The McGuire Institute

What The McGuire Institute does

The McGuire Institute (iMc) is a not-for-profit Contract Research Organization operating a practice-based clinical research network focused on dental and periodontal products. Founded by Dr. Michael McGuire, an internationally recognized periodontist and master clinician, the Institute runs a geographically distributed US network of 30-plus highly credentialed periodontists, oral surgeons, general dentists, and dental hygienists across roughly 20 practice sites in 14-plus states. It delivers full CRO services to pharmaceutical and medical device sponsors — including protocol development, IRB approval, study coordination, monitoring, biostatistics, regulatory submission, and publication support — and additionally operates an Implant Registry capturing real-world data from the network, proprietary Electronic Data Capture (EDC) databases, and interactive AI platforms used to accelerate clinical development plan drafting and data synthesis.

The business model rests on two revenue streams: fee-based CRO engagements with device and pharmaceutical sponsors (quote-based, professional services), and government/foundation grants such as NIDCR-funded projects routed through academic collaborators like the Michigan Regenerative Medicine Center. All retained earnings are reinvested into a fund supporting studies that would otherwise go unfunded. Customers are primarily dental product manufacturers and medical device companies seeking independent, practice-based real-world evidence to support regulatory submissions and adoption. The go-to-market motion is sales-led, anchored by direct enterprise engagement, supplemented by conference presence (AAP, SmileCon, Harvard Global Symposium on AI), peer-reviewed publications, the Legends of Oral Regeneration podcast, and academic and society partnerships. The organization is small — approximately 11 core staff members led by CEO Tom Rogers — with the broader clinical network operating as contracted investigators rather than employees.

Name

The McGuire Institute

Legal name

The McGuire Institute

Website

https://themcguireinstitute.org

Company type

Private

Founded year

2017

Operating status

Operating

Headcount range

11–50 employees

Short description

The McGuire Institute (iMc) is a not-for-profit practice-based clinical research network providing full CRO services — protocol design, study conduct, biostatistics, and regulatory support — to dental and medical device sponsors via 30-plus credentialed periodontists across 14-plus US states.

Ownership category

akta.pro rank

Product category

Dental Clinical Research Services

NAICS

Scientific Research and Development Services (5417)

SIC

Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Clinical CROs (Phase I–IV) (HLAGAAAA)

akta.pro secondary industries

Specialty Therapeutic-Area CROs (e.g., oncology/rare disease) (HLAGAAAL), Patient Recruitment, Site Feasibility & Trial Enablement CROs (HLAGAAAI)

Keywords

• Practice-based clinical research
• Dental clinical trials
• Contract research organization
• Periodontal research services
• Real-world evidence generation

Headquarters

HQ city

Spring Branch

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Marketing or Sales

Revenue model

1. Clinical Research Services (CRO): The organization operates as a not-for-profit Contract Research Organization (CRO) providing full-spectrum clinical research services to sponsors of dental and medical device products. Services include protocol development, study conduct, monitoring, biostatistics, regulatory support, and publication. All retained earnings go into a fund supporting studies that would otherwise not be funded.
2. Government and Foundation Grants: As a not-for-profit organization, The McGuire Institute receives funding support including grants such as NIDCR funding for collaborative research projects with academic institutions like the Michigan Regenerative Medicine Center.

Go-to-market motion1 record

Distribution channels1 record

Marketing channels5 records

Core offering

The McGuire Institute is a not-for-profit practice-based clinical research network that operates as a Contract Research Organization (CRO) providing full-spectrum clinical research services to sponsors of dental and medical device products. Services include protocol development, study conduct, monitoring, biostatistics, regulatory support, FDA approval guidance, and publication. The organization leverages a network of master clinicians (periodontists, oral surgeons, general dentists, dental hygienists) across the United States to generate real-world evidence in private practice settings.

Product overview

The McGuire Institute (iMc) operates as a practice-based clinical research network offering full Contract Research Organization (CRO) services for the dental and periodontal industry. The core offering includes a network of master clinicians conducting clinical research, supported by services such as Electronic Data Capture (EDC) databases, interactive AI platforms, Trial Master File management, and an Implant Registry. Research publications and the Legends of Oral Regeneration podcast serve as educational outputs from the network. The organization is structured as a not-for-profit, with all retained earnings supporting studies that would not otherwise be funded.

Differentiator

Problem solved

Functional benefit

Products and services

• Full CRO Services Complete Contract Research Organization services guiding sponsors through drug or device development from conception through FDA approval, including protocol development, IRB approval, study coordination, monitoring, biostatistics, regulatory submission, and publication support. Offered to pharmaceutical companies, medical device manufacturers, and dental product sponsors.
• Implant Registry An integrated registry information repository that captures real-world data from the network of periodontists, general dentists, oral surgeons, and dental hygienists, improving access, controlling costs, and providing opportunities for research publication. Designed for dental product manufacturers and academic researchers.
• Clinical Research Network Network of master clinicians strategically located throughout the United States who conduct high-quality clinical research in practice-based settings, generating real-world data where products are widely employed. Used by sponsors seeking clinically relevant research populations.
• Research Publications Peer-reviewed publications authored by network clinicians covering topics including periodontal regeneration, dental implants, soft tissue grafts, gingival recession treatment, and AI in periodontal therapy. Available for academic and clinical audiences.
• Legends of Oral Regeneration Podcast Podcast series (part of iMc podcasts including 'Dream Big' Legends of Oral Regeneration and 'Fireside Chat') featuring industry thought leaders discussing advances in oral regeneration and periodontal therapy, targeted to dental professionals and industry stakeholders.
• Research Studies Specific clinical research studies including treatment of gingival recession, extractions and ridge preservation, treatment of periodontitis and inflammation, long term evaluations of soft tissue grafts and implants, artificial intelligence in periodontal therapy, treatment of periodontal defects, product evaluations, implant registry, implant therapy, and histologic evaluations.

Quantifiable outcome

• High-quality clinical research conducted in the practice settings where most products are used
• +1 more outcomes

Named customers2 records

Segments2 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability1 record

Feature4 records

Partnerships

Four partnerships are on record, tiered core.

• Michigan Regenerative Medicine CentercoreStrategic or Co-development PartnerCollaborative partnership with NIDCR-funded Michigan Regenerative Medicine Center for tissue engineering research. The partnership enables translation of tissue engineering innovations into periodontal practice through McGuire Institute's network of clinicians.
• BIO LASEcoreStrategic or Co-development PartnerLandmark independent study conducted by The McGuire Institute confirming positive 12-month clinical outcomes for BIOLASE REPAIR PERIO PROTOCOL. Published as press release on BIO LASE investor relations website.
• American Academy of Periodontology (AAP)coreGTM or Marketing PartnerPrimary professional organization in periodontics. McGuire Institute and its network clinicians actively participate in AAP conferences, present research, and contribute to the profession. Dr. McGuire is past President and Dr. Chris Richardson serves as Vice President.
• National Institute of Dental and Craniofacial Research (NIDCR)coreStrategic or Co-development PartnerFederal research institution providing funding support for collaborative research projects through the McGuire Institute network, including tissue engineering research with academic partners.

Scale indicators3 records

Recent moves6 records

Expansion highlights5 records

Broad incumbents

• Medpace: Large, scientifically focused mid-size CRO with global footprint; competes with iMc for dental device sponsors who need scale, but with a much broader therapeutic portfolio rather than a dental niche.
• IQVIA: Largest global CRO with extensive dental and medical device capability; competes with iMc on the high end of dental sponsors' study portfolios where global scale and integrated data are required.
• ICON plc: Global CRO with a dedicated medical device and dental practice; competes with iMc on larger, multi-region dental device programs.
• Charles River Laboratories: Large CRO/CDMO that provides medical device and clinical trial services including dental research support; a broader incumbent competing for sponsor budgets that might otherwise flow to a specialty CRO like iMc.
• Syneos Health: Large biopharma and medical device CRO with meaningful dental device study experience; competes with iMc on full-service, sponsor-facing engagements.

Direct peers

• Premier Research: Specialty CRO with strong medical device and dental/orthopedic experience, providing protocol through regulatory support — directly comparable to iMc's full-service dental CRO offering.
• Clinipace Worldwide: Mid-sized, therapeutically focused CRO with deep dental and medical device trial experience; competes head-to-head with iMc for dental/periodontal device sponsors needing flexible mid-size CRO capacity.
• Clindatrix: Dental and medical device-focused CRO providing full-service clinical trial management; the closest niche-specialist competitor to iMc in the dental CRO category.
• Worldwide Clinical Trials: Mid-sized scientific CRO with medical device expertise and US-rooted investigator networks; comparable to iMc in scale and therapeutic focus on dental/medical device programs.
• PROMETRIK: Boutique CRO with strong biometrics, biostatistics, and clinical operations for medical device and specialty studies; overlaps with iMc's biostatistics and study design capabilities.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/themcguireinstitute
• LinkedInlinkedin.com/company/the-mcguire-institute

Revenue estimate

Valuation estimate

Number of profiles

Profiles11 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about The McGuire Institute