National Neuroscience Institute

What National Neuroscience Institute does

National Neuroscience Institute (NNI) is Singapore's national specialist centre for the clinical management and research of conditions affecting the brain, spine, nerves and muscles. Founded in 1999 and operated as a subsidiary of Singapore Health Services Pte Ltd (SingHealth), NNI delivers care through specialty clinics physically embedded across at least seven SingHealth hospitals — Tan Tock Seng Hospital (headquarters, 11 Jalan Tan Tock Seng), Singapore General Hospital, Changi General Hospital, Sengkang General Hospital, KK Women's and Children's Hospital, Khoo Teck Puat Hospital, and Woodlands Hospital — and offers over 20 neuroscience subspecialties spanning neurology, neurosurgery, and neuroradiology. Clinical services include diagnosis and treatment for stroke, dementia, Parkinson's disease, brain tumours, epilepsy, and movement disorders, complemented by rehabilitation medicine, neuropsychology, genetic counselling, and community programmes such as the Temasek Foundation–NNI Stroke Memory Rehabilitation (SMaRT) course and the S$1.4 million Rise community reintegration initiative.

The institute's research and technology layer is built around a portfolio of dedicated platforms: the Neurocognitive Research & Clinical Centre (NNRC) for dementia, the Singapore Parkinson's Disease Translation Clinical Programme (SPARK, Phase II, supported by the NMRC Open Fund Large Collaborative Grant), the ASEAN Microbiome Nutrition Centre (AMNC), a Genomics Platform focused on Asian-specific risk loci, BioNeuro-Computing for patient stratification and prognostic marker identification, and a Regenerative Medicine platform using patient-specific iPSC (viral-free, feeder-free, xeno-free). Notable technical and clinical milestones include the pTau217 blood biomarker test for Alzheimer's, the transorbital neuroendoscopic surgery (TONES) technique for minimally invasive brain-tumour removal (performed for the first time in Singapore in November 2025), and an AI-enabled hydrocephalus drainage device currently at prototype stage that was recognised by the 2025 NMRC Clinician Innovator Award.

NNI operates as a public healthcare institution under a hybrid revenue model: patient care services (consultations, procedures, inpatient stays) billed on a per-visit cadence through national healthcare financing schemes; research grants from the National Medical Research Council and Temasek Foundation; and donations routed through the NNI Fund. Go-to-market is referral-driven through SingHealth polyclinics, general practitioners, and private hospitals, supplemented by direct hospital-based appointments, telemedicine, and patient-support-group outreach via the Health Buddy app. Designated as a Parkinson's Foundation Centre of Excellence since 2006 (one of only two in Asia), NNI is structurally embedded in the SingHealth Duke-NUS academic medical centre with joint faculty appointments across Duke-NUS, NTU LKC Medicine, and A*STAR's Genome Institute of Singapore.

Name

National Neuroscience Institute

Legal name

National Neuroscience Institute of Singapore Pte Ltd

Website

https://nni.com.sg

Company type

Private

Founded year

1999

Operating status

Operating

Headcount range

251–500 employees

Short description

National Neuroscience Institute is Singapore's national specialist centre for conditions of the brain, spine, nerves and muscles. It delivers clinical neurology, neurosurgery, and neuroradiology services across multiple SingHealth hospitals, supported by research platforms in genomics, regenerative medicine, microbiome science, and community stroke programmes.

Ownership category

akta.pro rank

Product category

Neuroscience Healthcare Services

NAICS

General Medical and Surgical Hospitals (622110)

SIC

Services-Hospitals (8060), Services-Offices & Clinics Of Doctors Of Medicine (8011)

akta.pro primary industry

Neurology & Neurosurgical Specialty Hospitals (HLAFAHAD)

akta.pro secondary industries

General Neurology (HLAKAIAA), Neurologic Rehabilitation Centers (Stroke/TBI/SCI/MS/Parkinson’s) (HLADAJAH), Neurodiagnostic Centers (EEG/EMG/NCS) (HLAFAKAK)

Keywords

• Neurological care services
• Neurosurgery services
• Neuroradiology services
• Dementia care programs
• Movement disorder treatment

Headquarters

HQ city

Singapore

HQ country

Singapore

HQ region

Asia

Offices8 records

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Marketing or Sales

Revenue model

1. Patient Care Services: Public healthcare institution providing medical services to patients. Revenue generated through consultation fees, procedures, and treatments covered by national healthcare financing schemes.
2. Research Grants and Donations: Funded by Temasek Foundation grants, National Medical Research Council funding, and donor contributions through NNI Fund for research programmes and community care initiatives.

Pricing tiers

Go-to-market motion1 record

Distribution channels5 records

Marketing channels9 records

Core offering

National Neuroscience Institute (NNI) is Singapore's national specialist centre providing clinical diagnosis, treatment, and rehabilitation for neurological conditions affecting the brain, spine, nerves, and muscles. NNI delivers over 20 neuroscience subspecialties across six SingHealth hospitals, complemented by research programmes in genomics, regenerative medicine, microbiome science, and clinical trials, along with community care initiatives for stroke survivors and patients with Parkinson's and dementia.

Product overview

National Neuroscience Institute (NNI) is Singapore's national specialist centre for neuroscience conditions affecting the brain, spine, nerves and muscles. NNI operates as a distributed model across six SingHealth hospitals (Singapore General Hospital, Tan Tock Seng Hospital, Changi General Hospital, Sengkang General Hospital, KK Women's and Children's Hospital, and Khoo Teck Puat Hospital). The institution offers over 20 subspecialties including Neurology, Neurosurgery, and Neuroradiology clinical specialties. NNI combines clinical care with research through multiple dedicated platforms and centres: the Neurocognitive Research & Clinical Centre (NNRC) for dementia care, SPARK for Parkinson's disease research, the ASEAN Microbiome Nutrition Centre (AMNC), Genomics Platform, BioNeuro-Computing, and Regenerative Medicine platform. Community care is delivered through programmes like the SMaRT stroke memory rehabilitation and Rise community reintegration programme. Digital patient services include the Health Buddy App for appointment management and telemedicine consultations.

Differentiator

Problem solved

Functional benefit

Brands

• SPARK (Singapore Parkinson's disease Translation Clinical Programme): National programme for Parkinson's disease research supported by Singapore Ministry of Health's National Medical Research Council under its Open Fund Large Collaborative Grant, focused on identifying clinical, biochemical, imaging, and genetic biomarkers.
• Neurocognitive Research & Clinical Centre (NNRC)
• Parkinson Disease and Movement Disorders Centre
• ASEAN Microbiome Nutrition Centre (AMNC)

Products and services

• Neurology
• Neurosurgery
• Neuroradiology
• Neurodiagnostic Laboratory
• Neuroscience Clinical Laboratory
• Psychology Services
• Dementia Care Services
• Parkinson's Disease and Movement Disorders Programme Comprehensive clinical services for Parkinson's disease and movement disorders including medications, deep brain stimulation (DBS), botulinum toxin injections, and the community care partners programme. Designated as a Parkinson's Foundation Centre of Excellence since 2006.
• Rehabilitation Medicine Comprehensive interdisciplinary medical rehabilitation for patients with disability from stroke, traumatic brain injury, spinal cord injury, and other neurological conditions, offered at Sengkang General Hospital.
• Temasek Foundation-NNI Stroke Memory Rehabilitation (SMaRT) Programme Group-based post-stroke memory rehabilitation course meeting weekly for one hour over seven weeks, offered in English and Mandarin, teaching strategies for memory, concentration, wayfinding and planning skills. Over 200 graduates to date.
• Reintegration for Stroke community Endeavour (Rise) S$1.4 million initiative funded by Temasek Foundation to facilitate community reintegration for up to 1,000 mild to moderate stroke survivors and their caregivers, focusing on care coordination, caregiver training, and the STroke Empowerment Programme (Step).
• Video and Phone Consultation Virtual consultations for follow-up appointments and ongoing care, allowing patients to access NNI specialists remotely.
• Health Buddy App (SingHealth) Mobile application for managing appointments, refilling medicine, and accessing healthcare services from SingHealth institutions including NNI.
• pTau217 Blood Test for Alzheimer's Detection Blood-based biomarker test for predicting Alzheimer's disease in patients with cognitive symptoms, validated against Western research cohorts.
• Parkinson Disease and Movement Disorders Centre Dedicated centre for comprehensive care, research, education and training in Parkinson's disease and movement disorders, designated as a Parkinson's Foundation Centre of Excellence.
• Neurocognitive Research and Clinical Centre (NNRC) Specialised centre for clinical care, research and education in neurocognition and dementia, providing diagnosis and treatment for individuals with cognitive disorders.

Quantifiable outcome

• Over 200 graduates from SMaRT stroke memory rehabilitation programme
• +1 more outcomes

Named customers4 records

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability4 records

Feature7 records

Partnerships

18 partnerships are on record, tiered core and major.

• Duke-NUS Medical SchoolcoreStrategic or Co-development Partner · 1 January 2026Academic partnership for research and medical education. Joint research programmes including SPARK (Singapore Parkinson's Disease Translation Clinical Programme) and collaborative clinical trials. Faculty members hold joint appointments.
• Parkinson's FoundationcoreStrategic or Co-development PartnerInternational organization designating NNI as a Centre of Excellence for Parkinson's disease care and research since 2006. Provides access to global research networks and best practices.
• MJ Fox FoundationmajorStrategic or Co-development PartnerMichael J. Fox Foundation for Parkinson's Research collaborates on SPARK programme research initiatives for biomarker identification and therapeutic studies.
• Genome Institute of Singapore (GIS/A*STAR)coreTechnology or IntegrationResearch collaboration on genomics platform for neurological disorders. Joint research on brain organoids and stem cells for Parkinson's disease models. Professor Ng Huck Hui serves as Scientific Advisory Board member.
• Sunway University (Malaysia)coreStrategic or Co-development PartnerBidirectional partnership between Singapore and Malaysia for ASEAN Microbiome Nutrition Centre (AMNC). Dr Say Yee How leads Malaysia research activities at Sunway University. Joint research on gut microbiome and healthy aging.
• Brain Bank SingaporemajorStrategic or Co-development PartnerCommunity partner providing brain tissue for neurological research. Supports NNI's research efforts in understanding neurological disorders.
• Lien FoundationmajorStrategic or Co-development PartnerCommunity partner supporting neurological care initiatives and awareness programmes including Neuropal project for dementia care.
• National University of Singapore (NUS)coreStrategic or Co-development PartnerAcademic partnership through ASEAN Microbiome Nutrition Centre with research activities based at NUS Kent Ridge Campus. LKC School of Medicine collaboration on Parkinson's research.
• Nanyang Technological University (NTU)majorStrategic or Co-development PartnerLKC School of Medicine partnership with Professor Lim Kah Leong contributing to SPARK programme pathophysiology research.
• Karolinska Institutet (Sweden)majorStrategic or Co-development PartnerInternational academic partner collaborating on microbiome and neurobiology research through AMNC platform. Professor Sven Pettersson maintains connections with Karolinska.
• Imperial College London (UK)majorStrategic or Co-development PartnerInternational research partner within AMNC virtual network collaborating on gut microbiome and aging research.
• UK Dementia Research CentremajorStrategic or Co-development PartnerInternational collaboration on dementia research through AMNC neurobiology programme and neurocognitive research initiatives.
• Dementia Singapore (formerly Alzheimer's Disease Association)majorStrategic or Co-development PartnerCollaborates on ESTEEM Programme for Young Onset Dementia patients. Joint caregiver support and awareness initiatives.
• Agency for Integrated Care (AIC)majorStrategic or Co-development PartnerGovernment agency collaborating on Stroke Memory Rehabilitation Programme (SMaRT) for post-stroke cognitive care.
• SingHealth PolyclinicsmajorStrategic or Co-development PartnerCollaboration on dementia screening and diagnosis programmes within primary care settings.
• KK Women's and Children's HospitalmajorStrategic or Co-development PartnerSingHealth cluster partner collaborating on AMNC oral health research and pediatric brain tumor awareness events (PBSTA Day).
• Tan Tock Seng HospitalcoreStrategic or Co-development PartnerPrimary hospital host for NNI main campus. Houses Parkinson's Disease and Movement Disorders Centre, Neurosurgery department, and main research facilities.
• Singapore General HospitalcoreStrategic or Co-development PartnerHost for NNI Neuroscience Clinic and key research centre. Venue for Singapore International Stroke Conference.

Scale indicators6 records

Recent moves5 records

Expansion highlights5 records

Broad incumbents

• Cleveland Clinic Neurological Institute: Large integrated multi-subspecialty neuroscience service line within Cleveland Clinic, combining neurology, neurosurgery and rehabilitation. Comparable to NNI in scale and the breadth of subspecialties offered under a unified institute.
• Johns Hopkins Department of Neurology: Global leader in academic neurology and neurosurgery research and clinical care. Comparable to NNI's research-driven, multi-subspecialty clinical model combined with active translational and clinical trial programmes.
• Duke Department of Neurology: Academic neurology department that connects to NNI via the Duke-NUS Medical School partnership and SPARK programme. Comparable in scale, subspecialty depth, and translational clinical trial infrastructure.
• Charité – Universitätsmedizin Berlin, Department of Neurology: One of Europe's largest academic neurology and neurosurgery departments with an embedded research profile. Comparable to NNI's academic-clinical model within a large hospital system, though Charité operates across many specialties.
• Mass General Brigham Neurology and Neurosurgery: Major academic neurology and neurosurgery service at Mass General Brigham with deep research and clinical-trial infrastructure. Comparable to NNI's university-affiliated clinical-research model.
• Karolinska Institutet — Department of Neurobiology, Care Sciences and Society: Swedish academic neuroscience department that collaborates with NNI through the AMNC platform. Comparable as a partner institution working on microbiome, neurobiology and aging research with translational capabilities.

Direct peers

• National Hospital for Neurology and Neurosurgery (NHNN, UK): The UK's dedicated national specialty hospital for neurology and neurosurgery, hosted within UCLH. It is the closest analogue to NNI in terms of national designation, multi-subspecialty neuroscience scope, and integration with academic research.
• Montreal Neurological Institute-Hospital (The Neuro): McGill-affiliated national specialty hospital and research institute combining neurology, neurosurgery, and advanced neuroscience research. Comparable to NNI as a single-specialty neuroscience centre with bundled clinical and research missions.

Regional players

• National Center of Neurology and Psychiatry (NCNP, Japan): Japan's national centre for neurology, psychiatry and neurosurgery under the Inter-Ministerial Research Fund. Comparable to NNI as an Asia-based national specialty neuroscience centre with both clinical service and large-scale research programmes.
• Asan Medical Center Neuroscience (South Korea): Leading Asian tertiary neuroscience centre combining clinical neurology, neurosurgery and active research. Comparable to NNI's regional role within East/Southeast Asia and similar patient mix including stroke and movement disorders.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• YouTubeyoutube.com/user/NNISingapore
• Facebookfacebook.com/nni.sg
• LinkedInlinkedin.com/company/nni.sg
• Instagraminstagram.com/nni.sg

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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Frequently asked questions about National Neuroscience Institute