Evidence-Based Toxicology Collaboration

What Evidence-Based Toxicology Collaboration does

The Evidence-Based Toxicology Collaboration (EBTC) is a member-driven organization founded in 2011 at the Johns Hopkins Bloomberg School of Public Health, focused on adapting and developing evidence-based medicine methodologies for toxicology, environmental health, and regulatory decision-making. EBTC organizes its work around four thematic working groups — Research Methods, Evidence Synthesis, Open Science, and Evidence & Decisions — and has produced a portfolio of methodological frameworks including the FEAT appraisal-tool framework, PECO statements, INVITES-IN for in vitro study internal validity, preregistration templates co-developed with the Center for Open Science, and a GRADE Evidence-to-Decision framework adapted for environmental and occupational health. In 2023, EBTC launched its official open-access journal Evidence-Based Toxicology with Taylor & Francis as its flagship publishing venue and primary monetization channel. The organization is led by a Board of Trustees including senior figures from Johns Hopkins, US EPA (IRIS Division), EFSA, McMaster University, and ToxStrategies, and counts approximately 250 members across 25+ countries with 60+ research contributions to date.

EBTC's business model rests on free individual membership (no dues or obligations) combined with journal article processing charges from its Taylor & Francis-published journal, supplemented by donations and institutional support implied by its nonprofit-style governance. Distribution is global and primarily digital — through the ebtox.org website, newsletter subscription, calls for papers, working-group participation, and presence at major toxicology conferences such as SOT and Eurotox. Customer segments are organized horizontally across toxicology and environmental-health researchers, regulatory and policy professionals, and early-career researchers seeking training in evidence-based methods. With 1–10 employees and no disclosed funding rounds, the organization operates as a lean, expert-led consortium rather than a venture-backed entity.

Name

Evidence-Based Toxicology Collaboration

Legal name

Evidence-Based Toxicology Collaboration

Website

https://ebtox.org

Company type

Private

Founded year

2011

Operating status

Operating

Headcount range

1–10 employees

Short description

Evidence-Based Toxicology Collaboration is a member-driven organization founded in 2011 at Johns Hopkins that develops evidence-based methodologies and frameworks for toxicology and environmental-health research, serving approximately 250 members across 25+ countries through working groups and its open-access journal.

Ownership category

akta.pro rank

Headquarters

HQ city

Baltimore

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Marketing or Sales, Others

Revenue model

1. Membership Dues: EBTC operates as a member-driven organization with free membership. There are no membership fees or obligations for joining.
2. Journal Article Processing Charges (APCs): The organization publishes Evidence-Based Toxicology journal through Taylor & Francis. APC waivers are available for manuscripts, suggesting article processing charges are part of the revenue model.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels5 records

Core offering

Evidence-Based Toxicology Collaboration (EBTC) is a member-driven organization that develops and disseminates evidence-based methodologies, frameworks, and appraisal tools for toxicology and environmental health research. Its core offerings include a peer-reviewed open science journal (Evidence-Based Toxicology, launched 2023 with Taylor & Francis), four thematic working groups, methodological frameworks (FEAT, PECO, Preregistration Templates, INVITES-IN, GRADE EtD), and a research contributions database — all focused on improving the conduct, reporting, and synthesis of toxicological evidence for regulatory and public health decision-making.

Product overview

The Evidence-Based Toxicology Collaboration (EBTC) is a membership-driven organization founded in 2011 at Johns Hopkins Bloomberg School of Public Health. Rather than a unified software product, EBTC operates as a collaborative network centered on its peer-reviewed journal 'Evidence-Based Toxicology' (published with Taylor & Francis since 2023), supplemented by four working groups (Research Methods, Evidence Synthesis, Open Science, and Evidence & Decisions), preregistration template publications, and ongoing calls for papers. The organization also offers newsletters and maintains a database of research contributions, all focused on advancing evidence-based methodologies in toxicology and environmental health decision-making.

Differentiator

Problem solved

Functional benefit

Brands

• Evidence-Based Toxicology (EBT): The official journal of EBTC, launched in 2023 in partnership with Taylor & Francis, serving as an open science journal for environmental health sciences.

Products and services

• Evidence-Based Toxicology Journal The official open science journal of EBTC, published in partnership with Taylor & Francis since 2023, providing full open access peer-reviewed publication of evidence-based toxicology research for the environmental health sciences, with article processing charges (waivers available).
• EBTC Working Groups Collaborative research working groups organized around four thematic areas — Research Methods, Evidence Synthesis, Open Science, and Evidence & Decisions — through which members contribute to projects that improve research quality, evidence synthesis methods, and evidence-based policy in toxicology and environmental health.

Quantifiable outcome

• Launched open science journal Evidence-Based Toxicology in 2023
• +1 more outcomes

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

Three partnerships are on record, tiered core and flagship.

• Center for Open SciencecoreStrategic or Co-development Partner · 1 January 2024Joint special issue on preregistration templates for toxicology and environmental health research. The collaboration leverages Center for Open Science's expertise in preregistration and open science practices, with joint review processes and the potential for templates to be approved as 'supported templates' on the Open Science Framework.
• Taylor & FrancisflagshipStrategic or Co-development Partner · 1 January 2023EBTC partnered with Taylor & Francis to launch Evidence-Based Toxicology, the official open science journal of the collaboration, in 2023. Taylor & Francis publishes the journal, providing editorial and publishing infrastructure while EBTC maintains editorial control and mission alignment.
• GRADE Working GroupcoreStrategic or Co-development PartnerEBTC collaborated with the GRADE Working Group to develop the first GRADE Evidence-to-Decision (EtD) Perspective for environmental health recommendations, adapting the framework for environmental and occupational health contexts.

Scale indicators4 records

Recent moves7 records

Expansion highlights5 records

Direct peers

• Center for Open Science: Operates the Open Science Framework and promotes preregistration, open data, and reproducibility. EBTC collaborates formally with COS on the preregistration templates special issue, making it a partner and the most comparable peer in open-science methodology development.
• Cochrane: Global leader in systematic reviews and evidence synthesis in healthcare. EBTC mirrors Cochrane's model of community-driven methodology development and is the toxicology counterpart attempting to extend evidence-based methods beyond clinical medicine.
• GRADE Working Group: Develops the GRADE framework for assessing evidence and moving from evidence to decisions/health recommendations. EBTC directly adapted GRADE for environmental health via its EtD Framework, making GRADE both a partner and the most analogous methodology peer.
• Joanna Briggs Institute (JBI): International research organization developing evidence-based tools, appraisal instruments, and systematic review methods for healthcare and beyond. Closely comparable to EBTC in mission, methodology focus, and global community-driven model.

Regional players

• ToxStrategies: Consulting firm providing toxicology, risk assessment, and evidence-based evaluation services. Board member Daniele Wikoff leads its Health Sciences practice, making ToxStrategies an industry-services peer closely tied to EBTC's regulatory application work.

Emerging players

• CAMARADES: Edinburgh-based collaboration developing systematic review and meta-analysis methods for preclinical animal studies. Emily Sena, a CAMARADES convener, sits on EBTC's board, making it the closest methodological peer in preclinical evidence synthesis.
• Center for Alternatives to Animal Testing (CAAT): Johns Hopkins-based program promoting alternatives to animal testing and evidence-based toxicology. Closely affiliated with EBTC via Thomas Hartung, CAAT is a peer institution in the same university ecosystem advancing methodological reform in toxicology.
• Health and Environmental Sciences Institute (HESI): Non-profit that convenes scientists from academia, government, and industry to develop scientific assessments for environmental and human health. Operates in an adjacent space to EBTC with cross-sector convening power comparable to EBTC's working-group model.

Broad incumbents

• Society of Toxicology (SOT): Largest professional society for toxicologists worldwide. EBTC engages SOT via conference attendance and member recruitment, but SOT is the broad incumbent in the toxicology professional community where EBTC operates as a methodological niche.
• European Food Safety Authority (EFSA): EU regulatory agency conducting evidence-based chemical and food safety risk assessments. EBTC's frameworks are designed to feed into EFSA's regulatory pipelines (e.g., via Didier Verloo on EBTC's board), making EFSA an institutional peer and primary adopter-of-methods counterpart.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/EBToxC

Revenue estimate

Valuation estimate

Number of profiles

Profiles12 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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Frequently asked questions about Evidence-Based Toxicology Collaboration