Mayo Clinic Laboratories

What Mayo Clinic Laboratories does

Mayo Clinic Laboratories is the reference laboratory operating division of Mayo Foundation for Medical Education and Research, a nonprofit academic medical center headquartered in Rochester, Minnesota with additional facilities in Jacksonville, Florida and Phoenix/Scottsdale, Arizona. The organization provides esoteric and specialized clinical laboratory testing services — over 4,300 tests and pathology services covering genetics, hematology, oncology, neurology, microbiology, immunology, and rare disease diagnostics — to hospitals, health systems, biopharmaceutical companies, group purchasing organizations, and international healthcare providers. It performs approximately 28 million tests annually, supported by advanced diagnostic technologies including next-generation sequencing, molecular diagnostics, AI-enabled workflow automation, and proprietary liquid biopsy assays such as LiquidHALLMARK.

The business operates on a registered client-account model with subscription-style monthly billing: clients must register and be approved before ordering tests through MayoACCESS or MayoLINK ordering platforms, and invoices are issued monthly with payment due within 30 days. Revenue is generated through two primary streams — clinical laboratory testing services for healthcare providers and biopharma contract testing services for clinical trial support and companion diagnostics. Distribution is direct enterprise sales with global reach, supported by a dedicated international sales team, specimen shipping/courier logistics, and 24/7 clinical consultation access to 6,000+ Mayo Clinic physicians and scientists. The company maintains comprehensive regulatory accreditations including CAP, AABB, ASHI, CLIA, ISO 15189, and SOC 2 Type 2.

Strategic positioning rests on the Mayo Clinic brand, which carries 150+ years of institutional medical knowledge and global recognition for diagnostic excellence. MCL continuously expands its test catalog — with 25+ new tests launched in the first half of 2026 — and pursues partnerships (e.g., Progentec Diagnostics for lupus biomarkers, Karius for metagenomic infectious disease detection) to broaden capabilities without diluting the core brand of physician-backed, subspecialist-interpreted esoteric testing. As a nonprofit operating division, revenues are reinvested into medical education, research, and patient care rather than distributed to shareholders.

Name

Mayo Clinic Laboratories

Legal name

Mayo Foundation for Medical Education and Research

Website

https://www.mayocliniclabs.com

Company type

Private

Founded year

1971

Operating status

Operating

Headcount range

5,001–10,000 employees

Ownership category

akta.pro rank

Product category

Clinical Reference Laboratory Services

NAICS

Medical Laboratories (621511)

SIC

Services-Medical Laboratories (8071)

akta.pro primary industry

Reference & Esoteric Testing Laboratories (HLAFAMAJ)

akta.pro secondary industries

Clinical Biomarker Testing Services (central labs, trial enrollment/monitoring assays) (HLAAAMAC), Specialty & Biomarker Laboratory Services (Immunoassays/Flow/Cytometry) (HLAGAEAB)

Keywords

• Clinical laboratory testing
• Reference laboratory services
• Molecular diagnostics
• Esoteric testing services
• Pathology services

Headquarters

HQ city

Rochester

HQ country

United States

HQ region

North America

Offices4 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Marketing or Sales, Supply Chain

Revenue model

1. Clinical Laboratory Testing Services: Mayo Clinic Laboratories generates revenue through providing esoteric and specialized clinical laboratory testing services to healthcare professionals, hospitals, health systems, and biopharma companies. Tests are ordered through MayoACCESS or MayoLINK ordering applications with billing processed monthly. The organization offers over 4,300 tests and pathology services covering full range of clinical specialties including genetics, hematology, oncology, neurology, and rare disease diagnostics.
2. Biopharma and Contract Testing Services: Provides specialized diagnostic services and testing solutions to biopharmaceutical companies for clinical trials, companion diagnostics, and drug development support.

Pricing tiers

Go-to-market motion1 record

Distribution channels4 records

Marketing channels6 records

Core offering

Mayo Clinic Laboratories provides over 4,300 esoteric and routine clinical laboratory tests and pathology services to hospitals, health systems, biopharma companies, group purchasing organizations, and international healthcare providers. Testing spans all major clinical specialties (genetics, hematology, oncology, neurology, microbiology, immunology, gastroenterology, etc.) with specimens shipped to facilities in Rochester, Jacksonville, and Phoenix for analysis. Tests are ordered through proprietary MayoACCESS and MayoLINK platforms by registered enterprise clients who receive monthly billing and 24/7 access to Mayo Clinic physicians and scientists for consultation.

Differentiator

Problem solved

Functional benefit

Brands

• LiquidHALLMARK: Liquid biopsy test combining DNA and RNA analysis for comprehensive cancer profiling.
• MayoACCESS
• MayoLINK

Products and services

• Clinical Laboratory Testing Services Comprehensive esoteric and routine clinical laboratory testing services spanning all major clinical specialties. Tests are ordered by registered enterprise clients via MayoACCESS or MayoLINK, processed at Mayo Clinic facilities in Rochester, Jacksonville, and Phoenix, with 24/7 access to Mayo Clinic physicians and scientists for consultation.
• Pathology Services Anatomic and clinical pathology services supporting complex disease diagnosis, including hereditary genetics, oncology, and rare disease diagnostics. Backed by Mayo Clinic's subspecialist pathologists and integrated with the laboratory testing menu.
• LiquidHALLMARK Liquid Biopsy Proprietary liquid biopsy test combining DNA and RNA analysis to detect fusions in 1,445 genes for more accurate cancer profiling. Helps patients access targeted therapies and clinical trial eligibility. Used by oncologists and cancer care teams for advanced solid tumor profiling from blood or cerebrospinal fluid.
• MayoACCESS Ordering Platform Web-based proprietary test ordering and results management platform for registered enterprise clients. Enables electronic ordering, specimen tracking, and result delivery for the 4,300+ test catalog.
• MayoLINK Universal Test Management Universal test management platform for ordering tests and managing results, designed for registered enterprise clients integrating Mayo Clinic Laboratories testing into their laboratory information systems.
• BioPharma Diagnostics Services Specialized diagnostic services for biopharmaceutical companies including clinical trial support, companion diagnostics, and drug development testing. Includes validated assays, regulatory-compliant workflows, and biomarker development support.
• Genome-Wide Methylation Array Analysis (Neuro-Oncology) First-in-class genome-wide methylation array assay for neuro-oncology tumor profiling, co-developed with the National Institutes of Health. Used by neuropathologists and oncology centers for brain tumor classification and diagnosis.
• Hereditary Pancreatitis Gene Panel Hereditary pancreatitis gene panel built on a whole exome sequencing backbone, analyzing nine carefully selected genes with strong clinical relevance. Used by gastroenterologists and geneticists diagnosing hereditary pancreatitis.
• aiSLE DX Lupus Biomarker Tests Lupus biomarker tests (aiSLE DX FRI for flare risk and aiSLE DX DAI for disease activity) made available through Mayo Clinic Laboratories in partnership with Progentec Diagnostics, with CMS Medicare reimbursement at $840.65 per test.
• Karius Infectious Disease Detection Tests Infectious disease detection tests (Karius Focus for bronchoalveolar lavage and Karius Spectrum for plasma) using metagenomic sequencing to directly detect pathogens from clinical specimens, offered through Mayo Clinic Laboratories in partnership with Karius.

Quantifiable outcome

• 28 million tests performed annually delivering fast, accurate answers
• +2 more outcomes

Named customers5 records

Segments4 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

One partnership is on record.

• Progentec DiagnosticscoreStrategic or Co-development Partner · 27 January 2025Progentec Diagnostics partnered with Mayo Clinic Laboratories to make available the aiSLE DX FRI and aiSLE DX DAI lupus biomarker tests. CMS assigned PLA codes (0446U and 0447U) with Medicare payment rate of $840.65 per test when covered, effective January 1, 2025. The aiSLE DX FRI identifies lupus patient's future risk of flare while aiSLE DX DAI measures disease activity levels.

Scale indicators5 records

Recent moves6 records

Expansion highlights5 records

Broad incumbents

• Sonic Healthcare: Global medical diagnostics company operating reference laboratories across the U.S. (e.g., Sonic Reference Laboratory), Europe, and Australia. Comparable in providing esoteric and specialty reference testing with international footprint; competing with Mayo Clinic Laboratories in international markets.
• Laboratory Corporation of America (Labcorp): Major clinical laboratory operator providing routine, esoteric, and anatomic pathology testing to hospitals, physicians, biopharma, and consumers. Comparable reference lab and biopharma services portfolio; competes broadly with Mayo Clinic Laboratories especially in esoteric and specialty diagnostics.
• Quest Diagnostics: One of the largest U.S. clinical laboratory networks offering routine and esoteric testing to hospitals, physicians, and patients. Directly comparable to Mayo Clinic Laboratories in clinical lab services but operates as a public, for-profit entity at much broader scale.
• Eurofins Scientific: Global group of laboratories providing clinical diagnostics and pharmaceutical testing services across multiple continents. Comparable in operating reference laboratory and biopharma testing services at international scale; broader portfolio including food, environmental, and pharma product testing.

Direct peers

• BioReference Laboratories: Full-service clinical and esoteric reference laboratory providing specialized testing to hospitals, physicians, and patients. Comparable enterprise hospital reference lab model, though BioReference has broader routine testing exposure versus Mayo Clinic Laboratories' esoteric focus.
• Natera: Molecular diagnostics company specializing in cell-free DNA testing across oncology, reproductive health, and organ transplant monitoring. Comparable to Mayo Clinic Laboratories in molecular specialty testing, especially oncology liquid biopsy and biopharma clinical trial support.
• ARUP Laboratories: Nonprofit reference laboratory affiliated with the University of Utah, offering a deep esoteric test menu to hospitals and health systems nationwide. Closest structural peer to Mayo Clinic Laboratories given its nonprofit academic-medical-center parentage, esoteric focus, and direct enterprise sales to hospitals.
• Guardant Health: Liquid biopsy-focused molecular diagnostics company with proprietary blood-based cancer profiling tests. Direct competitor to Mayo Clinic Laboratories' LiquidHALLMARK liquid biopsy franchise in oncology precision medicine and clinical trial enrollment applications.
• Foundation Medicine: Molecular diagnostics company specializing in comprehensive genomic profiling of solid tumors and liquid biopsies for oncology treatment selection. Highly comparable to Mayo Clinic Laboratories' LiquidHALLMARK and oncology molecular testing offerings; serves biopharma and clinical decision-making similar use cases.
• NeoGenomics: Specialty oncology-focused clinical laboratory providing molecular and esoteric cancer testing to hospitals, oncologists, and biopharma. Directly comparable to Mayo Clinic Laboratories' oncology, molecular, and biopharma services arms, though smaller and purely commercial.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/mayocliniclabs
• YouTubeyoutube.com/channel/UC86NU7Pk0MqJI6pk8J99CVw
• Facebookfacebook.com/mayocliniclabs
• LinkedInlinkedin.com/company/mayo-clinic-laboratories
• Instagraminstagram.com/mayocliniclabs

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments1 record

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Mayo Clinic Laboratories