SIFRA EST

What SIFRA EST does

S.I.F.RA. EST S.p.A. (Società Italiana Farmaceutici Ravizza Est S.p.A.) is an Italian pharmaceutical and medical packaging manufacturer founded in 1988 in Trieste as a subsidiary of the Ravizza family pharmaceutical group. The company designs and produces empty IV bags, medical-grade tubing, tubular films, connectors, and PVC compound granules used as primary packaging for infusion, injectable, and dialysis solutions. Its core technology stack spans in-house PVC and PVC-free (polypropylene) compounding, extrusion (tubes and films), bag-welding on 9 automatic lines, and injection molding, with production capacity exceeding 80 million IV bags and 8.5 million kg of PVC compound annually.

The product portfolio is organized around two material platforms: PVC-based products under the SIFLEX®, SIFTUBE®, and SIFLAT® brands, including DEHP-FREE variants (TOTM, DEHTP, DINCH), and the PVC-free MAGIFLEX® line of PP bags, tubes, and films. All products are manufactured under ISO 13485 certification held since 1992 and are compatible with autoclave (121°C) and e-beam sterilization. Manufacturing is concentrated on a single 12,000 m² Trieste site with an adjoining 5,500 m² logistics hub, a 500 m² ISO 8 clean room for PVC-free production, and a 750 m² controlled-class area for PVC production. The company operates one of the largest private photovoltaic plants in the region as part of its sustainability posture.

Commercially, SIFRA EST sells directly via B2B quote-based pricing to pharmaceutical and medical device manufacturers across 34 export countries, generating over €29 million in 2023 revenue from more than 250 customers. Lead times range from 4 to 12 weeks depending on format and volume, and customer relationships are structured as multi-year contracts. Marketing channels include the company's multilingual website, organic social media, and international trade fair participation (e.g., CPHI India 2025). Leadership passed to CEO Leonardo Maghetti in 2020 alongside second-generation family members, while founder Gemma Ravizza remains associated with the business.

Name

SIFRA EST

Legal name

S.I.F.RA. EST S.p.A. (Società Italiana Farmaceutici Ravizza Est S.p.A.)

Website

https://sifraest.com

Company type

Private

Founded year

1988

Operating status

Operating

Headcount range

101–250 employees

Short description

SIFRA EST is an Italian pharmaceutical packaging manufacturer (founded 1988, Trieste) producing PVC and PVC-free empty IV bags, tubing, films, and connectors for over 250 pharmaceutical and medical device customers across 34 countries, with 2023 revenue above €29 million.

Ownership category

akta.pro rank

Product category

Pharmaceutical Packaging Manufacturing

NAICS

Medical Equipment and Supplies Manufacturing (3391), Medical Equipment and Supplies Manufacturing (33911)

SIC

Plastics Products, Nec (3089), Plastic Material, Synth Resin/Rubber, Cellulos (No Glass) (2820)

akta.pro primary industry

Pharmaceutical & Medical Plastic Packaging Manufacturing (IMANAEAK)

akta.pro secondary industries

Sterile & Aseptic Medical Packaging (Pouches, Wraps, Sterile Barriers) (IMALAIAB), Primary Pharmaceutical Packaging (Blister Packs, Bottles, Vials, Ampoules) (IMALAIAA)

Keywords

• Medical packaging manufacturing
• IV bag production
• Pharmaceutical packaging
• PVC compounding
• Medical tubing

Headquarters

HQ city

Trieste

HQ country

Italy

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Personnel, Infrastructure, Technology or R&D, Marketing or Sales

Revenue model

1. Medical Device & Pharmaceutical Packaging Manufacturing: Revenue generated from the design, manufacture, and sale of empty IV bags (PVC and PP), medical-grade tubing, PVC and PVC-free films/tubulars, connectors, and PVC compound granules to pharmaceutical and medical device companies globally. Products are sold as finished or semi-finished goods with customization options (print, tube configuration, closures).

Pricing tiers

Go-to-market motion1 record

Distribution channels1 record

Marketing channels4 records

Core offering

SIFRA EST designs and manufactures medical-grade primary packaging for pharmaceutical infusion, injectable, and dialysis solutions, including empty PVC and PVC-free (polypropylene) IV bags, medical tubing, tubular films, PVC compound granules, and connectors. Production is fully integrated in-house, from raw granule compounding through extrusion and bag-welding to finished packaging, with ISO 13485 quality certification and annual output exceeding 80 million bags supplied to pharmaceutical and medical device companies in 34 countries.

Product overview

S.I.F.RA. EST S.p.A. is an Italian pharmaceutical and medical packaging manufacturer offering a comprehensive portfolio of primary packaging solutions for infusion and injectable solutions. The product portfolio consists of two main material categories: PVC-based products (SIFLEX PACK® bags, SIFTUBE® tubing, SIFLAT® tubular film, and SIFLEX® compound) and PVC-free alternatives (MAGIFLEX® bags, tubes, and films made from polypropylene). Supporting components include medical-grade connectors for infusion systems. All products are manufactured in-house through an integrated production chain spanning compounding, extrusion, bag welding, and injection molding, with ISO 13485 certified quality assurance.

Differentiator

Problem solved

Functional benefit

Products and services

• SIFLEX PACK® PVC Bags Empty PVC flexible IV bags for infusion and dialysis solutions, fully autoclavable at 121°C, available from 50 ml to 6 L with customizable print, tube configuration, and closures. Manufactured for pharmaceutical filling operations using SIFLEX® PVC compound.
• MAGIFLEX® Bag (PVC-Free PP) Polypropylene PVC-free empty IV bags manufactured by thermal welding, sterilizable at 121°C with excellent drug compatibility and flexible design options (one or two tubes). Designed for pharmaceutical manufacturers seeking PVC-free primary packaging solutions.
• SIFTUBE® PVC Tubing Non-toxic, transparent, flexible medical-grade PVC tubing for infusion and dialysis systems, available in hardness ranges from Shore A 57 to Shore A 89 with various sizes, finishes, and packaging options. Supplied to pharmaceutical and medical device manufacturers.
• MAGIFLEX® Tube (PVC-Free PP) Tri-state polypropylene PVC-free tubing for infusion systems, used in manufacturing MAGIFLEX® bags with continuous in-process quality controls. Designed for medical device manufacturers producing PVC-free infusion systems.
• SIFLAT® PVC Tubular Film Steam-sterilizable PVC tubular film produced from SIFLEX® PVC, suitable for medical and pharmaceutical flexible container production with various widths, thicknesses, and finishes. Supplied for use in flexible container manufacturing.
• MAGIFLEX® Film (PVC-Free PP) Three-layer polypropylene PVC-free film for flexible container production, compatible with manual machines and Form-Fill-Seal (FFS) systems, featuring drug compatibility, sterilizability at 121°C, sealability, elasticity, and transparency. Designed for use in pharmaceutical flexible container manufacturing.
• SIFLEX® PVC Compound Medical-grade non-toxic PVC granules serving as the base material for all SIFRA EST PVC product lines, produced under GMP and ISO standards with Shore A hardness from 58 to 90 and available in standard and DEHP-FREE variants (TOTM, DEHTP, DINCH). Annual granulation capacity exceeds 8.5 million kg; supplied to pharmaceutical and medical device manufacturers.
• Medical-Grade Connectors Range of medical-grade connectors including vial stoppers, twist-off ports, stoppers, breakable cones, and injection ports designed for sealing bag tubing after filling or for assembly of infusion sets. Supplied to pharmaceutical and medical device manufacturers.

Quantifiable outcome

• Over 80 million IV bags produced annually across 9 automatic production lines
• +2 more outcomes

Named customers1 record

Segments2 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Scale indicators10 records

Recent moves7 records

Expansion highlights4 records

Direct peers

• Gerresheimer AG: German-headquartered global manufacturer of pharmaceutical packaging including plastic containers, prefillable syringes, and vials. Closely comparable to SIFRA in B2B plastic primary packaging for injectable and infusion drugs, though with a much broader product portfolio and global manufacturing footprint.
• Stevanato Group: Italian-listed manufacturer of pharmaceutical glass and plastic packaging, including vials, syringes, and drug delivery systems. Highly comparable in customer base (global pharma), product category (primary packaging), and geography (Italian/European origin with global reach).
• West Pharmaceutical Services: US-listed global specialist in elastomer stoppers, seals, syringe components, and primary packaging for injectable drugs. Direct overlap with SIFRA's connector business (vial stoppers, twist-off ports) and the same pharmaceutical customer base, though West is much larger and elastomer-focused.
• Nipro Corporation: Japanese medical device and pharmaceutical packaging manufacturer with direct overlap in IV bags, dialysis products, and medical tubing. Comparable product range, similar B2B pharma model, and similar focus on primary plastic medical packaging components.
• Terumo Corporation: Japanese global medical device company with significant IV and blood bag manufacturing. Direct competitor in IV bag primary packaging, with comparable products (PVC and PVC-free blood/IV containers), pharmaceutical customers, and growing global footprint.

Broad incumbents

• B. Braun Melsungen: German family-owned global medical company producing IV solutions, infusion sets, and IV bags. Both a potential customer for SIFRA's components and a competitor in finished IV containers, with much broader product portfolio and global manufacturing.
• Fresenius Kabi: German global player in IV solutions, infusion technology, and clinical nutrition, with significant IV bag production. Comparable in IV bag primary packaging but operates at vastly greater scale and across a much wider clinical nutrition and medical device portfolio.
• Baxter International: US-listed global medical products company with significant IV solutions and IV bag manufacturing. Direct overlap in IV bag primary packaging, but operates at much greater scale and across a much broader hospital products and medical device portfolio.
• Becton Dickinson (BD): US-listed global medical technology company with broad IV and injection systems portfolio, including medical-grade tubing and IV bag components. Comparable in B2B medical plastics and IV-related product categories, with far greater global scale and R&D.
• SCHOTT AG: German-headquartered global specialty materials company with pharmaceutical packaging (primarily glass vials, syringes, ampoules) and a growing polymer solutions offering. Comparable in primary pharmaceutical packaging customer base, though predominantly glass-led and far larger in scale.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• YouTubeyoutube.com/channel/UCuQlLHz0n2z5D-hrKLnTndQ
• Facebookfacebook.com/Sifra.Est.1988
• LinkedInlinkedin.com/company/s.i.f.ra.-est---societa-italiana-farmaceutici-ravizza-est-s.p.a.
• Xx.com/sifraestspa

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about SIFRA EST