Pbserum

What Pbserum does

Pbserum (legal entity PROTEOS BIOTECH S.L.) is a Spanish biotechnology company founded in 2010 that develops, manufactures, and distributes recombinant enzyme-based products for the medical-aesthetic and cosmetic markets. The company is built around a proprietary two-generation recombinant biotechnology platform that produces five bacterial-origin enzymes — Keratinase PB333, Collagenases G/H PB220, Lipase PB500, Lyase PB72K, and Hyaluronidase PB3000 — using a lyophilization process that the company states preserves 100% of enzymatic activity without preservatives. The portfolio is split into two commercial categories: injectable medical devices (the HA Low/Medium/High system for post-surgical fibrosis, scars, facial contouring, and localized fat, plus HA Corrector for managing hyaluronic acid filler complications) and cosmetic product lines (Smartker, Specific, Plus, and the recently launched Veluria bioremodeling line).

The business operates as a B2B distributor-and-direct-sales model targeting credentialed medical professionals — aesthetic doctors, dermatologists, and plastic surgeons — who access product information, training, and certification through a restricted professional portal. Sales are executed through official local distributors in at least 11 countries across Europe (Spain, UK, Italy, Austria), North America (USA, Mexico), and South/Central America (Brazil, Peru, Venezuela, Ecuador, Guatemala), with a dedicated US-facing site supporting North American distribution. Manufacturing is conducted at a high-technology laboratory in Albacete and is certified to ISO 22716 for cosmetics, ISO 13485 for injectable medical devices, and carries the CE Mark, enabling cross-border distribution of sterile pharmaceutical-grade products.

The company employs nearly 100 people across its Madrid headquarters and Albacete laboratory and reports no disclosed revenue, funding rounds, or institutional investors, indicating founder/management ownership. Its commercial posture is anchored by clinical evidence claims — including 0% serious adverse events across over 200 HA-treated patients, 86.9%-94.7% patient satisfaction across indications, and a 95% statistically significant rejuvenating effect for the Specific line — and was reinforced at IMCAS Paris 2026 with the launch of "The Bioremodeling Era" as a new aesthetic medicine category based on recombinant biotechnology.

Name

Pbserum

Legal name

PROTEOS BIOTECH S.L.

Website

https://pbserum.com

Company type

Private

Founded year

2010

Operating status

Operating

Headcount range

101–250 employees

Short description

Pbserum (PROTEOS BIOTECH S.L.) is a Spanish biotech that develops and distributes proprietary recombinant enzyme products for aesthetic medicine, selling injectable medical devices and cosmetic lines exclusively through medical professionals and local distributors across more than ten countries.

Ownership category

akta.pro rank

Product category

Aesthetic Biotechnology Products

NAICS

Biological Product (except Diagnostic) Manufacturing (325414), Pharmaceutical and Medicine Manufacturing (3254)

SIC

Biological Products, (No Disgnostic Substances) (2836), Surgical & Medical Instruments & Apparatus (3841), Perfumes, Cosmetics & Other Toilet Preparations (2844)

akta.pro primary industry

Wound Healing & Skin Regeneration (advanced dressings, skin substitutes) (HLAAAGAG)

akta.pro secondary industry

Professional Skincare & Facial Treatments (CRABALAF)

Keywords

• Recombinant enzyme biotechnology
• Aesthetic medical devices
• Biocosmeceutical products
• Regenerative aesthetic medicine
• Professional skincare enzymes

Headquarters

HQ city

Madrid

HQ country

Spain

HQ region

Europe

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Personnel, Supply Chain, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Recombinant Enzyme Medical Devices: Sale of injectable recombinant enzyme medical devices (HA Low/Medium/High, HA Corrector) for use by aesthetic medical professionals in treating conditions such as post-surgical fibrosis, scars, HA complications, and localized fat. Sold through official local distributors globally.
2. Cosmetic Product Lines: Sale of cosmetic recombinant enzyme products (Plus, Specific, Veluria) for topical professional and home use. These are supplied in lyophilized format for professional cosmetic protocols and registered as cosmetic products for topical use only.

Go-to-market motion1 record

Distribution channels2 records

Marketing channels5 records

Core offering

Pbserum manufactures and markets proprietary recombinant enzyme-based injectable medical devices and cosmetic products for the aesthetic medicine and dermatology markets. Its portfolio comprises five proprietary recombinant enzymes (Keratinase PB333, Collagenases G/H PB220, Lipase PB500, Lyase PB72K, Hyaluronidase PB3000) formulated into product lines such as HA (Low/Medium/High), HA Corrector, Specific, Plus, Smartker, and Veluria, used by aesthetic doctors, dermatologists, and plastic surgeons for tissue remodeling, scar treatment, HA filler complication management, facial rejuvenation, and localized fat reduction.

Product overview

Pbserum (PROTEOS BIOTECH S.L.) is a biotechnology company founded in 2010 in Spain specializing in recombinant enzymes for medical and cosmetic applications. The company offers five proprietary recombinant enzymes (Keratinase PB333, Collagenases G/H PB220, Lipase PB500, Lyase PB72K, Hyaluronidase PB3000) developed through advanced recombinant technology. The product portfolio is organized into two main categories: injectable medical devices (HA system for fibrosis, fat reduction, and facial contouring; HA Corrector for hyaluronic acid complication management) and cosmetic products (Specific for anti-aging treatments, Plus for professional topical applications, Smartker for skin health, and Veluria for cosmetic bioremodeling).

Differentiator

Problem solved

Functional benefit

Brands

• Smartker: Product line containing Keratinase PB333 enzyme for skin health and hydration applications.
• Specific
• Plus
• HA
• HA Corrector
• Veluria
• HA 2.0
• HYAL Balance
• Reveal

Products and services

• Smartker Cosmetic product line based on the proprietary Keratinase PB333 recombinant enzyme, used by medical professionals and at home to improve skin hydration, softness, and radiance and to address signs of skin damage including post-sun exposure.
• Specific Cosmetic line combining recombinant enzymes Collagenases G/H PB220, Lyase PB72K, and Keratinase PB333 with antioxidants for facial rejuvenation, periocular treatment, hand rejuvenation, acne scars, and striae, achieving 95% statistically significant rejuvenating effect and 90% patient satisfaction.
• Plus Professional cosmetic line supplied in lyophilized format containing recombinant enzymes for topical protocols, with variants including Slim+ (Lipase PB500), Smooth+ (Collagenase GH PB220), and Drain+ (Hyaluronidase PB3000).
• HA (Low, Medium, High) Injectable medical device system (HA Low, Medium, High) combining Collagenases PB220, Lipase PB500, and Lyase PB72K for treating localized fat, facial contouring, cellulitis, post-surgical fibrosis, and scars, with 0% serious adverse events reported across over 200 patients.
• HA Corrector Medical device based on Hyaluronidase PB3000 for degrading hyaluronic acid filler complications, with HA Partial Corrector for mild cases and HA Total Corrector for severe complications such as vascular occlusion and necrosis.
• Veluria Professional cosmetic bioremodeling line comprising Silk Skin (Collagenase G&H, Exosomes, PDRN), Ultra Lift (DMAE, Vitamins C and E), Skin Pearl Tone (Glutathione, Hyaluronic Acid), and Hair Force+ (Collagenase G&H, Hyaluronidase, VEGF recombinant, Saw Palmetto).

Quantifiable outcome

• 0% serious adverse events reported in over 200 patients treated with HA enzyme products
• +5 more outcomes

Named customers16 records

Segments1 record

Ideal customer profiles1 record

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

One partnership is on record.

• Official Local DistributorscoreChannel Partner/ Reseller/ DistributorProducts are distributed internationally through official local distributors in various countries who manage sales to medical professionals. Distributors handle local market compliance, registration, and distribution of pbserum recombinant enzyme products.

Scale indicators9 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• IBSA (Institut Biochimique SA): Swiss pharmaceutical company that manufactures hyaluronidase products (e.g., HYALURONIDASE IBSA) and other injectable aesthetic/medical devices. Directly comparable because it uses biologic enzymes for HA-related complications and aesthetic indications, overlapping with Pbserum's HA Corrector and HA product lines.
• Teoxane Laboratories: Swiss aesthetics company specializing in hyaluronic acid-based dermal fillers (RHA line) and complementary skincare. Comparable because it sells injectables and cosmeceuticals to the same aesthetic medical professionals and competes in facial rejuvenation indications.
• Sinclair Pharma: Aesthetic medicine company (now under Huadong Medicine) selling Ellansé, MaiLi, and complementary regenerative products to dermatologists and plastic surgeons. Comparable through its aesthetic injectable and biostimulator portfolio in overlapping facial rejuvenation indications.
• Croma-Pharma: Austrian aesthetics company producing hyaluronic acid fillers (Princess line), PRP systems, and professional skincare. Comparable because it sells HA-based injectables and supporting skincare through the same medical professional channel as Pbserum.

Broad incumbents

• Galderma: Global dermatology and aesthetics major (parent Nestlé Skin Health / EQT) offering Restylane fillers, Sculptra biostimulators, and comprehensive aesthetic portfolios. Comparable because it competes in the same channel of dermatologists and plastic surgeons that Pbserum targets, with overlapping indications like facial rejuvenation and skin quality.
• Allergan Aesthetics (AbbVie): AbbVie division behind BOTOX Cosmetic, Juvéderm HA fillers, and Skinmedica skincare. Comparable as the dominant incumbent in aesthetic injectables served by the same medical professional customer base and competing for the same per-treatment spend against Pbserum.
• Merz Aesthetics: Global aesthetics company behind Belotero, Radiesse, and Ultherapy, selling injectables, biostimulators, and energy-based devices to aesthetic practitioners. Comparable through the same dermatologist/plastic surgeon channels and competing in the regenerative and tissue remodeling narrative.

Emerging players

• Anika Therapeutics: US-based specialty biopharmaceutical company with hyaluronic acid-based products in orthopedics and aesthetics. Comparable because it uses HA/biological technology platforms across multiple medical indications, including regenerative applications adjacent to Pbserum's tissue remodeling focus.
• Symatese: French regenerative medicine company producing injectable biomaterials, fillers, and skin remodeling products for aesthetic medicine. Comparable because it competes in regenerative/biologic aesthetics, including HA-based and tissue remodeling solutions targeting plastic surgeons and dermatologists.
• Promoitalia Group: Italian aesthetics and regenerative medicine company producing biorevitalization injectables, HA products, and aesthetic devices. Comparable through its focus on injectable regenerative and biostimulation products sold to the same medical professional customer profile in European and Latin American markets.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xx.com/pbserum
• Facebookfacebook.com/pbserum
• LinkedInlinkedin.com/company/proteosbiotech

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Pbserum