-stem cells, and non-human species (mouse, pig, cat, dog, Chinese hamster, rat, sheep, chicken), Fluorescence In Situ Hybridization (FISH) analysis, and the Duo iCS-Karyo combination package that pairs G-band karyotyping with digital PCR (via Stem Genomics partnership). The company has recently expanded into safety testing services including sterility testing, mycoplasma detection by qPCR (covering 120+ strains), and human virus screening by qPCR (HIV, HTLV, HBV, HCV). Services are offered at Research Use Only (RUO) level from Durham, NC, with GMP-grade certified release testing available through Clean Cells France.

Differentiator

Problem solved

Functional benefit

Products and services

• Standard G-band Chromosome Analysis Cytogenetic analysis service for human (and other) cell samples that includes brief cell culture, metaphase arrest, cell fixation, stained/banded slide preparation, and microscope analysis of 20 metaphase chromosome spreads. Detects defects down to 5–10 Megabases including deletions, additions, breaks, translocations, trisomies, monosomies, duplications, inversions, isochromosomes, and polyploidy. Report includes chromosome count, gender information, description of aberrations, written summary, and one representative karyotype image; typical turnaround 15 business days; performed in a GLP-compliant environment. Designed for stem cell and other research laboratories.
• Complex G-band Chromosome Analysis Enhanced G-band karyotyping service that analyzes 20 metaphase spreads and provides two representative karyotype images plus an Excel table listing details of every chromosome of each of the 20 spreads. Built for human non-stem cell samples requiring more detail than the Standard analysis.
• Duo iCS-Karyo Package Combination package that performs both G-band karyotype analysis and a digital PCR assay (24 probes for the most frequent abnormalities in human pluripotent stem cells) from a single cell sample submission, in conjunction with partner Stem Genomics. Includes assessment of chromosome 20q11.21 band amplification (too small to be detected by G-band karyotyping) found in more than 20% of worldwide cultured hPSCs. Final analysis emailed within approximately 10 working days of receipt of live cells. Designed to verify genomic integrity of human pluripotent stem cells.
• Human Non-Stem Cell Karyotyping G-band chromosome analysis service for human cell samples that are not stem cells, available in Standard or Complex analysis options. Includes brief cell culture, processing to arrest cells in metaphase, cell fixation, preparation of stained/banded slides, and microscope analysis of karyotypes of chromosome spreads.
• Non-Human Species Karyotyping Karyotyping service for multiple species including mouse, pig, cat, dog, Chinese hamster, rat, sheep, and chicken. KaryoLogic attempts to karyotype other species not on the standard list using customer-provided published karyotypes as reference.
• Fluorescence In Situ Hybridization (FISH) DNA probe hybridization analysis on metaphase chromosome spreads. Capabilities include point probes or whole chromosome paint probes, single or dual probe analysis, with a third fluorescent color for chromosome counterstain.
• Sterility Testing Quality control testing ensuring cell cultures and biologics are free from bacterial and fungal contamination by direct inoculation using nutrient-rich broth media supporting growth of aerobic and anaerobic bacteria as well as fungi. Available as RUO for R&D workflows, with GMP-grade certified release testing available through Clean Cells France.
• Mycoplasma Detection (by qPCR) Validated qPCR mycoplasma panel covering more than 120 strains. Detects cell wall-free organisms that cannot be detected microscopically yet can disrupt cellular metabolism. Available for development and R&D workflows; GMP-grade testing and release documentation available via Clean Cells France.
• Human Virus Screening (by qPCR) qPCR-based virus screening service designed to protect laboratory personnel working with human-derived biological materials. Tests for HIV-1/2, HTLV-1/2, Hepatitis B, and Hepatitis C. Flexible panels for R&D needs; validated release assays provided via Clean Cells France.

Quantifiable outcome

• Detection of genetic aberrations down to 5-10 Megabases via G-band karyotyping
• +3 more outcomes

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

Feature4 records

Partnerships

Three partnerships are on record, tiered core and major.

• Clean CellscoreStrategic or Co-development Partner · 1 April 2025Clean Cells, part of the Clean Biologics group, acquired KaryoLogic in April 2025. This strategic acquisition establishes Clean Cells' operational presence in the US. Clean Cells provides GMP-certified release testing, advanced biosafety profiling (retrovirus detection, gene therapy vector safety testing, TEM), and full regulatory documentation for IND and IMPD submissions through their France facility.
• Stem GenomicscoreTechnology or IntegrationPartnership with Stem Genomics for digital PCR assay component of the Duo iCS-Karyo package. The combined service performs both G-band karyotype analysis and Stem Genomics' digital PCR assay from one cell sample submission, covering 24 probes for the most frequent abnormalities in human pluripotent stem cells.
• Clean Cells FrancemajorStrategic or Co-development PartnerClean Cells France facility provides GMP-grade microbiology and viral safety testing with full regulatory documentation for programs requiring certified release testing. Advanced capabilities include retrovirus detection, RCAAV and RCL assays, and transmission electron microscopy.

Scale indicators4 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• WiCell Cytogenetic Services: WiCell's cytogenetic services division performs G-band karyotyping for hPSC lines and is the closest direct competitor to KaryoLogic's core offering, sharing the same target customer (stem cell researchers) and methodology.
• Cell Line Genetics: Cell Line Genetics provides karyotyping, FISH, and CNV analysis services specifically for pluripotent stem cells and cell therapy products, directly overlapping KaryoLogic's Duo iCS-Karyo and FISH service lines.
• Applied StemCell: Applied StemCell offers cell line characterization services including karyotyping and genetic stability testing for research and cell therapy clients, competing head-to-head with KaryoLogic's human stem cell cytogenetic services.

Emerging players

• CTGT (Cell Therapy Genetic Testing): CTGT provides genetic testing services specifically for cell and gene therapy programs, including cytogenetic assays relevant to hPSC and CAR-T QC workflows, intersecting with KaryoLogic's cell therapy customer base.
• Genetic Technologies Inc: Genetic Technologies provides genomic risk assessment and cytogenetic-related testing services, operating in a broader genomics testing category that overlaps KaryoLogic's focus on chromosome analysis for research and clinical applications.

Broad incumbents

• Stemcell Technologies: Stemcell Technologies is a larger stem cell-focused life science company that offers karyotyping and cell characterization services alongside reagents, competing with KaryoLogic on the cytogenetic service side while serving overlapping academic and cell therapy customers.
• Eurofins Lancaster Laboratories: Eurofins is a global testing services giant with biopharmaceutical and cell therapy QC capabilities including sterility, mycoplasma, and viral safety testing that overlap with KaryoLogic's recently launched safety testing services, though at much broader scale.
• Charles River Laboratories: Charles River offers end-to-end cell therapy and biologics QC testing services including cytogenetic, sterility, mycoplasma, and viral safety testing, competing with KaryoLogic and its Clean Cells parent across the broader cell therapy services market.
• Labcorp Drug Development: Labcorp's central laboratory and drug development services include safety testing and cell-based assay capabilities that overlap KaryoLogic's RUO microbiology/viral safety services, serving similar biopharma and academic clients at scale.

Others

• Bio-Techne: Bio-Techne supplies reagents, proteins, and analytical tools used by stem cell researchers and cell therapy QC laboratories, including qPCR and cytogenetic-related reagents, making it an adjacent ecosystem participant rather than direct service competitor.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/karyologic-inc.

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about KaryoLogic