GenXPro

What GenXPro does

GenXPro GmbH is a Frankfurt am Main-based (Germany) specialty genomics services and bioinformatics company founded in 2005 and independently owned by its co-founders Dr. Ralf Horres and Dr. Björn Rotter. The company operates a single NGS laboratory out of the Frankfurter Innovationszentrum Biotechnologie (FIZ) and focuses on highly sensitive sequencing applications — particularly those involving challenging sample types such as FFPE tissue, single cells, exosomal RNA, and partially degraded input material. Its technical foundation is the patented TrueQuant UMI adapter chemistry (WO2009152928A2, invented 2008) for PCR bias reduction, extended through the proprietary MACE-Seq 3'mRNA-sequencing protocol and a broad kit portfolio (MACE-Seq Kit, TrueQuant smallRNA-Seq Kit V2, cfDNA-Seq Kit, TQ Universal Adaptors, 16S rRNA V3V4 Kit).

The company monetizes through four streams: (1) fee-for-service sequencing across transcriptomics, genomics, epigenomics, microbiomics, and specialty applications (RNA-Seq, MACE-Seq, smallRNA-Seq, PanRNA-Seq, Exome-Seq, Whole Genome, Methyl-Seq, ATAC-Seq, Ribo-Seq, CAGE-Seq, amplicon/aptamer sequencing); (2) one-time reagent kit and adapter sales; (3) a cloud-based subscription bioinformatics platform (bioinformatics.genxpro.net) providing automated FASTQ-to-report pipelines; and (4) a SARS-CoV-2 diagnostic product line spanning CE-IVD qRT-PCR assays and variant-specific detection kits (Omicron BA.2/4/5, Delta, Alpha/Beta/Gamma, Mu, Lambda, N501Y, E484K) plus the ReLy viral lysis/storage buffer. Distribution is direct, quote-based via sales.genxpro.net, and the company has extended into digital PCR (STILLA naica) and long-read sequencing support (SAGE Pippin Prep) more recently.

Customer segments are diversified across Health/Pharma (precision medicine, biomarker discovery, liquid biopsy — primary), Agro-science (plant/animal breeding, genotyping-by-sequencing), non-model organism research, and biomarker/diagnostic development. The company is embedded in several EU-funded research consortia (FemNAT-CD, List_MAPS, Triple-T/Eurostars) and maintains an active peer-reviewed publication record serving as scientific-marketing collateral.

Name

GenXPro

Legal name

GenXPro GmbH

Website

https://genxpro.net

Company type

Private

Founded year

2005

Operating status

Operating

Headcount range

11–50 employees

Short description

GenXPro GmbH is a Frankfurt, Germany-based NGS services and bioinformatics company offering patented TrueQuant UMI-based library preparation, MACE-Seq 3'mRNA sequencing, reagent kits, a cloud bioinformatics platform, and SARS-CoV-2 qPCR diagnostics to academic researchers, pharma/biotech firms, and agricultural research clients worldwide.

Ownership category

akta.pro rank

Product category

Genomics & NGS Services

NAICS

Medical Laboratories (621511), Medical and Diagnostic Laboratories (6215), Research and Development in Biotechnology (except Nanobiotechnology) (541714), Scientific Research and Development Services (5417), Software Publishers (5132)

SIC

Services-Medical Laboratories (8071), Services-Commercial Physical & Biological Research (8731), In Vitro & In Vivo Diagnostic Substances (2835), Laboratory Analytical Instruments (3826)

akta.pro primary industry

Genomics & Next-Generation Sequencing (NGS) Services (HLAGANAA)

akta.pro secondary industries

Transcriptomics & Gene Expression Profiling Services (HLAGANAE), Molecular Diagnostics & Genomics Laboratories (HLAFAMAE), Genetic & Genomic Testing (germline, somatic, carrier, pharmacogenomics) (HLAAALAD), Genomic & Multi-Omic Biomarkers (NGS panels, transcriptomics, proteomics, metabolomics) (HLAAAMAJ), Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF), Genomics & Molecular Diagnostics (Trial Support) (HLAGAEAD)

Keywords

• NGS sequencing services
• Library preparation kits
• Bioinformatics analysis
• Biomarker discovery
• QPCR diagnostic assays

Headquarters

HQ city

Frankfort

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Infrastructure, Marketing or Sales

Revenue model

1. NGS Services: Comprehensive next-generation sequencing services including project planning, consulting, sample preparation, sequencing and bioinformatics. Services cover transcriptomics, genomics, epigenomics, and microbiomics applications for research projects.
2. NGS Kit Sales: Sale of proprietary reagent kits including MACE-Seq Kit, small RNA-Seq Kit, pan RNA-Seq Kit, 16S rRNA-Seq Kit, cfDNA-Seq Kit, and TrueQuant Universal Adaptors with UMIs for various NGS applications.
3. Bioinformatics as a Service: Cloud-based bioinformatics platform providing automated NGS data analysis. Customers upload FASTQ files and receive comprehensive results including QC metrics, differential expression analysis, pathway analysis, and publication-ready reports.
4. SARS-CoV-2 Diagnostic Kits: qPCR assay kits for SARS-CoV-2 detection and variant identification including research-use-only and CE-IVD marked products. Kits available for various variants of concern and mutations.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels5 records

Core offering

GenXPro provides end-to-end next-generation sequencing (NGS) laboratory services covering project planning, consulting, sample preparation, sequencing, and bioinformatics for transcriptomics, genomics, epigenomics, and microbiomics applications. The company also sells proprietary reagent kits built on its patented TrueQuant UMI and MACE-Seq technologies, a portfolio of SARS-CoV-2 qPCR diagnostic assays, and a cloud-based bioinformatics platform that delivers automated NGS data analysis and publication-ready reports.

Product overview

GenXPro offers a comprehensive NGS solutions portfolio centered on patented library preparation methods and bioinformatics analysis. The core offerings include: (1) NGS service laboratory with sample preparation and sequencing (MACE-Seq, RNA-Seq, smallRNA-Seq, PanRNA-Seq, 16S rRNA-Seq, cfDNA-Seq, Whole Genome/Exome Sequencing, ATAC-Seq, Methyl-Seq, and specialty services like Ribo-Seq and CAGE-Seq), (2) proprietary TrueQuant kit products featuring patented UMI adapters for bias reduction (MACE-Seq Kit, small RNA-Seq Kit V2, Universal DNA Adaptors, cfDNA-Seq Kit, 16S rRNA V3V4 Kit), (3) COVID-19/SARS-CoV-2 molecular diagnostic product line including qPCR assays (FluoGene Q, variant-specific assays for Omicron, Delta, Alpha, Beta, Gamma, Lambda, Mu, N501Y, E484K mutations), RELY-viral lysis buffer, and genomic sequencing services, and (4) cloud-based bioinformatics platform enabling automated NGS data analysis. The TrueQuant technology (patented WO2009152928A2) using unique molecular identifiers for PCR bias reduction underpins the kit products and services.

Differentiator

Problem solved

Functional benefit

Products and services

• MACE-Seq Service (3' mRNA Sequencing) High-sensitivity 3'mRNA-sequencing service using patented MACE-Seq methodology for genome-wide gene-expression analysis of poly-adenylated RNA from single cells, FFPE-derived samples, and low-input or partially degraded material; for research and biomarker discovery customers.
• RNA-Seq Service Full-length RNA sequencing targeting poly-adenylated or non-ribosomal RNA for high-resolution transcription profiling, non-coding RNA study, and gene-expression dynamics across diverse sample types.
• smallRNA-Seq Service (miRNA / piRNA / siRNA / tRF) High-sensitive small RNA sequencing using TrueQuant UMI adapters to profile RNA molecules of 20-80 bp including miRNA, piRNA, siRNA, snRNA, snoRNA, tRF, ysRNA, viral, and bacterial RNA.
• PanRNA-Seq Service Simultaneous analysis of smallRNA and mRNA of model organisms, sequencing the entire spectrum of RNA species in a single workflow.
• Targeted Metagenomics (16S/18S) Service Analysis of 16S rRNA V3/V4 and 18S rRNA V4 regions for high-resolution quantification of bacterial and microbial communities by NGS.
• Exome-Seq Service Sequencing of coding regions of the human genome via hybrid capture using Illumina whole-exome sequencing chemistry 2.5.
• Methyl-Seq Service Genome-wide DNA methylation analysis by Methyl-Seq, optimized for high sensitivity and precision across diverse DNA samples including low-input and partially degraded sources.
• CoV-Seq (SARS-CoV-2 Genome Sequencing) Service SARS-CoV-2 genomic sequencing service for variant identification and surveillance; demonstrated capacity to sequence more than 10,000 SARS-CoV-2 genomes (up to ~400/day).
• CAGE-Seq Service Sequencing of capped 5' mRNAs using CAGE-Seq methodology for transcription-start-site and promoter analysis.
• Ribo-Seq Service Ribosome-footprinting analysis of ribosome-bound mRNA fragments for translatome profiling using the TrueQuant smallRNA-Seq protocol.
• tRNA-Seq Service High-sensitive analysis of tRNA fragments (tRFs) based on the TrueQuant smallRNA sequencing protocol adapted for tRNA analysis.
• ATAC-Seq Service ATAC-Seq service for genome-wide profiling of chromatin accessibility.
• Whole-Genome-Seq Service Sequencing of the entire genome for comprehensive genomic analysis including variant detection, copy-number variation, and genome-structure studies.
• DNA-Seq Service Sequencing of genomic DNA for variant analysis, copy-number variation, and genome-structure analysis.
• Amplicon-Seq Service NGS sequencing of PCR amplicons for quantitative and qualitative determination of different amplicons; used in aptamer and biomarker workflows.
• Aptamer-Seq Service Sequencing of aptamers using specialized library preparation and analysis for diagnostic and therapeutic aptamer-discovery workflows.
• Degradome-Seq Service Sequencing of Degradome-Seq libraries for analysis of RNA degradation products.
• Digital qPCR Service (ddPCR) Digital PCR service using the STILLA naica 6-color system for simultaneous quantification of up to six targets per sample, applied to liquid biopsies, microbiome, transcriptome, and other applications.
• Pippin Prep Service (High Molecular Weight DNA Selection) Service for selection of high-molecular-weight DNA for third-generation sequencing (Oxford Nanopore or PacBio) using the SAGE-Pippin Prep Instrument.
• GenXPro Bioinformatics Platform (Cloud)
• TrueQuant MACE-Seq Kit Library-preparation kit with patented UMI and UDI technology (WO2009152928A2) for high-sensitivity 3' mRNA-Seq, enabling genome-wide gene-expression analysis of poly-adenylated RNA with PCR-bias reduction; for research laboratories.
• TrueQuant small RNA-Seq Kit V2 Library-preparation kit V2 with patented UMI adapters (WO2009152928A2) for high-sensitive smallRNA-Seq of RNA between 20-80 bps, including miRNA, piRNA, siRNA, snRNA, snoRNA, tRF, ysRNA, viral, and bacterial RNA; suited for EV-derived and single-cell inputs.
• GXP-16s V3V4 rRNA Kit
• TQ cfDNA-Seq Kit
• TQ Universal Adaptors (UMIs)
• ReLy Viral Lysis & Storage Buffer Viral lysis and storage buffer that instantly neutralizes SARS-CoV-2 virus particles rendering them non-infectious while stabilizing viral RNA at room temperature for at least 10 days; for diagnostic and research sample transport.
• Covid-19 FluoGene Q Dual-Target SARS-CoV-2 qPCR CE-IVD marked dual-target multiplex qRT-PCR assay for qualitative detection of SARS-CoV-2 specific RNA, targeting M and N1 genes plus RNase P internal control; for clinical and diagnostic laboratories.
• SARS-CoV-2 Variant-of-Concern qPCR Assay Portfolio Portfolio of variant-specific qPCR assays for SARS-CoV-2, including VoXcreen/VoXident Omicron PCR tests (BA.2, BA.4, BA.5), Delta (B.1.617) Dual-Plex, Lambda variant assay (del246-252), Mu variant assay (B.1.621), Quad-Plex All-In-One (N501Y), E484K-specific assay, and combined Alpha/Beta/Gamma/Delta (ABGD) kit; for surveillance and diagnostic laboratories.

Quantifiable outcome

• Capacity to sequence up to 400 SARS-CoV-2 genomes per day
• +3 more outcomes

Named customers2 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability2 records

Feature6 records

Partnerships

Three partnerships are on record, tiered core and minor.

• FemNAT-CD ConsortiumcoreStrategic or Co-development PartnerEuropean Commission-funded research project studying sex differences in behavior. GenXPro contributes genomic and transcriptomic expertise to analyze brain structure and function in children aged 9-18 years across Europe. Project coordinated by Goethe University Frankfurt.
• List_MAPS ConsortiumminorStrategic or Co-development PartnerMarie-Sklodowska Curie Innovative Training Network (ITN) focused on Listeria monocytogenes adaptation through proteomic and transcriptome deep sequencing analysis.
• Triple-T (Eurostars)coreStrategic or Co-development PartnerEurostars project combining expertise of University Medical Center Groningen, GenXPro GmbH, and PamGene International BV for genomic and kinase activity profiling to provide rational treatment selection for therapy-resistant lung tumors.

Scale indicators4 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• Lexogen GmbH: Austria-based developer of RNA-Seq library preparation kits including small RNA/miRNA library prep. Closely comparable to GenXPro in size, geography (DACH), product mix (RNA-Seq kits), and target customers (academic and pharma research labs).
• LC Sciences: US-based specialist in small RNA / miRNA sequencing services and analysis, with comparable focus on transcriptomics services and proprietary bioinformatics pipelines. Directly competes in miRNA-Seq and biomarker discovery services.
• CeGaT GmbH: German NGS services provider offering exome, genome, RNA-Seq, and panel sequencing for clinical and research customers. Operates from Tübingen with a similar boutique scale and academic/pharma customer base as GenXPro.
• SeqCenter LLC: US-based NGS services provider acquired by ARCHIMED in 2024, offering sequencing services to academic and industrial customers. Comparable in service-led NGS business model and customer mix.

Broad incumbents

• Novogene: Global NGS services provider with extensive capacity across RNA-Seq, exome, genome, and single-cell applications. Competes for the same academic and pharma service contracts but at substantially greater scale and global footprint.
• Eurofins Genomics: Part of Eurofins Scientific, offering high-throughput oligo synthesis, DNA sequencing, and genomics services worldwide. Overlaps with GenXPro in NGS services and kit/reagent distribution, with much broader portfolio and reach.
• Macrogen: Korea-headquartered global genomics services company providing sequencing, microarrays, and bioinformatics. Competes for international RNA-Seq and whole-genome service contracts.
• BGI Genomics: China-based global genomics organization offering NGS services, sequencing platforms, and bioinformatics at massive scale. Competes on cost for high-throughput NGS service work and has overlap in transcriptomics and clinical sequencing.
• QIAGEN: Global life science tools and molecular diagnostics company offering sample-prep kits, NGS library prep, and bioinformatics (e.g., QIAseq products). Adjacent competitor in library-prep kits and broader molecular workflow solutions.
• Illumina: Dominant NGS instrument and reagent provider whose sequencing platforms underpin most of GenXPro's service work, and which itself offers sequencing services and library-prep kits. Sets the competitive baseline for the entire NGS ecosystem.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks7 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/genxpro-gmbh
• Xx.com/GenXProGmbH

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about GenXPro