Kress Works Institute
Kress Works Institute is a 501(c)(3) nonprofit scientific research organization founded in 2010 that applies systems engineering, molecular dynamics, and quantum chemistry to develop a patient-specific methodology for the systematic treatment of Ewing's Sarcoma, intended to extend to other cancers.
- Company typePrivate
- Founded2010
- HeadquartersNorthville, United States
- Headcount1–10
- GTM typeB2B
- OfferingServices
What Kress Works Institute does
Kress Works Institute (also known as The KressWorks Foundation) is a 501(c)(3) nonprofit scientific research corporation founded in 2010 by Dr. James Kress in Northville, Michigan, focused on developing a systems-engineering approach to cancer treatment. The organization's primary current project is a patient-specific, whole-body, multi-compartment methodology for the systematic treatment of Ewing's Sarcoma, intended to be extensible to other cancers and diseases. The core technology stack combines computational modeling, molecular dynamics (GROMACS, ReaxFF), quantum chemistry (Firefly), and multi-omic integration to characterize cancer as a complex, dynamic, evolving system — formalized in the co-invented Systematic Treatment Methodology (STM) covered by U.S. Provisional Patent Application No. 62/215,353 (2015).
The institute's outputs are research outputs and educational content rather than commercial products. It does not sell products or services; all funding derives from donations, corporate matching programs, memorial gifts, planned giving, and bequests. Distribution of the scientific approach occurs through the kressworks.org website, blog posts, earned media coverage in Detroit-area publications, radio interviews, and community fundraising events. A Technical Advisory Board drawn from Wayne State University, Penn State, Moscow State University (Firefly Project), and Children's Hospital of Philadelphia provides domain expertise in systems biology, quantum physics, reactive force fields, and pediatric oncology. Partnerships include an unnamed external Systems Biology firm for PK/PD and PBPK modeling, and minor alternative-giving channel relationships with Amazon Smile and iGive.
The organization is founder-led, with Dr. James Kress as Founder and Dr. James Bosley as General Manager/Principal, supported by a small governing board and technical advisory board. Strategic positioning centers on being the first to deliver an integrated, mechanistic, systematic treatment framework for Ewing Sarcoma — contrasting explicitly with the prevailing "art-based" oncological approach. Operational scale is minimal (1-10 employees), and there is no documented revenue, no recent fundraising milestones, and no commercialization pathway articulated in the source material, framing the institute as a research venture operating at the proof-of-concept stage.
Kress Works Institute firmographics
Firmographics- Name
- Kress Works Institute
- Legal name
- The KressWorks Institute
- Website
- https://kressworks.org
- Company type
- Private
- Founded year
- 2010
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Short description
- Kress Works Institute is a 501(c)(3) nonprofit scientific research organization founded in 2010 that applies systems engineering, molecular dynamics, and quantum chemistry to develop a patient-specific methodology for the systematic treatment of Ewing's Sarcoma, intended to extend to other cancers.
- Ownership category
- akta.pro rank
Kress Works Institute industry classification
Industry- Product category
- Cancer Research
- NAICS
- Research and Development in the Physical, Engineering, and Life Sciences (54171), Research and Development in Biotechnology (except Nanobiotechnology) (541714)
- SIC
- Services-Commercial Physical & Biological Research (8731)
- akta.pro primary industry
- Oncology Pathways & Precision Medicine Decision Support (HLACAGAH)
Keywords
Where Kress Works Institute is headquartered
LocationHeadquarters
- HQ city
- Northville
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Kress Works Institute business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Technology or R&D, Operations, Marketing or Sales
Revenue model
- Donations and Charitable Contributions: The organization operates as a 501(c)(3) nonprofit corporation that raises funds through individual donations, corporate matching programs, memorial gifts, planned giving, and bequests. Revenue is used entirely to fund cancer research activities.
Go-to-market motion1 record
Distribution channels1 record
Marketing channels4 records
Kress Works Institute product offering
Product offeringCore offering
KressWorks Institute is a charitable 501(c)(3) nonprofit scientific research corporation that applies Systems Engineering and Systems Biology approaches to cancer research, with a primary current project focused on developing a patient-specific methodology for the systematic treatment of Ewing's Sarcoma. The organization combines computational modeling, molecular dynamics, quantum chemistry, and multi-omic analysis to develop systematic cancer treatment methodologies, with outputs consisting of research findings, treatment methodologies, and scientific publications rather than commercial products.
Product overview
KressWorks Institute is a charitable 501(c)(3) nonprofit scientific research corporation focused on cancer research, specifically Ewing's Sarcoma. The organization applies Systems Engineering and computational methods to develop the Systematic Treatment Methodology (STM) for systematic cancer treatment. Rather than offering commercial products or services, the institute conducts foundational research in computational chemistry, molecular dynamics, quantum chemistry, and systems biology to advance understanding of cancer mechanisms and develop treatment approaches.
Differentiator
Problem solved
Functional benefit
Products and services
- Systematic Treatment Methodology (STM) Research Patient-specific systematic cancer treatment methodology that characterizes cancers as complex, dynamic and evolving systems, consolidates fragmented science to make the human body work in its own favor, and facilitates methodical and personalized treatments and cures. Developed for healthcare providers and pharmaceutical researchers treating cancer patients.
- Reactive Force Field Method for Nucleic Acid Analysis Computational method for predicting break points in DNA using Reactive Force Field Molecular Dynamics, enabling identification of diseases or disorders based on calculated break point locations. Intended for pharmaceutical and biomedical researchers.
- Ewing Sarcoma Disease Progression Model (DPM) First integrated, detailed, systemic mechanistic computational representation of Ewing Sarcoma providing patient-specific methodology for systematic treatment, biomarker identification, and drug repurposing/development. Designed for clinicians, healthcare providers, and pharmaceutical researchers working on pediatric cancer treatment.
Quantifiable outcome
- Facilitate early diagnosis allowing shift from disease treatment to disease prevention
- +2 more outcomes
Companies that use Kress Works Institute
Customer profileSegments3 records
Ideal customer profiles2 records
Kress Works Institute technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature7 records
Kress Works Institute partnerships and signals
Strategic signalPartnerships
Eight partnerships are on record, tiered core and minor.
- External Systems Biology Firm (unnamed)coreWorking with an external, well known Systems Biology firm with extensive expertise in the application of methodologies such as PK/PD, PBPK and other Biophysical/Biochemical modeling and simulation techniques necessary to complete the development and begin implementation of the whole body, multi-compartment, patient specific methodology for the systematic treatment of Ewing's Sarcoma. This methodology will be extensible to treatment of many other forms of cancer and other diseases.
- Dr. Alexander A. Granovsky - Firefly Project/Moscow State UniversitycoreTechnical Advisory Board member providing world recognized expertise in Quantum Physics, Biotechnology and Computational Chemistry, particularly applications to physical chemical/ biological/ biochemical systems. Firefly quantum chemistry tool is a key software platform used by the institute.
- Dr. Sorin Draghici - Wayne State UniversitycoreTechnical Advisory Board member holding Robert J. Sokol MD Endowed Chair in Systems Biology. Head of Intelligent Systems and Bioinformatics Laboratory. Provides expertise in Systems Biology and bioinformatics for the research approach.
- Dr. Adri van Duin - Pennsylvania State UniversitycoreTechnical Advisory Board member providing world class expertise in Kinetics, chemical reaction network and mechanism analysis, and Atomistic and Molecular computer simulations of chemical reaction systems. Development and application of reactive force fields (ReaxFF).
- Dr. Patrick J. Grohar - Children's Hospital of PhiladelphiacoreTechnical Advisory Board member, attending physician with Cancer Center and Director of Translational Research with Center of Childhood Cancer Research. Member of Children's Oncology Bone Tumor Steering Committee and vice-chair of Ewing Sarcoma Biology Committee of Children's Oncology Group.
- Clermont, Bosley LLC (Dr. James Bosley)coreGoverning Board member providing expertise in pharmaceutical research productivity through pioneering use of mechanistic computer models of disease and drug action. Co-inventor of Systematic Treatment Methodology. Previous clients include Pfizer and Merck.
- Amazon Smile ProgramminorDonations can be made through Amazon Smile Program as an alternative giving option.
- iGive ProgramminorDonations can be made through iGive Program as an alternative giving option for supporters.
Scale indicators3 records
Recent moves7 records
Expansion highlights4 records
Kress Works Institute competitors and assessment
Company assessmentBroad incumbents
- Foundation Medicine: Molecular profiling company (Roche subsidiary) that uses genomic and other omic data to inform personalized cancer treatment, addressing overlapping precision-oncology goals as KressWorks' STM.
- Tempus Labs: Precision medicine company building data libraries and computational models to enable personalized oncology treatment, addressing the same clinical gap KressWorks targets but at vastly greater scale.
- Schrödinger, Inc. Public computational chemistry and molecular simulation company that uses physics-based modeling (including quantum chemistry and molecular dynamics) for drug discovery. Directly comparable technology stack and precision-medicine angle, but commercial and far larger scale.
Emerging players
- Insilico Medicine: AI-driven drug discovery company applying computational biology and chemistry pipelines to oncology and other diseases, using systematic, model-driven approaches paralleling KressWorks' STM philosophy.
- GNS Healthcare: Precision medicine company using causal AI and multi-omic integration to model disease biology and predict treatment response in oncology, overlapping with KressWorks' multi-omic, patient-specific modeling approach.
- Recursion Pharmaceuticals: AI-driven drug discovery company combining high-throughput biology with computational modeling to systematically map disease biology, conceptually adjacent to KressWorks' systems-engineering approach to cancer.
Direct peers
- Institute for Systems Biology: Nonprofit research organization applying systems biology approaches to disease, including cancer. Most directly comparable to KressWorks given shared nonprofit structure and systems-level biological research mission.
- Sage Bionetworks: Nonprofit biomedical research organization focused on computational biology, multi-omic data integration, and open-science approaches to disease, mirroring KressWorks' multi-omic systems methodology.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat3 records
Key risks5 records
Key highlights6 records
Customer concentration
Kress Works Institute social profiles
Digital presenceKress Works Institute financial estimates
Financial estimateRevenue estimate
Valuation estimate
Kress Works Institute leadership team
Management profileNumber of profiles
Profiles9 records
Kress Works Institute funding detail
Funding detailFunding overview
Funding rounds
Investors
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Kress Works Institute M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Kress Works Institute
What does Kress Works Institute do?
KressWorks Institute is a charitable 501(c)(3) nonprofit scientific research corporation that applies Systems Engineering and Systems Biology approaches to cancer research, with a primary current project focused on developing a patient-specific methodology for the systematic treatment of Ewing's Sarcoma. The organization combines computational modeling, molecular dynamics, quantum chemistry, and multi-omic analysis to develop systematic cancer treatment methodologies, with outputs consisting of research findings, treatment methodologies, and scientific publications rather than commercial products.
Is Kress Works Institute a public or private company?
Kress Works Institute is a private company. It is classified as nonprofit foundation owned and is currently operating.
When was Kress Works Institute founded?
Kress Works Institute was founded in 2010. It employs 1 to 10 people.
Where is Kress Works Institute based?
Kress Works Institute is headquartered in Northville, United States, in the North America region.
How does Kress Works Institute make money?
One revenue line is on record: donations and Charitable Contributions.
Who are Kress Works Institute's main competitors?
Broad incumbents on record are Foundation Medicine, Tempus Labs and Schrödinger, Inc.. Emerging players are Insilico Medicine, GNS Healthcare and Recursion Pharmaceuticals. Direct peers are Institute for Systems Biology and Sage Bionetworks.
Does Kress Works Institute have an API?
No public API is recorded for Kress Works Institute.
What industry is Kress Works Institute in?
Kress Works Institute's product category is Cancer Research. Its primary akta.pro industry code is HLACAGAH, Oncology Pathways & Precision Medicine Decision Support. Its NAICS code is 54171 and its SIC code is 8731.