Calmare Therapeutics

What Calmare Therapeutics does

Calmare Therapeutics Incorporated (CTI / Calmare) is a privately held, specialty medical device company founded in 2008 and headquartered in Shelton, Connecticut (Fairfield County). The company develops, manufactures, and distributes the Calmare® Pain Therapy Medical Device (model MC-5A), a non-invasive, Class II prescription hardware product that treats chronic neuropathic and oncologic pain — including chemotherapy-induced peripheral neuropathy (CIPN) and cancer-related pain resistant to narcotics — by delivering biophysical, transdermal electrical "no-pain" signals to nerves via surface electrodes. The platform is U.S. FDA 510(k)-cleared and European CE mark-certified. The product line includes the MC-5A console (a five-channel unit with dial selectors, per-channel meters, indicator lights, and an LCD), a deluxe mobility/storage cart, three Axelgaard-branded snap-electrode SKUs differentiated by shape and contact area (CTI3001 oval, CTI2020 square, CTI2040 rectangle), and an MC-W73 snap leadwire — together forming both a capital-equipment sale and a recurring consumables/accessories revenue stream.

Calmare's go-to-market is sales-led and channel-differentiated. In the United States, commercial sales are run directly by regional representatives (Eastern/Mid-Atlantic, Southern, Central, Western territories). A separate, dedicated U.S. Government sales function targets U.S. Military and VA facilities, where the device has documented deployments at Andrews AFB, Eglin AFB, Madigan Army Medical Center, San Antonio Military Medical Center, Tripler Army Medical Center, Naval Medical Centers in Portsmouth, San Diego, Bethesda, and Camp Lejeune, plus Boston VA Healthcare and Hunter Holmes McGuire VAMC. Internationally, Calmare sells through exclusive distributors covering the Americas, Australia/New Zealand, the Middle East and North Africa (Mediterranean for Integration and Technology), and Asia Pacific. The buyer base spans academic medical centers running clinical trials on the technology (Mayo Clinic, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Virginia Commonwealth University, University of Wisconsin-Madison), independent chronic-pain and physical-therapy clinics, and government healthcare systems.

The firm is lean (1–10 employees) and founder/management-owned, with no disclosed institutional investors, funding rounds, or M&A activity. Leadership consists of President & CEO Conrad Mir and Chief Medical Officer Dr. Stephen D'Amato. Pricing is not publicly disclosed — quotes are obtained through direct sales contact. Revenue is undisclosed. The product is positioned as a non-pharmaceutical alternative for drug-resistant chronic pain, with documented claims of relief extending from one to three months (and in some cases up to one year) following a standard 10–12 treatment cycle. Expansion direction is incremental: deepening the military/VA footprint, adding regional clinical and therapeutic channels in the U.S., and extending international reach through distributor partnerships rather than owned entities.

Name

Calmare Therapeutics

Legal name

Calmare Therapeutics Incorporated

Website

https://calmarett.com

Company type

Private

Founded year

2008

Operating status

Operating

Headcount range

1–10 employees

Short description

Calmare Therapeutics is a privately held medical device company that develops and sells the FDA 510(k)-cleared Calmare® MC-5A pain therapy device, a non-invasive biophysical hardware treatment for chronic neuropathic and cancer pain, serving U.S. healthcare providers, Military/VA facilities, and international distributors.

Ownership category

akta.pro rank

Product category

Pain Management Medical Devices

NAICS

Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)

SIC

Electromedical & Electrotherapeutic Apparatus (3845)

akta.pro primary industry

Rehabilitation Therapy Equipment (PT/OT Modalities, Exercise & Balance Devices) (HLAHAMAG)

akta.pro secondary industry

Posture, Musculoskeletal & Pain-Relief Devices (Posture Trainers, TENS/EMS, Massage Devices) (CRACAQAK)

Keywords

• Medical device manufacturing
• Chronic pain management
• Neuropathic pain therapy
• Scrambler therapy devices
• Non-invasive pain relief

Headquarters

HQ city

Fairfield

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Operations, Supply Chain, Marketing or Sales, Technology or R&D, Personnel

Revenue model

1. Medical Device Sales: Sale of Calmare® MC-5A pain therapy medical devices and accessories (electrodes, leadwires, carts) to healthcare providers, clinics, and facilities.

Go-to-market motion1 record

Distribution channels3 records

Marketing channels4 records

Core offering

Calmare Therapeutics designs, manufactures, and sells the Calmare® MC-5A Pain Therapy Medical Device, an FDA 510(k)-cleared and CE mark-certified hardware system that uses biophysical transdermal modulation to deliver a no-pain signal through surface electrodes for non-invasive treatment of chronic neuropathic and oncologic pain. The company sells the core MC-5A device together with a supporting accessory ecosystem (deluxe mobile cart, Axelgaard snap electrodes, and medical leadwires) to U.S. healthcare providers, U.S. Military and VA facilities, and international distributors.

Product overview

Calmare Therapeutics offers a single unified product—the Calmare® Pain Therapy Medical Device (MC-5A)—a non-invasive hardware device that uses biophysical transdermal modulation technology to treat chronic neuropathic and oncologic pain. The portfolio includes the core MC-5A device and a supporting ecosystem of accessories: the Deluxe Calmare Device Cart for mobility and storage, and a line of Axelgaard-branded snap electrodes (CTI3001 oval, CTI2020 square, CTI2040 rectangle) plus Medical Leadwire (MC-W73) for treatment delivery. The device is FDA 510(k)-cleared and CE mark-certified for clinical use.

Differentiator

Problem solved

Functional benefit

Products and services

• Calmare® Pain Therapy Medical Device (MC-5A) U.S. FDA 510(k)-cleared and European CE mark-certified non-invasive medical device for the treatment of chronic neuropathic and oncologic pain using biophysical transdermal modulation technology. Features five separate channels with dial selectors, channel meters, indicator lights, and an LCD display. Sold to healthcare providers, military and VA facilities, and international distributors.
• Deluxe Calmare Device Cart Premium medical cart with high-mobility castors, locking mechanism, and door-enclosure storage compartments designed to add mobility and storage to the Calmare Pain Therapy Medical Device.
• Axelgaard Little PALS® Snap Electrodes (CTI3001) Oval-shaped snap electrodes (0.9" x 1.1") designed for small contact areas such as fingers and toes, with semi-reusable functionality for moving during treatment sessions.
• Axelgaard UltraStim® Snap Electrodes (CTI2020) Square snap electrodes (2" x 2") with white fabric top, reusable over the typical 10-12 treatment regimen with enhanced distribution of electric current to eliminate hotspots.
• Axelgaard Snap Electrodes (CTI2040) Rectangle-shaped medical electrodes (2" x 4") for use with the Calmare device.
• Medical Leadwire (MC-W73) Snap-type lead wire with colored connectors for connecting electrodes to the Calmare device.

Quantifiable outcome

• Mean VAS score reduction for patients with VAS >7 on 0-10 scale; effects on monoradicular neuropathies can extend to greater than three months; pluriradicular neuropathy effects last one to three months
• +1 more outcomes

Named customers7 records

Segments3 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Partnerships

Two partnerships are on record, tiered core.

• InterWest Pain SolutionscoreChannel Partner/ Reseller/ DistributorRegional sales representative covering the Western Region (AK, AZ, CA, CO, HI, ID, MT, NM, NV, OR, UT, WA, WY) for Calmare device sales.
• Mediterranean for Integration and TechnologycoreChannel Partner/ Reseller/ DistributorInternational distributor for Middle East and North Africa region including Algeria, Bahrain, Egypt, Iraq, Jordan, Kuwait, Lebanon, Libya, Mauritania, Morocco, Oman, Qatar, Saudi Arabia, Tunisia, United Arab Emirates, and Yemen.

Scale indicators2 records

Recent moves6 records

Expansion highlights4 records

Market position

Weaknesses4 records

Competitive moat4 records

Key risks6 records

Key highlights6 records

Customer concentration

• Xx.com/CalmareCTTC
• Facebookfacebook.com/Calmaretherapeutics
• LinkedInlinkedin.com/company/10672822

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Calmare Therapeutics