G21

What G21 does

G21 S.r.l. is a privately held Italian medical-device manufacturer founded in 2009 and headquartered in San Possidonio (Modena), within the so-called Italian Medical Valley. The company specializes in the production of acrylic-based bone cements for orthopedic surgery (arthroprosthesis fixation) and spinal surgery (vertebral consolidation procedures including vertebroplasty and kyphoplasty). Its proprietary cement formulas target low polymerization temperature to limit thermal tissue damage, high viscosity control to reduce leakage risk, and high osseointegration.

G21’s product portfolio is organized along two clinical axes. The orthopedic line comprises bone cements, mixing/injection accessories, and Spaceflex modular spacers for articular functional rehabilitation. The vertebral consolidation line comprises high-viscosity V-STEADY cement and low-viscosity V-FIX and V-FAST variants (with distinct radiopaque agents BaSO4 and ZrO2), alongside dedicated kits for vertebroplasty and kyphoplasty. Products are manufactured at the company’s Italian facility and exported to over 35 countries under ISO 13485 quality-management certification and CE marking (MDD 93/42/EEC).

G21 operates a B2B enterprise field-sales model, selling through international medical-device distributors and engaging orthopedic and spinal surgeons directly at industry exhibitions including Arab Health, AAHKS, Eurospine, EFORT, and EBJIS. End customers are hospitals and surgical specialists performing arthroprosthesis and vertebral augmentation procedures. Pricing is quotation-based and not publicly disclosed; revenue is generated from hardware sales of cements, accessories, and modular spacers. The company is founder-led, privately funded with no institutional investors disclosed, and operates with 11-50 employees.

Name

G21

Legal name

G21 S.r.l.

Website

https://g-21.it

Company type

Private

Founded year

2009

Operating status

Operating

Headcount range

11–50 employees

Short description

G21 S.r.l. is an Italian medical-device manufacturer founded in 2009 that develops proprietary acrylic-based bone cements, modular spacers, and procedure-specific kits for orthopedic arthroprosthesis and spinal vertebral consolidation, selling to hospitals and surgeons across 35+ countries via medical-device distributors.

Ownership category

akta.pro rank

Product category

Orthopedic Medical Devices

SIC

Orthopedic, Prosthetic & Surgical Appliances & Supplies (3842)

akta.pro primary industry

Orthopedic Joint Reconstruction Implants (Hip/Knee/Shoulder/Elbow/Ankle) (HLAHAEAA)

akta.pro secondary industry

Spine Implants & Motion Preservation (Fusion/Disc/Interspinous) (HLAHAEAC)

Keywords

• Orthopedic bone cements
• Vertebral consolidation devices
• Spinal surgery cements
• Kyphoplasty vertebroplasty products
• Arthroprosthesis medical devices

Headquarters

HQ city

San Vendemiano

HQ country

Italy

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Operations, Supply Chain, Technology or R&D, Marketing or Sales, Others

Revenue model

1. Medical Device Sales: G21 generates revenue through the sale of medical devices, specifically acrylic-based bone cements, accessories, and modular spacers for orthopedic and spinal surgery procedures. Products are sold to hospitals and medical professionals globally.

Go-to-market motion1 record

Distribution channels1 record

Marketing channels1 record

Core offering

G21 manufactures and sells acrylic-based bone cements and related accessories for orthopedic and spinal surgery. Its portfolio includes proprietary V-STEADY (high viscosity), V-FIX and V-FAST (low viscosity) bone cements for arthroprosthesis and vertebral consolidation (vertebroplasty/kyphoplasty) procedures, together with procedure-specific kits, mixing/injection accessories, and Spaceflex modular spacers. Products are CE-marked, ISO 13485 certified, and exported to over 35 countries for use by hospitals and surgical specialists.

Product overview

G21 is a medical device company specializing in acrylic-based bone cements for orthopedic and spinal surgery applications. The company's product portfolio comprises two main categories: Orthopedic bone cements for arthroprosthesis surgeries (hip and knee replacements), and Vertebral consolidation products for treating vertebral fractures through vertebroplasty and kyphoplasty procedures. The vertebral consolidation line includes V-STEADY (high viscosity cement), V-FAST and V-FIX (low viscosity cements with different radiopaque agents), along with procedure-specific kits for mixing, injection, and application. Supporting accessories include Spaceflex modular spacers and a complete range of mixing and injection accessories. G21 positions itself in the biomaterials and medical devices sector, exporting products to over 35 countries worldwide.

Differentiator

Problem solved

Functional benefit

Brands

• V-STEADY: High viscosity acrylic-based radiopaque bone cement for vertebral consolidation with long working time.
• V-FIX
• V-FAST
• Spaceflex

Products and services

• V-STEADY High-viscosity acrylic-based radiopaque bone cement with long working time, ready for use approximately 2 minutes after mixing, providing about 9 minutes of injecting time and total hardening within 15 minutes. Designed for kyphoplasty and vertebroplasty surgeries with reduced risk of cement leakage.
• V-FIX Low-viscosity acrylic-based radiopaque bone cement (BaSO4) for vertebral consolidation with the longest working time among G21's cement range, particularly suitable for procedures on multiple vertebral levels.
• V-FIX DH Double-package configuration of V-FIX low-viscosity acrylic-based radiopaque bone cement (BaSO4) for vertebral consolidation; no CE Mark.
• V-FAST Low-viscosity acrylic-based radiopaque bone cement (ZrO2) for vertebral consolidation with slightly shorter waiting and working times compared to V-FIX, characterized by reduced polymerization time. Available in single package (20 g) and double package (2x10 g) configurations.
• V-FAST DH Double-package configuration of V-FAST low-viscosity acrylic-based radiopaque bone cement (ZrO2) for vertebral consolidation; no CE Mark.
• Orthopedic Bone Cements Proprietary acrylic bone cements developed for arthroprosthesis surgeries, providing safe and durable fixing of prosthetic implants, fast application, high degree of osseointegration, and among the lowest polymerization temperatures.
• Spaceflex Modular Spacers Modular spacers for orthopedic applications designed for articular functional rehabilitation.
• Orthopedic Accessories for Bone Cements Mixing and Injection Accessories for mixing and injection of bone cements for orthopedic applications, supporting proper preparation and application of bone cement during surgeries.
• Vertebral Consolidation Accessories for Mixing and Injection Accessories for mixing and injection of bone cements specifically developed for percutaneous or minimally invasive vertebral consolidation procedures.
• Kyphoplasty Products Products and kits specifically developed for kyphoplasty procedures, a vertebral augmentation technique for treating vertebral compression fractures.
• Vertebroplasty Products Products and kits specifically developed for vertebroplasty procedures, a minimally invasive technique for stabilizing vertebral fractures.
• FLEX BEADS Product available for the US market; specific details not specified in available source data.

Quantifiable outcome

• Products exported to over 35 countries worldwide

Segments2 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Scale indicators3 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• Heraeus Medical: Heraeus Medical is one of the world's largest dedicated bone cement manufacturers with the PALACOS and COPAL brands used in joint arthroplasty. It is the closest direct competitor to G21 across both orthopedic and vertebral consolidation cements.
• Teknimed: Teknimed is a French specialty manufacturer of bone cements and related spine/orthopedic biomaterials. Its product line directly overlaps with G21's V-STEADY/V-FIX/V-FAST vertebral cements and orthopedic cements for arthroplasty.
• Tecres: Tecres is an Italian medical device company specializing in bone cements, spacers and antibiotic-loaded cements for orthopedic and trauma applications. It is a fellow Italian specialty manufacturer directly comparable to G21's product mix.
• Exactech: Exactech is a US-based orthopedic device company marketing joint replacement implants and bone cements. It is comparable to G21 as a mid-sized, focused orthopedic specialist rather than a conglomerate.

Broad incumbents

• Stryker: Stryker is a leading global orthopedic medical device company that offers bone cements alongside its joint replacement and spine portfolios. It competes with G21 through bundled implant-plus-cement solutions to hospitals.
• Zimmer Biomet: Zimmer Biomet is a global orthopedic giant with bone cement products used in hip and knee arthroplasty. It represents a broad incumbent competitor that supplies hospitals with integrated implant and cement systems.
• DePuy Synthes (Johnson & Johnson): DePuy Synthes is Johnson & Johnson's orthopedic and spine franchise, offering vertebral augmentation cements (e.g., CONFIENCE) alongside its spine implants. It competes directly with G21 in the vertebral consolidation segment.
• Smith & Nephew: Smith & Nephew is a diversified medical device company with orthopedic reconstruction and sports medicine offerings that include bone cements. It is a broad incumbent overlapping with G21's arthroplasty cement line.

Emerging players

• OsteoRemedies: OsteoRemedies is a US-focused orthopedic company with antibiotic-loaded bone cements and spacers used in joint reconstruction. It overlaps with G21's Spaceflex spacer line and arthroplasty cement offering.

Others

• Lima Corporate: Lima Corporate is an Italian orthopedic implant manufacturer that also distributes certain G21 bone cements in select markets. It is comparable as a distribution and adjacent-implant partner rather than a direct cement competitor.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks5 records

Key highlights6 records

Customer concentration

• Xx.com/g21srl

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about G21