Eurotransplant

What Eurotransplant does

Eurotransplant International Foundation is a Leiden-based, non-profit organization founded in 1967 and mandated by the governments of Austria, Belgium, Croatia, Germany, Hungary, Luxembourg, the Netherlands, and Slovenia to allocate deceased donor organs across these member states. It operates the Eurotransplant Network Information System (ENIS), a 24/7 central database that ingests donor characteristics and generates instant match lists for transplant centers based on blood group, waiting time, urgency, and member-state sharing rules. In 2025 the network allocated 7,366 organs from 2,221 deceased donors across 76 transplant centers and 203 active programs, with 20.5% of organs exchanged cross-border.

The product surface extends well beyond ENIS. The Eurotransplant Reference Laboratory (ETRL), situated at Leiden University Medical Center, provides quality assurance for tissue typing laboratories through External Proficiency Testing, a 24/7 immunological on-call service, and management of the Acceptable Mismatch program for highly sensitized patients. Proprietary clinical tools include the reMELD-Na calculator (deployed March 2025 for liver allocation), the Lung Allocation Score calculator, the ETRL calculator suite (vPRA, ABO compatibility, HLA-EMMA), and a Virtual Crossmatch system built on 11-locus HLA typing implemented in January 2023. The Eurotransplant Registry and an ETRL reference database of 10,000 HLA profiles sourced from DKMS underpin both operational tools and the kidney/liver allocation simulators developed by the biostatistics team.

Funding comes from national governments and regulatory authorities in the eight member states rather than from commercial pricing. There are no venture capital, private equity, or public ownership structures. Distribution runs exclusively through the password-protected member site (my.eurotransplant.org), direct ENIS integration with transplant centers, donor hospitals, and tissue typing laboratories, and credentialing requirements (EFI or ASHI accreditation) for any laboratory reporting histocompatibility data to the network. The organization operates as a mandated intermediary in a closed, regulated healthcare ecosystem rather than a commercial technology vendor.

Name

Eurotransplant

Legal name

Eurotransplant International Foundation

Website

https://eurotransplant.org

Company type

Private

Founded year

1967

Operating status

Operating

Headcount range

101–250 employees

Short description

Eurotransplant is a Leiden-based non-profit foundation mandated by eight European governments to allocate deceased donor organs across 76 transplant centers, running the 24/7 ENIS matching platform, ETRL reference laboratory, and clinical scoring tools that allocated 7,366 organs in 2025.

Ownership category

akta.pro rank

Product category

Organ Allocation Services

NAICS

Blood and Organ Banks (621991), Medical and Diagnostic Laboratories (62151), General Medical and Surgical Hospitals (622110)

SIC

Hospital & Medical Service Plans (6324), Services-Medical Laboratories (8071)

akta.pro primary industry

Public Health & Immunization Data Exchange (ELR, case reporting, registry reporting) (HLACABAL)

akta.pro secondary industry

Terminology Services & Semantic Interoperability (SNOMED/LOINC/RxNorm mapping) (HLACABAJ)

Keywords

• Organ allocation services
• Transplant coordination
• Immunogenetics services
• Tissue typing laboratory
• Deceased donor matching

Headquarters

HQ city

Leiden

HQ country

Netherlands

HQ region

Europe

Offices2 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Others

Revenue model

1. Government-funded operations: Eurotransplant is an international non-profit organization mandated by eight countries to perform organ allocation. Funding comes from national governments and regulatory authorities in member states rather than commercial revenue streams.

Go-to-market motion1 record

Distribution channels3 records

Marketing channels7 records

Core offering

Eurotransplant operates a centralized organ allocation platform (ENIS) that matches deceased donor organs to patients on waiting lists across eight European member states (Austria, Belgium, Croatia, Germany, Hungary, Luxembourg, Netherlands, Slovenia). Using sophisticated computer algorithms applying allocation rules based on blood group, waiting time, and relative urgency, the system generates instant match lists 24/7. Supporting services include the ETRL Reference Laboratory for histocompatibility testing and quality assurance, the Acceptable Mismatch Program for highly sensitized patients, HLA-based calculators, and a Virtual Crossmatch system across 11 HLA loci.

Product overview

Eurotransplant is an international non-profit organization operating as a unified organ allocation platform responsible for matching deceased donor organs to patients across eight European member states. The core offering is the ENIS (Eurotransplant Network Information System) allocation platform, which runs round-the-clock to generate match lists based on blood group, waiting time, and urgency. Supporting this core platform are the ETRL Reference Laboratory (providing immunological backup and quality assurance), the Acceptable Mismatch Program (for highly sensitized kidney patients), the Virtual Crossmatch system, the ETRL Calculators Suite (vPRA, ABO matching, AM program eligibility), the public clinical calculators (LAS Calculator and reMELD-Na Calculator), the Statistics Report Library, and the Annual Meeting program including the Jon van Rood Award.

Differentiator

Problem solved

Functional benefit

Products and services

• Eurotransplant Network Information System (ENIS) — Central Organ Allocation System Central computer platform that instantly generates match lists for every organ made available by a deceased donor, applying predefined allocation rules based on blood group, time on waiting list, and relative urgency across eight member states (Austria, Belgium, Croatia, Germany, Hungary, Luxembourg, Netherlands, Slovenia). Operates 24/7 for transplant centers, donor hospitals, and tissue typing laboratories.
• Eurotransplant Reference Laboratory (ETRL) Integral part of Eurotransplant providing 24/7 immunological backup, External Proficiency Testing (EPT) for tissue typing laboratories, and management of the Acceptable Mismatch program for highly sensitized patients. Situated at Leiden University Medical Center, the Netherlands.
• Acceptable Mismatch (AM) Program Special allocation program for highly sensitized patients who have accumulated extensive lists of unacceptable HLA antigens. Defines acceptable HLA antigens pre-transplantation through laboratory testing and allocates organs based on patient's own HLA with addition of acceptable antigens, achieving graft survival rates comparable to non-sensitized patients.
• Virtual Crossmatch Digital crossmatch system for kidney, kidney+pancreas, and pancreas allocation, enabling HLA-based virtual matching without physical crossmatch and supporting 11-locus HLA typing across HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQB1, -DQA1, -DPB1, -DPA1.
• ReMELD-Na Calculator Public calculator for the refitted MELD-Natrium score assessing 90-day mortality risk for liver transplant candidates, incorporating serum creatinine, bilirubin, sodium, and INR. Validated for the Eurotransplant population and not equivalent to UNOS/OPTN MELD-Na.
• Lung Allocation Score (LAS) Calculator Publicly accessible calculator that determines ranking order for lung transplant offers based on medical urgency prior to transplantation and probability of success after transplantation using a net benefit concept.
• ETRL Calculators Suite (vPRA, ABO Compatibility, HLA-EMMA) Suite of professional calculators including virtual PRA percentage within Eurotransplant donor population, chance of ABO-identical/ABO-compatible/ABO-modified-compatible transplant offers, AM program eligibility for highly sensitized patients, and HLA-EMMA amino acid compatibility analysis. Based on ETRL reference database v4.0 with 10,000 HLA profiles from DKMS.
• External Proficiency Testing (EPT) Scheme Proficiency testing scheme for Eurotransplant-affiliated tissue typing laboratories covering HLA typing, screening for HLA-specific antibodies, and crossmatching of tissue typing centers, including patient-based case exercises. The only EPT scheme enabling center-to-center comparison within Eurotransplant. Participants must fulfill EFI requirements.
• Statistics Report Library Extensive online database of pre-generated reports covering donation, waiting lists, allocation, transplants, and follow-up outcomes. Supports reports by type, organ, region, year, and characteristic with PDF and XLSX export.

Quantifiable outcome

• 22.5% of all allocated organs exchanged cross-border between member states, enabling patients to receive suitable organs faster
• +2 more outcomes

Named customers6 records

Segments6 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability4 records

Feature9 records

Partnerships

Nine partnerships are on record, tiered core and major.

• Hungary / Hungarian National Blood Transfusion ServicecoreStrategic or Co-development PartnerHungary became full member of Eurotransplant in 2013. During 10 years, 924 donor organs were received from abroad benefiting Hungarian patients, accounting for 24% of total 3,922 domestic transplants. After joining, patients on waiting list increased by 39%. Kidney transplants showed improved immunological compatibility leading to longer organ function.
• Leiden University Medical Center (LUMC)coreStrategic or Co-development PartnerETRL (Eurotransplant Reference Laboratory) is situated in the LUMC. Histocompatibility assay services delegated to Leiden HLA diagnostics laboratory (NLBTT) under Service Level Agreement.
• European Federation for Immunogenetics (EFI)coreStrategic or Co-development PartnerEurotransplant was first organ exchange organization to establish EPT for DNA typing and requires EFI accreditation for laboratories reporting histocompatibility data to ENIS.
• American Society for Histocompatibility and Immunogenetics (ASHI)coreStrategic or Co-development PartnerASHI accreditation is accepted alongside EFI for laboratories reporting histocompatibility data to Eurotransplant Network Information System.
• International Society for Heart and Lung Transplantation (ISHLT)majorStrategic or Co-development PartnerCollaboration agreement signed in 2025 for creating impact with data in advanced heart and lung failure field. Part of plenary session 'Creating Impact with Data' at Annual Meeting 2025.
• DKMS (Deutsche Knochenmarkspenderdatei)majorTechnology or IntegrationDKMS provides genotype frequencies used in ETRL reference database v4.0 containing HLA data of 10,000 individuals for calculator functionality.
• National Competent Authorities (NCAs)coreStrategic or Co-development PartnerNational regulatory authorities in member states that approve allocation rule recommendations developed by Eurotransplant biostatisticians and advisory committees.
• European Society for Organ Transplantation (ESOT)majorStrategic or Co-development PartnerStarting 2028, Eurotransplant Annual Meeting will be held every two years alternating with ESOT congress. Collaboration facilitates knowledge sharing and prevents scheduling conflicts.
• Eurotransplant Affiliated Tissue Typing LaboratoriescoreStrategic or Co-development PartnerAll tissue typing laboratories from Eurotransplant member states must participate in ETRL EPT exercises and fulfill EFI requirements. Also includes laboratories from outside Eurotransplant region.

Scale indicators8 records

Recent moves8 records

Expansion highlights6 records

Direct peers

• Scandiatransplant: Scandiatransplant is a Nordic organ exchange organization covering Denmark, Finland, Iceland, Norway, Sweden, and Estonia — the same fundamental model as Eurotransplant (multi-country deceased-donor allocation with HLA-matched cross-border exchange). Comparable in scope, technology platform maturity, and governance approach.
• United Network for Organ Sharing (UNOS): UNOS operates the U.S. Organ Procurement and Transplantation Network (OPTN) — the direct international counterpart to Eurotransplant. Both are non-profit, government-mandated organ allocation systems running centralized matching algorithms across multi-state/multi-country networks with HLA-based compatibility logic. UNOS is the closest functional analog globally.

Others

• European Society for Organ Transplantation (ESOT): ESOT is the umbrella scientific society for transplantation in Europe, partnering with Eurotransplant starting 2028 on biennial congress scheduling. Not a peer in services but a closely linked scientific/governance counterpart shaping pan-European transplant policy.

Regional players

• Canadian Blood Services: Canadian Blood Services operates the Canadian Transplant Registry and integrates deceased-donor organ allocation with broader tissue/blood services — a vertically integrated version of Eurotransplant's allocation function. Mandated by provincial/territorial authorities similar to how Eurotransplant serves member states.
• Centro Nazionale Trapianti (CNT): Italy's national transplant center (CNT) coordinates organ allocation nationally and participates in cross-border exchange, including via the EU-funded FOEDUS/COORENOR projects. Same regulatory mandate-driven, multilateral-matching operating model as Eurotransplant but at a national scope.
• NHS Blood and Transplant (NHSBT): NHSBT runs organ donation and transplantation for the United Kingdom, functioning as a national organ allocation authority analogous to a single-country version of Eurotransplant. Comparable patient population (~68M), comparable mandate structure, but operates as a national rather than international alliance.
• Agence de la Biomédecine: France's national biomedicine agency administers organ allocation, including cross-border exchange within and outside Eurotransplant, with sophisticated HLA-based matching similar in capability to Eurotransplant but at single-country scale.
• Asociación Española de Trasplantes / Organización Nacional de Trasplantes (ONT): Spain's national transplant organization, globally renowned for its leadership in donation rates and allocation policy. While not formally part of Eurotransplant's alliance, it operates a national-level organ allocation system with comparable scientific and regulatory depth.

Emerging players

• DKMS: DKMS provides genotype frequencies used in Eurotransplant's ETRL reference database and operates the largest bone-marrow donor registry in Europe. While focused on stem cells rather than solid organs, it shares HLA-matching, donor typing, and reference-database methodology.
• NMDP (formerly National Marrow Donor Program): NMDP runs HLA-matched hematopoietic stem cell (marrow) donor allocation in the U.S. using analogous HLA-matching algorithms and reference databases — the same domain expertise of Eurotransplant's ETRL/AM program applied to a different tissue type. Strong adjacency for tissue-matching technology convergence.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/eurotransplant

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

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M&A

Investments

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Frequently asked questions about Eurotransplant