What Sys2Diag does

Sys2Diag (CNRS UMR 9005) is a French mixed research unit jointly established under an alliance between CNRS, France's largest government scientific research institution, and ALCEN, a French mid-size industrial group operating in defense, security, energy, medical, aeronautics, and space sectors. The unit conducts research in modeling and engineering of complex biological systems for diagnostic applications, spanning two axes: integrative and systems biology (mechanisms, biomarkers and targets) and synthetic biology (biosensors and biological systems engineering for diagnosis). Sys2Diag is headquartered at Parc Euromédecine in Montpellier, France, led by Director Franck Molina and Deputy Director Victor Petit, and operates educational programs at French universities (Montpellier, Rennes) and international partner institutions in Brazil, Vietnam, and Taiwan.

Sys2Diag's product and service portfolio comprises four freely distributed bioinformatics research tools and three fee-based technological platforms. The software tools include PEPOP (web-based antigenic peptide prediction from 3D protein structures), DUP (a curated database of 1,800+ normal human urinary proteins), Sili2DGel (graph-theoretic algorithm for automated 2D gel electrophoresis spot alignment), and BioNetCAD (a CellDesigner plug-in for computer-assisted design of synthetic biology networks, interoperable with CompuBioTicDB and HSim). The three service platforms are the ISO9001-certified Clinical Proteomics Platform (PPC) for biomarker discovery and validation, the SHREC platform providing clinical study design and GDPR compliance support for human studies, and the MinEDIT platform for miniaturized RNA epitranscriptomic modification measurement. Clinical focus areas span psychiatry (bipolar disorder, depression, schizophrenia), cancer, diabetes/nephropathy, and inflammatory/infectious diseases.

Sys2Diag operates as a non-commercial public research entity rather than a revenue-driven company. Service income, where generated, arises from quote-based prestations arrangements for platform access (PPC, SHREC, MinEDIT) requested through online forms by academic and private research teams; software tools are distributed free for non-commercial academic use. The customer base consists of French and European academic research teams, private pharmaceutical/biotech/medical device companies, and international collaborators reached through educational and publication channels. As a CNRS UMR, Sys2Diag does not disclose revenue, does not raise venture or private equity funding, and is sustained by institutional funding from CNRS and ALCEN together with competitive research grants.

Name

Sys2Diag

Legal name

SYS2DIAG – CNRS UMR 9005

Website

https://sys2diag.cnrs.fr

Company type

Private

Founded year

1939

Operating status

Operating

Short description

Sys2Diag is a CNRS-ALCEN mixed research unit (UMR 9005) in Montpellier, France, developing systems biology, synthetic biology, and digital biology approaches for medical diagnostics. It operates ISO9001-certified proteomics, clinical study, and epitranscriptomics platforms serving academic and private research teams in psychiatry, cancer, and metabolic disease.

Ownership category

akta.pro rank

Product category

Biomedical Diagnostics Research

NAICS

Research and Development in the Physical, Engineering, and Life Sciences (54171), Scientific Research and Development Services (5417), Research and Development in Biotechnology (except Nanobiotechnology) (541714), Medical and Diagnostic Laboratories (62151)

SIC

Services-Commercial Physical & Biological Research (8731), Services-Medical Laboratories (8071)

akta.pro primary industry

Proteomics & Biomarker Analytical Testing (HLAGADAG)

akta.pro secondary industries

Clinical Biomarker Testing Services (central labs, trial enrollment/monitoring assays) (HLAAAMAC), Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF) (HLAGAJAM)

Keywords

• Biomarker discovery
• Clinical proteomics
• Bioinformatics software
• Systems biology
• Synthetic biology

Headquarters

HQ city

Paris

HQ country

France

HQ region

Europe

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Infrastructure, Others

Distribution channels1 record

Marketing channels3 records

Core offering

Sys2Diag is a CNRS-ALCEN mixed research unit that develops proprietary bioinformatics software tools (PEPOP, DUP, Sili2DGel, BioNetCAD) and operates service platforms (Clinical Proteomics Platform ISO9001, SHREC, MinEDIT) for medical diagnostic research. It combines integrative systems biology, synthetic biology, and digital biology to discover biomarkers and engineer next-generation interactive medical devices for complex multifactorial diseases including psychiatry, cancer, diabetes, and nephropathy. The unit delivers research services, certified platform access, and downloadable software tools to academic and industrial research clients.

Product overview

Sys2Diag is a CNRS-ALCEN research unit developing bioinformatics tools and operating technological platforms for medical diagnostic research. The product portfolio includes four standalone software tools: PEPOP (antigenic peptide prediction from 3D protein structures), DUP (urinary proteome database with 1800+ proteins), Sili2DGel (automated 2D gel spot alignment using graph theory), and BioNetCAD (synthetic biology design as a CellDesigner plugin with HSim simulation capability). The organization also operates three service platforms (Clinical Proteomics Platform ISO9001, SHREC clinical study support, MinEDIT epitranscriptomics) which provide research services rather than standalone software products.

Differentiator

Problem solved

Functional benefit

Products and services

• PEPOP Web-based tool for prediction of antigenic and immunogenic peptides. Representative peptides of a protein of interest are predicted from its 3D structure for epitope localization, antibody targeting, and sandwich immunoassay development. Available for non-commercial research use.
• DUP (Database of Urinary Proteins) Reference database of over 1,800 non-redundant normal urinary proteins compiled from proteomic analysis studies. Contains protein names, molecular weights, descriptions, sequences, and interactive links to cited articles. Includes search tools by SwissProt/IPI accession, keyword, or sequence similarity. Used for renal disease biomarker research and urinary proteome reference.
• Sili2DGel Algorithm for automatic spot alignment in 2D gel electrophoresis using graph theory. Uses data from recursive gel matching to return meaningful Spot Alignment Positions (SAP) for a given set of gels. Outputs include clickable synthetic gel, text files, and graph visualization files (Tulip-compatible .tlp format). Requires JRE (Java Runtime Environment). Available for non-commercial use.
• BioNetCAD Computer-assisted design tool for synthetic biology delivered as a CellDesigner plug-in. Allows designing abstract biochemical networks that can be implemented via the CompuBioTicDB database. Enables simulations with HSim software for modeling biochemical systems.
• Clinical Proteomics Platform (PPC) ISO9001-certified service platform for biomarker discovery and validation in complex human pathologies. Provides proteomics, biostatistics (R-based), peptide arrays (Intavis Multipep synthesis), and microfluidics capabilities. Uses Progenesis Samespot for image analysis, Cytoscape for functional protein network analysis, and Luminex multiplexed analysis (Bioplex, Biorad). Accessible via service request to [email protected].
• SHREC Platform (Support Platform for Research and Clinical Studies in Humans) Service platform assisting with clinical study design, regulatory procedures, and GDPR compliance for research and clinical studies in humans. Provides technical management and clinical research engineering support. Accessible via service request to [email protected].
• MinEDIT Platform Miniaturized technological platform for measuring RNA epitranscriptomic modifications in health domains including psychiatry, cancer, inflammation, and infectiology. Provides faster turnaround and lower cost than traditional NGS or mass spectrometry methods.

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration10 records

AI capability6 records

Feature5 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• Alcediag: Sister company under ALCEN focused on RNA-editing-based biomarkers for psychiatric diagnostics. Directly comparable on technology (RNA editing/AI), clinical focus (psychiatry), and institutional structure (ALCEN-affiliated entity).
• INSERM: French national institute for health and medical research. Operates mixed research units in proteomics, biomarker discovery, and clinical proteomics across French academic hospitals — directly comparable in mission, funding model, and research scope.
• Institut Pasteur: French biomedical research institution with deep expertise in proteomics, biomarker discovery, and infectious disease diagnostics. Comparable as a national public research institution conducting diagnostic innovation alongside Sys2Diag's CNRS-ALCEN framework.
• CEA (Biomedical division): French government research organization with strong proteomics, biomarker, and translational diagnostics programs. Comparable as a co-funded French public research entity pushing biomarker discovery into clinical use.

Broad incumbents

• INRIA: French national institute for digital science research with computational biology and bioinformatics teams. Comparable in French public research structure and bioinformatics methods applied to life sciences, but broader in mathematical/CS scope.
• Thermo Fisher Scientific: Global leader in mass spectrometry, proteomics, and bioinformatics software (e.g., Proteome Discoverer). Comparable as the dominant ecosystem supplier for proteomics and biomarker workflows Sys2Diag supports.
• Eurofins Genomics: Global CRO operating proteomics, biomarker, and molecular diagnostics services at scale. Comparable on clinical proteomics service offering and CRO-style delivery, but vastly larger and commercialized versus Sys2Diag's public research unit.
• Bio-Rad Laboratories: Major life sciences tools and clinical diagnostics company offering 2D gel electrophoresis, Luminex multiplexed proteomics, and protein quantification consumables. Comparable on the proteomics instruments and workflows Sys2Diag uses and serves.

Emerging players

• PhenoSwitch Bioscience: Specialized proteomics services provider focused on biomarker discovery and immune monitoring using mass spectrometry. Comparable scope in clinical proteomics services for biomarker discovery, but commercial and smaller in scale.
• Caprion Biosciences: Specialized proteomics and immune monitoring CRO offering biomarker discovery and validation services. Comparable on clinical proteomics and biomarker validation deliverables Sys2Diag's PPC platform provides.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/cnrs

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds

Investors

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M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Sys2Diag