What AdaBio does

AdaBio Co., Ltd. (アダバイオ株式会社) is a privately held Japanese biotechnology company founded in March 2002 by cancer and immunology researchers, headquartered in Takasaki City, Gunma Prefecture, Japan's second-largest plum-producing region. The company develops, manufactures, and sells functional foods, pharmaceuticals, medical devices, and pet supplements built around a proprietary MK615 heated Japanese plum (ume) juice concentrate. Its core innovation platform rests on the proprietary MK615 extract and a patented novel compound ASP Citrimide, both derived from ume and backed by over 25 peer-reviewed scientific publications demonstrating anti-proliferative, anti-inflammatory, and hepatoprotective properties. AdaBio also holds a Class 3 Medical Device Manufacturing/Marketing license (obtained December 2008), enabling medical device products.

The company's commercial portfolio is organized under four brand families: the Misatol line of plum-extract supplements (Delicious GL, Clear, Rich, ME) for health-conscious consumers; Misatol Rhinolocation, a nasal irrigation device with proprietary cleaner for upper pharyngeal care, sold through medical institutions; Misatol GV, palatability-enhanced pet supplements co-developed with Gunma veterinarians; and An.d, a plum and citrus jam line including Yuzu and Lemon Mixed Jams. AdaBio monetizes through unit-priced retail (e.g., the dedicated Rhinolocation cleaner at 2,310 yen from October 2025), combining direct-to-consumer e-commerce (corporate website, Rakuten Marketplace launched May 2024) with furisato-tax donation platforms (Satofull, Furusato Choice, Rakuten Furusato-tax), an official LINE marketing account, and medical-institution sales for healthcare products. Partnerships with Gunma plum farmers (sourcing including hail-damaged fruit for the jam line), the Japan Focal Disease Research Society, and the Gunma Prefectural Industrial Technology Center anchor its regional supply chain and research ecosystem.

Name

AdaBio

Legal name

AdaBio株式会社

Website

https://adabio.co.jp

Company type

Private

Founded year

2002

Operating status

Operating

Short description

AdaBio is a Japanese biotechnology company that develops, manufactures, and sells plum (ume) extract-based functional foods, medical devices, and pet supplements under the Misatol, Rhinolocation, and An.d brands, serving health-conscious consumers, medical institutions, and pet owners in Japan.

Ownership category

akta.pro rank

Product category

Functional Foods & Health Supplements

NAICS

Spice and Extract Manufacturing (311942), Toilet Preparation Manufacturing (32562)

SIC

Food And Kindred Products (2000), Surgical & Medical Instruments & Apparatus (3841), Canned, Frozen & Preservd Fruit, Veg & Food Specialties (2030)

akta.pro primary industry

Probiotics & Digestive Health Supplements (CRADAGAF)

akta.pro secondary industries

Extracts, Oleoresins & Essential Oils (Spice Extracts for Flavoring) (AFAJANAJ), Hand Hygiene & Skin Antisepsis (Soaps, Sanitizers, Surgical Scrubs, CHG Prep) (HLAHANAE)

Keywords

• Functional food products
• Dietary supplements
• Pet health supplements
• Medical devices
• Nasal irrigation systems

Headquarters

HQ city

Takasaki

HQ country

Japan

HQ region

Asia

Offices1 record

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Personnel, Supply Chain, Operations, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. Functional Food Products: Sales of functional foods and processed foods centered on plum extract supplements (Misatol series) and plum jams (An.d brand). These products are sold directly to consumers through e-commerce and indirectly through marketplace channels.
2. Healthcare Products: Sales of medical devices (Misatol Rhino Lotion and dedicated cleaners) and healthcare products targeting upper pharyngeal care. Sold through medical institutions and direct channels.
3. Pet Health Supplements: Sales of pet health supplements (Misatol GV series) for dogs and cats, developed in collaboration with veterinarians.

Pricing tiers

Go-to-market motion2 records

Distribution channels4 records

Marketing channels4 records

Core offering

AdaBio is a health science company that researches, develops, manufactures, and sells plum (ume) extract-based products across three business fields: functional food supplements (Misatol brand), upper pharyngeal care medical devices (Rhinolocation), and pet health supplements (Misatol GV). The company's flagship offering is built on its proprietary MK615 heated ume extract compound, with products sold directly to consumers via its website, Rakuten marketplace, and furisato-tax platforms, and to medical institutions for healthcare devices.

Product overview

AdaBio is a health science company specializing in plum (ume) research and product development. The company operates across three main business fields: functional foods, healthcare (nasopharyngeal care), and pet health supplements. The core product line centers on the proprietary MK615 plum extract, marketed under the Misatol brand, which includes supplements (Misatol Delicious GL, Clear, Rich, ME), healthcare products (Rhinolocation for nasopharyngeal washing), and pet supplements (Misatol GV). Additional product lines include the An.d jam brand featuring plum-based preserves, and accessory products like mouth tape and cleaning agents. The portfolio is unified by the company's plum extract technology and research, with products ranging from internal supplements to topical/instrumental healthcare devices.

Differentiator

Problem solved

Functional benefit

Brands

• ミサトール (Misatol): Plum extract supplement product line, including Misatol Delicious GL, Misatol Clear, Misatol Rich, and Misatol ME variants.
• リノローション (Rinolocation)
• An.d (アンド)
• ミサトールジーブイ (Misatol GV)
• 優肌絆 口とじテープ (Yugeban Kuchitoji Tape)

Products and services

• Misatol Plum Extract Supplements (ミサトール) Plum extract supplement brand based on proprietary MK615 ume extract, available in multiple formulations including Misatol Delicious GL (launched 2004/renewed 2022), Misatol Clear (renewed/newly launched 2022-10), Misatol Rich (renewed/newly launched 2022-10), and Misatol ME (launched November 2007 for domestic Japan and Italian export). Targeted at health-conscious consumers seeking natural wellness solutions.
• Misatol Rhinolocation (ミサトールリノローション) Nasopharyngeal washing solution containing ume extract, developed based on the focal disease concept for upper pharyngeal care. Includes a dedicated cleaning agent. The solution is formulated to match body fluid concentration for non-irritating use, with approximately 1.5mL per application. Sold as a Class 3 medical device through medical institutions and direct channels in Japan.
• Misatol GV Pet Health Supplements (ミサトールジーブイ) Dog and cat health supplement containing ume extract, co-developed with veterinarians in Gunma Prefecture. Formulated with improved palatability to address the strong acidity and bitterness that made standard plum extracts unpalatable to animals. Available in liquid (GV Plus) and powder (GV Powder) forms for senior pets and aging-related health concerns.
• An.d Brand Plum Jams (An.d / アンド) Jam brand featuring plum-based jams using domestic plums and yellow fruits. Products include Shirakawa-ga, Orihime plum jams, Yuzu Plum Mixed Jam, and Lemon Plum Mixed Jam. Uses plum pectin instead of gelatinizing agents for jelly-like texture, made only with domestic plums, yellow fruits, and sugar. The An.d brand name represents 'Another' (追加/owari) and 'no detection' (n.d.) - jam with nothing extra added.
• Yugeban Kuchitoji Tape Mouth Tape (優肌絆 口とじテープ) Mouth tape for promoting nasal breathing during sleep, addressing snoring and mouth dryness. Features skin-friendly design that prevents skin damage while keeping the mouth closed, perforated for easy cutting, designed for daily use (25mm width x 7m length, approximately 140 days supply).
• Misatol Rhinolocation Dedicated Cleaning Agent (ミサトールリノローション専用洗浄剤) Dedicated cleaning agent sold as an accessory for the Misatol Rhinolocation nasal irrigation device. Sold through medical institutions and direct consumer channels.

Quantifiable outcome

• Over 25 scientific papers published on MK615 plum extract compound
• +1 more outcomes

Named customers1 record

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

Four partnerships are on record, tiered core.

• Japan Focus on Inflammation (JFiR) / Japan Focal Disease Research SocietycoreStrategic or Co-development Partner · 1 October 2009AdaBio has supported the Japan Focal Disease Research Society since its founding. The company's Misatol Rhino Lotion was developed based on research insights from this society regarding upper pharyngeal inflammation and its connection to focal diseases affecting various body systems.
• Gunma Prefectural Gunma Industrial Technology CentercoreStrategic or Co-development PartnerEstablished research laboratory within the Gunma Prefectural Gunma Industrial Technology Center in April 2005 to conduct product development and research activities in partnership with public research institutions.
• Gunma Prefecture VeterinarianscoreStrategic or Co-development PartnerCollaborative development of pet health supplements (Misatol GV series) with veterinarians across Gunma Prefecture. Development was initiated when the company president's aging shepherd dog benefited from plum extract supplementation under veterinary supervision.
• Gunma Prefecture Plum FarmerscoreStrategic or Co-development PartnerPartnership with local Gunma Prefecture plum farmers to source high-quality青梅 (green plums) for MK615 extract production. This partnership addresses farmer concerns about declining plum consumption and helps create new value for locally-grown produce, including utilizing hail-damaged plums for new product lines like An.d jam.

Scale indicators3 records

Recent moves8 records

Expansion highlights5 records

Broad incumbents

• Kobayashi Pharmaceutical: Major Japanese OTC pharmaceutical and healthcare products company with extensive retail distribution. Broad incumbent serving overlapping consumer health needs including nasal care products that compete with AdaBio's Rhino Lotion line.
• House Wellness Foods: Japanese food manufacturer with health-focused product lines including supplements and functional foods. Broad incumbent that overlaps with AdaBio's functional foods and supplements positioning with significantly larger scale and retail penetration.

Direct peers

• Wakamoto Pharmaceutical: Japanese pharmaceutical company specializing in gastrointestinal health supplements (Wakamoto Intestinal Medicine). Comparable niche positioning to AdaBio in digestive/daily health supplement category with similar domestic distribution approach.
• Api Co., Ltd. Japanese supplement company with broad product portfolio including health drinks and supplements similar to Misatol line. Comparable in scale and target market of health-conscious Japanese consumers via direct and retail distribution.
• NeilMed Pharmaceuticals: Global leader in nasal irrigation products (neti pots and saline solutions). Directly comparable to AdaBio's Misatol Rhino Lotion nasal washing system, though NeilMed operates at much larger global scale.
• DHC Corporation: Leading Japanese supplements and cosmetics company with broad DTC e-commerce distribution. Comparable to AdaBio in leveraging direct-to-consumer sales channels for health/beauty products and holding cosmetics manufacturing permits.
• Fancl Corporation: Major Japanese supplement and functional food company offering health-focused products similar to AdaBio's Misatol supplement line. Both target health-conscious Japanese consumers seeking scientifically-formulated dietary supplements through DTC and retail channels.
• Yamada Bee Farm: Japanese natural supplement company specializing in propolis and bee-derived health products with strong DTC presence. Comparable to AdaBio in single-ingredient focus, scientific research backing, and Japan-centric health supplement positioning.
• ITOH Kanpo Pharmaceutical: Japanese traditional medicine (Kanpo) company that bridges traditional Japanese health remedies with modern scientific research, directly paralleling AdaBio's positioning of ume extract between folk medicine and pharmaceutical research.

Regional players

• Aisei Pharmaceutical: Japanese pharmaceutical company with health supplement portfolio. Regional player with similar scale and DTC supplement business model, though with broader therapeutic positioning rather than AdaBio's single-ingredient ume focus.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/ume_by_adabio
• Facebookfacebook.com/profile.php

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about AdaBio