ActiGraph
Ametris (formerly ActiGraph, a Signant Health Company) provides FDA-cleared medical-grade wearable devices, a cloud-based remote monitoring platform (CentrePoint), and validated digital measures for clinical trials. It serves pharmaceutical sponsors, CROs, and academic researchers across 150+ countries.
- Company typePrivate
- Founded2004
- HeadquartersPensacola, United States
- Headcount—
- GTM typeB2B
- OfferingSoftware
What ActiGraph does
Ametris (formerly ActiGraph, now a Signant Health Company) provides an end-to-end digital health technology platform for clinical trials, combining FDA-cleared, medical-grade wearable hardware with cloud-based remote monitoring and data analytics. Its core technology stack centers on the ActiGraph LEAP multi-sensor wearable (combining accelerometer, photoplethysmography, skin temperature, and microphone sensors), the CentrePoint cloud platform deployed on AWS and Microsoft Azure, the Ametris Connect patient engagement application (acquired from Biofourmis Connect in January 2025), the ActiLife desktop analysis software, and an Algorithm Marketplace that integrates partner-validated algorithms from empatica (PKG movement-disorder measures), Mobilise-D (gait and mobility), Hyfe (cough detection), and CSEM (PPG-based vital signs). The company has accumulated 30,000+ peer-reviewed publications using its technology, 285+ industry-sponsored clinical trial deployments, and a customer footprint across 150+ countries.
Ametris serves pharmaceutical and biotechnology sponsors (named customers include Pfizer, Takeda, UCB, and Johnson & Johnson), contract research organizations (Parexel), and academic and public-health researchers (Stanford, Johns Hopkins, Harvard, Vanderbilt, University of Alabama at Birmingham). It sells a combination of hardware (LEAP, wGT3X-BT, GT9X Link, CentrePoint Insight Watch, ActiSleep), software subscriptions (CentrePoint, ActiLife), professional services (digital biomarker development, digital endpoint development and biostatistics, DHT regulatory science), algorithm licensing through its marketplace, and managed full-service trial enablement. Pricing is quote-based and not publicly disclosed, with multi-year contracts scoped per study. Distribution combines direct enterprise field sales, an owned e-commerce academic storefront, international resellers in 40+ countries, CRO channel partnerships, and demand generation through the annual ActiGraph Digital Data Summit (ADDS) plus heavy conference presence.
Ametris was founded in 2004 as ActiGraph, rebranded to Ametris in 2024, acquired the Biofourmis Connect life science business in January 2025, and was subsequently acquired by Signant Health. The company is headquartered in Pensacola, Florida, and maintains a PhD-led in-house science team covering data science, biostatistics, and regulatory science. Compliance posture includes FDA-cleared hardware, GDPR-aligned data processing, and EU-U.S., UK Extension, and Swiss-U.S. Data Privacy Framework certifications.
ActiGraph firmographics
Firmographics- Name
- ActiGraph
- Legal name
- Ametris, L.L.C.
- Website
- https://theactigraph.com
- Company type
- Private
- Founded year
- 2004
- Operating status
- Acquired
- Short description
- Ametris (formerly ActiGraph, a Signant Health Company) provides FDA-cleared medical-grade wearable devices, a cloud-based remote monitoring platform (CentrePoint), and validated digital measures for clinical trials. It serves pharmaceutical sponsors, CROs, and academic researchers across 150+ countries.
- Ownership category
- akta.pro rank
ActiGraph industry classification
Industry- Product category
- Clinical Trial Digital Health Technology
- NAICS
- Custom Computer Programming Services (541511), Surgical and Medical Instrument Manufacturing (339112), Scientific Research and Development Services (5417)
- SIC
- Services-Prepackaged Software (7372), In Vitro & In Vivo Diagnostic Substances (2835)
- akta.pro primary industry
- Safety/Pharmacovigilance (PV) & Clinical Safety Systems (HLACAOAH)
- akta.pro secondary industries
- Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF) (HLAGAJAM), Specialty Pharmacy & Complex Therapy Management Platforms (HLACAKAG), Patient Intake, Digital Registration & eForms (HLACAEAF), Signal Detection & Safety Analytics (Epidemiology/RWE) (HLAGALAC)
Keywords
Where ActiGraph is headquartered
LocationHeadquarters
- HQ city
- Pensacola
- HQ country
- United States
- HQ region
- North America
Offices3 records
Markets served
ActiGraph business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure, Supply Chain
Revenue model
- Hardware Sales (Wearable Devices): Sale of FDA-cleared, medical-grade ActiGraph wearable devices (ActiGraph LEAP, wGT3X-BT, GT9X Link, CentrePoint Insight Watch, ActiSleep) plus device firmware and accessories to academic and clinical customers, distributed via a company-owned e-commerce store and international resellers. FedEx 2-day shipping domestically; international shipments routed through customs with duties paid by recipient. All sales are final with a one-year limited warranty.
- Software & Platform Subscriptions: Licensing of the CentrePoint cloud platform (AWS/Azure-hosted) and the ActiLife desktop software to clinical trial sponsors and academic researchers for device management, real-time data capture, adherence monitoring, and regulatory-grade archiving. Versioned software releases (e.g., CentrePoint v5.3.3.1, ActiLife v7.3.2.0) and CentrePoint Data Hub offered under product-key access.
- Professional Services (Data Analytics & Regulatory Science): Consultative fee-based services including digital biomarker development, digital endpoint development and biostatistics, DHT feasibility/usability evaluation, regulatory engagement, content/clinical validity evaluation, fit-for-purpose regulatory dossier development, manuscript development, and statistical analysis plan design for sensor data.
- Algorithm Licensing (Partnership-based): Licensing and resale of validated third-party algorithms integrated into the Ametris ecosystem (PKG by empatica movement-disorder measures, Mobilise-D gait/mobility measures, Hyfe cough detection, CSEM PPG vital signs), typically packaged with hardware/software offerings.
- Managed / Full-Service Trials Enablement: Operational support services for clinical trials including site training, logistics, data transfer, archiving, and real-time study monitoring for sponsors — a managed-service overlay on top of the DHT technology stack.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Other | Multi-year contract | Quote-based / Not publicly disclosed |
| Unit Pricing | Pay-as-you-go | Hardware unit sales (actigraphy devices) |
| Outcome Based/ Performance | Multi-year contract | Professional services (Data Analytics & Regulatory Science) |
Go-to-market motion3 records
Distribution channels5 records
Marketing channels10 records
ActiGraph product offering
Product offeringCore offering
ActiGraph (now Ametris, a Signant Health Company) provides FDA-cleared, medical-grade wearable hardware (notably the ActiGraph LEAP multi-sensor device) paired with the CentrePoint cloud monitoring platform, ActiLife desktop software, and the Ametris Connect patient engagement app, plus an Algorithm Marketplace of validated third-party algorithms (PKG, Mobilise-D, Hyfe, CSEM PPG). It sells this end-to-end digital health technology stack to pharmaceutical and biotech sponsors, CROs, and academic researchers for use in decentralized and hybrid clinical trials, supported by Data Analytics & Regulatory Science Services.
Product overview
Ametris (formerly ActiGraph, now a Signant Health Company) offers an end-to-end digital health technology (DHT) platform-plus-modules architecture for clinical trials, rather than a single product. The core operational backbone is the CentrePoint Platform, which ingests raw sensor data from FDA-cleared wearable devices — most notably the ActiGraph LEAP multisensor wearable, plus legacy ActiGraph devices such as the CentrePoint Insight Watch, wGT3X-BT, and GT9X Link — and processes it through the ActiLife desktop software and the ActiSync transfer utility. On top of this core, Ametris layers modular offerings: the Ametris Connect patient engagement platform (acquired via the Biofourmis Life Science Business), the Algorithm Marketplace distributing partner-validated algorithms from PKG by empatica, Hyfe, CSEM, and Mobilise-D, the Digital Outcomes and Biomarkers portfolio covering sleep, physical activity, gait, vital signs, and cardinal symptoms, and supporting service lines such as Data Analytics & Regulatory Science Services, the Usability Evaluation Program, Trials Enablement (Adherence Monitoring + Digital Health Operations), and the DECODE research collaborations.
Differentiator
Problem solved
Functional benefit
Brands
- CentrePoint®: Remote monitoring platform for clinical trials and scientific research, including CentrePoint® Insight Watch and CentrePoint® Data Hub products.
Products and services
- CentrePoint Platform Scalable cloud remote monitoring and data management platform that ingests raw sensor data from ActiGraph wearables, applies validated digital measures, and serves as the operational backbone for site training, device deployment, real-time study monitoring, and data transfer/archiving in clinical trials.
- ActiGraph LEAP Wearable Device FDA-cleared, medical-grade, multi-sensor wrist-worn wearable combining accelerometer, gyroscope, PPG, skin temperature, and microphone sensors; the primary hardware feeding CentrePoint and the Algorithm Marketplace with raw data for movement, vital sign, sleep, and respiratory measures.
- CentrePoint Insight Watch Wrist-worn activity monitor used as a CentrePoint-managed accelerometer device for population health and academic research, with firmware supporting event markers and CPIW accelerometer data in ActiLife 7.
- ActiGraph wGT3X-BT Bluetooth-enabled wrist/waist/hip activity monitor used in academic research and earlier clinical studies, still supported with downloadable firmware and user manuals on the support downloads page.
- ActiLife Software Desktop data analysis and device initialization software (current release v7.3.2.0) used by academic researchers to initialize devices, score raw data, run sleep analysis, validate wear time, and export results.
- ActiSync Software Companion sync application (current release v3.25.1) used to move data between ActiGraph wearables and a PC, complementing ActiLife and the CentrePoint ecosystem.
- Ametris Connect Platform Patient engagement platform integrated into the Ametris Digital Health Technology ecosystem to provide in-app messaging, reminders, and adherence support for trial participants using Ametris wearables.
- Data Analytics & Regulatory Science Services Expert services spanning Digital Biomarker Development, Digital Endpoint Development & Biostatistics, and DHT Regulatory Science, including algorithm validation, content/clinical validity, statistical analysis plans for continuous sensor data, manuscript development, and fit-for-purpose regulatory dossiers for sponsors.
- Trials Enablement Services Operational offering combining Adherence Monitoring solutions and Digital Health Operations (site training, logistics, data management, data transfer and archiving, real-time study monitoring) to operationalize DHTs across global clinical trials.
- ActiGraph Academic Storefront Owned e-commerce academic store (store.ametris.com) where researchers can purchase ActiGraph LEAP, wGT3X-BT, CentrePoint Insight Watch, and ActiSleep devices, plus download software and firmware.
Quantifiable outcome
- 30,000+ peer-reviewed scientific publications using ActiGraph/Ametris technology
- +5 more outcomes
Companies that use ActiGraph
Customer profileNamed customers10 records
Segments5 records
Ideal customer profiles4 records
ActiGraph technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration6 records
AI capability3 records
Feature9 records
ActiGraph partnerships and signals
Strategic signalPartnerships
Twelve partnerships are on record, tiered flagship, core, major and minor.
- Biofourmis (Biofourmis Connect / Life Science Business)flagshipOn January 7, 2025 ActiGraph announced the transformational acquisition of the Biofourmis Connect life science business to accelerate clinical trial modernization, strengthen its digital health platform for clinical research with high-precision digital data capture and AI-driven analytics, and support drug development across the lifecycle.
- Signant HealthflagshipAmetris (formerly ActiGraph) is now a Signant Health Company. Signant Health acquired Ametris to create an end-to-end eCOA and wearables platform that combines deeper patient insights, stronger efficacy evidence, and more streamlined clinical trial execution. Signant is the parent/strategic owner of Ametris.
- CSEM (Swiss Centre for Microelectronics and Microtechnology)coreAmetris has partnered with CSEM to deliver a suite of validated vital sign measures based on photoplethysmography (PPG) data — including heart rate, HRV, respiratory rate, A-Fib detection, and oxygen saturation — alongside accelerometry-based movement outcomes on ActiGraph LEAP devices. CSEM is also a Networking Level Sponsor of ADDS 2025.
- PKG by empaticacoreAmetris has partnered with PKG by empatica to deliver a suite of clinically validated algorithms for measuring abnormal movements in movement disorders — bradykinesia score, dyskinesia score, percent time tremor, fluctuations score — enabling use of wearable devices for Parkinson's disease, Huntington's disease, and Essential Tremor research.
- Mobilise-D ConsortiumcoreAmetris supports the Mobilise-D device-agnostic, clinically validated digital mobility algorithms (e.g., stride velocity 95th centile, gait speed, cadence) on its hardware/software platform. Mobilise-D is a 5-year, 300+ partner research collaboration advancing digital mobility outcomes for COPD, Parkinson's, MS, and proximal femoral fracture populations.
- HyfecoreAmetris has partnered with Hyfe to integrate validated AI-powered cough detection algorithms into the ActiGraph LEAP multi-sensor wearable device alongside Ametris' digital measures for physical activity, sleep, and vital signs, supporting respiratory clinical research.
- Johnson & Johnson Innovative MedicinemajorAmetris partnered with Johnson & Johnson Innovative Medicine to optimize wearable adherence in the global Phase 3 LIBERTAS trial for a metastatic castration-sensitive prostate cancer (mCSPC) therapy. Actigraphy devices were used for more than 12 months to continuously measure sleep quality and physical activity as objective proxies for hot flash burden.
- Amazon Web Services (AWS)coreCentrePoint is implemented within the cloud infrastructure of Amazon Web Services (AWS), whose qualifications have been verified by third-party assessments. AWS acts as a subprocessor for personal data hosting, transmission, and storage for clinical trial customers.
- Microsoft AzurecoreCentrePoint is implemented within the cloud infrastructure of Microsoft Azure, whose qualifications have been verified by third-party assessments. Azure acts as a subprocessor for personal data hosting, transmission, and storage for clinical trial customers.
- CSEM (ADDS Networking Level Sponsor)minorCSEM serves as a Networking Level Sponsor of the ActiGraph Digital Data Summit (ADDS) 2025, complementing its technology partnership on vital signs measures. CSEM is a public-private Swiss innovation centre developing low-power wireless sensors, signal processing, AI/ML, and ISO 13485-certified digital health technology.
- Digital Medicine Society (DiMe)minorCandice Taguibao, Program Lead at the Digital Medicine Society, presented at the ADDS 2024 Scientific Poster Session — indicating collaborative engagement with the digital medicine community and DHT standards work.
- FedExminorFedEx is the primary shipping carrier for both domestic (2-day delivery) and international orders; provides shipment tracking, delivery confirmation emails, and is the basis for the shipping policy.
Scale indicators8 records
Recent moves6 records
Expansion highlights7 records
ActiGraph competitors and assessment
Company assessmentEmerging players
- Evidation Health: Evidation Health generates real-world evidence from wearable and sensor data for healthcare and research — an emerging player that competes for digital-measure and patient-engagement contracts in clinical research.
- Empatica: Empatica develops its own FDA-cleared EpiMonitor/Embrace wearables and the PKG movement-disorder algorithms that Ametris licenses — a partial competitor whose own hardware overlaps with Ametris LEAP while its algorithms are integrated into Ametris's Algorithm Marketplace.
- Koneksa Health: Koneksa Health provides wearable and digital biomarker solutions for clinical trials, with a comparable focus on validated sensor-based digital endpoints in respiratory, CNS, and rare-disease studies — a focused emerging competitor to Ametris in DHT-enabled trials.
Broad incumbents
- IQVIA (Clinical Technologies): IQVIA's eCOA and decentralized clinical trial solutions, built on the former Cenduit/Oracle Clinical One platform assets, position it as a broad incumbent competing with the Ametris-Signant stack for pharma wearable DHT and digital endpoint programs.
- Signant Health: Signant Health is the parent company of Ametris and a leading provider of eCOA, IRT, and patient-centric clinical trial solutions — its broader eCOA platform wraps around Ametris wearables and competes with Clario and Medidata.
- Medidata (Dassault Systèmes): Medidata's Rave Clinical Cloud offers eCOA, sensor data ingestion, and decentralized trial capabilities through its unified platform — a broader clinical-trial technology incumbent that increasingly competes in the same wearable DHT space as Ametris.
Regional players
- Ypsomed (YpsoMate / YDS / mySmartShare): Ypsomed provides connected injection devices and digital therapeutic management platforms primarily in Europe; its wearable-style connected device offerings overlap with Ametris's patient-engagement and adherence offerings in decentralized trials, especially in European sponsor studies.
Direct peers
- Clario: Clario (formed from the merger of ERT and CRF Health) delivers eCOA, cardiac safety, respiratory, and wearable DHT solutions for clinical trials — directly overlapping with Ametris's eCOA + wearables positioning following Signant Health's acquisition of Ametris.
- Biofourmis: Biofourmis is the parent of the Connect life-science business acquired by Ametris in January 2025; its remaining care-delivery franchise is adjacent but the historical Biofourmis platform competed directly with Ametris in wearable-driven decentralized clinical trials.
- VivoSense: VivoSense is a direct peer offering wearable sensor-based digital clinical outcome assessments for clinical trials, with a similar focus on regulatory-grade digital endpoints across therapeutic areas — competing head-to-head for the same pharma/biotech sponsor contracts as Ametris.
Market position
Strengths5 records
Weaknesses2 records
Competitive moat7 records
Key risks6 records
Key highlights6 records
Customer concentration
ActiGraph social profiles
Digital presenceActiGraph compliance and trust
Trust signalCompliance3 records
ActiGraph financial estimates
Financial estimateRevenue estimate
Valuation estimate
ActiGraph leadership team
Management profileNumber of profiles
Profiles7 records
ActiGraph subsidiaries and ownership
Company hierarchySubsidiaries1 record
ActiGraph funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
ActiGraph M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about ActiGraph
What does ActiGraph do?
ActiGraph (now Ametris, a Signant Health Company) provides FDA-cleared, medical-grade wearable hardware (notably the ActiGraph LEAP multi-sensor device) paired with the CentrePoint cloud monitoring platform, ActiLife desktop software, and the Ametris Connect patient engagement app, plus an Algorithm Marketplace of validated third-party algorithms (PKG, Mobilise-D, Hyfe, CSEM PPG). It sells this end-to-end digital health technology stack to pharmaceutical and biotech sponsors, CROs, and academic researchers for use in decentralized and hybrid clinical trials, supported by Data Analytics & Regulatory Science Services.
Is ActiGraph a public or private company?
ActiGraph is a private company. It is classified as corporate owned and is currently acquired.
When was ActiGraph founded?
ActiGraph was founded in 2004.
Where is ActiGraph based?
ActiGraph is headquartered in Pensacola, United States, in the North America region.
How does ActiGraph make money?
Five revenue lines are on record. Hardware Sales (Wearable Devices) is the primary driver. The others are software & Platform Subscriptions, professional Services (Data Analytics & Regulatory Science), algorithm Licensing (Partnership-based) and managed / Full-Service Trials Enablement.
Who are ActiGraph's main competitors?
Emerging players on record are Evidation Health, Empatica and Koneksa Health. Broad incumbents are IQVIA (Clinical Technologies), Signant Health and Medidata (Dassault Systèmes). Ypsomed (YpsoMate / YDS / mySmartShare) is listed as a regional player. Direct peers are Clario, Biofourmis and VivoSense.
Does ActiGraph have an API?
No public API is recorded for ActiGraph.
What industry is ActiGraph in?
ActiGraph's product category is Clinical Trial Digital Health Technology. Its primary akta.pro industry code is HLACAOAH, Safety/Pharmacovigilance (PV) & Clinical Safety Systems, with a secondary code of HLAGAJAM, Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF). Its NAICS code is 541511 and its SIC code is 7372.