Biox Systems Ltd.

What Biox Systems Ltd. does

Biox Systems Ltd. is a privately held UK scientific instrument company founded in 2000 and headquartered in London, specialising in research-grade measurement devices for the skin research industry. Its product portfolio centres on the AquaFlux™ Model AF200, a patented condenser-chamber closed measurement system that uses an electronically cooled condenser maintained below freezing to control the microclimate at the skin surface and quantify Trans Epidermal Water Loss (TEWL) at roughly two flux readings per second, and the Epsilon™ Model E100, a skin hydration instrument using a 76,800-element capacitance contact imaging sensor with a proprietary ε-filter for calibrated dielectric permittivity measurement. Supporting offerings include the EpsilonAnalyser™ image-analysis software, a proprietary droplet calibration method verified by the UK National Physical Laboratory, and an annual Passport Service that returns instruments to near-new condition through full calibration, hardware, and firmware updates.

The company's commercial model is sales-led and enterprise-focused, with revenue generated primarily through hardware sales of specialised scientific instruments, a recurring Passport Service managed-services annuity tied to the installed base, and professional services for installation, training, and ongoing technical support delivered by its in-house scientific team. Pricing is quote-based with multi-year contracts; no public list prices are available. Distribution combines direct enterprise sales with a global distributor network spanning 35+ countries across Europe, North America, and Asia Pacific.

Biox serves cosmetics and personal care multinationals (L'Oréal, Procter & Gamble, Unilever, Estée Lauder, Beiersdorf, Colgate-Palmolive, Kao, Henkel, Shiseido, Amore Pacific), pharmaceutical companies (Pfizer, GSK, Johnson & Johnson), chemicals and ingredients suppliers (DSM, Croda, Sederma), contract research organisations (Charles River Laboratories, Dermatest, Innovaderm, proDERM), and academic and clinical research institutions. The customer base of over 100 logos is concentrated in skincare efficacy testing, claims substantiation, dermatological formulation research, and academic skin biology. The company holds patents on the AquaFlux condenser-chamber method and, since April 2016, a non-exclusive worldwide licence from L'Oréal for the SkinChip patents underlying the Epsilon ε-filter technology.

Name

Biox Systems Ltd.

Legal name

Biox Systems Ltd

Website

https://bioxsystems.com

Company type

Private

Founded year

2000

Operating status

Operating

Headcount range

1–10 employees

Short description

Biox Systems Ltd. develops and sells research-grade AquaFlux TEWL and Epsilon skin hydration measurement instruments, serving cosmetics, pharmaceutical, CRO, and academic research customers in 35+ countries via direct sales and distributor channels.

Ownership category

akta.pro rank

Product category

Dermatological Skin Measurement Instruments

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Analytical Instruments (3826)

akta.pro primary industry

Microscopy, Imaging & Flow Cytometry Instruments (HLAGAIAE)

akta.pro secondary industries

Dermocosmetics & Medical-Grade Skincare (CRABAAAF), Laser & Energy-Based Dermatology (HLAKACAF)

Keywords

• Skin measurement instruments
• TEWL measurement devices
• Dermatological research equipment
• Skin hydration analysis
• Cosmetics testing instruments

Headquarters

HQ city

London

HQ country

United Kingdom

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales

Revenue model

1. Scientific Instrument Sales: Sale of precision scientific measurement instruments including AquaFlux TEWL devices and Epsilon skin hydration measurement systems. Revenue generated from initial hardware purchase with accompanying software and calibration accessories.
2. Passport Service (Annual Maintenance): Annual service program that returns instrument to near-new condition, including all checks, calibrations, hardware/firmware updates, and performance verification.
3. After-Sales Support and Training: In-house scientific team provides installation, training, calibration support, and ongoing technical assistance as part of customer service offering.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels5 records

Core offering

Biox Systems Ltd. designs, manufactures, and sells research-grade scientific instruments that measure Trans Epidermal Water Loss (TEWL) and skin hydration for dermatological, cosmetic, and pharmaceutical research. Its flagship AquaFlux™ AF200 device uses a patented closed condenser-chamber method, and the Epsilon™ E100 instrument uses capacitance contact imaging with proprietary ε-filter correction, both supported by EpsilonAnalyser™ software and an annual Passport Service calibration program.

Product overview

Biox Systems Ltd. develops a specialized portfolio of skin research measurement instruments centered on two core products: the AquaFlux™ Model AF200 for Trans Epidermal Water Loss (TEWL) measurement using a patented condenser-chamber closed measurement system, and the Epsilon™ Model E100 for skin hydration assessment via capacitance contact imaging with a fingerprint sensor. These are supported by the EpsilonAnalyser™ image analysis software and accompanied by calibration services including the proprietary Droplet Calibration Method and an annual Passport Service for instrument maintenance. The company has operated since 2000, serving pharmaceutical, cosmetics, and dermatological research institutions globally.

Differentiator

Problem solved

Functional benefit

Products and services

• AquaFlux™ Model AF200 Patented Trans Epidermal Water Loss (TEWL) measurement device using a closed condenser-chamber method with an electronically cooled condenser maintained below freezing point, recording approximately 2 flux readings per second and maintaining precise microclimate control at the skin surface. Used by cosmetics companies, pharmaceutical firms, and research institutions for skin barrier and product efficacy studies.
• Epsilon™ Model E100 Skin hydration measurement instrument using capacitance contact imaging technology with a Fujitsu fingerprint sensor containing 76,800 sensing elements. Provides calibrated linear dielectric permittivity measurements for quantitative skin hydration assessment, designed for cosmetics and dermatological research.
• EpsilonAnalyser™ Image analysis software for processing and analyzing capacitance contact images captured by the Epsilon device, enabling visualization and quantitative assessment of skin hydration distribution. Used by skin researchers analyzing Epsilon measurement data.
• Passport Service Annual calibration and maintenance service for AquaFlux and Epsilon instruments that returns devices to as near new condition as possible, including all checks, calibrations, hardware/firmware updates, and performance verification. Sold to existing instrument customers.
• Consultancy Services Consultancy services provided by Biox Systems' in-house scientific team, covering measurement support, training, technical advice, and ongoing scientific collaboration for skin research customers.

Quantifiable outcome

• AquaFlux in-vitro coefficient of variation (CV) of 0.93% vs. VapoMeter CV of 10.3% - more than 10x better repeatability
• +4 more outcomes

Named customers17 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

One partnership is on record.

• L'OréalcoreOEM/ Whitelabel/ Licensing PartnerSince April 2016, Biox Systems holds an unrestricted, non-exclusive, world-wide licence from L'Oréal to exploit their SkinChip patents (EP1438922 & EP1177766) relating to non-optical imaging on non-dermatoglyphic skin, hair and mucous membranes. This licensing agreement enables the Epsilon instrument's unique calibrated response technology and allows all Epsilon images and measurements to be used for commercial purposes including claims support and advertising.

Scale indicators3 records

Recent moves6 records

Expansion highlights4 records

Broad incumbents

• Keysight Technologies: Major electronic measurement and analytical instrumentation company with strength in precision sensors and signal analysis. Adjacent to Biox's capacitance/imaging measurement expertise and a potential acquirer of niche measurement instrument businesses.
• Mettler-Toledo International Inc. Global leader in precision laboratory analytical instruments (balances, titrators, density meters). Operates broadly in laboratory measurement but does not specialize in skin TEWL/hydration; represents the scale incumbent Biox could be benchmarked against for analytical instrument operations and global reach.

Direct peers

• Courage + Khazaka electronic GmbH: German manufacturer of the Tewameter (TEWL) and Corneometer (skin hydration) — the most established direct competitor in research-grade skin measurement. Biox's own data shows r=0.98 correlation between AquaFlux and Tewameter, confirming direct comparability.
• RiverD International B.V. Dutch developer of the MoistureMap SC and SkinChip — the original non-optical skin contact imaging technology whose patents (EP1438922, EP1177766) underpin Biox's Epsilon via a L'Oréal sub-licence. Most direct technology peer in capacitance contact imaging.
• Delfin Technologies Ltd: Finnish maker of the VapoMeter (closed-chamber TEWL) and MoistureMeter skin hydration instruments. Explicitly cited by Biox as a competitor with 10.3% in-vitro CV vs AquaFlux's 0.93%, making it the most direct benchmark for performance comparison.

Emerging players

• Callegari S.p.A. Italian manufacturer of specialized dermatology and skin testing instrumentation including Dermotech devices. A regional/niche competitor in the same research-grade skin measurement category with overlapping cosmetic and clinical customers.
• cyberDERM Inc. US-based skin measurement instrument company offering TEWL and hydration tools (e.g., VapoMeter distribution) for clinical and research use. Smaller niche player but a direct competitor in the same North American dermatology research market Biox serves.
• Miravex Limited: Irish developer of the Antera 3D camera for skin topography and pigmentation analysis. Competes with Biox's Epsilon in research-grade skin imaging and visual assessment for cosmetics and dermatology R&D.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks7 records

Key highlights7 records

Customer concentration

• Xx.com/BioxS
• YouTubeyoutube.com/watch?v=8Eb9aQoqKvM&list=PLlhUJL_qfbYYYyxeQtRd9GHsybGHG9h6J
• Facebookfacebook.com/Biox-Systems-Ltd-2147565985353684
• LinkedInlinkedin.com/company/biox-systems-ltd

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Biox Systems Ltd.