NEJM Knowledge+

What NEJM Knowledge+ does

NEJM Knowledge+ is a medical education platform that provides adaptive, question-based board exam preparation for physicians preparing for specialty certification in Internal Medicine, Family Medicine, and Pediatrics. Originally developed by NEJM Group, a division of the Massachusetts Medical Society, the product was acquired by AMBOSS in March 2025 as part of a €240 million financing round backed by KIRKBI, M&G Investments, and Lightrock. The core technology stack is a cloud-based adaptive learning platform that personalizes the question sequence based on individual learner performance, delivered through the AMBOSS QBank App on iOS and Android and integrated with the AMBOSS Medical Knowledge Library, which contains over 2,000 physician-curated, disease- and symptom-based articles used for both deeper study and point-of-care clinical reference.

The product surface spans three specialty board review subscriptions sold on an annual or multi-year basis directly to clinicians through AMBOSS's self-serve website and mobile apps, plus a separate free Pain Management and Opioids CME/CE training module delivered via a dedicated NEJM Group portal (securepmmcme.nejm.org). The 10-hour CME module satisfies the DEA's one-time eight-hour training requirement for DEA-registered practitioners and functions as a lead-generation and retention funnel rather than a direct revenue source. Marketing is delivered through co-branded NEJM Group and AMBOSS channels, including dedicated product pages, email outreach, and phone-based customer support, with no named enterprise or institutional contracts visible in the data.

Post-acquisition, NEJM Knowledge+ operates as a product within AMBOSS rather than as an independent company, with NEJM Group retaining involvement through the co-branded CME module and continued brand association. The operating footprint is small (1-10 employees listed in the firmographic data), consistent with NEJM Knowledge+ functioning as a focused product unit inside the larger AMBOSS organization rather than a standalone business.

Name

NEJM Knowledge+

Legal name

Massachusetts Medical Society (operating NEJM Knowledge+ and NEJM Group)

Website

https://knowledgeplus.nejm.org

Company type

Private

Operating status

Operating

Headcount range

1–10 employees

Short description

NEJM Knowledge+ is an adaptive, question-based board exam preparation platform serving physicians studying for Internal Medicine, Family Medicine, and Pediatrics specialty boards, now operated by AMBOSS following a March 2025 acquisition and integrated with AMBOSS's QBank App and 2,000+ article Medical Knowledge Library.

Ownership category

akta.pro rank

Product category

Medical Education and Board Exam Preparation

NAICS

Business Schools and Computer and Management Training (6114), Computer Training (611420), Professional, Scientific, and Technical Services (54)

SIC

Services-Educational Services (8200), Services-Health Services (8000)

akta.pro primary industry

Healthcare & Clinical Professional Development (CME/CE) (EDAGANAJ)

akta.pro secondary industry

Medicine & Allied Health (Clinical) (EDAGABAG)

Keywords

• Medical board review
• Adaptive learning platform
• CME/CE training
• Clinical decision support
• QBank preparation

Headquarters

HQ city

Waltham

HQ country

United States

HQ region

North America

Markets served

GTM type

B2C

Offering type

Software

Cost components

Technology or R&D, Personnel, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Board Review Subscription: NEJM Knowledge+ offers specialty board review subscriptions (Internal Medicine, Family Medicine, Pediatrics) sold directly to clinicians via the AMBOSS platform. Purchased on an annual or multi-year basis.
2. CME/CE Training: The Pain Management and Opioids CME training is offered free of charge to DEA-registered practitioners. This likely serves as a lead-generation and retention tool rather than a direct revenue driver.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels4 records

Core offering

NEJM Knowledge+ is an adaptive medical learning platform for physicians and clinicians that provides specialty board exam preparation for Internal Medicine, Family Medicine, and Pediatrics. It delivers board review questions through the AMBOSS QBank App (iOS and Android), grants access to an integrated Medical Knowledge Library of over 2,000 physician-curated articles, and offers a free Pain Management and Opioids CME/CE training module satisfying the DEA's one-time eight-hour training requirement.

Product overview

NEJM Knowledge+ is a medical education and board exam preparation platform, now operating as part of AMBOSS following its acquisition. The core offering includes NEJM Knowledge+ Specialty Board Review for Internal Medicine, Family Medicine, and Pediatrics, accessible through the AMBOSS QBank App (iOS and Android) and integrated with the AMBOSS Medical Knowledge Library. Additionally, NEJM Group offers the Pain Management and Opioids Adaptive Learning CME product as a separate free training resource.

Differentiator

Problem solved

Functional benefit

Brands

• Internal Medicine Board Review: Specialty board exam preparation for Internal Medicine physicians
• Family Medicine Board Review
• Pediatrics Board Review

Products and services

• NEJM Knowledge+ Specialty Board Review Medical learning platform for specialty board exam preparation covering Internal Medicine, Family Medicine, and Pediatrics. Now integrated into AMBOSS, providing access to the AMBOSS QBank App and Medical Knowledge Library of over 2,000 physician-curated articles, sold as annual or multi-year subscriptions to clinicians via the AMBOSS website.
• Pain Management and Opioids Adaptive Learning A free 10-hour CME/CE adaptive learning training module on the treatment and management of patients with opioid or other substance use disorders, developed by NEJM Group (a division of the Massachusetts Medical Society), satisfying the DEA's one-time eight-hour training requirement for DEA-registered practitioners. Distributed via the securepmmcme.nejm.org portal.
• AMBOSS QBank App Mobile application (iOS and Android) hosting the NEJM Knowledge+ question bank and integrated study tools for medical board exam preparation. Used by board review subscribers to study via mobile devices.
• AMBOSS Medical Knowledge Library Over 2,000 physician-curated, disease- and symptom-based articles integrated with the NEJM Knowledge+ question bank for deeper understanding, available to Internal Medicine, Family Medicine, and Pediatrics board review subscribers. Also accessible via the AMBOSS Knowledge Library App for point-of-care clinical decision support.

Segments2 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Partnerships

One partnership is on record.

• NEJM Group (Massachusetts Medical Society)coreStrategic or Co-development PartnerNEJM Group, a division of the Massachusetts Medical Society and publisher of the New England Journal of Medicine, co-brands NEJM Knowledge+ and jointly delivers Pain Management and Opioids CME training with AMBOSS. NEJM Group continues to support the Pain Management and Opioids CME content and portal, while AMBOSS hosts the board review subscriptions.

Scale indicators3 records

Recent moves5 records

Expansion highlights5 records

Direct peers

• AMBOSS: The acquiring platform and now the direct operating home of NEJM Knowledge+. AMBOSS provides the QBank, Knowledge Library, and adaptive learning engine that power NEJM Knowledge+ subscriptions, making it the most direct comparable.
• UWorld: Largest US medical board prep QBank competitor serving USMLE, Step 1/2/3, and specialty board review. Directly competes for the same resident and board-eligible physician learner with similar subscription-based, self-serve delivery.
• BoardVitals: Specialty board review QBank platform offering question banks across a broad range of medical specialties with similar subscription pricing and self-serve model. Competes head-to-head in Internal Medicine, Family Medicine, and Pediatrics review.
• TrueLearn: Board-style question bank platform focused on USMLE and medical specialty boards with adaptive learning features. Closely comparable in product mechanics and target audience of medical residents and fellows.
• Rosh Review: Board-style QBank with question banks across medical specialties and a focus on adaptive learning and personalized study plans. Now part of the USMLE-Rx family under Wolters Kluwer.

Broad incumbents

• Lecturio: Broader medical education platform combining video lectures, QBank, and study planning across medical school and board prep. Overlaps with NEJM Knowledge+ on board review but extends to full medical school curriculum.
• Kaplan Medical: Established test prep incumbent offering USMLE and medical board review courses, QBanks, and live instruction. Competes for the same resident learner base with a much broader portfolio.
• Osmosis (Elsevier): Visual medical education platform with video libraries, questions, and study tools across the full medical curriculum. Now owned by Elsevier; overlaps with NEJM Knowledge+ on integrated content + QBank for board prep.

Emerging players

• Sketchy Medical: Visual storytelling-based medical education platform with USMLE, COMLEX, and clinical content. Adjacent in learner segment with a differentiated memorization methodology rather than pure QBank approach.
• Mayo Clinic Board Review: Institutionally-branded board review content and courses from Mayo Clinic, leveraging a similarly prestigious medical brand. Overlaps on specialty board review content quality and brand-driven credibility positioning.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/nejmkplus
• Facebookfacebook.com/NEJMKnowledgeplus

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about NEJM Knowledge+