Supp.ai

What Supp.ai does

Supp.ai is a free, non-commercial web application that uses natural language processing to extract and present evidence of supplement-drug interactions from the scientific literature. The system was developed and is operated by the non-profit Allen Institute for AI (AI2), and provides a searchable corpus of 2,044 dietary and herbal supplements, 2,866 drugs, and 59,096 documented interactions, with each interaction linked to evidence sentences and source papers via Semantic Scholar. The underlying architecture normalizes entities using UMLS Concept Unique Identifiers (CUIs), enabling consistent retrieval across heterogeneous terminology, and the work is documented in an arxiv publication (1909.08135). The product is offered through three free channels: a public web search interface at supp.ai, a RESTful API for programmatic access, and a 38.4MB downloadable dataset for offline research use, all subject to the Semantic Scholar Dataset License Agreement.

The intended user base spans three segments: physicians, pharmacists, and other healthcare providers seeking scientifically grounded interaction data for patient counseling; consumers and patients researching potential interactions between supplements and their medications; and academic researchers studying pharmacokinetics and nutrition who need a curated corpus for downstream analysis. There is no commercial sales motion — Supp.ai does not charge for access, has no paid tiers, and generates no revenue; it is funded entirely through AI2's non-profit research model and is explicitly described as independent of third-party commercial influence.

From a strategic posture, Supp.ai functions as a long-lived public good rather than a growth-stage venture. The dataset was last refreshed approximately five years ago, no commercial expansion, hiring, or funding signals are associated with the project, and the team roster reflects the original 2019 researchers. The service is operationally stable and remains accessible, but the absence of corpus updates or product evolution indicates a maintenance trajectory under its current structure.

Name

Supp.ai

Legal name

Allen Institute for Artificial Intelligence

Website

https://supp.ai

Company type

Private

Founded year

2019

Operating status

Operating

Short description

Supp.ai is a free, non-commercial AI tool from the Allen Institute for AI that uses NLP to extract supplement-drug interactions from scientific literature, serving healthcare providers, consumers, and academic researchers via web, API, and downloadable dataset.

Ownership category

akta.pro rank

Product category

Drug Interaction Database

NAICS

Software Publishers (513210), Web Search Portals, Libraries, Archives, and Other Information Services (5192), Web Search Portals, Libraries, Archives, and Other Information Services (519)

SIC

Services-Prepackaged Software (7372), Services-Misc Health & Allied Services, Nec (8090)

akta.pro primary industry

Software as a Medical Device (SaMD) – Clinical Decision & Diagnostic Software (HLACANAD)

akta.pro secondary industry

SaMD – Monitoring, Triage & Risk Stratification Software (HLACANAE)

Keywords

• Supplement-drug interactions
• Drug interaction database
• Biomedical NLP
• Scientific literature mining
• Pharmacology knowledge base

Headquarters

HQ city

Seattle

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Technology or R&D, Personnel, Infrastructure, Operations

Revenue model

1. Free Public Service: Supp.ai is a free service provided by the non-profit Allen Institute for AI (AI2). No revenue is generated from the service. It is funded through AI2's non-profit research funding model.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels3 records

Core offering

Supp.ai is a free AI-powered web tool that automatically extracts evidence of supplement-drug interactions from scientific literature and presents them in a searchable corpus of 2,044 supplements, 2,866 drugs, and 59,096 interactions. The service is offered alongside a free RESTful API for programmatic access and a downloadable dataset, and is operated as a non-commercial service by the Allen Institute for AI (AI2).

Product overview

Supp.ai is a single unified product offering from the Allen Institute for AI (AI2) that provides a free web-based tool for discovering supplement-drug interactions, accompanied by a public API for programmatic access and a downloadable dataset. The core tool uses AI to automatically extract interaction evidence from scientific literature, presenting findings with supporting research citations.

Differentiator

Problem solved

Functional benefit

Products and services

• Supp.ai Web Tool A free AI-powered web tool for discovering supplement-drug interactions by automatically extracting evidence from scientific literature, enabling users to search supplements or drugs and explore related research papers.
• Supp.ai API A free REST API providing programmatic access to the supplement-drug interaction database with endpoints for search, agent metadata, agent interactions, and interaction evidence retrieval.
• Supp.ai Public Dataset A publicly downloadable 38.4Mb dataset containing the supplement-drug interaction corpus for offline analysis and research use.

Quantifiable outcome

• 2,044 supplements indexed
• +2 more outcomes

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

AI capability4 records

Feature4 records

Partnerships

One partnership is on record.

• Allen Institute for AI (AI2)coreOthersSupp.ai is a free service operated by the non-profit Allen Institute for AI (AI2). AI2 provides the institutional backing, funding, and research infrastructure for the project. As the parent organization, AI2 funds and operates the service as part of its non-profit AI research mission. The service is explicitly independent of third-party commercial influences.

Scale indicators3 records

Recent moves5 records

Expansion highlights3 records

Direct peers

• Natural Medicines (formerly Natural Medicines Database): Clinical reference database focused on dietary supplements and natural medicines, including documented interactions with prescription and OTC drugs. Directly comparable to Supp.ai as a supplement-drug interaction reference, though it is a commercial, subscription-based product with active editorial maintenance.
• Drugs.com: Major consumer-facing drug information site with a widely used drug interaction checker covering prescription drugs and supplements. Directly comparable as a free public tool for users researching medication interactions, but it is a commercial property serving consumer search demand at scale.
• Medscape Drug Interaction Checker: Free drug interaction tool widely used by clinicians, including interactions involving supplements and OTC products. Comparable in providing free, evidence-linked interaction lookups for healthcare professionals, though it is part of a commercial clinical reference platform.
• Epocrates (Wolters Kluwer): Clinician-facing drug and interaction reference app with curated, frequently updated interaction data. Comparable in serving healthcare providers with drug interaction information, though it is integrated into a broader commercial clinical decision support ecosystem.

Broad incumbents

• IBM Micromedex: Enterprise clinical decision support suite covering drug interactions, IV compatibility, and reference content. Comparable in providing evidence-based interaction data to clinicians, but operates as a large commercial incumbent serving hospitals and health systems rather than a free public tool.
• First Databank (FDB): Provider of drug knowledge and drug-interaction decision support datasets embedded in EHRs and pharmacy systems. Comparable as a foundational drug-interaction data vendor, but operates as a B2B data infrastructure provider rather than a consumer-facing tool.
• Wolters Kluwer Clinical Effectiveness (UpToDate, Medi-Span): Suite of clinical reference and drug-interaction products (UpToDate, Medi-Span, Lexicomp) used by clinicians worldwide. Comparable in delivering evidence-based drug interaction information to healthcare providers, but operates across multiple specialized commercial products.

Others

• RxNav (NIH National Library of Medicine): Free NIH browser for RxNorm and drug interaction data produced from NDF-RT, providing publicly available drug-drug interaction relationships. Comparable as a free, non-commercial drug information resource, though it focuses on drug-drug rather than supplement-drug interactions.
• Semantic Scholar (Allen Institute for AI): AI2's flagship scientific literature search engine, which Supp.ai directly links to for source-paper retrieval. Comparable as a sibling AI2 research tool applying NLP to scientific literature, and an infrastructure dependency for Supp.ai's evidence-linking feature.
• OpenFDA: Public FDA dataset and API platform covering drugs, adverse events, and labeling. Comparable as a free, non-commercial, API-accessible health data resource for researchers and developers, though its scope is regulatory data rather than curated supplement-drug interaction evidence.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat3 records

Key risks5 records

Key highlights6 records

Customer concentration

Revenue estimate

Valuation estimate

Number of profiles

Profiles9 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Supp.ai