SEIN

What SEIN does

SEIN (Stichting Epilepsie Instellingen Nederland) is a Dutch non-profit foundation headquartered in Heemstede that operates as the country's national tertiary expertise center for epilepsy and sleep medicine. Founded in 1998, SEIN delivers integrated multidisciplinary care across 13 outpatient clinics, three Sleep-Wake Centres, two inpatient clinics for extended EEG monitoring, and three residential facilities — including the largest complex-epilepsy residential site in the Netherlands at Cruquius with approximately 270 long-stay clients. The organization serves patients across the full lifespan with refractory epilepsy, complex sleep disorders (sleep apnea, narcolepsy, circadian rhythm disorders, parasomnia), and patients requiring 24-hour residential support due to co-occurring intellectual or other disabilities.

SEIN's service stack combines clinical care, scientific research, and digital tooling. Clinical services are delivered by neurologists, somnologists, clinical psychologists, behavioral scientists, social workers, and specialized nurses under one operational model. Proprietary technology assets include the HUME-sock (a sensor-based wearable for stress detection deployed in long-term residential care), the MijnSEIN patient and client portal with secure access to records, appointments, video consultations (via Microsoft Teams), and e-consults, plus the HiX mobile app. Research programs run in collaboration with LUMC, UMC Utrecht, Erasmus UMC, Amsterdam UMC, UCL, and others, with ZonMw and patient-foundation funding. SEIN also operates the SEIN-SKUH Comprehensive Epilepsy and Sleep Centre in Tbilisi, Georgia as an international knowledge-export partnership.

The revenue model is healthcare reimbursement-driven: clinical care falls under the Dutch basic health insurance package (basisverzekering), with SEIN holding contracts across all Dutch health insurers enabling 100% reimbursement for insured patients (less the €385 compulsory deductible in 2024). Residential and day-care services are funded through long-term care insurance (Wlz) and municipal care packages. Pricing is administered, not market-based, and growth is gated by clinical volume, residential capacity, and research grant capture rather than commercial sales.

Name

SEIN

Legal name

Stichting Epilepsie Instellingen Nederland

Website

https://sein.nl

Company type

Private

Founded year

1998

Operating status

Operating

Headcount range

1,001–5,000 employees

Short description

SEIN is a Dutch non-profit foundation operating the Netherlands' national tertiary expertise center for epilepsy and sleep medicine, delivering multidisciplinary diagnosis, treatment, and 24-hour residential care across 13 outpatient clinics, three Sleep-Wake Centres, and three residential facilities serving complex/refractory patients of all ages.

Ownership category

akta.pro rank

Product category

Specialty Epilepsy and Sleep Medicine Healthcare

NAICS

Offices of Physicians, Mental Health Specialists (621112), Offices of Mental Health Practitioners (except Physicians) (621330), Nursing Care Facilities (Skilled Nursing Facilities) (62311), Home Health Care Services (62161)

SIC

Services-Offices & Clinics Of Doctors Of Medicine (8011), Services-Specialty Outpatient Facilities, Nec (8093), Services-Skilled Nursing Care Facilities (8051)

akta.pro primary industry

Epilepsy & Seizure Disorders (HLAKAIAB)

akta.pro secondary industries

Ambulatory Sleep Medicine Centers (HLAFABAJ), Neurology Telemedicine Platforms (HLALAGAC)

Keywords

• Epilepsy diagnosis treatment
• Sleep medicine services
• Specialty neurological care
• Residential epilepsy care
• Sleep-wake disorders

Headquarters

HQ city

Heemstede

HQ country

Netherlands

HQ region

Europe

Offices6 records

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Infrastructure, Technology or R&D, Marketing or Sales

Revenue model

1. Healthcare Services Reimbursement: All care delivered by SEIN falls under the Dutch basic health insurance package. SEIN has contracts with all Dutch health insurers, resulting in 100% reimbursement for insured patients. Patients pay compulsory deductible (€385 in 2024) and potential co-pays for non-contracted services.
2. Residential Care and Day Care: Residential facilities and day care activities for clients with complex epilepsy and associated problems, funded through long-term care insurance (Wlz) and municipal care packages.

Pricing tiers

Go-to-market motion3 records

Distribution channels7 records

Marketing channels8 records

Core offering

SEIN is the Netherlands' tertiary expertise centre for epilepsy and sleep medicine, providing comprehensive diagnosis, treatment, residential care, and scientific research for individuals with complex epileptic seizures and complex sleep disorders. Services are delivered through 13 outpatient clinics, 3 Sleep-Wake Centres, 2 inpatient clinics for extended observation, and 3 residential facilities including the country's largest complex-epilepsy residence housing approximately 270 residents. The organization integrates clinical care with research collaborations across Dutch academic centres and operates the MijnSEIN digital portal for patient records, e-consult messaging, and video consultations.

Product overview

SEIN (Stichting Epilepsie Instellingen Nederland) operates as a single integrated healthcare platform providing comprehensive epilepsy and sleep medicine services. The organization functions as a single unified offering rather than a platform-plus-modules architecture. Core services include 13 outpatient clinics, three Sleep-Wake Centres, two inpatient clinics for extended observation and EEG monitoring, 24-hour residential care with specialized epilepsy support for approximately 270 residents, day activity programs, and special needs education. Digital access is provided through MijnSEIN, a secure patient/client portal enabling access to medical records, appointment scheduling, video consultations via Microsoft Teams, e-consult messaging, and prescription management. The HiX Patiënt App provides mobile access to MijnSEIN functionality. Research programs complement clinical care through collaborations with academic institutions.

Differentiator

Problem solved

Functional benefit

Products and services

• Epilepsy Outpatient Clinics (Poliklinieken) Network of 13 outpatient clinics across the Netherlands providing neurologist consultations, diagnostic workups, treatment planning, and follow-up care for epilepsy patients of all ages. Services include standard EEG, neurological examination, and second opinions.
• Sleep-Wake Centres (Slaap-Waakcentra)
• Inpatient Epilepsy Clinics (Klinieken)
• Residential Care (Wonen en Logeren)
• Day Activity Centre (Dagactiviteitencentrum / DAC)
• Special Needs Education (Speciaal Onderwijs)
• MijnSEIN Patient and Client Portal Secure online portal for patients and clients to access medical records, test results, appointments, medical letters, medication details, and laboratory results. Enables scheduling year controls, requesting repeat prescriptions, sending medical questions, conducting video consultations, and accessing electronic client records (ECD) for residential clients.
• Video Consultation (Videoconsult)
• E-consult Secure Messaging
• Scientific Research Programme

Quantifiable outcome

• Approximately 30% of epilepsy patients have refractory epilepsy not responding to first-line drug treatment
• +1 more outcomes

Named customers4 records

Segments5 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

17 partnerships are on record, tiered core and minor.

• SEIN-SKUH Comprehensive Epilepsy and Sleep CentrecoreStrategic or Co-development Partner · 1 November 2016SEIN collaborates with Simon Khechinashvili University Hospital (SKUH) in Tbilisi, Georgia, sharing knowledge and information. Jointly opened an epilepsy clinic in November 2016, expanded with a Sleep Centre in 2017 to become a comprehensive epilepsy and sleep center.
• KempenhaeghecoreStrategic or Co-development PartnerLike SEIN, Kempenhaeghe is a centre of expertise in scientific research and training on epilepsy. SEIN and Kempenhaeghe collaborate extensively, including the Leerhuis Epilepsie (epilepsy study centre) initiative and a biobank for narcolepsy research at LUMC.
• Brain Centre UMC UtrechtcoreStrategic or Co-development PartnerEpilepsy surgery procedures are performed by neurosurgeons at the Brain Centre of UMC Utrecht. SEIN performs pre-surgical tests and assessments to evaluate patient candidacy for epilepsy surgery. SEIN also supervises depth EEG recordings at UMC Utrecht.
• Leiden University Medical Centre (LUMC)coreStrategic or Co-development PartnerResearch collaboration on paroxysmal disorders and comorbidity, narcolepsy biobank, genetic research, and computational pathology. Joint research priority with SEIN.
• EpilepsieNLcoreGTM or Marketing PartnerCommunity organization of 200,000 people with epilepsy in the Netherlands. EpilepsieNL funds research and shares knowledge. SEIN collaborates on events including the annual Epilepsieloop charity run.
• Dutch League Against Epilepsy (NLE)minorStrategic or Co-development PartnerProfessional organization providing information about epilepsy care, aiming to bring together professionals involved with epilepsy. Part of International League Against Epilepsy (ILAE).
• University Medical Center UtrechtcoreStrategic or Co-development PartnerCollaboration on clinical genetics and epilepsy surgery. SEIN supervises depth EEG recordings at UMC Utrecht. Partnership in research and training.
• International Bureau for Epilepsy (IBE)minorStrategic or Co-development PartnerSEIN has been a member since 1990. IBE is the international organization for medical and non-medical aspects of epilepsy, supporting collaborative research projects.
• University of Leiden (Centre for Drug Research)minorStrategic or Co-development PartnerAcademic research collaboration on drug research related to epilepsy treatment development.
• University College London (UCL)minorStrategic or Co-development PartnerInternational academic research collaboration on epilepsy and related conditions.
• Amsterdam UMCminorStrategic or Co-development PartnerResearch collaboration on child psychology, neuropathology, and causes of epilepsy development.
• Erasmus UMC RotterdamminorStrategic or Co-development PartnerResearch collaboration on neuroinflammation related to epilepsy.
• Dutch Tuberous Sclerosis Foundation (STSN)minorGTM or Marketing PartnerPatient organization contact for tuberous sclerosis complex, a genetic disorder often associated with epilepsy.
• Dutch/Flemish Dravet Syndrome FoundationminorGTM or Marketing PartnerPatient organization for Dravet syndrome, a rare genetic epilepsy often requiring specialized treatment.
• Vera Vitaal FoundationminorGTM or Marketing PartnerPatient interest organization supporting people with epilepsy and related conditions.
• Epilepsie &zominorGTM or Marketing PartnerPeer platform for people affected by epilepsy to connect and share experiences.
• Stichting Wakker Worden Wakker WordenminorGTM or Marketing PartnerFoundation established by Jochem Myjer focused on narcolepsy research and awareness. Raised 162,964 euros through benefiet performances, partially benefiting SEIN for narcolepsie research.

Scale indicators8 records

Recent moves9 records

Expansion highlights6 records

Direct peers

• Kempenhaeghe: Dutch center of expertise for epilepsy with a similar model of multidisciplinary care, residential facilities, sleep medicine, and scientific research. Collaborates with SEIN through the Leerhuis Epilepsie and narcolepsy biobank, making it the most directly comparable Dutch peer.
• Mara Hospital (Bethel Epilepsy Center): Germany's leading epilepsy specialty center, operating as a tertiary referral institution with residential care, diagnostics, and research — a structural parallel to SEIN across the Dutch border.

Broad incumbents

• University College London Hospitals (UCLH) - National Hospital for Neurology and Neurosurgery: Major UK tertiary neurology and neurosurgery center with a dedicated epilepsy surgery program and research portfolio. Broader academic medical center but with overlapping epilepsy specialty capabilities.
• King's College Hospital - King's Epilepsy Group: UK-based tertiary center running one of Europe's largest epilepsy surgery programs. Comparable in tertiary epilepsy care depth, embedded in a broader academic hospital.
• Cleveland Clinic Epilepsy Center: Large US-based integrated health system with a dedicated epilepsy center offering diagnostics, surgery, and research — overlapping clinical services at greater scale.
• UMC Utrecht Brain Centre: Dutch academic medical center where SEIN-supervised depth EEG recordings and epilepsy surgeries are performed. Competes indirectly for advanced epilepsy cases while also serving as a research partner.
• Charité - Universitätsmedizin Berlin: Germany's largest university hospital with neurology and sleep medicine capabilities. Regional European incumbent with overlapping specialty offerings.

Regional players

• Sleep & Lung Centre (Netherlands sleep medicine): Dutch specialty outpatient provider focused on sleep disorders; competes with SEIN's Sleep-Wake Centres for sleep referrals within the same Dutch geography.

Emerging players

• Empatica: Wearable seizure detection company developing consumer/clinical devices (e.g., Embrace) for epilepsy monitoring. Represents a digital-health entrant that could compete with SEIN's HUME-sock in remote monitoring.
• PsyQ: Dutch mental health provider that collaborates with SEIN on PNES (psychogenic non-epileptic seizure) referrals. Adjacent behavioral health overlap within the Dutch specialty care landscape.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/epilepsiesein
• YouTubeyoutube.com/channel/UCmG20od1ZffaO7G4e4xqZdw
• Facebookfacebook.com/Epilepsiecentrum.SEIN
• LinkedInnl.linkedin.com/company/stichting-epilepsie-instellingen-nederland
• Instagraminstagram.com/epilepsiesein

Revenue estimate

Valuation estimate

Number of profiles

Profiles8 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about SEIN