What Enzyme Research Laboratories does

Enzyme Research Laboratories Inc. (ERL) is a privately held, Indiana-domiciled manufacturer and global distributor of purified coagulation proteins, activated enzymes, coagulation inhibitors, monoclonal and polyclonal antibodies, paired ELISA antibodies, and chromogenic substrates for basic coagulation and hemostasis research. Founded in 1980 and headquartered in South Bend, Indiana, the company isolates zymogens, active-site blocked enzymes, and cofactors from human and bovine plasma, and also offers multi-species proteins (canine, murine, porcine, rabbit, rat) for preclinical and veterinary research. Products are non-sterile and sold for research use only; quality is documented via ISO 9001:2015 certification, Certificates of Analysis, SDS-PAGE verification, and communicable disease testing on plasma-derived material.

The revenue model is purely transactional: one-time catalog purchases of physical reagents with no subscription, licensing, or software component, and no publicly disclosed pricing — customers must email [email protected] (or [email protected] for the UK subsidiary) for a current price list. Distribution is direct via email for US and Canada customers and via a network of more than 20 named regional distributors internationally, supplemented by the company's wholly-owned UK subsidiary (Enzyme Research Laboratories, Ltd., Swansea). A sister-company relationship with r² Diagnostics extends the protein supply chain into clinical diagnostic kit manufacturing, giving ERL a downstream channel into the regulated clinical hemostasis laboratory segment beyond its core academic research customer base. There are no funding rounds, no M&A activity, no management team disclosure, and no disclosed headcount; the operating model is consistent with a focused, owner-managed specialty life-science reagent business.

Name

Enzyme Research Laboratories

Legal name

Enzyme Research Laboratories Inc.

Website

https://enzymeresearch.com

Company type

Private

Founded year

1980

Operating status

Operating

Headcount range

11–50 employees

Short description

Enzyme Research Laboratories, founded 1980 and headquartered in South Bend, Indiana, manufactures and globally distributes purified coagulation proteins, activated enzymes, and matched monoclonal/polyclonal antibodies from human and bovine plasma for basic coagulation and hemostasis research laboratories.

Ownership category

akta.pro rank

Product category

Coagulation Research Reagents

NAICS

In-Vitro Diagnostic Substance Manufacturing (325413)

SIC

In Vitro & In Vivo Diagnostic Substances (2835)

akta.pro primary industry

Hematology & Coagulation Diagnostics (HLAHAAAB)

akta.pro secondary industry

Clinical Chemistry & Hematology Diagnostics (automated analyzers, blood testing) (HLAAALAH)

Keywords

• Coagulation proteins
• Hemostasis reagents
• Monoclonal antibodies
• Polyclonal antibodies
• Blood coagulation research

Headquarters

HQ city

South Bend

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Personnel, Operations, Technology or R&D, Infrastructure, Marketing or Sales

Revenue model

1. Coagulation Research Products: Sale of purified coagulation proteins, enzymes, antibodies, and ELISA reagents to research and diagnostic communities worldwide. Products include zymogens, activated enzymes, inhibitors, cofactors, fibrinogen, platelet proteins, and specialized substrates. Products are non-sterile and for research use only. All sales are final due to the nature of the products.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels3 records

Core offering

Enzyme Research Laboratories manufactures and distributes purified coagulation proteins and complementary antibodies derived primarily from human and bovine plasma for basic coagulation and hemostasis research. Its catalog spans zymogens, activated enzymes, active-site blocked enzymes, cofactors, inhibitors, fibrinogens, platelet proteins, species-specific proteins (canine, murine, porcine, rabbit, rat), chromogenic substrates, snake venom proteins, monoclonal antibodies, polyclonal antibodies (with HRP/AP/FITC conjugates), and paired antibody sets for sandwich ELISAs.

Product overview

Enzyme Research Laboratories (ERL) is a leading manufacturer and distributor of coagulation proteins and antibodies for basic coagulation research, serving the research and diagnostic communities for over 40 years. The company offers a comprehensive portfolio organized into two primary species categories: Human Coagulation products (including zymogens, activated enzymes, cofactors, inhibitors, platelet/plasma proteins, and fibrinogen variants) and Bovine Coagulation products (mirror human products for comparative research). Supporting the protein portfolio are three antibody types: Monoclonal Antibodies (murine, targeting 30+ coagulation factors), Polyclonal Antibodies (sheep/goat, in multiple formats including purified IgG, affinity-purified, and enzyme conjugates), and Paired Antibodies for ELISA applications (20+ factor detection kits). Additional offerings include Chromogenic Substrates (PlasminChrom, ThrombinChrom, RGR-XaChrom) for enzymatic detection, Snake Venom Proteins (Factor X Activator-RVV), and species-specific proteins (Canine, Murine, Porcine, Rabbit, Rat). Specialty products include Des-Gla Proteins (gamma-carboxyglutamic acid region removed) and Inactivated Proteins (active-site blocked) for research controls. Products are for research use only (non-sterile). Sister company r2 Diagnostics converts ERL's high-purity proteins into clinical diagnostic kits for the hemostasis laboratory.

Differentiator

Problem solved

Functional benefit

Brands

• r² Diagnostics: A sister company to Enzyme Research Laboratories that provides general and specialty reagents to the clinical coagulation laboratory, incorporating ERL's high purity proteins into clinical diagnostic kits

Products and services

• Human Coagulation Zymogens Purified zymogens prepared from fresh frozen human plasma, including Human Prothrombin, Factor VII, Protein C, Factor IX, Factor X, Factor XI, Factor XII, Factor XIII, Prekallikrein, single-chain and two-chain High Molecular Weight Kininogen, Glu-Plasminogen, and Lys-Plasminogen. For research use only (non-sterile).
• Human Coagulation Enzymes (Activated) Activated human coagulation enzymes including Human Alpha Thrombin, Gamma Thrombin, Factor VIIa, Activated Protein C, Factor IXa Beta, Factor Xa, Factor XIa, Factor Alpha-XIIa, Factor XIIa Beta, Factor XIIIa, Kallikrein, and Plasmin, derived from human plasma. For research use only (non-sterile).
• Human Coagulation Cofactors Non-enzymatic cofactor proteins for the coagulation cascade, including Human Protein S, Protein Z, and Fibronectin. For research use only (non-sterile).
• Human Coagulation Inhibitors Coagulation inhibitor proteins including Human Antithrombin, Corn Trypsin Inhibitor, and Alpha2-Antiplasmin that regulate the cascade by inhibiting specific clotting factors. For research use only (non-sterile).
• Human Platelet and Plasma Proteins Platelet and plasma proteins purified from human platelets, including Human GPIIbIIIa (fibrinogen receptor), Apolipoprotein-H (Beta2-Glycoprotein-1), and Platelet Factor 4. For research use only (non-sterile).
• Human Fibrinogen Products Three types of purified human fibrinogen (FIB 1: Plasminogen Depleted; FIB 2: Plasminogen and vWF Depleted; FIB 3: Plasminogen, vWF and Fibronectin Depleted), plus Peak 1 Fibrinogen (XIII free) and Peak 2 Fibrinogen, all >95% clottable. For research use only (non-sterile).
• Bovine Coagulation Products Full line of bovine coagulation proteins including Bovine Protein C, Prothrombin, Factor IX, Factor X, Plasminogen, Activated Protein C, Alpha-Thrombin, Factor IXa Beta, Factor Xa, Factor XIa, Factor V/Va, Antithrombin, and Fibrinogen (Plasminogen Depleted). For research use only (non-sterile).
• Monoclonal Antibodies (to Coagulation Factors) Murine monoclonal antibodies targeting 30+ human coagulation factors including Factor V, VII, VIII (multiple clones), IX, X (including light and heavy chain specific), XI, XII, XIII, Antithrombin, Thrombin, Prothrombin, Protein C, Tissue Factor, vWF, GPIIbIIIa, Plasminogen, Vitronectin, C4 Binding Protein, PA Kringles, Fibrinogen, and Tissue Plasminogen Activator, available in 0.1 mg and 0.5 mg sizes. For research use only (non-sterile).
• Polyclonal Antibodies (to Coagulation Factors) Sheep and goat polyclonal antibodies targeting fibrinogen, fibrin fragments, fibrinopeptide A, prothrombin, thrombin, Factor V, VII, VIII:C, IX, X, XI, XII, XIII (including A subunit), Prekallikrein, Protein C, Protein S, Plasminogen, PAI-1, TAFI, tPA, Antithrombin III, Heparin Cofactor-II, Alpha1-Antitrypsin, Alpha2-Macroglobulin, Platelet Factor 4, B2-Glycoprotein-1, von Willebrand Factor, Tissue Factor, TFPI, C1-Inhibitor, Neutrophil Elastase, GPIIb/IIIa, and non-immune sera controls. Offered as purified IgG, affinity-purified IgG, and peroxidase conjugates (HRP, AP-HRP, fluorescein conjugates). For research use only (non-sterile).
• Paired Antibodies for Sandwich ELISA Paired capture and detecting antibody pairs for sandwich ELISA detection of vWF, Factor V, VII, VIII:C, IX, X, XI, XII, XIII, Prothrombin, Protein S, Protein C, Alpha1 Antitrypsin, Antithrombin III, Plasminogen, tPA, Fibrinogen, Apolipoprotein-H, Canine Factor IX, and Prekallikrein. Supplied with full instructions for performing sandwich ELISAs for research and clinical purposes. For research use only (non-sterile).
• Chromogenic Substrates Chromogenic peptide substrates for enzymatic detection: PlasminChrom (H-D-Val-Leu-Lys-pNA·2HCl, cat# 100-01), ThrombinChrom (H-D-Phe-Pip-Arg-pNA·2HCl, cat# 100-02), and RGR-XaChrom (Z-D-Arg-Gly-Arg-pNA·2HCl, cat# 100-03), each provided in 5 mg size. For research use only (non-sterile).
• Snake Venom Proteins (Factor X Activator-RVV) Russell's Viper Venom (RVV-X) Factor X Activator protein (cat# RVV-X) used for activation of Factor X to Factor Xa in research applications. For research use only (non-sterile).
• Canine Coagulation Proteins Canine-specific coagulation proteins including Canine Fibrinogen, Thrombin, Factor IX, Factor X, and Factor Xa for veterinary research applications. For research use only (non-sterile).
• Murine Coagulation Proteins Mouse/rat coagulation proteins including Murine Fibrinogen, Antithrombin III, Thrombin, Factor XIII, and Plasminogen for preclinical research. For research use only (non-sterile).
• Porcine Coagulation Proteins Porcine-specific coagulation proteins including Porcine Factor Xa, Thrombin, and Fibrinogen for veterinary and translational research. For research use only (non-sterile).
• Rabbit Coagulation Proteins Rabbit-specific coagulation proteins including Rabbit Fibrinogen, Factor Xa, Factor X, and Thrombin for research applications. For research use only (non-sterile).
• Rat Coagulation Proteins Rat-specific coagulation proteins including Rat Fibrinogen, Thrombin, and Factor Xa for preclinical research models. For research use only (non-sterile).
• Des-Gla Proteins Modified coagulation proteins with the gamma-carboxyglutamic acid (Gla) region removed, including Des-Gla Human Protein C (HPC-GD), Des-Gla Activated Protein C (APC-GD), Des-Gla Factor X (HFX-GD), Des-Gla Factor Xa beta (HFXab-GD), Des-Gla Factor VIIa (HFVIIaGD), and Des-Gla Prothrombin (HP-GD), intended for research where calcium-binding properties are not required. For research use only (non-sterile).
• Inactivated Proteins (Active-Site Blocked) Coagulation enzymes with active site blocked, including Human Thrombin Inactivated (HTi), Human Factor VIIa Inactivated (HFVIIai), Human Factor IXa Beta Inactivated (HFIXai), and Human Activated Protein C Inactivated (APCi), used as controls or for binding studies. For research use only (non-sterile).
• r² Diagnostics (Sister-Company Clinical Coagulation Reagents) r² Diagnostics is a sister company to Enzyme Research Laboratories that provides general and specialty reagents for the clinical coagulation laboratory. It incorporates ERL's high-purity proteins into clinical diagnostic kits with end-to-end control over materials and processes, specializing in specialty reagents and kits for hemostasis diagnostic assays.

Segments2 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

19 partnerships are on record, tiered core and minor.

• r² DiagnosticscoreStrategic or Co-development Partnerr² Diagnostics is a sister company to Enzyme Research Laboratories. It was organized to incorporate ERL's high-purity proteins and reagents into clinical diagnostic kits manufactured with 'end-to-end' control over materials and processes. r² Diagnostics provides general and specialty reagents to the clinical coagulation laboratory and specializes in developing specialty reagents and kits for hemostasis diagnostic assays.
• Banksia ScientificminorChannel Partner/ Reseller/ DistributorAustralian distributor covering Australia. Located at Unit 3, 160 Lytton Rd, Bulimba QLD 4171, Australia. Contact: Mr. Stephen Edwards, [email protected]
• CoaChrom Diagnostica GmbHminorChannel Partner/ Reseller/ DistributorAustrian distributor. Located at Hauptstrasse 5, 2344 Maria Enzerdorf, Austria. Contact: Mr. Bernhard Kolmer, [email protected]
• Stago BNL B.V.minorChannel Partner/ Reseller/ DistributorDistributor covering Belgium, Denmark, France, and the Netherlands. Located at PO Box 4018, NL-2301 RA Leiden, the Netherlands. Contact: Pascal Molenaar, [email protected]
• Asnail BiotechnologyminorChannel Partner/ Reseller/ DistributorChinese distributor. Located at Building 5-215, No. 1 Courtyard, Guantang East Road, Chaoyang District, Beijing China, 100102. Contact: [email protected]
• BIOHUB INTERNATIONAL TRADE CO LTDminorChannel Partner/ Reseller/ DistributorChinese distributor. Located at Chuansha Rd.#6619, Pudong, Shanghai, 201200 P.R.China. Contact: [email protected]
• Annoron (Beijing) Biotechnology Co., LtdminorChannel Partner/ Reseller/ DistributorChinese distributor. Located at 4th Floor, #35A Building, Tian Ji Zhi Gu, #109 Jinghai 3rd Road, BDA, Beijing, 100176, China. Contact: Jessica Bian, [email protected]
• Nordic Diagnostica ABminorChannel Partner/ Reseller/ DistributorDistributor covering Finland, Norway, and Sweden. Located at Tryckarevagen 7, Kungsbacka 434 37 Sweden. Contact: Carl Bergstrom, [email protected]
• Haemochrom Diagnostica GmbHminorChannel Partner/ Reseller/ DistributorGerman distributor. Located at Renteilichtung 1, Essen, Germany DE-45134. Contact: Andreas Karst, [email protected]
• r2 Hemostasis DiagnosticsminorChannel Partner/ Reseller/ DistributorDistributor covering India and SAARC Countries. Located at FF-26, Omaxe Park Plaza, Shakti Khand -2, Indirapuram, Ghaziabad Delhi NCR-201010, India. Contact: Sumit Agarwal, [email protected]
• Tarom Applied Technologies Ltd.minorChannel Partner/ Reseller/ DistributorIsraeli distributor. Located at Petach Tikva Israel 49517. Contact: Mr. Zvi Barr, [email protected]
• Cabru s.a.s.minorChannel Partner/ Reseller/ DistributorItalian distributor. Located at Via Forlanini 52, 20862 Arcore (MB), Italy. Contact: Dr. Bruno Casagrande, [email protected]
• Cosmo Bio CompanyminorChannel Partner/ Reseller/ DistributorJapanese distributor. Located at 2-2-20, Toyo Koto-ku, Tokyo, 135 Japan. Contact: [email protected]
• Omnicell Pte LtdminorChannel Partner/ Reseller/ DistributorSingapore distributor. Located at 48 Toh Guan Road East, #04-138 Enterprise Hub, Singapore 608586. Contact: [email protected]
• IMMUNO AMERICAN CORP.minorChannel Partner/ Reseller/ DistributorSouth American distributor. Contact: Phone: +1-786-823-1113, Email: [email protected] or [email protected]
• Kim & Friends, IncminorChannel Partner/ Reseller/ DistributorSouth Korean distributor. Located at Ace High-End Tower 8th #1703, 84 Gasan digital 1-ro, Geumcheon-gu, Seoul, Korea. Contact: [email protected]
• Milan Analytica, AGminorChannel Partner/ Reseller/ DistributorSwiss distributor. Located at Baslerstrasse 15, Rheinfelden 4310, Switzerland. Contact: Dr. Alfred Lampart, [email protected]
• ASSIST PHARM LLCminorChannel Partner/ Reseller/ DistributorUkrainian distributor. Located at 15 Efremova Academika Str., 03179 Kiev, Ukraine. Contact: Tatiana Kutorga, [email protected]
• Enzyme Research Laboratories, Ltd.coreChannel Partner/ Reseller/ DistributorUK subsidiary of Enzyme Research Laboratories. Located at Glamorgan House, Charter Court, Enterprise Park, Swansea SA7 9DD, United Kingdom. Handles UK orders directly. Tel: +44 1792 686070, Fax: +44 1792 466366, Email: [email protected]

Scale indicators2 records

Recent moves5 records

Expansion highlights5 records

Direct peers

• Haematologic Technologies: Haematologic Technologies (HTI) is the closest direct competitor to ERL — a specialty manufacturer of purified coagulation factors, zymogens, and plasma proteins used in coagulation research. It competes head-to-head in the same customer base with overlapping protein catalogs.
• r² Diagnostics: r² Diagnostics is the sister company of ERL that packages ERL's high-purity proteins into clinical coagulation diagnostic kits. It is comparable because it operates in the same coagulation reagent value chain, just at the clinical diagnostic kit stage rather than the research reagent stage.

Broad incumbents

• Diagnostica Stago: Diagnostica Stago is a broad incumbent in hemostasis and coagulation diagnostics, offering analyzers, reagents, and consumables for clinical coagulation labs. It is comparable as a downstream customer/competitor in the coagulation reagent space, with much broader scope.
• Siemens Healthineers: Siemens Healthineers (including its Siemens Healthcare Diagnostics portfolio) offers coagulation/hemostasis testing systems and reagents as part of a broad IVD portfolio. Comparable as a much larger incumbent operating across the coagulation diagnostics workflow.
• Sysmex Corporation: Sysmex is a broad incumbent in hematology and hemostasis diagnostics, offering analyzers, reagents, and consumables. Comparable as a large established player in the same blood/coagulation testing space.
• Bio-Rad Laboratories: Bio-Rad is a broad life science research tools and clinical diagnostics company with products that overlap with coagulation/hematology research reagents. Comparable as a broad incumbent serving research labs with reagent portfolios.
• Merck (Millipore Sigma): Merck's life science tools business (Millipore Sigma / Sigma-Aldrich) supplies a broad catalog of research reagents including proteins, antibodies, and ELISA kits. Comparable as a broad incumbent in research reagent distribution.
• Thermo Fisher Scientific: Thermo Fisher supplies a broad catalog of research antibodies, proteins, ELISA kits, and life science consumables through brands like Invitrogen and Thermo Scientific. Comparable as a broad incumbent serving research labs with overlapping reagent categories.
• Abbott Diagnostics: Abbott Diagnostics is a broad incumbent in IVD, including hemostasis and coagulation testing on platforms used by clinical labs. Comparable as a much larger player operating in the clinical coagulation diagnostics market that ERL ultimately serves via r² Diagnostics.

Emerging players

• Helena Laboratories: Helena Laboratories manufactures specialty coagulation/hemostasis reagents and instruments for clinical and research use. Comparable as a focused participant in coagulation diagnostics with overlapping reagent products.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

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Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Enzyme Research Laboratories