Prime-R

What Prime-R does

Prime-R (legal name 新医療リアルワールドデータ研究機構株式会社; brand: PRiME-R) is a Kyoto-headquartered, NTT-owned clinical real-world data (RWD) company founded in February 2020 as an industry-academia partnership between Nippon Telegraph and Telephone (NTT), Kyoto University Original and Kyoto University Hospital. The company standardizes oncology and disease-specific data captured at the point of care by integrating its inputs directly into hospital electronic medical record terminals and turning it into a structured, query-ready registry asset for pharmaceutical companies, academic researchers and medical institutions.

The product portfolio is anchored by the Cyber R Series — an EHR-integrated family that includes Cyber Oncology® (multi-vendor EMR-connected oncology input templates with CTCAE-coded adverse events, OncoTree classification, and direct submission to the national Cancer Genome Information Management Center, C-CAT), Cyber PMS (post-marketing surveillance with ER/ES guideline compliance), Cyber Ortho and Cyber Neurology. These feed the J-CONNECT multi-institutional solid-tumor registry, which holds 200,000+ cancer cases from 25+ medical institutions, and the Cyber Oncology Analysis BI overlay. The technology stack combines proprietary NLP and image processing for biomarker and adverse-event extraction, an LLM-based semi-automatic medical document generator (commercialized in 2026 as the movacal.hospital AI Document Creation Support Option), and a stage-4 lung-cancer prognostic model (~80% accuracy). Adjacent offerings include OrganoInsight™ (Japan's first patient-derived-organoid-plus-RWD service, co-developed with KBBM) and registry construction support for bodies such as JOHBOC.

Prime-R monetizes through three revenue streams: (1) project-based Registry Data Utilization Support Services to pharmaceutical companies and researchers, (2) recurring Clinical Research and PMS Support Services delivered via Cyber Oncology® and Cyber PMS under multi-year contracts, and (3) Registry Construction Support services for medical institutions and consortia. Pricing is custom per project, the go-to-market is sales-led (Prime Promotion Department) plus academic conference presence, and distribution runs entirely through direct enterprise engagement with no intermediaries. The company operates as part of the NTT Precision Medicine Group alongside NTT Life Sciences, NTT Precision Medicine (cloud EHR movacal.hospital), CSS and mMEDICI, with the Japan Precision Medicine Platform (JPP) developed in partnership with BC Platforms AG serving as the group's national data-circulation layer. ISO/IEC 27001:2022 / JIS Q 27001:2023 certification and a Medical Ethics Governance Committee underpin compliance.

Name

Prime-R

Legal name

新医療リアルワールドデータ研究機構株式会社

Website

https://prime-r.inc

Company type

Private

Founded year

2020

Operating status

Operating

Headcount range

1–10 employees

Short description

Prime-R is a Kyoto-based, NTT-owned clinical real-world data company that integrates Cyber Oncology® and the J-CONNECT registry into Japanese hospital EMRs, selling structured oncology data and post-marketing surveillance services to pharmaceutical companies, academic researchers, and medical institutions.

Ownership category

akta.pro rank

Product category

Healthcare Real-World Data Analytics

NAICS

Research and Development in the Physical, Engineering, and Life Sciences (54171), Scientific Research and Development Services (5417)

SIC

Services-Health Services (8000)

akta.pro primary industry

Real-World Data (RWD) / Real-World Evidence (RWE) & Observational Research Platforms (HLACAOAM)

akta.pro secondary industries

Real-World Data (RWD) Platforms & Clinical Data Curation (HLACAIAJ), Clinical & Translational Informatics (Clinical Data Integration/Real-World Data for R&D) (HLAGAJAF)

Keywords

• Real-world data solutions
• Clinical research services
• Medical data analytics
• Post-marketing surveillance
• EHR data integration

Headquarters

HQ city

Kyoto

HQ country

Japan

HQ region

Asia

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Infrastructure, Marketing or Sales

Revenue model

1. Registry Data Utilization Support Services: Providing aggregated and analyzed real-world data from solid cancer registries to pharmaceutical companies and researchers. Services include feasibility surveys, individual case analysis, data provision, and analytical support. Revenue generated through project-based data provision contracts.
2. Clinical Research and PMS Support Services: Supporting clinical studies and post-marketing surveillance through Cyber Oncology® and Cyber PMS systems. Services include system provision, data collection, study setup, operation, and data delivery. One-stop solution supporting pharmaceutical companies and medical institutions.
3. Registry Construction Support Services: Supporting construction and management of disease registries in collaboration with medical institutions. Includes system integration, data collection support, and ongoing operational management.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels5 records

Core offering

Prime-R collects, standardizes, and analyzes real-world clinical data from Japanese medical institutions via its proprietary Cyber R Series platform, anchored by Cyber Oncology® and Cyber PMS, which integrate with hospital EHR systems to produce structured oncology and post-marketing surveillance datasets. The company also operates the J-CONNECT multi-institutional cancer registry and offers LLM-based medical document generation services, delivering registry data, analytics, and clinical research support to pharmaceutical companies, hospitals, and academic researchers.

Product overview

PRiME-R offers a suite of real-world data (RWD) solutions centered on its Cyber R Series product family, which includes Cyber Oncology® (oncology-specific EHR input support), Cyber PMS (post-marketing surveillance built on Cyber Oncology®), Cyber Ortho, and Cyber Neurology. These products connect to hospital EHR systems and auto-import structured clinical data for clinical research and registry use. J-CONNECT serves as the national-scale multi-institutional solid tumor registry powered by Cyber Oncology® data. The Cyber Oncology Analysis BI tool provides data visualization for participating institutions. Under SIP Phase 3, the company developed an LLM-based medical document semi-automatic generation system (marketed as mobakal.hospital AI文書作成支援オプション), which generates discharge summaries and other documents from EHR data. Additional offerings include OrganoInsight™ (organoid + RWD service with KBBM), and registry data utilization and clinical research support services for pharmaceutical companies.

Differentiator

Problem solved

Functional benefit

Brands

• Cyber Oncology®: Electronic medical record input support system for standardizing and structuring real-world data in cancer treatment
• Cyber PMS
• Cyber R Series
• J-CONNECT
• Cyber Oncology Analysis
• Cyber Oncology®

Products and services

• Cyber Oncology® Electronic medical record input support system that standardizes and structures oncology real-world data. Connects with major Japanese EHR systems to auto-import lab and medication data, and supports CTCAE-coded adverse event registration, OncoTree cancer classification, and C-CAT data submission for cancer genomic medicine. Targeted at medical institutions and pharmaceutical companies.
• Cyber PMS Post-marketing surveillance (PMS) support system built on Cyber Oncology®. Enables PMS data collection through electronic medical record terminals alone, compliant with ER/ES guidelines (audit trail, electronic signature, account management). Reduces dual data entry burden and improves data quality for pharmaceutical companies and medical institutions.
• Cyber R Series Family of EHR-linked input support systems developed by PRiME-R. Includes Cyber Oncology® (oncology), Cyber Ortho (orthopedics), Cyber Neurology (neurology), and others for various disease areas. Collects structured RWD from connected EHRs for clinical research and registry purposes.
• Cyber Oncology Analysis Real-world data visualization and BI tool for Cyber Oncology® users. Provides in-facility data aggregation by cancer type and time period, customizable filtering (~20 conditions), and CSV export for clinical research and operational decision-making.
• J-CONNECT National-scale solid tumor registry platform created by Kyoto University Hospital and PRiME-R. Collects comprehensive oncology RWD from approximately 25 institutions including cancer registry data, biomarker information, DPC data, and genomic test results. Supports clinical research, drug development, and real-world evidence generation.
• mobakal.hospital AI Document Creation Support Option (mobakal.hospital AI文書作成支援オプション) AI-powered medical document semi-automatic generation option for NTT Precision Medicine's cloud-based EHR 'movacal.hospital'. Uses LLM to generate discharge summary drafts from patient EHR data. Targeted at hospitals and healthcare institutions using the cloud-based EHR platform.
• OrganoInsight™ Joint service with KBBM combining high-quality patient-derived organoids from Kyoto University Hospital with Cyber Oncology® RWD to support drug discovery screening, biomarker development, and personalized medicine applications for pharmaceutical companies.
• Case Report / Medical History Summarization Support System (症例報告・病歴要約支援システム) LLM-based semi-automatic medical document generation system developed under SIP Phase 3 (テーマB-3). Extracts treatment change points using proprietary algorithms and generates draft medical documents (discharge summaries, nursing summaries, referral letters) from EHR data for hospitals and clinical sites.
• Registry Data Utilization Support Service (レジストリデータ活用支援サービス) Service that provides aggregated and analyzed real-world data from solid cancer registries to pharmaceutical companies and researchers. Includes feasibility surveys, individual case analysis, data provision, and analytical support, with project-based data provision contracts.
• Clinical Research and PMS Support Service (臨床研究・PMS支援サービス) Service supporting clinical studies and post-marketing surveillance through Cyber Oncology® and Cyber PMS systems. Includes system provision, data collection, study setup, operation, and data delivery as a one-stop solution for pharmaceutical companies and medical institutions.
• Registry Construction Support Service Service supporting the construction and management of disease registries in collaboration with medical institutions, including system integration, data collection support, and ongoing operational management.

Quantifiable outcome

• Physician document creation time reduced to approximately 1/3 of previous time using LLM-based discharge summary generation
• +3 more outcomes

Named customers6 records

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration4 records

AI capability9 records

Feature5 records

Partnerships

13 partnerships are on record, tiered core and moderate.

• mMEDICIcoreStrategic or Co-development Partner · 25 June 2026Three-party partnership with NTT Precision Medicine and mMEDICI for RWD utilization in clinical research and PMS. Integrates JPP platform, mMEDICI's research/business conception design and decision support expertise, and PRiME-R registry solutions. Target of 3 priority use cases within 1 year and expansion to approximately 10 research projects within 3 years.
• IQVIA Japan (IQVIAサービシーズジャパン)coreStrategic or Co-development Partner · 13 May 2026One-stop solution partnership for clinical research and PMS using Cyber Oncology® and Cyber PMS. Combines IQVIA's PMS experience and CRO expertise with PRiME-R's RWD platform. PRiME-R designated as IQVIA Qualified Vendor. Supports full product lifecycle from survey planning to re-examination application.
• NTT Precision Medicine (NTTプレシジョンメディシン)coreStrategic or Co-development Partner · 31 March 2026Parent company within NTT Precision Medicine Group. Co-development of LLM-based medical document generation system integrated with movacal.hospital EMR. PRiME-R develops the AI technology while NTT PM provides the cloud-based EMR platform. Active collaboration on Japan Precision Medicine Platform (JPP).
• CLINICAL STUDY SUPPORT (CSS)coreStrategic or Co-development Partner · 12 February 2026Three-party partnership with NTT Precision Medicine and CSS for integrated clinical research and PMS support. Combines JPP platform, CSS clinical research expertise (study design, statistical analysis, medical writing), and PRiME-R registry solutions to provide comprehensive RWD utilization from study planning through implementation, analysis, and reporting.
• KBBMmoderateStrategic or Co-development Partner · 28 August 2025Joint service launch of OrganoInsight™ - Japan's first organoid utilization service combining KBBM's patient-derived organoids with PRiME-R's real-world data for drug discovery and personalized medicine support.
• Japan Hereditary Breast and Ovarian Cancer General Consortium (JOHBOC)moderateStrategic or Co-development Partner · 8 May 2025Entrusted database business for hereditary diseases. PRiME-R constructs and manages HBOC database using EDC system with protocol-compliant input system. Supporting data analysis and publication for participating researchers.
• Nara Institute of Science and Technology (奈良先端科学技術大学院大学)moderateStrategic or Co-development Partner · 26 March 2025Joint research on medical data extraction and structuring from electronic medical records. Combines NAIST's medical language processing expertise with PRiME-R's RWD construction experience. Successfully developed high-precision biomarker data structuring algorithm.
• BC Platforms AGcoreTechnology or Integration · 15 April 2024Strategic partnership for Japan Precision Medicine Platform (JPP) utilizing BC Platforms' globally-proven data utilization services and technology. NTT Life Sciences serves as service provider with PRiME-R providing Cyber Oncology® data from 47+ medical institutions. Partnership enables secure medical data circulation and utilization.
• Kyoto University (京都大学)coreStrategic or Co-development Partner · 24 October 2023Founding academic partner through industry-academia collaboration. Kyoto University Hospital leads J-CONNECT registry with 25 participating institutions. Joint research on RWD collection and utilization. Professor Mutoh serves as principal investigator for CONNECT research.
• NTT Life Sciences (NTTライフサイエンス)coreStrategic or Co-development PartnerService provider for Japan Precision Medicine Platform (JPP). Holds Genovision® service presence in 59+ health examination institutions and approximately 80,000 genetic test information/time-series health examination member data. PRiME-R provides Cyber Oncology® data as data source for platform.
• NTT Data (株式会社NTTデータ)moderateTechnology or IntegrationTechnology partnership for AI model development and data analysis. Supported REAL-WIND study for lung cancer prognosis prediction and provides technical expertise for clinical research data management.
• Bio-Accelerator (バイオ・アクセラレーター)moderateImplementation/ SI/ Consulting PartnerJapanese partner for BC Platforms AG, providing installation and operation support for JPP platform implementation in Japan since 2020.
• West Japan Oncology Group (西斯日本がん研究機構/WJOG)moderateStrategic or Co-development PartnerCollaborative research partner for REAL-WIND study on AI-based lung cancer prognosis prediction. PRiME-R provides data management and technical support for multi-institutional registry research.

Scale indicators5 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• COTA Healthcare: US-based oncology real-world data and analytics company providing curated EHR-derived datasets for pharma R&D. Comparable to Prime-R's J-CONNECT as an oncology-specific RWD curation platform for pharma and clinical research.
• M3 Inc. Japanese healthcare data and digital platform company (m3.com physician network, clinical research services). Comparable as a Japanese healthcare data and pharma-services platform serving physician networks and pharma R&D, with overlapping pharma customers.
• Medical Data Vision (MDV): Japan-listed health data analytics company focused on DPC and claims-based real-world data for pharma and academia. Directly comparable as a domestic Japanese RWD provider serving the same pharma R&D and PMS workflows that Prime-R targets.
• Tempus Labs: US-based AI-powered precision medicine company combining genomic and clinical RWD for oncology. Directly comparable to Prime-R's combination of structured oncology RWD, biomarker extraction, and AI prognostic modeling.
• Flatiron Health: US-based oncology real-world data and EHR abstraction platform acquired by Roche. Directly comparable to Prime-R's J-CONNECT and Cyber Oncology® model of structuring EHR-derived oncology data for pharma R&D and clinical research.
• JMDC Inc. Japan-listed health insurance claims and RWD analytics provider for pharma, academia, and government. Comparable to Prime-R in providing structured Japanese real-world data to pharma for clinical research and post-marketing analysis.

Broad incumbents

• IQVIA: Global CRO and RWD leader and Prime-R's designated partner. Operates at much larger scale across clinical research, RWE, and PMS; overlaps with Prime-R in Japanese pharma RWD services and competes for the same pharma wallet share.
• NTT Precision Medicine: Prime-R's parent within the NTT Precision Medicine Group. Operates overlapping precision medicine capabilities including JPP and absorbed several Prime-R functions in the April 2026 restructuring; relevant as the controlling entity shaping Prime-R's strategic direction.

Regional players

• EPS Holdings: Japanese CRO providing clinical research, PMS, and data management services. Comparable to Prime-R in providing PMS and clinical research support to Japanese pharma, including post-marketing data collection workflows.
• DeNA Healthcare / SOMPO Health Support: Japanese digital health and healthcare data subsidiary focused on health management platforms and insurance-linked RWD. Comparable as a Japan-centric healthcare data platform serving overlapping payer/provider stakeholders.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/primerrwd

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

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Frequently asked questions about Prime-R