deltaDOT
deltaDOT Ltd is a London-based life-sciences spin-out from Imperial College that designs and markets the HPCE-512 capillary electrophoresis instrument, using proprietary label-free multipixel detection (LFII®) to deliver mass-spectrometry-comparable biomolecule analysis for life-sciences research, biopharma QC, and veterinary diagnostics.
- Company typePrivate
- Founded2000
- HeadquartersLondon, United Kingdom
- Headcount11–50
- GTM typeB2B
- OfferingHardware or Manufacturing
What deltaDOT does
deltaDOT Ltd is a London-based life-sciences instrumentation company, spun out of Imperial College London in 2000, that designs, manufactures, and markets the HPCE-512 high-performance capillary electrophoresis (HPCE) instrument and offers related analytical and contract-research services from its London BioScience Innovation Centre laboratories. Its core technical differentiator is the proprietary Label Free Intrinsic Imaging (LFII®) technology, which uses a 512-pixel photodiode array to track biomolecules without labels, stains, dyes, or radioisotopes, combined with the EVA vertexing and GST fusion algorithms that deliver up to 10x improvements in signal-to-noise versus single-point detection. The platform is positioned as a lower-cost, label-free alternative to mass spectrometry and HPLC for protein, nucleic acid, carbohydrate, viral, and small-molecule analysis, with published evidence of MS-comparable performance for glycoform and monoclonal antibody characterization.
The company monetizes through three channels: direct worldwide sales of HPCE-512 instruments into life-sciences research, biopharmaceutical, and diagnostic laboratories; analytical services and contract research run from its London labs (covering GFR testing, amino acid analysis, antibody analysis, glycoform analysis, and the deltaTITER viral titration kit co-developed with GSK); and technology licensing, notably a 2017 deal with a Chinese partner for local manufacturing and distribution in China. Customers include NHS Quality Control North West (regulatory biosimilar stability studies), the Royal Veterinary College (the IRIS-accepted iohexol GFR assay for companion animals), the Laboratory of the Government Chemist, Huazhong University of Science and Technology, and unnamed major biopharma firms. DeltaDOT is privately held with no disclosed parent or external PE/VC backing since 2007 and reports a small team of roughly 10-15 staff led by Managing Director Nigel Stokes and CSO Stuart Hassard.
deltaDOT firmographics
Firmographics- Name
- deltaDOT
- Legal name
- deltaDOT Ltd
- Website
- https://deltadot.com
- Company type
- Private
- Founded year
- 2000
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- deltaDOT Ltd is a London-based life-sciences spin-out from Imperial College that designs and markets the HPCE-512 capillary electrophoresis instrument, using proprietary label-free multipixel detection (LFII®) to deliver mass-spectrometry-comparable biomolecule analysis for life-sciences research, biopharma QC, and veterinary diagnostics.
- Ownership category
- akta.pro rank
deltaDOT industry classification
Industry- Product category
- Analytical Laboratory Instruments
- NAICS
- Analytical Laboratory Instrument Manufacturing (334516), Navigational, Measuring, Electromedical, and Control Instruments Manufacturing (33451)
- SIC
- Laboratory Analytical Instruments (3826), Services-Testing Laboratories (8734), Services-Commercial Physical & Biological Research (8731)
- akta.pro primary industry
- Mass Spectrometry & Spectroscopy Instruments (HLAGAIAB)
- akta.pro secondary industries
- Proteomics & Mass Spectrometry Services (HLAGANAB), Laboratory Developed Tests (LDTs) & Specialized Clinical Lab Assays (HLAAALAN)
Keywords
Where deltaDOT is headquartered
LocationHeadquarters
- HQ city
- London
- HQ country
- United Kingdom
- HQ region
- Europe
Offices1 record
Markets served
deltaDOT business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Personnel, Technology or R&D, Supply Chain, Marketing or Sales, Operations
Revenue model
- HPCE Instrument Sales: Sale of HPCE-512 analytical instruments designed, manufactured, and marketed worldwide to life sciences, biopharmaceutical, and diagnostic clients.
- Analytical Services: Contract research and scientific collaboration from London laboratories using deltaDOT's HPCE instruments. Services include GFR testing, amino acid analysis, antibody analysis, viral titer analysis, and glycoform analysis.
- Technology Licensing: Licensing of HPCE technology, software, and IP to international partners for local instrument manufacturing and distribution, with initial payments and milestone-related payments.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Other | Multi-year contract | HPCE-512 Instrument - enterprise analytical instrument |
Go-to-market motion2 records
Distribution channels3 records
Marketing channels5 records
deltaDOT product offering
Product offeringCore offering
deltaDOT designs, manufactures, and markets the HPCE-512 high performance capillary electrophoresis analytical instrument, which uses its proprietary Label Free Intrinsic Imaging (LFII®) technology with a 512-pixel photodiode array to separate and analyze proteins, nucleic acids, carbohydrates, viruses, bacteria, and small molecules without labels or stains. The company also offers Analytical Services/contract research from its London laboratories and licenses its HPCE technology and software to international partners for local manufacturing.
Product overview
deltaDOT offers a portfolio of analytical products centered on its HPCE-512 instrument, which incorporates the proprietary Label Free Intrinsic Imaging (LFII®) technology for high-performance capillary electrophoresis. The core HPCE-512 system uses a 512-pixel photodiode array to achieve multipoint detection without requiring labels, providing superior resolution, sensitivity, and repeatability compared to conventional CE systems. Alongside instrument sales, deltaDOT provides Analytical Services including contract research and the deltaTITER viral titration kit (developed with GSK). The company also operates a Veterinary Diagnostics division offering GFR testing via iohexol clearance, developed in partnership with the Royal Veterinary College and accepted by IRIS guidelines. The technology serves Life Sciences research, drug testing, diagnostics, and biopharmaceutical manufacturing sectors.
Differentiator
Problem solved
Functional benefit
Brands
- HPCE-512: High Performance Capillary Electrophoresis instrument based on multi-point detection technology using proprietary Label Free Intrinsic Imaging (LFII®)
- LFII® (Label Free Intrinsic Imaging)
- deltaTITER
Products and services
- HPCE-512
Quantifiable outcome
- 10x improvement in signal-to-noise ratio using GST algorithm vs. single-point detection
- +4 more outcomes
Companies that use deltaDOT
Customer profileNamed customers6 records
Segments5 records
Ideal customer profiles4 records
deltaDOT technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature5 records
deltaDOT partnerships and signals
Strategic signalPartnerships
Seven partnerships are on record, tiered minor and core.
- Huazhong University of Science and TechnologyminorHosted delegation from Huazhong University to explore collaborations between deltaDOT, Chinese partner, and Chinese businesses. Opportunity to expand technology adoption in China.
- Leading Chinese Company (Technology Partner)coredeltaDOT licensed HPCE technology, software, and IP to a Chinese company for local manufacturing and domestic distribution. Initial payment received with two milestone-related payments over 12 months. Partner focuses on food/drug testing in agriculture, chemical engineering, and environmental protection sectors.
- UCL Advanced Centre for Biochemical EngineeringminordeltaDOT is part of the Future Targeted Healthcare Manufacturing Hub, valued over £20M over 7 years, addressing manufacturing and regulatory challenges for biological medicines.
- Optra SystemsminorExternal consultants who worked with deltaDOT for over 6 months on software validation for CFR 21 Part 11 compliance, ensuring FDA data requirements are met.
- Quality Control North West (NHS Liverpool)coreQCNW, an NHS division conducting regulatory studies for pharma, used HPCE-512 for stability studies on mAb biosimilar (trastuzumab biosimilar ABP-980) for human use approval. Presented data at scientific meetings.
- Royal Veterinary College (RVC)coreJoint partnership since 2012 for development of iohexol-based GFR assay for companion animals. IRIS accepted the assay for clinical use. Published 5-year comparison study validating assay against SDMA and creatinine markers.
- GSK (GlaxoSmithKline)coreJointly developed deltaTITER kit-based baculovirus titration methodology with GSK. Fast and accurate titration - 18 samples per hour with <10% repeatability vs 50% for traditional plaque assays.
Scale indicators2 records
Recent moves7 records
Expansion highlights5 records
deltaDOT competitors and assessment
Company assessmentBroad incumbents
- Bruker Corporation: Scientific instrument vendor with mass spectrometry (timsTOF, MALDI-TOF) and biopharma characterization offerings, including proteomics and glycoform analysis tools that compete with HPCE-512 in discovery and QC settings.
- Thermo Fisher Scientific: Largest life sciences tools provider with broad CE, MS, and chromatography portfolio including the Q Exactive and Orbitrap lines. Competes with deltaDOT in mAb characterization and biosimilar QC; substantially larger sales and applications infrastructure.
- Agilent Technologies: Global analytical instrument leader offering capillary electrophoresis systems (7100 CE), mass spectrometers, and chromatography platforms. Direct comparator for HPCE-512, particularly in biopharma QC, with much broader portfolio and global sales reach.
- PerkinElmer (Revvity): Diversified life sciences analytical tools vendor serving biopharma, diagnostics, and food safety markets with overlapping reagent, assay, and instrument offerings relevant to deltaDOT's QC and drug testing segments.
- Waters Corporation: Established analytical instruments vendor specializing in chromatography, mass spectrometry (ACQUITY, Xevo), and biopharmaceutical characterization workflows that compete with deltaDOT's HPCE-512 in mAb and protein analysis.
- Beckman Coulter Life Sciences: Historical leader in capillary electrophoresis via the PA 800 series and ProteomeLab, serving biopharma and clinical diagnostics with protein characterization workflows overlapping with deltaDOT's HPCE-512 value proposition.
Others
- SCIEX (Danaher): Leading CE and mass spectrometry vendor (PA 800 Plus, BioPhase 8800) widely used in biopharmaceutical characterization, glycoform analysis, and biosimilar QC — the same core applications deltaDOT targets. Operates as part of Danaher's life sciences platform.
Emerging players
- 908 Devices: Specialty analytical instrument company offering handheld and benchtop mass spectrometry for bioprocess, forensics, and life sciences — overlaps with deltaDOT's bioprocess analytics and food/drug testing ambitions.
- ProteinSimple (Bio-Techne): Developer of capillary Western blotting (Wes, Sally Sue) and protein analysis instruments, overlapping with deltaDOT in protein characterization and biopharma QC use cases. Larger Bio-Techne platform but similar product positioning.
Direct peers
- Sebia: Specialized clinical diagnostics and life sciences company focused on capillary electrophoresis (Hydrasys, CAPILLARYS) for protein, hemoglobin, and immunotyping analysis. Closely comparable niche CE specialist with similar hardware-and-consumables model.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
deltaDOT social profiles
Digital presencedeltaDOT financial estimates
Financial estimateRevenue estimate
Valuation estimate
deltaDOT leadership team
Management profileNumber of profiles
Profiles5 records
deltaDOT funding detail
Funding detailFunding overview
Funding rounds3 records
Investors3 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
deltaDOT M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about deltaDOT
What does deltaDOT do?
deltaDOT designs, manufactures, and markets the HPCE-512 high performance capillary electrophoresis analytical instrument, which uses its proprietary Label Free Intrinsic Imaging (LFII®) technology with a 512-pixel photodiode array to separate and analyze proteins, nucleic acids, carbohydrates, viruses, bacteria, and small molecules without labels or stains. The company also offers Analytical Services/contract research from its London laboratories and licenses its HPCE technology and software to international partners for local manufacturing.
Is deltaDOT a public or private company?
deltaDOT is a private company. It is classified as venture growth investor backed and is currently operating.
When was deltaDOT founded?
deltaDOT was founded in 2000. It employs 11 to 50 people.
Where is deltaDOT based?
deltaDOT is headquartered in London, United Kingdom, in the Europe region.
How does deltaDOT make money?
Three revenue lines are on record. HPCE Instrument Sales are the primary driver. The others are analytical Services and technology Licensing.
Who are deltaDOT's main competitors?
Broad incumbents on record are Bruker Corporation, Thermo Fisher Scientific, Agilent Technologies, PerkinElmer (Revvity), Waters Corporation and Beckman Coulter Life Sciences. SCIEX (Danaher) is listed as an others. Emerging players are 908 Devices and ProteinSimple (Bio-Techne). Sebia is listed as a direct peer.
Does deltaDOT have an API?
No public API is recorded for deltaDOT.
What industry is deltaDOT in?
deltaDOT's product category is Analytical Laboratory Instruments. Its primary akta.pro industry code is HLAGAIAB, Mass Spectrometry & Spectroscopy Instruments, with a secondary code of HLAGANAB, Proteomics & Mass Spectrometry Services. Its NAICS code is 334516 and its SIC code is 3826.