What Enantis does

Enantis s.r.o. is a privately-held biotechnology company headquartered at INBIT, Kamenice 771/34 in Brno, Czech Republic, founded as a spin-off from Loschmidt Laboratories at Masaryk University by Professors Jiri Damborsky and Zbynek Prokop. The firm engineers hyper-stable proteins through a proprietary platform that combines in silico design with experimental validation, anchored by three patented thermostable fibroblast growth factor variants — FGF2-STAB®, FGF10-STAB®, and FGF18-STAB® — that deliver 19°C higher melting temperature, 2-year room-temperature shelf-life versus <1 month for native FGF2, and 5-20x lower dosage requirements while retaining full biological activity. Beyond the FGF franchise, Enantis is the world's only commercial supplier of engineered haloalkane dehalogenases and is the exclusive distributor of nine protein engineering software tools (HotSpot Wizard, FireProt, FireProt-ASR, Caver Web, CaverDock, EnzymeMiner, CalFitter, LoopGrafter, SoluProt) developed alongside its academic partners. The company is ISO 9001:2016 certified for protein research, development, and production and holds granted or pending patents across the US, EP, CA, JP, KR, SG, and AU jurisdictions.

Enantis serves four primary customer segments: life science researchers requiring stable growth factors for stem cell and iPSC culture; cosmetic manufacturers building anti-aging and hair-growth formulations (commercial launches include LOBEY Laboratories' Growth Factor Serum Intense, SynCare, and Panakeia); cultured meat producers needing to reduce FGF2's ~60% media-cost share; and pharmaceutical and industrial biotechnology companies (BASF, Asahi Kasei) using its contract research services. Distribution runs through a hybrid model of direct e-commerce (enantis.com), regional distributors (McKinley Resources for North America from November 2025; Sollice Biotech globally for cosmetics from April 2026), and direct enterprise sales for contract research and bulk orders under CDA/MTA. Revenue is generated from one-time product sales (FGF proteins from 225 EUR; HLD screening kit at 4,000 EUR), annual software licensing (1,000-8,000 EUR per professional tool), and contract research fees.

The product roadmap is increasingly oriented toward therapeutics: FGF2-STAB is in preclinical testing for hard-to-heal wounds, FGF10-STAB in preclinical for ARDS, and FGF18-STAB is being explored for osteoarthritis, layering a clinical-grade pipeline on top of the existing research reagents and cosmetics business. Recognition includes the inaugural Estée Lauder Companies New Incubation Ventures BRKTHRU VOICES Prize (2024) and Most Innovative Product at InCosmetics Global 2024. No external funding rounds, parent company, or M&A activity are disclosed; the company operates as a privately-held, founder-led Czech entity (Enantis s.r.o., ID 276 76 013).

Name

Enantis

Legal name

Enantis s.r.o.

Website

https://enantis.com

Company type

Private

Founded year

2006

Operating status

Operating

Headcount range

11–50 employees

Short description

Brno-based Enantis is a privately-held biotech spin-off from Masaryk University that engineers hyper-stable fibroblast growth factors (FGF2-, FGF10-, FGF18-STAB), engineered haloalkane dehalogenases, and protein engineering software for cosmetics, cultured meat, life science research, and preclinical therapeutic applications.

Ownership category

akta.pro rank

Product category

Recombinant protein biotechnology

NAICS

Biological Product (except Diagnostic) Manufacturing (325414), Research and Development in Biotechnology (except Nanobiotechnology) (541714)

SIC

Biological Products, (No Disgnostic Substances) (2836)

akta.pro primary industry

Protein Engineering & Directed Evolution Platforms (enzyme/therapeutic protein optimization) (HLAAAIAC)

akta.pro secondary industries

Engineered Protein Therapeutics (de novo/AI-designed proteins, novel scaffolds) (HLAAAAAJ), Specialty & Novel Proteins (Single-Cell Protein, Cell-Cultured/Animal-Free Proteins) (AFAJAHAL)

Keywords

• Thermostable protein design
• Fibroblast growth factors
• Protein engineering software
• Haloalkane dehalogenase kits
• Cultured meat media proteins

Headquarters

HQ city

Brno

HQ country

Czechia

HQ region

Europe

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Product Sales (FGFs): Sale of FGF proteins for research, cosmetics, and cultured meat applications in various sizes with one-time purchase pricing.
2. Haloalkane Dehalogenases: Sale of HLD screening kit and engineered haloalkane dehalogenases. HLD screening kit priced at 4,000 EUR.
3. Protein Engineering Software Licensing: Licensing of commercial protein engineering software tools including HotSpot Wizard Professional (from 1,000 EUR), FireProt Professional (from 8,000 EUR), Caver Web Professional (from 1,000 EUR), and others.
4. Contract Research Services: Protein engineering services where Enantis applies its proprietary technology to stabilize customers' molecules. First free-of-charge in silico analysis to assess feasibility, followed by contract research. Carried out under CDA/MTA confidentiality.

Pricing tiers

Go-to-market motion2 records

Distribution channels5 records

Marketing channels7 records

Core offering

Enantis designs, manufactures and sells hyper-stable fibroblast growth factor proteins (FGF2-STAB®, FGF10-STAB®, FGF18-STAB®) in research, cosmetics and cultured-meat variants; produces engineered haloalkane dehalogenases and HLD screening kits; and is the exclusive distributor of nine commercial protein-engineering software tools. The company also provides contract research services for protein and enzyme stabilization under CDA/MTA, leveraging a proprietary in silico-plus-experimental protein engineering platform originating from Masaryk University.

Product overview

Enantis offers a portfolio of hyper-stable fibroblast growth factor (FGF) products (FGF2-STAB®, FGF10-STAB®, FGF18-STAB®) available in research, cosmetics, and cultured meat media variants, along with engineered haloalkane dehalogenases and a suite of 9 proprietary protein engineering software tools (HotSpot Wizard, FireProt, FireProt-ASR, Caver Web, CaverDock, EnzymeMiner, CalFitter, LoopGrafter, SoluProt). The company also provides contract research services for protein stabilization. The FGF products form the core biotech offerings with different formulations for research, cosmetics, and cultured meat applications, while the software products complement the engineering services by enabling computational protein design.

Differentiator

Problem solved

Functional benefit

Products and services

• FGF2-STAB® Thermostable human recombinant fibroblast growth factor 2 designed for research use, with significantly improved stability and retained biological activity compared to native FGF2 (19°C increased thermal stability, >20 days activity at 37°C vs <10 hours native, 5-20x lower dosage required). Priced from 225.00 EUR in 50ug-1mg sizes.
• FGF2-STAB® MEAT Thermostable FGF2 variants of different species (bovine/porcine, eel, salmon, tuna/grouper) for cultured meat media, with much lower dosage requirements and longer half-life to reduce media cost (FGF2 represents ~60% of wild-type media cost). Priced from 225.00 EUR with up to 5 weeks lead time.
• FGF2-STAB® Cosmetics Thermostable FGF2 developed for cosmetics use with proven anti-aging properties including skin hydration retention, wrinkle reduction and skin softening; 2-year shelf life at room temperature.
• FGF10-STAB® Thermostable FGF10 for research use with significantly improved half-life at 37°C (>24 hours vs <11 hours for native) and fully retained biological activity for cell cultivation applications. Priced from 225.00 EUR in 50ug-1mg sizes.
• FGF10-STAB® Cosmetics Thermostable FGF10 developed for cosmetics with hair regeneration properties, enhancing hair follicle activity and elongating the anagen phase. Distributed through regional partners and directly from Enantis in Czech Republic.
• FGF18-STAB Thermostable FGF18 for research use with 15-times enhanced digestion half-life vs native FGF18 and no harmful stabilizing additives. Priced from 260.00 EUR in 50ug-1mg sizes.
• HLD Screening Kit Haloalkane dehalogenase screening kit for research applications; priced at 4,000.00 EUR. Enantis is the world's only supplier of engineered haloalkane dehalogenases.
• HotSpot Wizard Professional Professional protein engineering software for automated design of mutations and smart libraries based on sequence input information; licensed annually from 1,000 EUR.
• FireProt Professional Professional protein engineering software for automated design of thermostable proteins using energy- and evolution-based computational methods; licensed annually from 8,000 EUR.
• FireProt-ASR Professional Professional software for automated design of thermostable proteins incorporating ancestral sequence reconstruction methods; licensed annually from 1,000 EUR.
• Caver Web Professional Professional software for analysis and visualization of tunnels and channels in protein structures and molecular dynamics trajectories; licensed annually from 1,000 EUR.
• CaverDock Professional Professional software for computational design and high-throughput screening of therapeutic enzymes; licensed annually from 6,000 EUR.
• EnzymeMiner Professional Professional software for exploration of enzyme diversity by integrating bioinformatics with expression analysis and biochemical characterization; licensed annually from 1,000 EUR.
• CalFitter Professional Professional software for calibration and fitting analysis of protein engineering data; licensed annually from 3,000 EUR.
• LoopGrafter Professional Professional software for loop grafting in protein engineering applications; licensed annually from 6,000 EUR.
• SoluProt Professional Professional software for solubility prediction and optimization of recombinant proteins; licensed annually from 1,000 EUR.
• Protein/Enzyme Engineering Services Contract research services for protein and enzyme stabilization, including in silico feasibility analysis, confidential IP handling under CDA/MTA, and custom molecule optimization for pharmaceutical, chemical and biotech customers (e.g. BASF, Asahi Kasei).

Quantifiable outcome

• FGF2-STAB: 5-20x lower dosage required compared to native FGF2
• +6 more outcomes

Named customers7 records

Segments5 records

Ideal customer profiles5 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

Six partnerships are on record, tiered core and minor.

• Sollice BiotechcoreChannel Partner/ Reseller/ Distributor · 27 April 2026Strategic distribution partnership announced at In-Cosmetics Global 2026 in Paris. Sollice Biotech will distribute Enantis products, expanding geographic reach in the cosmetics ingredients market.
• McKinley ResourcescoreChannel Partner/ Reseller/ Distributor · 12 November 2025Partnership to bring highly stable fibroblast growth factor products to North America. McKinley Resources will distribute Enantis FGF products including FGF2-STAB, FGF10-STAB, and FGF18-STAB for research, cosmetics, and cultured meat applications.
• Loschmidt Laboratories (Masaryk University)coreStrategic or Co-development PartnerClose collaborative relationship with Loschmidt Laboratories, a world-renowned academic institution focused on development of protein engineering software. Jointly organize the Hands-on Computational Enzyme Design Course. Co-founders Jiri Damborsky and Zbynek Prokop are Loschmidt Chair Professors at Masaryk University.
• BASFminorStrategic or Co-development PartnerCustomer for protein engineering contract research services. BASF utilizes Enantis's proprietary protein stabilization technology.
• Asahi KaseiminorStrategic or Co-development PartnerCustomer for protein engineering contract research services. Asahi Kasei utilizes Enantis's protein stabilization technology.
• Accure (INTERREG Project)minorStrategic or Co-development PartnerCollaboration on INTERREG project for 3D-printed in vitro skin model development as part of Austria-Czech Union of Regenerative Medicine for Acute and Chronic Wounds.

Scale indicators5 records

Recent moves6 records

Expansion highlights7 records

Direct peers

• Codexis: Codexis is a leading protein engineering company that develops optimized enzymes and biotherapeutics using proprietary platform technologies. Directly comparable to Enantis in its use of computational design and directed evolution to engineer improved proteins for industrial, pharmaceutical, and life science applications, with substantially greater scale and public market funding.
• Bota Bio: Bota Bio is a synthetic biology company that designs and engineers proteins and microorganisms for industrial applications. Directly comparable to Enantis in its use of computational protein design and engineering services for industrial customers, including applications in personal care and specialty chemicals.

Broad incumbents

• Ginkgo Bioworks: Ginkgo Bioworks operates a synthetic biology platform for programming cells and engineering proteins at industrial scale. Comparable to Enantis in its protein engineering capabilities and biotech customer base, but Ginkgo operates at a much larger scale across multiple end-markets including therapeutics, food/agriculture, and industrial biotech.
• Amyris: Amyris is a synthetic biology company that engineers yeast strains to produce specialty ingredients, with a strong presence in cosmetics (squalane, hyaluronic acid) and food markets. Comparable to Enantis in its biotech-enabled cosmetic ingredient strategy, though Amyris is a much larger, publicly-traded company with broader portfolio.
• Miltenyi Biotec: Miltenyi Biotec is a major supplier of cell culture reagents, growth factors, and instruments for life science research and clinical applications. Comparable to Enantis as a supplier of growth factors for stem cell and cell culture research, though at substantially greater scale and product breadth.
• PeproTech (Thermo Fisher Scientific): PeproTech, acquired by Thermo Fisher Scientific, is a leading global supplier of recombinant cytokines and growth factors including FGFs for research and clinical applications. Directly comparable to Enantis's research-grade FGF2/10/18-STAB products, though PeproTech operates at much greater scale and broader product portfolio.

Emerging players

• Geltor: Geltor is a biotech company producing animal-free proteins (e.g., human and bovine collagen) via precision fermentation for cosmetics and food. Comparable to Enantis in its positioning of biotech-engineered specialty proteins as premium ingredients for cosmetics and food/cultured meat, though focused on different protein classes.
• Schrödinger: Schrödinger provides computational chemistry and physics-based software for drug discovery and materials design, including protein engineering and molecular simulation tools. Comparable to Enantis in its protein engineering software licensing business (HotSpot Wizard, FireProt, Caver), though Schrödinger's platform is broader and serves pharmaceutical R&D.
• Arctus Therapeutics: Arctus Therapeutics is a biotechnology company developing engineered protein therapeutics using computational design and directed evolution. Comparable to Enantis in its use of protein engineering to develop improved therapeutic proteins, though focused on different therapeutic targets.

Regional players

• REPROCELL: REPROCELL is a Japanese stem cell and regenerative medicine company that supplies cell culture reagents and growth factors for iPSC and stem cell research. Comparable to Enantis as a supplier of FGFs and growth factors for stem cell research applications, though primarily serving the Asian market.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks4 records

Key highlights7 records

Customer concentration

• Xx.com/enantis
• LinkedInlinkedin.com/company/enantis-s-r-o-

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles8 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Enantis