What Chirogate International does

Chirogate International Inc. (佳和桂科技股份有限公司) is a privately held specialty pharmaceutical manufacturer founded in 1999 and headquartered in Yangmei District, Taoyuan City, Taiwan. The company exclusively focuses on the development and manufacture of prostaglandin (PG) Active Pharmaceutical Ingredients (APIs), with a portfolio of over 20 commercial products including Latanoprost, Bimatoprost, Travoprost (glaucoma treatments), Treprostinil, Beraprost, Iloprost (pulmonary arterial hypertension), Misoprostol, Alprostadil, Dinoprostone, Carboprost, Lubiprostone, and veterinary Cloprostenol Sodium in various salt formulations.

Chirogate's core technology is a proprietary synthetic chemistry platform for prostaglandin manufacturing, employing novel organic synthesis and biochemical approaches that significantly reduce total synthetic steps and minimize stereo-isomer impurities in final products. The company has developed hundreds of novel PG intermediates and holds four US patents covering synthesis of PGF2α-related compounds and isomer-free prostaglandin processes. Manufacturing is conducted across four dedicated cGMP-compliant plants in the Taoyuan area (Youth/Wulin, Zhongli/ChungLi, Yangmei), each featuring independent production lines and HVAC systems to prevent cross-contamination. All facilities are designed to ICH and PIC/S guidelines, and the company has passed three US FDA inspections (2006, 2009, 2016), Japan PMDA inspection (2016), Mexico COFEPRIS inspection, and is certified as a US Pharmacopeia reference standard supplier.

The company operates a B2B enterprise sales model supplying prostaglandin APIs directly to global pharmaceutical companies, with over 90% of customers being foreign pharma firms in regulated markets (US, EU, Japan) and non-regulated markets worldwide. Pricing is quote-based and undisclosed, reflecting the high-value, small-volume nature of niche PG APIs. Revenue streams include direct API sales and custom synthesis services (process development, degradants, impurities, isomers, working standards, and metabolites synthesis). Active DMFs are maintained with US FDA (3 active), with additional filings across EU, Japan, Canada, China, Australia, and New Zealand, enabling global product distribution.

Name

Chirogate International

Legal name

佳和桂科技股份有限公司 Chirogate International Inc.

Website

https://chirogate.com

Company type

Private

Founded year

1999

Operating status

Operating

Headcount range

101–250 employees

Short description

Chirogate International is a Taiwan-based specialty pharmaceutical manufacturer founded in 1999 that exclusively develops and produces prostaglandin Active Pharmaceutical Ingredients (APIs), supplying over 20 commercial products to global pharmaceutical companies with over 90% of customers being foreign pharma firms in regulated and non-regulated markets.

Ownership category

akta.pro rank

Product category

Active Pharmaceutical Ingredients (APIs)

NAICS

Pharmaceutical and Medicine Manufacturing (3254), Pharmaceutical Preparation Manufacturing (325412)

SIC

Medicinal Chemicals & Botanical Products (2833), Pharmaceutical Preparations (2834), Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Small-Molecule API Commercial Manufacturing (HLAGAHAB)

akta.pro secondary industries

Chiral / Asymmetric Synthesis & Complex Chemistry Services (HLAGAHAE), Small-Molecule Generics (Branded/Unbranded) (HLAIABAA), Regulatory Affairs, Labeling & Advertising/Promotion Compliance (HLAJADAI)

Keywords

• Prostaglandin APIs
• Active pharmaceutical ingredients
• Custom synthesis services
• CGMP API manufacturing
• Pharmaceutical intermediates

Headquarters

HQ city

Taoyüan

HQ country

Taiwan

HQ region

Asia

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Operations, Personnel, Technology or R&D, Infrastructure, Supply Chain

Revenue model

1. Active Pharmaceutical Ingredient (API) Sales: Manufacture and sale of prostaglandin Active Pharmaceutical Ingredients to pharmaceutical companies worldwide. Products are described as small-volume, high-price niche products with high added value and pharmacological activity.
2. Custom Synthesis Services: Custom manufacturing services for prostaglandins including custom synthesis, process development, degradants synthesis, impurities synthesis, isomers synthesis, working standards synthesis, and metabolites synthesis.

Go-to-market motion1 record

Distribution channels1 record

Core offering

Chirogate International is a specialty pharmaceutical manufacturer that produces and globally supplies prostaglandin Active Pharmaceutical Ingredients (APIs) such as Latanoprost, Bimatoprost, Travoprost, Treprostinil, Misoprostol, Alprostadil, and Dinoprostone to pharmaceutical companies worldwide. The company also provides custom synthesis, process development, and reference standard manufacturing services. Over 90% of customers are foreign pharmaceutical firms, and all products are manufactured in cGMP-compliant facilities following ICH and PIC/S guidelines.

Product overview

Chirogate International is a specialty pharmaceutical manufacturer focused exclusively on prostaglandin (PG) Active Pharmaceutical Ingredients (APIs). The company offers a portfolio of over 20 commercial-scale prostaglandin products including Treprostinil, Beraprost, Iloprost, Latanoprost, Bimatoprost, Travoprost, Tafluprost, Misoprostol, Lubiprostone, Dinoprost, Alprostadil, Dinoprostone, and Cloprostenol Sodium in various formulations (base, sodium salts, tromethamine salts). Additionally, the company provides contract manufacturing services including custom synthesis, process development, and synthesis of degradants, impurities, isomers, working standards, and metabolites. All products are manufactured in cGMP-compliant facilities with dedicated production lines for each product to prevent cross-contamination.

Differentiator

Problem solved

Functional benefit

Products and services

• Latanoprost Prostaglandin F2α analog Active Pharmaceutical Ingredient used by pharmaceutical manufacturers for glaucoma and ocular hypertension treatments.
• Bimatoprost Prostaglandin analog API used by pharmaceutical companies for glaucoma treatment and eyelash growth formulations.
• Travoprost Prostaglandin F2α analog API used in finished drugs for glaucoma and ocular hypertension treatment.
• Treprostinil (and Treprostinil Sodium, Treprostinil Diethanolamine) Prostaglandin analog API supplied in base, sodium salt, and diethanolamine salt forms for vasodilator applications including pulmonary arterial hypertension treatment.
• Beraprost Sodium (and Beraprost-314d) Prostaglandin I2 analog API used as a vasodilator and antiplatelet agent, including an extended-acting formulation (Beraprost-314d).
• Iloprost (and Iloprost Tromethamine) Prostaglandin analog API used in finished drugs for pulmonary arterial hypertension and peripheral vascular disease, available as base and tromethamine salt.
• Carboprost (and Carboprost Tromethamine) Prostaglandin F2α analog API used as a uterotonic agent for treatment of postpartum hemorrhage, supplied as base and tromethamine salt.
• Misoprostol (and Misoprostol 1% HPMC) Prostaglandin E1 analog API used by pharmaceutical manufacturers for gastric ulcer prevention and labor induction, including an HPMC formulation variant.
• Alprostadil Prostaglandin E1 API used in finished drugs for erectile dysfunction and peripheral vascular disease treatment.
• Dinoprostone Prostaglandin E2 API used in finished drugs for labor induction and cervical ripening.
• Dinoprost / PGF2α (and Dinoprost Tromethamine) Natural prostaglandin F2α API supplied as base and tromethamine salt for labor induction and veterinary applications.
• Latanoprostene Bunod Nitric oxide-donating prostaglandin analog API used by pharmaceutical companies for glaucoma treatment formulations.
• Unoprostone Isopropyl Prostaglandin F2α analog API used in finished drugs for glaucoma treatment.
• Tafluprost Prostaglandin analog API used by pharmaceutical manufacturers for glaucoma and ocular hypertension formulations.
• Lubiprostone Prostaglandin E1 derivative API used in finished drugs for chronic constipation treatment.
• Cloprostenol Sodium Synthetic prostaglandin F2α analog API supplied to veterinary pharmaceutical manufacturers.
• Custom Synthesis & Contract Manufacturing Services Bespoke contract manufacturing services including custom synthesis, process development, degradants synthesis, impurities synthesis, isomers synthesis, working standards synthesis, and metabolites synthesis for prostaglandin-related compounds. Services are tailored to pharmaceutical customer specifications for research, development, and quality control applications.

Quantifiable outcome

• Successfully commercialized over 10 prostaglandin products
• +2 more outcomes

Named customers1 record

Segments1 record

Ideal customer profiles1 record

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Scale indicators6 records

Recent moves14 records

Expansion highlights6 records

Direct peers

• Toronto Research Chemicals: Canadian specialty chemical manufacturer producing prostaglandin intermediates, impurities, metabolites, and reference standards. Closely comparable in custom synthesis and chiral prostaglandin chemistry services for the pharmaceutical industry.
• Cayman Chemical: US-based manufacturer of prostaglandins, eicosanoids, and related bioactive lipids for research and pharmaceutical use. Directly comparable as a prostaglandin-focused specialty API/reagent manufacturer with similar customer overlap in pharma R&D and reference-standards supply.
• Polypeptide Laboratories (PolyPeptide Group): Swiss-headquartered contract manufacturer of peptides and small-molecule APIs for the pharmaceutical industry. Comparable as a privately held, technology-driven CDMO serving global pharma with a focus on complex, high-purity API manufacturing.
• Carbogen Amcis: Swiss API development and manufacturing organization (part of Dishman Carbogen Amcis) with strong capabilities in chiral chemistry and prostaglandin synthesis. Directly comparable as a CDMO serving regulated pharmaceutical markets with complex small-molecule APIs.

Emerging players

• ChemPartner: China-headquartered CRO/CDMO with API manufacturing capabilities including custom synthesis and small-molecule API supply. Comparable as a chemistry-focused CDMO competing in the custom synthesis and API manufacturing space, particularly in Asia.

Broad incumbents

• Divis Laboratories: Indian listed API manufacturer producing prostaglandin APIs (including Latanoprost) and other complex generic APIs at scale. Comparable as a global prostaglandin API supplier competing in the same molecule categories as Chirogate with a cost-advantaged footprint.
• Johnson Matthey (Pharma Services / Macfarlan Smith): UK-based specialty chemicals company with a pharmaceutical API and custom synthesis business including prostaglandin chemistry. Comparable as a long-established, multi-site cGMP API manufacturer serving global pharma with chiral synthesis expertise.
• Bachem: Swiss-listed CDMO specializing in peptide and oligonucleotide APIs, also offering prostaglandin-related custom synthesis. Comparable as a high-quality, cGMP-compliant API manufacturer with global regulatory inspection history and pharma customer base.
• Fermion (subsidiary of Orion Corporation): Finnish API manufacturer producing generic APIs and intermediates, including prostaglandin and complex chiral molecules. Comparable as a cGMP-compliant API manufacturer with global DMF presence supplying regulated pharmaceutical markets.
• Axplora (formerly Novasep Pharma Solutions): European CDMO offering custom synthesis and manufacturing of complex APIs, including prostaglandin-related molecules. Comparable as a cGMP API manufacturer with strong chiral chemistry expertise serving global pharmaceutical customers.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/soundfo

Compliance7 records

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Chirogate International