NOxBOX

What NOxBOX does

NOxBOX is a UK-based medical device company that designs and manufactures inhaled nitric oxide (iNO) delivery and monitoring systems for hospital use. Its flagship product, NOxBOXi, is a small-footprint prescription-only device that delivers and monitors nitric oxide therapy, primarily for neonatal ICU settings where iNO is used to treat conditions such as persistent pulmonary hypertension of the newborn (PPHN), with positioning extending into adult ICU and emergency-room applications. The product family includes dedicated variants — NOxBOXmobile, NOxBOXlite, and NOxBOX+ — addressing different clinical and portability requirements, and is validated for integration with leading ventilator brands used in respiratory-therapy workflows.

The company operates as a wholly-owned subsidiary of Linde Gas & Equipment Inc., part of Linde plc, which gives it access to Linde's authorized distributor network spanning 80+ countries. NOxBOX is a small organization (1-10 employees) and does not disclose revenue, suggesting the unit functions as a focused product line within Linde's broader healthcare and medical-device portfolio rather than as a standalone scaled business. Its intellectual property is protected through registered trademarks (NOxBOX, NOxBOXi, NOxBOXmobile, NOxBOXlite, NOxBOX+) across jurisdictions where the device is sold.

Commercially, NOxBOX sells a prescription-only medical device to hospitals via Linde's distributor channel, with go-to-market driven by clinical adoption in respiratory-therapy departments rather than direct sales. The company maintains technical-support, training, and clinical-resources functions tied to its product, and is positioned in a narrow therapeutic niche where regulatory clearance (FDA, CE marking, and equivalents) and ventilator-platform validation form the primary barriers to entry.

Name

NOxBOX

Legal name

NOxBOX Ltd.

Website

https://noxboxltd.com

Company type

Private

Founded year

2015

Operating status

Operating

Headcount range

1–10 employees

Short description

NOxBOX is a UK-based, Linde-owned medical device company that designs and manufactures the NOxBOXi inhaled nitric oxide delivery and monitoring system for hospital neonatal, adult ICU, and emergency-room use, distributed globally through Linde's authorized distributor network.

Ownership category

akta.pro rank

Product category

Inhaled Nitric Oxide Delivery and Monitoring Medical Devices

NAICS

Electromedical and Electrotherapeutic Apparatus Manufacturing (334510), Surgical and Medical Instrument Manufacturing (339112)

SIC

Surgical & Medical Instruments & Apparatus (3841), Electromedical & Electrotherapeutic Apparatus (3845)

akta.pro primary industry

Anesthesia & Respiratory Gas Delivery Equipment (Breathing Circuits, Vaporizers, Gas Mixers) (HLAHAGAK)

akta.pro secondary industries

Medical & Healthcare Gases (IMAEACAF), Oxygen Therapy Systems (Concentrators, Cylinders, Liquid O2, HFNC) (HLAHAGAD)

Keywords

• Nitric oxide therapy
• Medical gas monitoring
• Respiratory therapy equipment
• Critical care ventilation
• Neonatal respiratory care

Headquarters

HQ city

Sittingbourne

HQ country

United Kingdom

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Operations, Technology or R&D, Personnel, Supply Chain, Marketing or Sales, Infrastructure

Revenue model

1. Medical Device Sales: Sale of NOxBOXi nitric oxide delivery and monitoring systems for healthcare facilities. Products are prescription (Rx) only medical devices. Inhaled nitric oxide therapy is available by prescription only, currently for neonates in the US.

Pricing tiers

Go-to-market motion1 record

Distribution channels1 record

Marketing channels3 records

Core offering

NOxBOX designs, manufactures, and distributes inhaled nitric oxide delivery and monitoring systems for healthcare, centered on the NOxBOXi platform with intelligent closed-loop delivery, real-time NO/NO2/O2 monitoring, and integrated NOxMixer continuous-flow delivery for emergency applications. Products are prescription-only medical devices sold to hospitals and healthcare facilities through an authorized global distributor network backed by Linde's worldwide infrastructure.

Product overview

NOxBOX Ltd offers a portfolio of inhaled nitric oxide delivery and monitoring systems for healthcare. The core product is the NOxBOXi system, which provides comprehensive delivery and monitoring of inhaled nitric oxide therapy with intelligent closed-loop control. The NOxBOXi integrates the NOxMixer system for continuous NO delivery mixed with oxygen for emergency applications. Additional product variants include NOxBOX+, NOxBOXmobile, NOxBOX02, and NOxBOXlite, though limited details are available for these variants. The NOxBOXi is designed primarily for hospital use with a portable, detachable monitor for transit and transfer conditions. All inhaled nitric oxide therapy products require prescription and are distributed globally through an authorized distributor network.

Differentiator

Problem solved

Functional benefit

Brands

• NOxBOX®i: Nitric oxide delivery and monitoring system providing comprehensive means of delivering and monitoring inhaled nitric oxide therapy.
• NOxBOX+
• NOxBOXmobile
• NOxBOX02
• NOxBOXlite
• NOxMixer™

Products and services

• NOxBOXi Nitric Oxide Delivery and Monitoring System The NOxBOXi system delivers and monitors nitric oxide for use in inhaled nitric oxide therapy in both continuous and synchronous delivery modes. It features an intelligent closed-loop delivery system with NO dose delivery from 0 to 80 ppm in intelligent mode, a step-by-step guided touch-screen interface, automatic cylinder switchover, and real-time NO, NO2, and O2 monitoring. It is an Rx-only medical device intended for hospitals and healthcare facilities (ICU, ER, neonatal, and transport settings) and is independently validated for use with most common ICU and ER ventilators, including invasive and non-invasive ventilation.
• NOxMixer Continuous-Flow NO and O2 Mixing Subsystem Permanently affixed to the NOxBOXi system, the NOxMixer is intended to deliver a continuous flow of nitric oxide (NO) mixed in line with oxygen (O2) for emergency applications and to manually ventilate a patient. It is targeted at hospitals and clinical teams that need emergency NO/O2 mixing on the same delivery platform used for routine inhaled nitric oxide therapy.
• NOxBOX+ Product Variant NOxBOX+ is a product variant of the NOxBOX inhaled nitric oxide portfolio, referenced through NOxBOX's technical support and service channels. Detailed product specifications, indications, and launch date are not available in the provided source material.
• NOxBOXmobile Product Variant NOxBOXmobile is a product variant of the NOxBOX inhaled nitric oxide portfolio, referenced through the company's technical support and service channels, consistent with a portable or transport-oriented configuration. Detailed product specifications and launch date are not available in the provided source material.
• NOxBOX02 Product Variant NOxBOX02 is a product variant of the NOxBOX inhaled nitric oxide portfolio, referenced through the company's technical support and service channels. Detailed product specifications and launch date are not available in the provided source material.
• NOxBOXlite Product Variant NOxBOXlite is a product variant of the NOxBOX inhaled nitric oxide portfolio, referenced through the company's technical support and service channels, consistent with a lighter or simplified configuration. Detailed product specifications and launch date are not available in the provided source material.
• Noxivent Nitric Oxide Product Line Noxivent is a registered NOxBOX trademark covering nitric oxide products described on the NOxBOX website. These products are subject to local regulatory approvals and labeling requirements, and may not be distributed, sold, or used outside of those approvals.

Segments1 record

Ideal customer profiles1 record

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

Feature8 records

Partnerships

One partnership is on record.

• Linde Gas & Equipment Inc.coreOthersNOxBOX Ltd is a wholly-owned subsidiary of Linde Gas & Equipment Inc., part of Linde plc. Linde is a leading global industrial gases and engineering company with operations spanning more than 80 countries and 2025 sales of $34 billion.

Scale indicators2 records

Recent moves5 records

Expansion highlights4 records

Emerging players

• Bellerophon Therapeutics: Developed INOpulse, an investigational inhaled NO delivery system targeting pulmonary hypertension. Comparable use-case overlap with NOxBOXi, though positioned as a development-stage therapy platform rather than a marketed delivery device.
• Hamilton Medical: Specialist ICU ventilator manufacturer with strong presence in neonatal ventilation — directly adjacent to NOxBOXi's primary neonatal use case and included in the validated ventilator ecosystem.

Broad incumbents

• Air Liquide: Global industrial and medical gases company with healthcare gases including nitric oxide. Structurally analogous to NOxBOX's parent (Linde) — supplies iNO gas and operates adjacent respiratory/home-care services.
• Dräger: Manufacturer of ICU/ER ventilators and anesthesia delivery systems. Competes for the same hospital respiratory equipment purchasing cycle and is part of the validated ventilator compatibility list for NOxBOXi.
• Getinge: Major ICU ventilator and respiratory care equipment manufacturer. Sells ventilators validated with NOxBOXi and competes for the same hospital respiratory capital budget.
• Philips Respiratory Care: Hospital ventilation and respiratory care portfolio. Competes for hospital respiratory capital and overlaps with the ICU/ER workflow in which NOxBOXi operates.
• Vyaire Medical: Respiratory care and ventilation company spun from CareFusion/BD. Operates in the same hospital respiratory capital equipment category and supports ventilator-compatible therapies.

Others

• ICU Medical (Maxtec): Acquired Maxtec, a manufacturer of gas blenders, flowmeters, and gas monitoring accessories used in respiratory therapy. Adjacent ecosystem supplier to nitric oxide delivery workflows.
• Intersurgical: Manufacturer of respiratory care consumables and gas delivery interfaces (breathing circuits, masks, filters). Comparable product category to NOxBOXi gas mixing/delivery subsystems and supplies adjacent ICU respiratory workflows.

Direct peers

• Mallinckrodt Pharmaceuticals: Sells INOMAX (delivered iNO) and the INOmax DSIR delivery system, the dominant US iNO therapy platform. Direct head-to-head competitor to NOxBOXi in hospital ICU/ER nitric oxide delivery.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat4 records

Key risks6 records

Key highlights6 records

Customer concentration

• Xtwitter.com/lindegroup
• YouTubeyoutube.com/lindegroup
• Facebookfacebook.com/LindeGroup
• LinkedInlinkedin.com/company/10510176

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about NOxBOX