What Chemtrix does

Chemtrix BV is a Netherlands-based designer and manufacturer of continuous flow microreactor systems used by pharmaceutical, fine chemical, specialty chemical, agrochemical, and academic customers worldwide. Founded in 2008, the company sells a complete scalable reactor portfolio spanning mg-scale laboratory screening (glass-based Labtrix Start, Labtrix S1, GramFlow, KiloFlow) through pilot (Protrix) to multi-tonne industrial production (Plantrix MR260 and MR555). Industrial-scale reactors are fabricated from 3M silicon carbide, selected for chemical compatibility with aggressive chemistries and superior heat transfer performance; the proprietary SOR-mixer architecture with integrated heat exchange is the company's underlying technical platform. Documented scale factors reach x340 from Protrix to Plantrix MR555, and 13,000x scale-up without parameter re-optimization has been demonstrated.

Chemtrix generates revenue from three streams: hardware sales of complete reactor systems and individual reactors (quote-based pricing across lab, pilot, and industrial tiers); Flow Process Development professional services (FlowScan theoretical assessment, feasibility assessment, pilot proof demonstration); and Industrial System Engineering (turn-key automated flow systems built to ATEX, CE, and cGMP standards, including ATEX/CE/cGMP-compliant skids for multi-metric tonne manufacture). Distribution combines direct enterprise sales with a global network of regional representatives across 14+ countries (Netherlands, UK, Poland, Lithuania, Hungary, Czech Republic, Slovenia, India, China, Japan, Korea, Taiwan, USA, Israel), supplemented by joint university laboratories in China and the company-organized Flow Chemistry Pavilion at ACHEMA exhibitions.

The company originated from Novartis-sponsored research at the University of Hull in 2000 (PhD work on "Microreactors in Organic Synthesis" by current CEO Dr. Charlotte Wiles) and evolved through a joint venture with Lionix BV before incorporating independently in the Netherlands in 2008. On December 29, 2023, Chemtrix BV was acquired by Japan's AGI Group, integrating its industrial flow scale-up capabilities with sister companies Syrris, Premex Reactor, and AGI Glassplant. Headcount remains 11-50, with Dr. Wiles continuing as CEO.

Name

Chemtrix

Legal name

Chemtrix BV

Website

https://chemtrix.com

Company type

Private

Founded year

2008

Operating status

Operating

Headcount range

11–50 employees

Short description

Chemtrix BV, a Netherlands-based subsidiary of Japan's AGI Group since December 2023, designs and manufactures scalable continuous flow microreactor systems (Labtrix, GramFlow, KiloFlow, Protrix, Plantrix) using glass and 3M silicon carbide reactors. The company serves pharmaceutical, fine chemical, agrochemical, and academic customers globally across lab, pilot, and industrial production scales.

Ownership category

akta.pro rank

Product category

Flow Chemistry Equipment / Process Intensification Reactors

NAICS

Analytical Laboratory Instrument Manufacturing (334516), Measuring, Dispensing, and Other Pumping Equipment Manufacturing (333914)

SIC

Laboratory Analytical Instruments (3826)

akta.pro primary industry

Flow Chemistry & Process Intensification Services (HLAGAHAK)

akta.pro secondary industries

Chemical Processing Equipment (Reactors, Mixers, Agitators) (IMAHAEAA), GMP Scale-Up, Tech Transfer & Process Validation (PPQ) (HLAGAHAL), Process Development & Tech Transfer (Upstream/Downstream/MSAT) (HLAGAGAE)

Keywords

• Continuous flow chemistry
• Microreactor systems
• Process intensification
• Flow reactor equipment
• Pharmaceutical manufacturing equipment

Headquarters

HQ city

Geleen

HQ country

Netherlands

HQ region

Europe

Offices6 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Supply Chain, Technology or R&D, Operations, Marketing or Sales

Revenue model

1. Flow Reactor Hardware Sales: Sale of flow reactor systems ranging from laboratory-scale (Labtrix, GramFlow) through pilot-scale (KiloFlow, Protrix) to production-scale (Plantrix MR260, MR555). Products are sold as complete systems with peripherals or as individual reactors.
2. Flow Process Development Services: Consulting services including feasibility assessments, proof of concept delivery, and pilot demonstrations. Services access over two decades of flow chemistry experience to evaluate process conversion feasibility.
3. Industrial System Engineering: Design and realisation of complete pilot or production systems. Turn-key, automated flow systems built to industry standards including basic engineering, detailed engineering, procurement, building, testing, delivery, and commissioning.

Go-to-market motion3 records

Distribution channels4 records

Marketing channels5 records

Core offering

Chemtrix supplies complete and customized microreactor (flow chemistry) systems for R&D and commercial manufacturing, spanning from mg-scale laboratory reaction screening through multi-tonne industrial-scale production. The portfolio includes glass flow reactors (Labtrix Start, Labtrix S1, GramFlow, KiloFlow) for lab and pilot work, and ceramic 3M silicon carbide reactors (Protrix, Plantrix MR260/MR555) for industrial production. The company also delivers professional Flow Process Development services and turn-key Industrial System Engineering for pharmaceutical, fine chemical, and specialty chemical customers.

Product overview

Chemtrix offers a scalable flow reactor portfolio enabling industry and academia to harness flow chemistry advantages from laboratory to industrial production scale. The product line comprises glass flow reactors (Labtrix Start, Labtrix S1, GramFlow, KiloFlow) selected for chemical resistance, optical transparency and familiarity to R&D chemists, transitioning to ceramic 3M silicon carbide flow reactors (Protrix, Plantrix MR260, Plantrix MR555) for pilot-production and full-scale manufacturing. Chemtrix provides end-to-end services including Flow Process Development (FlowScan, feasibility, pilot proof) and Industrial System Engineering (design, realisation, commissioning). The portfolio spans mg-scale reaction screening through multi-tonne industrial production, with recent acquisition by AGI Group (December 2023) expanding scale-up capabilities.

Differentiator

Problem solved

Functional benefit

Brands

• Labtrix: Automated continuous flow system for reaction screening and process optimisation at lab scale
• GramFlow
• KiloFlow
• Protrix
• Plantrix

Products and services

• Labtrix Start Manually operated, metal-free continuous flow reactor system for reaction screening and process optimisation. Features modular design with flexible feed lines, reactor type and volume options. Suitable for education and training applications.
• Labtrix S1 Automated continuous flow system for reaction screening and process optimisation. Features glass flow reactors at its heart with high chemical compatibility peripherals for challenging chemistries. Software enables automated recipe execution with data logging and automatic sample collection.
• GramFlow Glass flow reactor for lab-based screening and reaction optimisation with integrated heat exchange for optimal thermal control of challenging chemistries and process intensification.
• KiloFlow Glass flow reactor for process development and small-scale production with integrated heat exchange and metal-free flow path. Suitable for performing challenging chemistries and process intensification up to kg-scale.
• Protrix Ceramic (3M silicon carbide), metal-free flow reactor for process development and small-scale production. Offers unrivalled chemical compatibility and heat exchange performance for process intensification and reaction control.
• Plantrix MR260 Modular ceramic flow reactor for process development, pilot and full-scale production. Fabricated from 3M silicon carbide with integrated heat exchange for unrivalled chemical compatibility and process control.
• Plantrix MR555 Ceramic flow reactor for manufacturing at multi-metric tonne-scale. With integrated heat exchange, provides optimal control for scale-up of challenging chemistries and process intensification at industrial scale.
• Flow Process Development Expert flow chemistry services including FlowScan theoretical assessment, feasibility assessment for proof of concept, and pilot proof demonstrations. Offers over two decades of flow chemistry experience to evaluate the feasibility of converting processes from batch to continuous.
• Industrial System Engineering Turn-key, automated flow systems built to industry standards. Services include basic and detailed engineering, realisation, and commissioning. Specialises in ATEX, CE and cGMP compliant skids for multi-metric tonne-scale manufacture of chemicals and pharmaceuticals.

Quantifiable outcome

• 500+ MT of commercial-scale continuous manufacturing achieved in first year
• +4 more outcomes

Named customers19 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration4 records

Feature5 records

Partnerships

13 partnerships are on record, tiered core, major and minor.

• Perceptive EngineeringcoreStrategic or Co-development Partner · 31 March 2020Eureka GlobalStars award project (CONOPT) collaboration with Perceptive Engineering Singapore and a multinational pharmaceutical company. Project develops AI platform and Benefits Quantification Methodology for continuous flow manufacturing control and decision support.
• TKS PublishermajorGTM or Marketing Partner · 1 October 2019Partnership with TKS Publisher (TeknoScienze) to organize the Flow Chemistry Pavilion at ACHEMA exhibitions. TKS provides event organization, marketing, and symposium programming for the Flow Chemistry Community event.
• CCFlow ConsortiummajorStrategic or Co-development Partner · 1 July 2017Austrian Research Promotion Agency (FFG) K-Project 'CC FLOW - Center for Continuous Flow Synthesis and Processing'. Consortium includes AstraZeneca, Eli Lilly, Lonza, and others. Project focuses on process simplification, intensification, and integration with 4.7 M EUR funding over four years.
• Hebei University of TechnologyminorStrategic or Co-development Partner · 23 June 2017Micro Reactor Application Technology Cooperation Laboratory opened June 2017 for flow reactor demonstration and training with Labtrix Start, KiloFlow, and Protrix.
• Zhejiang UniversityminorStrategic or Co-development Partner · 1 July 2012Joint laboratory opened July 2012 at School of Pharmacy for demonstration and development of continuous flow processes using Labtrix Start and Plantrix MR260.
• CoRIAC ConsortiumminorStrategic or Co-development Partner · 1 January 2010Demonstration of Continuous Reactors with In-line Analytics for Fine Chemicals Production project (2010-2014) with partners including DSM, ISPT, ESK, Bronkhorst, Procter & Gamble, Mettler Toledo, Zeton, TU/e, and Koning & Hartman.
• Lionix BVcoreStrategic or Co-development Partner · 1 January 2003Strategic partnership formed in 2003 for manufacturing of glass micro reactors. Lionix BV manufactured high-quality reactors demonstrating repeatability between devices. Partnership led to formation of Chemtrix Ltd. in 2005 as joint venture.
• 3McoreStrategic or Co-development Partner3M provides silicon carbide (SiC) materials for Chemtrix's Protrix and Plantrix industrial flow reactors. 3M SiC enables unrivalled chemical compatibility and high corrosion resistance for aggressive chemistries and challenging conditions at industrial scale.
• Almac SciencesmajorStrategic or Co-development PartnerCDMO partner implementing Flow Assisted Synthesis Technology (FAST) for continuous flow processes. Collaboration includes joint presentations and case studies on successful implementation of continuous flow at CDMOs.
• Pi Process IntensificationminorChannel Partner/ Reseller/ DistributorIndia representative office and test facility for Chemtrix products, providing local sales and support.
• E-zheng TechnologyminorChannel Partner/ Reseller/ DistributorChina representative office for Chemtrix, also operating joint laboratories at Zhejiang University, Hebei University, and Fudan University.
• Fudan UniversityminorStrategic or Co-development PartnerFudan University, Chemtrix, and E-zheng Joint Laboratory for Continuous Reactor Technology enabling local research with Labtrix Start, GramFlow, and Protrix.
• Zuyd University of Applied SciencesminorStrategic or Co-development PartnerCollaboration on Flow4Nano project developing flow reactor for nano material production to increase solar panel efficiency. Partners include Brightlands Materials Center, TNO, and CHILL.

Scale indicators6 records

Recent moves7 records

Expansion highlights7 records

Direct peers

• Syrris: UK-based manufacturer of laboratory-scale continuous flow chemistry reactors (Asia flow, FRX, FLLEX). Now a sister company under AGI Group alongside Chemtrix, with overlapping technology and customer base at the laboratory end of the flow chemistry workflow.
• Vapourtec: UK manufacturer of flow chemistry systems including the R-Series, E-Series, and UV-150 photochemistry reactor. Directly competes with Chemtrix's Labtrix and KiloFlow lines in pharma and academic R&D accounts.
• AM Technology: UK-based designer and manufacturer of actively-mixed continuous flow reactors (Coflore ACR). Listed as a Chemtrix collaboration partner on the Cipla multi-step flow plant, indicating direct technical overlap in pharmaceutical flow reactor platforms.
• Ehrfeld Mikrotechnik (part of GMM Pfaudler): German microreactor technology company (now linked with GMM Pfaudler) offering flow reactors and process skid systems for fine chemicals and pharma. Competes with Chemtrix's Plantrix line for industrial-scale flow chemistry projects.
• Uniqsis: UK manufacturer of flow chemistry systems including FlowSyn and FlowReactor platforms, plus gas-liquid and photochemistry modules. Competes directly with Chemtrix Labtrix and GramFlow lines at the laboratory and process development scale.
• ThalesNano: Hungarian flow chemistry and hydrogenation reactor company offering the H-Cube and FlowCAT platforms. Competes with Chemtrix for academic and pharma lab customers seeking compact continuous reaction and hydrogenation solutions.
• Flowid: Netherlands-based spin-out from TU Eindhoven developing continuous flow process technology and skid-based reactors. Co-located with Chemtrix at Brightlands Chemelot Campus and competes in similar mid-TRL flow reactor projects.

Broad incumbents

• Corning Advanced-Flow Reactors: Business unit of Corning Incorporated supplying glass and silicon carbide continuous flow reactors for pharma and chemical manufacturing. A much larger incumbent offering overlapping products at lab, pilot, and industrial scales.

Regional players

• Pi Process Intensification: India-based chemical engineering consultancy and channel partner for Chemtrix, also delivering its own flow chemistry process development services across South Asia. Overlaps with Chemtrix's flow process development offering in the Indian market.

Emerging players

• Zaiput Flow Technologies: US-based manufacturer of flow chemistry peripherals, notably liquid-liquid separators and back-pressure regulators that integrate with Chemtrix reactors and competing platforms. An adjacent equipment peer serving the same continuous manufacturing ecosystem.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/chemtrix
• Facebookfacebook.com/236875239670325

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds3 records

Investors3 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Chemtrix