siTOOLs Biotech
siTOOLs Biotech GmbH is a German life-sciences reagents company that designs and sells proprietary siRNA pools (siPOOLs), rRNA depletion kits (riboPOOLs), and RNA library preparation tools (ARGO) to academic researchers, biotech firms, and pharma companies conducting gene silencing and RNA-Seq experiments across multiple species.
- Company typePrivate
- Founded2014
- HeadquartersPlanegg, Germany
- Headcount1–10
- GTM typeB2B
- OfferingHardware or Manufacturing
What siTOOLs Biotech does
siTOOLs Biotech GmbH is a privately held German biotech company founded in 2014 and headquartered in Planegg/Martinsried near Munich. It develops and commercializes molecular tools and kits for RNA research, serving academic researchers, biotechnology companies, and pharmaceutical organizations. The company is led by Executive Board member Dr. Michael Hannus and operates with 1–10 employees as a self-funded entity with no disclosed external funding rounds.
The company's product portfolio is built around three core platforms: siPOOLs (complex siRNA pools of 30 individual siRNAs per target gene designed via proprietary thermodynamic algorithms and genome-wide paralogue filtering to minimize off-target effects); riboPOOLs (rRNA depletion kits supporting RNA-Seq and ribosome profiling across multiple species, including the High-Input riboPOOL launched in April 2026 that processes up to 30 µg of total RNA per reaction); and the ARGO RNA library preparation kit (launched in 2026) that extends the offering into complete RNA-Seq workflows. Supporting products include siFractor, raPOOLs, Phenovault, RiboCut Marker, and eRibo Pro. Products are compatible with Oxford Nanopore Technologies and Pacific Biosciences long-read sequencing platforms.
The commercial model is direct-to-consumer via the company's webshop, supplemented by a global distributor network and quote-based direct sales for custom libraries and larger orders. Pricing is not publicly disclosed; products are sold in small nmol-scale units to individual labs. The company has accumulated over 200 peer-reviewed publications citing its products between 2013 and 2024, validating its technology across diverse applications and species. The customer base is heavily weighted toward academic researchers, with named case studies from the University of Lausanne and the MRC Prion Unit at UCL.
siTOOLs Biotech firmographics
Firmographics- Name
- siTOOLs Biotech
- Legal name
- siTOOLs Biotech GmbH
- Website
- https://sitoolsbiotech.com
- Company type
- Private
- Founded year
- 2014
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Short description
- siTOOLs Biotech GmbH is a German life-sciences reagents company that designs and sells proprietary siRNA pools (siPOOLs), rRNA depletion kits (riboPOOLs), and RNA library preparation tools (ARGO) to academic researchers, biotech firms, and pharma companies conducting gene silencing and RNA-Seq experiments across multiple species.
- Ownership category
- akta.pro rank
siTOOLs Biotech industry classification
Industry- Product category
- RNA Research Reagents
- NAICS
- Research and Development in Biotechnology (except Nanobiotechnology) (541714), Biological Product (except Diagnostic) Manufacturing (325414)
- SIC
- Services-Commercial Physical & Biological Research (8731), Laboratory Apparatus & Furniture (3821)
- akta.pro primary industry
- Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF)
- akta.pro secondary industries
- RNA Therapeutics Platforms & Design (sequence design, target ID/validation, AI/bioinformatics) (HLAAADAG), siRNA Therapeutics (gene silencing) (HLAAADAB), RNA Chemistry & Oligonucleotide Engineering (backbones, modifications, stereochemistry) (HLAAADAE)
Keywords
Where siTOOLs Biotech is headquartered
LocationHeadquarters
- HQ city
- Planegg
- HQ country
- Germany
- HQ region
- Europe
Offices2 records
Markets served
siTOOLs Biotech business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Personnel, Technology or R&D, Supply Chain, Operations, Marketing or Sales
Revenue model
- Research Kits and Reagents Sales: siTOOLs Biotech sells molecular biology research kits and reagents including siPOOLs, riboPOOLs, ARGO library preparation kits, and related products through their online shop. Products are available in various scales (2 nmol, 5 nmol, 10 nmol, 20 nmol for individual siPOOLs; 0.1-1 nmol for siPOOL libraries). The company sells directly to researchers at academic institutions, biotech companies, and pharmaceutical companies.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Unit Pricing | Pay-as-you-go | siPOOL Individual Products |
| Unit Pricing | Pay-as-you-go | siPOOL Controls |
| Unit Pricing | Pay-as-you-go | siPOOL Screening Libraries |
| Other | Multi-year contract | Custom siRNA Libraries |
Go-to-market motion2 records
Distribution channels3 records
Marketing channels4 records
siTOOLs Biotech product offering
Product offeringCore offering
siTOOLs Biotech develops and sells molecular biology research kits and reagents for RNA research, including complex siRNA pools (siPOOLs) for gene silencing, rRNA depletion kits (riboPOOLs and High-Input riboPOOLs) for RNA-Seq and long-read sequencing, and the ARGO RNA library preparation kit. Products are offered for any species (human, mouse, Drosophila, bacteria, archaea, fungi, plants) and distributed globally through a company-owned webshop and authorized distributors.
Product overview
siTOOLs Biotech offers a comprehensive portfolio of RNA research tools and molecular biology kits. The core product suite includes siPOOLs (complex siRNA pools for gene silencing using 30 individual siRNAs per pool to minimize off-target effects), riboPOOLs and High-Input riboPOOLs (rRNA depletion kits for RNA-Seq workflows supporting inputs from standard to 30 µg), and ARGO (RNA library preparation kit for transcriptome analysis). Supporting products include siFractor, raPOOLs, Phenovault, RiboCut Marker, and eRibo Pro. These products are designed to work across multiple species and sequencing platforms including Oxford Nanopore Technologies and Pacific Biosciences.
Differentiator
Problem solved
Functional benefit
Brands
- siPOOLs: Complex siRNA pools for gene silencing, consisting of 30 individual siRNAs per pool to minimize off-target effects
- riboPOOLs
- ARGO
- siFractor
- raPOOLs
- Phenovault
- RiboCut Marker
- eRibo Pro
Products and services
- riboPOOLs rRNA depletion kits that remove unwanted ribosomal RNA from total RNA samples, enabling clearer RNA-Seq and transcriptome analysis across multiple species.
- High-Input riboPOOL High-input rRNA depletion kit designed for total RNA inputs above 5 µg, processing up to 30 µg per reaction to enable direct RNA sequencing and long-read sequencing workflows with improved data quality.
- ARGO RNA library preparation kit for RNA sequencing workflows, supporting RNA-Seq library prep, transcriptome analysis, and gene expression studies.
- siPOOLs Complex siRNA pools consisting of 30 individual siRNAs targeting different sequences within the same gene, using low concentrations of each siRNA to minimize off-target effects while achieving robust silencing through cooperative activity.
- siFractor Product for RNA research applications, offered as part of the siTOOLs Biotech RNA research tools portfolio.
- raPOOLs Product for RNA research applications, offered as part of the siTOOLs Biotech RNA research tools portfolio.
- Phenovault Product for RNA research applications, offered as part of the siTOOLs Biotech RNA research tools portfolio.
- RiboCut Marker Molecular marker tool used in RNA research workflows.
- eRibo Pro Enhanced ribo product for advanced RNA research applications.
Quantifiable outcome
- 90-97% rRNA depletion efficiency achieved with Drosophila melanogaster riboPOOL
- +2 more outcomes
Companies that use siTOOLs Biotech
Customer profileNamed customers2 records
Segments3 records
Ideal customer profiles3 records
siTOOLs Biotech technology and API
TechnologyTechnology focussed No
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration2 records
Feature4 records
siTOOLs Biotech partnerships and signals
Strategic signalScale indicators2 records
Recent moves5 records
Expansion highlights5 records
siTOOLs Biotech competitors and assessment
Company assessmentBroad incumbents
- QIAGEN: QIAGEN provides RNA extraction, rRNA depletion (QIAseq FastSelect), and library prep kits, overlapping with siTOOLs' riboPOOL and ARGO products in RNA-Seq workflows and serving the same genomics customers.
- Thermo Fisher Scientific (Life Technologies / Ambion): Thermo Fisher's Ambion and Silencer Select siRNA lines, plus its RNA-Seq library prep portfolio, are direct functional competitors to siTOOLs across gene silencing, rRNA depletion, and library preparation, backed by far larger sales and distribution infrastructure.
- Sigma-Aldrich (Merck Life Science): Sigma-Aldrich / Merck sells MISSION siRNA libraries and a wide array of RNA research reagents, making it a broad incumbent competitor to siTOOLs in gene silencing consumables for academic and industrial research.
Direct peers
- Revvity (Dharmacon): Revvity's Dharmacon business is the dominant commercial supplier of siRNA reagents (ON-TARGETplus, Accell, SMARTpool), directly competing with siTOOLs' siPOOLs in gene silencing workflows and serving the same academic and pharma research customers.
- New England Biolabs (NEB): NEB offers rRNA depletion solutions (RiboMinus) and a broad RNA reagent portfolio, serving as both a direct competitor to riboPOOLs and an ecosystem peer in molecular biology consumables.
- Integrated DNA Technologies (IDT): IDT sells TriFECTa siRNA designs and a broad portfolio of RNA reagents and library prep tools, overlapping directly with siTOOLs across gene silencing, custom oligos, and RNA-Seq consumables.
- Lexogen: Lexogen specializes in RNA-Seq library prep kits (QuantSeq, CORALL, SIRVs spike-ins), directly competing with siTOOLs' ARGO product in transcriptome analysis workflows for academic and pharma research labs.
- TriLink BioTechnologies: TriLink manufactures custom oligonucleotides, mRNA, and siRNA reagents for research and therapeutic use, overlapping with siTOOLs in custom siRNA and RNA tool production for academic and biotech customers.
Others
- Oxford Nanopore Technologies: ONT is a sequencing platform partner rather than a reagent competitor, but its direct RNA sequencing chemistry is the primary application siTOOLs' High-Input riboPOOL is designed to serve, making platform adoption a key demand driver.
Emerging players
- Bioo Scientific (PerkinElmer): Bioo Scientific (now part of PerkinElmer) provides NEXTflex RNA-Seq library prep kits and small RNA workflows, partially overlapping with siTOOLs' ARGO and riboPOOL products in next-generation sequencing sample prep.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat4 records
Key risks7 records
Key highlights7 records
Customer concentration
siTOOLs Biotech social profiles
Digital presencesiTOOLs Biotech compliance and trust
Trust signalCompliance1 record
siTOOLs Biotech financial estimates
Financial estimateRevenue estimate
Valuation estimate
siTOOLs Biotech leadership team
Management profileNumber of profiles
Profiles1 record
siTOOLs Biotech funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
siTOOLs Biotech M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about siTOOLs Biotech
What does siTOOLs Biotech do?
siTOOLs Biotech develops and sells molecular biology research kits and reagents for RNA research, including complex siRNA pools (siPOOLs) for gene silencing, rRNA depletion kits (riboPOOLs and High-Input riboPOOLs) for RNA-Seq and long-read sequencing, and the ARGO RNA library preparation kit. Products are offered for any species (human, mouse, Drosophila, bacteria, archaea, fungi, plants) and distributed globally through a company-owned webshop and authorized distributors.
Is siTOOLs Biotech a public or private company?
siTOOLs Biotech is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was siTOOLs Biotech founded?
siTOOLs Biotech was founded in 2014. It employs 1 to 10 people.
Where is siTOOLs Biotech based?
siTOOLs Biotech is headquartered in Planegg, Germany, in the Europe region.
How does siTOOLs Biotech make money?
One revenue line is on record: research Kits and Reagents Sales.
Who are siTOOLs Biotech's main competitors?
Broad incumbents on record are QIAGEN, Thermo Fisher Scientific (Life Technologies / Ambion) and Sigma-Aldrich (Merck Life Science). Direct peers are Revvity (Dharmacon), New England Biolabs (NEB), Integrated DNA Technologies (IDT), Lexogen and TriLink BioTechnologies. Oxford Nanopore Technologies is listed as an others. Bioo Scientific (PerkinElmer) is listed as an emerging player.
Does siTOOLs Biotech have an API?
No public API is recorded for siTOOLs Biotech.
What industry is siTOOLs Biotech in?
siTOOLs Biotech's product category is RNA Research Reagents. Its primary akta.pro industry code is HLAGAIAF, Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays), with a secondary code of HLAAADAG, RNA Therapeutics Platforms & Design (sequence design, target ID/validation, AI/bioinformatics). Its NAICS code is 541714 and its SIC code is 8731.