Biostream

What Biostream does

Biostream International B.V. is a Netherlands-based manufacturer of bioreactors and fermentation equipment, founded in 2013 and headquartered in Doetinchem. The company designs, produces, and services bioreactors spanning 50 ml benchtop reactors up to 15 cubic meter pilot- and production-scale vessels, serving customers in four application verticals: food fermentation, biobased products (including PHA, ethanol, butanol, and hydrogen from biomass), microalgae cultivation, and cell culture research. Its product portfolio comprises the BioBench (12" touchscreen benchtop bioreactor), BioTwin (15" touchscreen dual-vessel system), and BioPilot (production-scale bioreactor up to 15 M3), supported by a range of custom glass and stainless steel vessels and proprietary control software featuring trendlines, cascade linking, and integrated instruction protocols.

The business model is built on direct sales of capital equipment via a website-driven inquiry process, complemented by service and maintenance work and quote-based pricing with milestone payments (60% pre-payment on orders above €10,000). The company also generates distribution revenue as DNA Script's channel partner for the SYNTAX benchtop DNA synthesis platform in Japan and South Korea, signed in March 2026, marking its first documented East Asian footprint. Customers are segmented by vertical (food, biobased, algae, cell culture) and by size tier (medium and large companies, institutions, and semi-government organizations). Notable strategic partnerships include a co-development alliance with AlgaePARC for algae cultivation commercialization and technology integrations with Broadley James (sensor technology) and Bioprocess Technology. The company is privately held with no disclosed funding rounds, M&A activity, or revenue figures.

Name

Biostream

Legal name

BIOSTREAM INTERNATIONAL B.V.

Website

https://biostream-international.com

Company type

Private

Founded year

2013

Operating status

Operating

Headcount range

11–50 employees

Ownership category

akta.pro rank

Product category

Bioreactor and Fermentation Equipment Manufacturing

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Apparatus & Furniture (3821), Laboratory Analytical Instruments (3826)

akta.pro primary industry

Upstream Bioprocessing Systems & Equipment (cell culture/fermentation, bioreactors, feeds/media) (HLAAAJAA)

akta.pro secondary industries

Cell Culture & Bioprocess Lab Equipment (Bioreactors, Single-Use Systems, Controllers) (HLAGAIAG), Bioprocess Facility, Cleanroom & Utility Systems (HVAC, WFI, CIP/SIP, containment) (HLAAAJAJ)

Keywords

• Bioreactor manufacturing
• Fermentation equipment
• Cell culture systems
• Pilot-scale bioreactors
• Photobioreactor technology

Headquarters

HQ city

Doetinchem

HQ country

Netherlands

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Technology or R&D, Personnel, Operations, Marketing or Sales

Revenue model

1. Bioreactor Equipment Sales: Biostream generates revenue from manufacturing and selling bioreactors, fermenters, and related vessels ranging from small-scale 50ml reactors to large-scale production vessels up to 15 M3. The company offers standard reactors as well as custom-designed solutions.
2. Custom Vessel Manufacturing: The company provides customized vessel designs for specific customer applications, including glass and stainless steel options for cell culture and microbiology fermentation.
3. Service and Maintenance: The company has evolved from service and maintenance of existing bioreactors to supplying complete ranges of standard reactors, indicating service revenue from maintenance and support.

Pricing tiers

Go-to-market motion2 records

Distribution channels2 records

Marketing channels3 records

Core offering

Biostream designs, manufactures, and services bioreactors and fermentation equipment ranging from 50 ml benchtop reactors to 15 m³ pilot-scale production vessels. The company sells standard systems (BioBench, BioTwin, BioPilot), custom vessel designs, and proprietary control software to food, biobased, algae, and cell culture customers worldwide.

Product overview

Biostream offers a portfolio of bioreactor products spanning research to production scale. The core product line consists of BioBench (benchtop bioreactor with 12" touchscreen), BioTwin (compact benchtop variant with 15" touchscreen), and BioPilot (large-scale production system up to 15 M3). These share compatible vessels (standard glass/stainless steel and custom designs), the proprietary Software platform for control and monitoring, and application-specific solutions for food, biobased, algae, and cell culture. The company also distributes DNA Script's SYNTAX DNA synthesis platform in South Korea and Japan.

Differentiator

Problem solved

Functional benefit

Brands

• BioBench: Benchtop bioreactor system with 12-inch touchscreen, supporting up to 6 units controlled simultaneously, designed for algae, cell culture, and fermentation applications.
• BioTwin
• BioPilot

Products and services

• BioBench

Quantifiable outcome

• Reduce dependence on overseas manufacturing through local DNA synthesis capabilities in Japan and South Korea

Segments5 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

Two partnerships are on record, tiered core.

• DNA ScriptcoreChannel Partner/ Reseller/ Distributor · 24 March 2026Biostream has signed a distribution agreement with DNA Script to distribute its SYNTAX benchtop DNA synthesis platform in Japan and South Korea. This partnership enables local researchers to synthesize oligonucleotides within hours, reducing dependence on overseas manufacturing and improving supply chain reliability. The agreement is part of DNA Script's strategy to broaden global adoption of its technology and accelerate local biomanufacturing capabilities in underserved regions.
• AlgaePARCcoreStrategic or Co-development PartnerBiostream collaborates with AlgaePARC to develop a sustainable and commercial production chain for algae cultivation. The company has produced a short movie explaining how these reactors are brought to market in collaboration with AlgaePARC. This partnership focuses on developing and commercializing algae bioreactor technology.

Scale indicators3 records

Recent moves5 records

Expansion highlights5 records

Broad incumbents

• Cytiva (formerly GE Healthcare Life Sciences): Supplies Xuri cell expansion and WAVE bioreactor systems as part of a full bioprocess workflow. Comparable to Biostream in cell-culture bioreactors but operates as a broad incumbent with single-use, filtration, and chromatography adjacencies.
• Sartorius AG: Global bioprocessing leader offering stainless-steel and single-use bioreactors (e.g., Biostat) from lab to production scale. Directly comparable to Biostream across the upstream bioprocess stack, but at vastly larger scale and with a much broader product portfolio.
• Eppendorf AG: Eppendorf sells the New Brunswick and BioFlo bioreactor families alongside its broader lab-consumables portfolio. Comparable to Biostream in benchtop and pilot bioreactors for research and small-scale production applications.
• Merck KGaA / MilliporeSigma: Through its Life Science segment, supplies Mobius bioreactors and a full bioprocess workflow. Overlaps with Biostream in upstream bioprocessing but competes as a much larger incumbent with media, single-use, and consumables adjacencies.

Direct peers

• Getinge (Applikon Biotechnology): Applikon (now part of Getinge) manufactures benchtop, pilot, and production bioreactors (my-Control, Bio Console) with proprietary controllers. The closest direct competitor to Biostream's BioBench/BioTwin/BioPilot line in cell culture and microbial fermentation.
• Infors HT: Swiss manufacturer of benchtop (Minifors, Multifors) and pilot bioreactors with proprietary eve software. Very close competitor to Biostream in the small-to-mid-scale bioprocess segment, especially in academic and industrial biotech.
• Solaris Biotechnology: Italian manufacturer of benchtop and pilot bioreactors and fermentation systems, including stirred-tank and single-use vessels. Comparable niche specialist competing with Biostream in custom-engineered small-to-mid-scale bioreactors.
• Pierre Guérin Technologies: French custom manufacturer of stainless-steel bioreactors and fermenters from lab to industrial scale. Closely comparable to Biostream's BioPilot and custom-vessel offering, especially in food and biobased fermentation applications.

Emerging players

• PBS Biotech: Specialises in single-use, vertical-wheel bioreactors for cell and gene therapy. Adjacent competitor to Biostream's cell-culture line with a more focused, single-use product orientation.

Regional players

• Zeta Group (Zeta Biopharma): Austrian/German engineering firm designing bioreactors and aseptic process skids, including photobioreactors and stainless-steel fermenters. Comparable custom-engineering profile to Biostream with stronger installed base in DACH industrial biotech.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/biostream-bv

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Biostream