What Mouse Metabolic Phenotyping Centers does

The National Mouse Metabolic Phenotyping Centers (MMPC-Live) is an NIDDK/NIH-funded research consortium operating through four regional academic medical centers — University of California Davis, University of Michigan Medical School, Vanderbilt University School of Medicine, and Yale University School of Medicine — with central coordination at Augusta University's Center for Biotechnology and Genomic Medicine and program oversight housed at the NIDDK offices in Bethesda. Established in 2001 and operating under RRID:SCR_008997, the consortium provides subsidized experimental phenotyping testing services on living mice to academic, institutional, and pharmaceutical researchers studying diabetes, obesity, diabetic complications, and related metabolic diseases.

The consortium's service portfolio spans six phenotyping categories — Endocrine, Cardiovascular, Energy Balance, Metabolism and Metabolomics, Gastrointestinal, and Analytical Resources and Histology — delivered through 100+ standardized protocols and supported by capital-intensive specialized equipment including CLAMS (Comprehensive Laboratory Animal Monitoring System), echocardiography, EchoMRI for body composition, and metabolic cages. Complementary offerings include a Protocols and Methods Library, a searchable MMPC Database compliant with the NIH Data Sharing and Management Policy 2022, the National MMPC Educational Portal (webinars, tracers training, glucose clamping courses), and integration with the CalR indirect calorimetry analysis tool.

MMPC-Live does not operate a commercial revenue model; it functions as a federally subsidized cost-recovery resource where researchers apply for services through a centralized online catalog and decision tree, receive pricing through the order process, and acknowledge NIDDK grant support (DK135044 consortium-wide; DK135074, DK135066, DK135073, DK134901 center-specific) in resulting publications. The go-to-market motion is essentially direct sales through each of the four regional centers, supplemented by webinars, scientific publications, and a presence on Twitter/X and BlueSky.

Name

Mouse Metabolic Phenotyping Centers

Legal name

National Mouse Metabolic Phenotyping Centers (MMPC-Live)

Website

https://mmpc.org

Company type

Private

Founded year

2001

Operating status

Operating

Headcount range

51–100 employees

Short description

The National Mouse Metabolic Phenotyping Centers (MMPC-Live) is an NIDDK/NIH-funded consortium of four academic medical centers providing subsidized metabolic phenotyping testing services on living mice to researchers studying diabetes, obesity, and related metabolic diseases.

Ownership category

akta.pro rank

Product category

Preclinical Research Services

NAICS

Medical Laboratories (621511), Research and Development in Biotechnology (except Nanobiotechnology) (541714)

SIC

Services-Medical Laboratories (8071), Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Metabolomics & Lipidomics Services (HLAGANAG)

Keywords

• Metabolic phenotyping services
• Mouse disease models
• Preclinical research services
• Diabetes obesity research
• Academic research consortium

Headquarters

HQ city

Bethesda

HQ country

United States

HQ region

North America

Offices6 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure

Revenue model

1. Subsidized Testing Services: NIH/NIDDK-sponsored resource providing subsidized experimental testing services on living mice to researchers. Services are subsidized rather than fully funded, suggesting a cost-recovery or subsidized pricing model for qualified researchers.

Pricing tiers

Go-to-market motion1 record

Distribution channels4 records

Marketing channels4 records

Core offering

The National Mouse Metabolic Phenotyping Centers (MMPC-Live) is an NIDDK-funded consortium of four regional centers (UC Davis, University of Michigan, Vanderbilt, Yale) coordinated through Augusta University that provides subsidized experimental phenotyping testing services on living mice to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases. Services span six categories: endocrine, cardiovascular, energy balance, metabolism and metabolomics, gastrointestinal, and analytical resources/histology, supported by standardized protocols, an educational portal, and a shared data repository compliant with NIH data sharing policy.

Product overview

The National Mouse Metabolic Phenotyping Centers (MMPC-Live) is a unified consortium of four NIH NIDDK-sponsored centers at UC Davis, University of Michigan, Vanderbilt University, and Yale University. The organization provides a coordinated portfolio of subsidized mouse phenotyping services, protocols, and data resources for researchers studying diabetes, obesity, diabetic complications, and metabolic diseases. Core offerings include metabolic phenotyping tests across six service categories (Endocrine, Cardiovascular, Energy Balance, Metabolism/Metabolomics, Gastrointestinal, and Analytical/Histology), supported by a standardized Protocols and Methods Library. The consortium also provides training through its Educational Portal and webinars, data access through searchable databases, and analysis tools including links to CalR for indirect calorimetry.

Differentiator

Problem solved

Functional benefit

Products and services

• Endocrine Phenotyping Testing Phenotyping tests covering diabetes, insulin and insulin function, pancreas/islets/beta cells, and hormone measurements, provided to researchers studying metabolic diseases.
• Cardiovascular Phenotyping Testing Phenotyping tests covering basic vitals, circulation, microvascular complications, blood count/chemistry, cardiac function, infusion/blood sampling, diabetes, and vascular function.
• Energy Balance Phenotyping Testing Tests covering body composition, energetics, obesity, carbohydrate metabolism, food/water intake, pancreas function, and diabetes in mouse models.
• Metabolism and Metabolomics Phenotyping Testing Tests covering amino acid metabolism, diabetes, lipid metabolism, obesity, carbohydrate metabolism, energy expenditure and exercise, and metabolite concentration and enrichment analyses.
• Gastrointestinal Phenotyping Testing Tests covering bariatric surgery, microbiota/microbiome analysis, and gastrointestinal surgery in mouse models.
• Analytical Resources and Histology Services Histology services including tissue sample preparation, pathology, immunohistochemistry, and specialized staining protocols, covering amino acid metabolism, hormone measurements, blood count/chemistry, lipid metabolism, and carbohydrate metabolism assays.
• Protocols and Methods Library A comprehensive library of standardized phenotyping protocols including breeding, diabetes induction, dissection, phenotype assays, staining, and surgical techniques used across MMPC centers.
• MMPC Educational Portal and Webinars Educational resources and training portal including webinars on tracers in metabolic research, isotope tracers, glucose clamping techniques, and an Education Portal for rigor and reproducibility.
• MMPC Data Search Searchable database of MMPC phenotyping data, histology images, IMPC/KOMP data, phenotype assays, and strain information, accessible per NIH Data Sharing and Management Policy 2022.

Quantifiable outcome

• Access to subsidized metabolic phenotyping services at 4 major research universities

Named customers1 record

Segments2 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Scale indicators3 records

Recent moves6 records

Expansion highlights4 records

Broad incumbents

• Crown Bioscience: Global preclinical CRO with oncology and metabolic disease in vivo services including mouse phenotyping. Overlaps with MMPC in metabolic disease drug discovery workflows, though scaled to commercial pharma clients rather than NIH-subsidized academic demand.
• The Jackson Laboratory (JAX): The leading nonprofit mouse-model and mouse-research-services organization, with deep expertise in metabolic phenotyping and a services arm that competes for similar academic and pharma mouse-research customers. Operates at a much larger scale than MMPC but overlaps on phenotyping services and educational resources.
• Charles River Laboratories: Large publicly-traded preclinical CRO offering animal model services, including metabolic and cardiovascular phenotyping. Competes with MMPC for pharma-sponsored metabolic research dollars, although MMPC's NIH-subsidized model targets a different (academic) segment.
• Inotiv: Preclinical research services provider (formerly Envigo/Harlan) offering animal model services, metabolic phenotyping, and contract research. Comparable commercial counterpart offering rat and mouse phenotyping services to academic and pharma clients.

Direct peers

• International Mouse Phenotyping Consortium (IMPC): International consortium conducting large-scale mouse phenotyping across multiple institutions, directly linked from the MMPC homepage. Operates the same core mission of standardized, systemic mouse phenotyping for the research community and serves as the global counterpart to MMPC's U.S.-focused effort.
• Taconic Biosciences: Commercial provider of genetically engineered mouse models and associated phenotyping services for biomedical research. Highly comparable in target customer (academic and pharma metabolic researchers) and core offering (mouse research services).
• Mutant Mouse Resource and Research Center (MMRRC): NIH-supported national repository and distribution network for mutant mouse lines, directly linked from the MMPC homepage. Provides adjacent infrastructure for the same mouse-research community, including strain repositories used by MMPC customers for phenotyping studies.

Emerging players

• KOMP Repository / KOMP2: NIH-funded program creating and distributing knockout mouse strains for phenotyping and disease modeling; data and strain resources are referenced from the MMPC website. Operates as an upstream complement to MMPC's downstream phenotyping services.
• Cyagen Biosciences: Provider of custom mouse/rat model generation and phenotyping services with strong presence in academic markets. Comparable in offering standardized phenotyping readouts, though primarily commercial rather than NIH-funded.

Regional players

• European Mouse Mutant Archive (EMMA / Infrafrontier): European infrastructure for mouse archiving, distribution, and standardized phenotyping. Operates a highly comparable public-funded phenotyping model in EMEA, parallel to MMPC's U.S. role, and a natural counterpart for international collaboration.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xx.com/nationalmmpc
• LinkedInlinkedin.com/company/mouse-metabolic-phenotyping-centers-mmpc

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Subsidiaries5 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Mouse Metabolic Phenotyping Centers