What Technobis Crystallization Systems does

Technobis Crystallization Systems B.V. (operating under Technobis Group B.V.) is a privately held Dutch laboratory instrumentation company headquartered in Alkmaar, Netherlands, founded in 2005 (as Avantium Crystallization Systems, acquired by Technobis BV in January 2015). The company designs, manufactures, and sells high-throughput parallel crystallizers and multi-reactor systems used in pharmaceutical and chemical research laboratories worldwide, with a stated installed base in "nearly every pharmaceutical research lab." Its core crystallization portfolio comprises CrystalBreeder (1 mg-scale discovery/development screens), Crystal16 (1 mL parallel reactors for solubility, solid-state, and process development work), and Crystalline (2.5–5 mL analytical instrument with eight in-line microscopic cameras). In 2024 the company expanded beyond crystallization into chemical process R&D with the launch of ReactALL, a five-reactor platform with overhead stirring and automated sampling, followed by the 2025 launch of DoseALL, an automated multi-syringe dosing module. Proprietary enabling technologies include SmartCap septum-free sampling and Thermopile contactless temperature control. Revenue is generated through capital instrument sales, recurring consumables, and Field Service Engineer-led technical support, installation, and maintenance contracts. Go-to-market combines five-region direct enterprise sales (USA West, USA East, UK/Ireland/Nordics/Benelux, EU West/DACHI, Eastern Europe/ME/LA/Asia) with a global distributor network, supported by an active program of webinars, publications, conferences, and customer workshops. Named customers span the largest global pharmaceutical companies (Merck, Pfizer, Novartis, GSK, AstraZeneca, Bayer, AbbVie, Eli Lilly, BMS, Boehringer Ingelheim, MSD, Takeda, Janssen, Sanofi, Novo Nordisk), leading CDMOs (Ardena, Hovione, CARBOGEN AMCIS, Veranova, Dr. Reddy's), agrochemical and industrial players (Corteva, ADM, Stora Enso), biotech (Amgen), and academic institutions (MIT, CMAC).

Name

Technobis Crystallization Systems

Legal name

Technobis Crystallization Systems B.V.

Website

https://crystallizationsystems.com

Company type

Private

Founded year

2005

Operating status

Operating

Headcount range

11–50 employees

Short description

Technobis Crystallization Systems is a Dutch laboratory instrumentation company that designs and sells high-throughput parallel crystallizers and multi-reactor systems (CrystalBreeder, Crystal16, Crystalline, ReactALL, DoseALL) for pharmaceutical, agrochemical, fine chemical, and academic research laboratories worldwide.

Ownership category

akta.pro rank

Headquarters

HQ city

Alkmaar

HQ country

Netherlands

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Supply Chain, Technology or R&D, Operations, Marketing or Sales

Revenue model

1. Laboratory Instrumentation Sales: Sale of high-tech laboratory instruments including CrystalBreeder, Crystal16, Crystalline, ReactALL, and DoseALL systems to pharmaceutical, chemical, and research organizations.
2. Technical Support & Maintenance Services: Technical product support including preventive maintenance, repairs, installation, and commissioning services provided by Field Service Engineers. Service contracts and SOPs offered.
3. Consumables: Sale of consumables for ReactALL and other instruments including syringes and specialized components listed in ReactALL consumables overview.

Go-to-market motion3 records

Distribution channels3 records

Marketing channels7 records

Core offering

Technobis Crystallization Systems designs, manufactures, and sells laboratory-scale crystallization and solid-state research instruments. Its product family of parallel crystallizers, reaction blocks, and dosing modules is used by pharmaceutical, agrochemical, fine chemical, and academic laboratories to perform polymorph screening, solubility studies, and reaction-screening experiments.

Product overview

Technobis Crystallization Systems offers a unified portfolio of laboratory technology spanning crystallization research and chemical process R&D. The crystallization R&D portfolio includes three core instruments: CrystalBreeder (for discovery and development crystallization screens using minimal sample), Crystal16 (parallel crystallizer for solubility and solid-state research at 1 mL scale), and Crystalline (analytical instrument with in-line microscopy for 2.5-5 mL scale). The chemical process R&D portfolio centers on ReactALL (multiple reactor system with automated sampling and overhead stirring for reaction screening and optimization). The DoseALL automated dosing module serves as an add-on to ReactALL, providing precision liquid handling. Together, these products enable scientists to perform controlled crystallization studies from hit identification through process scale-up and formulation development.

Differentiator

Problem solved

Functional benefit

Brands

• CrystalBreeder™: First crystallizer dedicated to both development and discovery, carrying out complete crystallization screens with as little as 1 mg of sample
• Crystal16®
• Crystalline™
• ReactALL™
• DoseALL™

Products and services

• CrystalBreeder A laboratory crystallization instrument used by pharmaceutical, agrochemical, fine chemical, and academic researchers to perform parallel crystallization experiments under controlled temperature and stirring conditions.
• Crystal16 A parallel crystallization platform used by industrial and academic laboratories to screen solubility and crystallization conditions across multiple samples simultaneously.
• Crystalline A solid-state research instrument used by pharmaceutical and chemical R&D labs for solid-form and crystallization studies at laboratory scale.
• ReactALL A parallel reaction platform used by chemists to screen and run multiple laboratory-scale reactions under controlled conditions in parallel.
• DoseALL An automated dosing module used to deliver precise quantities of reagents or solvents during laboratory crystallization and reaction workflows.

Quantifiable outcome

• ReactALL reduces material consumption by more than tenfold compared to conventional laboratory reactors while producing consistent datasets
• +2 more outcomes

Named customers26 records

Segments8 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature9 records

Partnerships

One partnership is on record.

• oneservicecoreStrategic or Co-development Partner · 1 January 2025Technobis partnered with oneservice to deliver enhanced customer support, expanding the partnership from the United States to Europe. This service partnership provides unified customer experience across US and European markets, offering preventive maintenance, repairs, and technical support through oneservice's service network.

Scale indicators4 records

Recent moves7 records

Expansion highlights6 records

Direct peers

• Hamilton Company: Manufacturer of precision laboratory automation, liquid handling, and process analytics products. Overlaps with Technobis in automated sampling, dosing, and parallel reactor workflows for pharmaceutical and chemical process R&D.
• Asynt: Provider of laboratory-scale reactors, parallel reaction blocks, and crystallization tools for chemistry R&D. Comparable in scale and product category to Technobis, with overlapping chemistry and pharmaceutical process development customers.
• Syrris (Blacktrace): Specialty manufacturer of flow chemistry and batch reactor systems (e.g., Atlas, Orb, Asia) for reaction screening, optimization, and process development. Directly comparable to Technobis's ReactALL multi-reactor platform in the same pharmaceutical and fine chemical R&D customer base.
• HEL Group: UK-based manufacturer of reaction calorimetry, crystallization, and process safety instrumentation (e.g., CrystalSCAN, PolBlock) targeting the same pharmaceutical process development and solid-form screening workflows served by Crystal16 and Crystalline.
• Unchained Labs: Specialty lab instrument company focused on biologics, formulation, and process development tools. Its portfolio of stability, particle characterization, and formulation instruments targets the same pharmaceutical formulation and solid-form screening workflows that Technobis addresses with Crystal16, CrystalBreeder, and Crystalline.

Broad incumbents

• IKA Works: Manufacturer of laboratory, processing, and analytical equipment including reactors, mixers, and process tools used in chemistry R&D. Broad incumbent that competes with Technobis in reactor and process development equipment sales to chemical and pharmaceutical labs.
• Mettler Toledo: Global leader in precision instruments including laboratory balances, titration, and reaction/process analytics that overlap with Technobis's crystallization and reaction monitoring use cases. A much larger, diversified incumbent serving similar pharma and chemical R&D customers.
• Bruker: Diversified scientific instrument manufacturer offering X-ray diffraction, NMR, and solid-state characterization solutions that compete at the analytical layer with Technobis's Crystalline in-line imaging and Crystal16 solid-state research workflows.
• Corning Advanced Flow Reactors: Business unit of Corning providing continuous flow reactor systems for pharmaceutical and fine chemical process development. Adjacent to ReactALL's batch-reactor workflow, with overlap in the same pharmaceutical process development customer base.

Emerging players

• ThalesNano: Specialty provider of flow chemistry and automated reaction screening systems for pharmaceutical process R&D. Comparable in workflow (reaction screening, optimization) and customer base to Technobis's ReactALL offering, though with a stronger flow-chemistry focus.

Market position

Strengths4 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/crystallizationsystems
• Facebookfacebook.com/TechnobisCrystallizationSystems

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Technobis Crystallization Systems