KBO Systems
KBO Systems is a pre-commercial Denver-based Medtech startup building an AI-powered EEG and AEP platform for perioperative brain monitoring, spanning pre-operative cognitive screening, intra-operative drug-aware depth guidance, and post-operative delirium detection for hospitals and ambulatory surgery centers.
- Company typePrivate
- Founded2021
- HeadquartersDenver, United States
- Headcount1–10
- GTM typeB2B
- OfferingHardware or Manufacturing
What KBO Systems does
KBO Systems is a Denver-based, pre-commercial medical device company founded in 2021 that is building an AI-powered perioperative brain health monitoring platform. The system integrates a wearable EEG headband with three forehead electrode pads, an in-ear auditory probe for auditory evoked potential (AEP) stimulation, and a clinical monitor that displays real-time brain-state metrics, intended to span pre-operative cognitive baseline screening, intra-operative drug-aware depth-of-sedation monitoring, and post-operative delirium detection and recovery trajectory forecasting on a single device and dataset.
The proprietary technology uses machine learning algorithms that recognize drug-specific neural signatures across propofol, sevoflurane, ketamine, and dexmedetomidine, and measures inter-regional signal propagation rather than compressing local electrical activity to a single number, which the company positions as the key differentiator versus legacy depth monitors. Clinical validation is in progress through IRB-approved studies at UC Davis Health and McLeod Health targeting 400 participants across four drug classes, with three ASA-targeted peer-reviewed manuscripts in preparation and an independent validation study from MIT published in March 2026. Patents are pending on core algorithms and hardware.
KBO Systems has not yet generated commercial revenue. Its intended business model combines hardware device sales (the EEG headband, in-ear probe, and clinical monitor) with recurring software and subscription services aligned to existing CPT reimbursement codes, sold through a direct enterprise sales motion targeting hospitals, ambulatory surgery centers, and office-based anesthesia settings. The company is currently in an active seed round with four pending non-dilutive grants (NSF, ARPA-H, APSF), an FDA 510(k) submission in progress, and an ISO 13485 manufacturing pathway underway with Triple Ring Technologies.
KBO Systems firmographics
Firmographics- Name
- KBO Systems
- Legal name
- KBO Systems, Inc.
- Website
- https://kbosystems.com
- Company type
- Private
- Founded year
- 2021
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Short description
- KBO Systems is a pre-commercial Denver-based Medtech startup building an AI-powered EEG and AEP platform for perioperative brain monitoring, spanning pre-operative cognitive screening, intra-operative drug-aware depth guidance, and post-operative delirium detection for hospitals and ambulatory surgery centers.
- Ownership category
- akta.pro rank
KBO Systems industry classification
Industry- Product category
- Perioperative Brain Monitoring Medical Devices
- NAICS
- Electromedical and Electrotherapeutic Apparatus Manufacturing (334510), Navigational, Measuring, Electromedical, and Control Instruments Manufacturing (33451)
- SIC
- Surgical & Medical Instruments & Apparatus (3841)
- akta.pro primary industry
- Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables) (HLAHACAE)
- akta.pro secondary industries
- Perioperative/Anesthesia & Surgical Documentation Systems (HLACAAAF), Clinical-Grade Vital Signs Monitoring (ECG, SpO2, BP, Temp, Respiration) (HLACAPAI)
Keywords
Where KBO Systems is headquartered
LocationHeadquarters
- HQ city
- Denver
- HQ country
- United States
- HQ region
- North America
Markets served
KBO Systems business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Technology or R&D, Personnel, Operations, Supply Chain, Marketing or Sales, Others
Revenue model
- Hardware Device Sales: Sale of wearable EEG headband and in-ear auditory probe combined with clinical monitor that displays real-time brain-state metrics.
- Software/Subscription Services: Ongoing software services for real-time brain-state monitoring, cognitive screening, and delirium detection. Designed to align with existing CPT codes creating reimbursable pathway.
Go-to-market motion1 record
Distribution channels1 record
Marketing channels4 records
KBO Systems product offering
Product offeringCore offering
KBO Systems develops a perioperative brain health monitoring platform combining a wearable EEG headband and in-ear auditory probe with a clinical monitor that displays real-time brain-state metrics. Proprietary machine learning algorithms deliver drug-aware depth-of-sedation monitoring across pre-operative cognitive screening, intra-operative anesthesia guidance, and post-operative delirium detection. The system is designed for hospitals, ambulatory surgery centers, and office-based anesthesia settings, and aligns with existing CPT reimbursement codes.
Product overview
KBO Systems offers a unified perioperative brain health monitoring platform comprising the KBO EEG Headband (wearable device with three electrode pads), KBO In-Ear Auditory Probe (AEP stimulation), and KBO Clinical Monitor (display unit). These components work together as one integrated system for continuous brain monitoring across all three phases of surgery: pre-operative cognitive baseline establishment using ML-driven screening (MoCA, Mini-Cog, passive EEG), intra-operative drug-aware depth guidance (real-time multi-region EEG and AEP), and post-operative recovery prediction with delirium detection.
Differentiator
Problem solved
Functional benefit
Products and services
- KBO Platform The core integrated perioperative brain health monitoring platform combining the KBO EEG headband, in-ear auditory probe, and clinical monitor, providing continuous brain-state monitoring across pre-operative cognitive baseline, intra-operative drug-aware depth, and post-operative recovery prediction for hospital and surgical customers.
- KBO EEG Headband A wearable EEG headband with three electrode pads positioned across the forehead that captures multi-region EEG signals for real-time brain monitoring during the intra-operative phase, for use by anesthesiology teams in hospitals and surgery centers.
- KBO In-Ear Auditory Probe An in-ear auditory probe that delivers auditory evoked potential (AEP) stimulation and records brain responses, enabling drug-aware depth monitoring that remains reliable across all major anesthesia agents, including propofol, sevoflurane, ketamine, and dexmedetomidine.
- KBO Clinical Monitor A clinical monitor deployed in the operating room that displays real-time brain-state metrics, integrating data from the EEG headband and auditory probe to deliver drug-aware guidance during surgery and recovery predictions post-operatively for anesthesiologists and perioperative teams.
Quantifiable outcome
- Target ≥0.90 AUROC for drug-aware depth monitoring
- +2 more outcomes
Companies that use KBO Systems
Customer profileNamed customers2 records
Segments2 records
Ideal customer profiles2 records
KBO Systems technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability6 records
Feature4 records
KBO Systems partnerships and signals
Strategic signalPartnerships
Six partnerships are on record, tiered core and minor.
- MIT (Massachusetts Institute of Technology)coreIndependent validation study confirming the core scientific thesis behind KBO's drug-agnostic approach to perioperative brain monitoring. Study published March 2026 confirming three anesthesia drugs all have the same effect on the brain.
- UC Davis HealthcoreLead clinical partner conducting IRB-approved study in Department of Anesthesiology. Co-Founder and Clinical Chair Dr. Nate Weitzel serves as Professor and Chair of Anesthesiology. Academic collaborator Dr. Zhibin Zhou provides expertise in anesthesiology and cognitive neuroscience.
- McLeod HealthcoreMulti-site data collection partner in cardiothoracic and outpatient surgery. Clinical Lead Rocky Cagle serves as Chief of Anesthesia at McLeod Health, leading multi-site data collection and clinical protocol design.
- Safe Brain InitiativeminorPartnership providing ROI calculator that estimates annual cost of postoperative delirium based on surgical volume and incidence rates. Built on Gou et al. (2021) data showing $44,291 per delirium case.
- Triple Ring TechnologiesminorMedical device contract manufacturer specializing in patient monitoring, listed as future manufacturing partner in the ISO 13485 pathway.
- Mike Ryan (Eliquent Life Sciences)minorRegulatory advisor providing anesthesia-device clearance strategy. Former FDA reviewer with expertise in regulatory pathway navigation.
Scale indicators5 records
Recent moves4 records
Expansion highlights6 records
KBO Systems competitors and assessment
Company assessmentOthers
- Compumedics: Manufactures EEG and sleep-diagnostics systems used in clinical and research settings. Adjacent to KBO in EEG hardware and signal-processing expertise, though primarily serving neurology and sleep rather than perioperative anesthesia.
Direct peers
- Masimo: Sells SedLine (PSI — Patient State Index), an FDA-cleared EEG-based depth-of-anesthesia monitor integrated with the Masimo Root platform. Direct competitor in intra-operative brain monitoring and a strategic acquirer of adjacent monitoring technologies.
- Medtronic: Markets the BIS (Bispectral Index) depth-of-anesthesia monitor, the most widely deployed EEG-based depth-of-sedation device in U.S. ORs. Directly competes with KBO in intra-operative brain monitoring and is the entrenched incumbent KBO is positioning against.
- GE HealthCare: Markets the E-Entropy EEG-based depth-of-anesthesia module integrated with the CARESCAPE patient monitoring platform. Direct competitor in intra-operative brain monitoring and a broad incumbent in perioperative patient monitoring.
Emerging players
- iMediSync: Develops EEG-based brain-mapping and brain-monitoring devices (e.g., NIRS-EEG systems) used for screening and longitudinal brain health assessment. Comparable emerging player in EEG-based clinical brain monitoring and overlapping positioning around early-stage brain diagnostics.
- Prolira: Develops DeltaScan, an EEG-based delirium detection device targeting post-operative and ICU settings. Directly comparable on the post-op delirium portion of KBO's platform and a relevant emerging competitor in the delirium-detection use case.
- Medasense: Markets the PMD-200 NOL (Nociception Level Index) monitor for pain/noci monitores under anesthesia. Comparable emerging player in objective intra-operative monitoring and adjacent to KBO's perioperative brain-state value proposition.
- Cortivision: Develops wearable fNIRS-based brain monitoring technology used in clinical research and pharmaceutical trials. Comparable emerging player in applied brain monitoring hardware and overlapping customer base in academic anesthesiology.
Broad incumbents
- Nihon Kohden: Major patient-monitoring and EEG diagnostics manufacturer with broad installed bases in hospitals globally. Overlaps KBO's clinical monitoring footprint through EEG hardware and integrated OR/ICU patient monitoring platforms.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks7 records
Key highlights7 records
Customer concentration
KBO Systems social profiles
Digital presenceKBO Systems compliance and trust
Trust signalCompliance1 record
KBO Systems financial estimates
Financial estimateRevenue estimate
Valuation estimate
KBO Systems leadership team
Management profileNumber of profiles
Profiles4 records
KBO Systems funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
KBO Systems M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about KBO Systems
What does KBO Systems do?
KBO Systems develops a perioperative brain health monitoring platform combining a wearable EEG headband and in-ear auditory probe with a clinical monitor that displays real-time brain-state metrics. Proprietary machine learning algorithms deliver drug-aware depth-of-sedation monitoring across pre-operative cognitive screening, intra-operative anesthesia guidance, and post-operative delirium detection. The system is designed for hospitals, ambulatory surgery centers, and office-based anesthesia settings, and aligns with existing CPT reimbursement codes.
Is KBO Systems a public or private company?
KBO Systems is a private company. It is classified as venture growth investor backed and is currently operating.
When was KBO Systems founded?
KBO Systems was founded in 2021. It employs 1 to 10 people.
Where is KBO Systems based?
KBO Systems is headquartered in Denver, United States, in the North America region.
How does KBO Systems make money?
Two revenue lines are on record. Hardware Device Sales are the primary driver. The others are software/Subscription Services.
Who are KBO Systems's main competitors?
Compumedics is listed as an others. Direct peers are Masimo, Medtronic and GE HealthCare. Emerging players are iMediSync, Prolira, Medasense and Cortivision. Nihon Kohden is listed as a broad incumbent.
Does KBO Systems have an API?
No public API is recorded for KBO Systems.
What industry is KBO Systems in?
KBO Systems's product category is Perioperative Brain Monitoring Medical Devices. Its primary akta.pro industry code is HLAHACAE, Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables), with a secondary code of HLACAAAF, Perioperative/Anesthesia & Surgical Documentation Systems. Its NAICS code is 334510 and its SIC code is 3841.