National Institute on Aging IMPACT Collaboratory

What National Institute on Aging IMPACT Collaboratory does

The NIA IMPACT Collaboratory is a national research infrastructure organization established in September 2019 through a five-year, $53.4 million cooperative agreement (U54AG063546) from the National Institute on Aging, awarded to Brown University and Hebrew SeniorLife. Its mission is to build the nation's capacity to conduct embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions for people living with dementia (PLWD) and their care partners within healthcare delivery systems. The organization operates through a structured network of cores and teams covering design and statistics, implementation, health care systems, patient/caregiver-relevant outcomes, and training, supported by a multi-institutional consortium of academic investigators and a Lived Experience Panel. Its geographic footprint is anchored in Providence, Rhode Island (Brown University) and Boston, Massachusetts (Hebrew SeniorLife/Harvard Medical School affiliate), with national dissemination through its website, annual scientific conference, Grand Rounds podcast series, and social media channels.

The Collaboratory's core technology is the embedded pragmatic clinical trial methodology, anchored by the NIH Stage Model for behavioral intervention development and structured through a proprietary framework called the RAPT Model (Readiness Assessment for Pragmatic Trials), which evaluates nine domains for feasibility and adoption, including a culturally adapted RAPT-Indigenous variant. Its product portfolio comprises research grant mechanisms (ePCT Planning Grants, Pilot Grants up to $300,000, Demonstration Projects up to $800,000), training programs (James L. Rudolph Career Development Award up to $240,000, Real World Data Scholars Program, Faculty Scholars Program, Health Care Systems Scholars Program), and knowledge resources (ePCT Video Learning Library, PCRO iLibrary, Knowledge Repository, Implementation iLibraries, TDC iLibrary, Statistical Tools). Data assets include the Long-Term Care Data Cooperative, which compiles comprehensive electronic health record data for nursing home residents nationwide, and the US Dementia Prevalence Estimates.

The organization is not a commercial entity; it is grant-funded and sells no products or services. Its "customers" are the researchers, healthcare systems, and stakeholders it serves: primary beneficiaries are academic clinical investigators conducting ePCTs, healthcare delivery organizations (hospitals, nursing homes, assisted living, primary care) embedding trials in care settings, and people living with dementia and their care partners who participate in stakeholder engagement. The organization is led by multiple principal investigators Susan L. Mitchell, MD, MPH and Vincent Mor, PhD (Brown University), with executive directors Jill Harrison, PhD and Ellen McCarthy, PhD, MPH, and core leaders including Joseph Gaugler, PhD (Implementation Core) and Heather Allore, PhD (Design and Statistics Core).

Name

National Institute on Aging IMPACT Collaboratory

Legal name

National Institute on Aging IMPACT Collaboratory

Website

https://impactcollaboratory.org

Company type

Private

Founded year

2019

Operating status

Operating

Headcount range

51–100 employees

Short description

The NIA IMPACT Collaboratory is a national research infrastructure funded by a $53.4M NIA grant, building the nation's capacity to conduct embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions for people living with dementia within healthcare systems.

Ownership category

akta.pro rank

Product category

Dementia Clinical Research Infrastructure

NAICS

Scientific Research and Development Services (5417), Research and Development in the Social Sciences and Humanities (54172)

SIC

Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Investigator & Site Training / GCP Support (HLAGACAF)

akta.pro secondary industry

Dementia/Alzheimer’s Care Management & Behavioral Support (HLADALAF)

Keywords

• Pragmatic clinical trials
• Dementia care research
• Healthcare systems research
• Clinical trial infrastructure
• Non-pharmacological interventions

Headquarters

HQ city

Boston

HQ country

United States

HQ region

North America

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales

Distribution channels1 record

Marketing channels8 records

Core offering

The NIA IMPACT Collaboratory is a national research infrastructure that funds, trains, and supports investigators to conduct embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions for people living with dementia and their care partners within healthcare systems. It provides research grants (planning, pilot, demonstration), career development and training programs, expert consultation through its cores (Design/Statistics, Implementation, Health Care Systems, Patient/Caregiver Relevant Outcomes, Health Equity), and curated data and learning resources for the dementia care research community.

Product overview

The NIA IMPACT Collaboratory is a research infrastructure organization (not a traditional product company) established to build the nation's capacity to conduct embedded pragmatic clinical trials (ePCTs) within healthcare systems for people living with dementia and their care partners. The organization offers a portfolio of research grants (ePCT Planning Grants, Pilot Grants, Demonstration Projects), training programs (Career Development Awards, Real World Data Scholars, Faculty Scholars), and knowledge resources (Grand Rounds, Video Learning Libraries, searchable databases including PCRO iLibrary, Knowledge Repository, Implementation iLibraries). Data resources include the Long-Term Care Data Cooperative and US Dementia Prevalence Estimates. The IMPACT Collaboratory functions as a collaborative network funded by NIA grant U54AG063546, connecting researchers across multiple institutions to advance non-pharmacological dementia care interventions through pragmatic clinical trial methodology.

Differentiator

Problem solved

Functional benefit

Products and services

• ePCT Planning Grant Program Supports collaborative planning activities with health care systems to develop fully specified protocols for future pilot or full-scale, Stage IV effectiveness embedded pragmatic clinical trials (ePCTs) evaluating non-pharmacological interventions for people living with dementia and their care partners.
• Pilot Grants Program Awards for pilot ePCTs designed to test the feasibility and inform the design of future full-scale, Stage IV effectiveness ePCTs to evaluate non-pharmacological interventions embedded in health care systems for people living with dementia and their care partners.
• Demonstration Projects Program Awards for demonstration projects designed as full-scale, Stage IV effectiveness ePCTs to evaluate the effectiveness of non-pharmacological interventions embedded in health care systems for people living with dementia and their care partners.
• James L. Rudolph Career Development Award Program Mentored training awards supporting the development of MD, PhD, or equivalent researchers who seek careers conducting ePCTs for people living with dementia and their care partners, providing up to $240,000 over 24 months.
• Real World Data Scholars Program A 1-year mentored training experience designed to build practical skills and professional networks for early-career investigators, postdoctoral fellows, and graduate students interested in using real-world data to improve care of people living with dementia and care partners.
• Health Care Systems Scholars Program Training program for scholars focused on embedded pragmatic clinical trials within health care systems for dementia care.
• Faculty Scholars Program Program enhancing career development of investigators in the design and conduct of ePCTs by integrating them into IMPACT Cores and Teams activities.
• Long-Term Care Data Cooperative A national data resource compiling comprehensive electronic health record data for nursing home residents nationwide to improve quality of care research.
• US Dementia Prevalence Estimates National data resource providing estimates of dementia prevalence across the United States.
• Grand Rounds and Podcasts Monthly educational sessions with recordings, podcasts, slides, and information on topics related to embedded pragmatic clinical trials and IMPACT cores.
• ePCT Video Learning Library Training modules to enhance skills in developing embedded pragmatic clinical trials for people living with dementia and their care partners.

Segments3 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature1 record

Recent moves6 records

Expansion highlights6 records

Direct peers

• PCORnet (National Patient-Centered Clinical Research Network): PCORI-funded national network for patient-centered pragmatic clinical research using real-world clinical data. Comparable as a federally funded national infrastructure for embedded pragmatic trials across U.S. healthcare systems, overlapping directly with IMPACT's mission of running ePCTs in routine care.
• Duke Clinical Research Institute (DCRI): Academic clinical research infrastructure organization that hosts IMPACT's Knowledge Repository and collaborates on pragmatic trial resources. Comparable as a large academic CRO/clinical trial infrastructure provider supporting multi-site pragmatic research in the same healthcare-system settings IMPACT targets.
• Health Care Systems Research Network (HCSRN): Consortium of integrated healthcare systems that conduct embedded pragmatic research in real-world care delivery. Comparable because IMPACT's Health Care Systems Core and HCSRN both enable pragmatic trials embedded in healthcare delivery organizations serving populations that include people living with dementia.
• Hebrew SeniorLife Institute for Aging Research: Harvard Medical School-affiliated research institute and co-recipient of the IMPACT grant, focused on aging research including dementia care in senior living settings. Comparable as a direct institutional partner running overlapping dementia and pragmatic care-delivery research from the same funding base.
• Brown University Center for Gerontology and Healthcare Research: Academic home of IMPACT's MPIs (Mitchell and Mor), focused on gerontology, long-term care, and health services research. Comparable because it shares leadership, datasets (e.g., Long-Term Care Data Cooperative), and the long-term care research focus that defines IMPACT's pragmatic trial agenda.

Broad incumbents

• Alzheimer's Association: Large national nonprofit that funds dementia research, advocates for federal dementia research funding (including at NIA), and convenes researchers in the same dementia-care ecosystem that IMPACT serves. Comparable because it is a major node in the U.S. dementia research funding and convening landscape that IMPACT interacts with.
• National Institute on Aging Alzheimer's Disease Research Centers: Network of NIA-funded academic centers conducting biomedical and clinical research on Alzheimer's disease and related dementias. Comparable as NIA-funded, multi-institutional research infrastructure focused on dementia, with overlapping investigator communities and shared funder.
• Clinical and Translational Science Awards (CTSA) Program: NCATS-funded national network of ~60 academic medical centers providing translational research infrastructure, including pragmatic trial support. Comparable as NIH-funded national research-infrastructure network that provides overlapping trial design, biostatistics, and training capabilities to academic investigators.

Emerging players

• Resource Centers for Minority Aging Research (RCMAR): NIA-funded centers focused on aging research in minority populations. Comparable as NIA-funded, multi-site research infrastructure for aging, with overlapping interest in health equity and dementia in underrepresented populations (an area IMPACT's Health Equity team explicitly addresses).

Regional players

• Claude D. Pepper Older Americans Independence Centers: NIA-funded centers focused on geriatric frailty, function, and independence research. Comparable as NIA-funded research infrastructure studying older adults, with overlapping interest in non-pharmacological interventions and pragmatic research in care delivery settings.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xx.com/IMPACTCollab1
• LinkedInlinkedin.com/company/impact-collaboratory

Revenue estimate

Valuation estimate

Number of profiles

Profiles14 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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