Genomic Medicine Institute

What Genomic Medicine Institute does

The Genomic Medicine Institute is a translational and clinical human genetics and genomics research department within Cleveland Clinic's Lerner Research Institute, headquartered at 9500 Euclid Avenue, Cleveland, Ohio. It conducts bench-to-bedside investigation across brain, cancer, heart and blood vessels, inflammation, and systems biology and bioinformatics, organized through individual labs such as the Feixiong Cheng Lab (network medicine and drug target identification), the Ignacio Mata Lab (Parkinson's disease genetics in Latino populations), and the Mihriban Karaayvaz Lab (breast cancer therapeutic vulnerabilities). It operates a portfolio of fee-for-service cores accessible globally via the iLab (Agilent) request portal, including SomaScan 7k and 11k Proteomic Platforms (the only such facility in Northeast Ohio), the Genomics core, the Genomic Medicine Institute Biorepository, and the CITI Computational Oncology Platform and Discovery Lab (HLA/TCR sequencing, bulk and single-cell RNA-seq, neoantigen screening). It also delivers clinical care through the Center for Personalized Genetic Healthcare.

Its core technology stack is a layered platform-plus-modules architecture: a translational genomics foundation anchored in proprietary analytical methods (GenT, a gene-level AI method for drug development; a network-medicine and systems-biology framework), supported by a clinical-genomic data infrastructure (MaGiC data warehouse, CCF cBioPortal, IOExplorer immunogenomics platform) that integrates internal sources (PLMI, Taussig Cancer Institute, Enterprise Analytics) with external panel providers (Tempus, Caris). Recent moves include the launch of GenT, expansion of IBM Quantum-based drug design work, and integration into the $500M Cleveland Innovation District (Global Center for Pathogen and Human Health Research).

The institute's revenue model is institutional rather than commercial. Research funding flows through Cleveland Clinic Research's $479M annual envelope (2025) across 236 labs and 2,400+ caregivers, sourced from federal agencies (NIH, DoD, NSF, AHRQ), foundations (AHA, PCORI), and state co-investment ($200M from JobsOhio plus $300M from Cleveland Clinic). Secondary revenue streams include usage-based core service fees through iLab, industry-sponsored bioinformatics and immuno-sequencing work, and technology commercialization via Cleveland Clinic Innovations (licensing and royalties). Customer segments span Cleveland Clinic investigators, external academic and clinical researchers, industry/pharma collaborators, patients of the Center for Personalized Genetic Healthcare, research participants/donors (including under-represented populations), and trainees from high school through postdoctoral levels.

Name

Genomic Medicine Institute

Legal name

Cleveland Clinic (Genomic Medicine Institute operates as a department within Cleveland Clinic)

Website

https://lerner.ccf.org

Company type

Private

Founded year

1921

Operating status

Operating

Headcount range

5,001–10,000 employees

Short description

The Genomic Medicine Institute is a translational and clinical human genetics and genomics research department within Cleveland Clinic's Lerner Research Institute, operating SomaScan proteomics, biorepository, and computational oncology cores, conducting disease-focused research across brain, cancer, cardiovascular, and inflammation, and delivering personalized genetic healthcare through the Center for Personalized Genetic Healthcare.

Ownership category

akta.pro rank

Product category

Genomics Research Services

NAICS

Medical Laboratories (621511)

SIC

Services-Medical Laboratories (8071)

akta.pro primary industry

Molecular Diagnostics & Genomics Laboratories (HLAFAMAE)

akta.pro secondary industries

Genomics & Molecular Diagnostics (Trial Support) (HLAGAEAD), Genetic & Genomic Testing (germline, somatic, carrier, pharmacogenomics) (HLAAALAD), Transcriptomics & Gene Expression Profiling Services (HLAGANAE)

Keywords

• Translational genomics research
• Clinical genetics services
• Proteomics core services
• Biorepository research
• Precision medicine

Headquarters

HQ city

Cleveland

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Supply Chain

Revenue model

1. Research grants and extramural funding: $479M annual research funding (2025) flowing through 236 labs at Cleveland Clinic Research, sourced from federal agencies (NIH, DoD, NSF, AHRQ), foundations (AHA, PCORI), and internal funding programs. Since 2018 the Office of Research Development has supported 425+ grant submissions and 110+ grant awards totaling $490M+.
2. State economic development co-investment: $200M from Ohio/JobsOhio plus $300M co-invested by Cleveland Clinic funds the Global Center for Pathogen & Human Health Research under the Cleveland Innovation District initiative, supporting Genomics-relevant research infrastructure.
3. Core service fees (fee-for-service): Cores and platforms charge for services through iLab (Agilent), including 3D Printing, Bioimage Analysis, BioRobotics, SomaScan & Biomarker, Genomics, Computational Oncology Platform, and the Genomic Medicine Institute Biorepository.
4. Technology commercialization and licensing: Cleveland Clinic Innovations, the commercialization arm, helps departments patent and commercialize therapies; Biomedical Engineering has a proven track record of patenting and product commercialization in cardiology, urology and neurology.
5. Industry-sponsored core services: CITI Computational Oncology Platform and Discovery Lab provide bioinformatics and immuno-sequencing services to academic, clinical and industry partners, including neoantigen screening, HLA/TCR sequencing, and bulk/single-cell RNA-seq analysis.

Pricing tiers

Go-to-market motion1 record

Distribution channels5 records

Marketing channels6 records

Core offering

The Genomic Medicine Institute is a translational and clinical human genetics and genomics research department within Cleveland Clinic's Lerner Research Institute that delivers research services, advanced proteomics and genomics core capabilities, biorepository access, and personalized genetic healthcare. It operates fee-for-service cores including SomaScan & Biomarker, the Genomic Medicine Institute Biorepository, Genomics, and the CITI Computational Oncology Platform, and partners with industry and academic collaborators on drug target identification and biomarker discovery.

Product overview

The Genomic Medicine Institute is a single unified department within Cleveland Clinic Research whose offering is a platform-plus-modules architecture: a translational and clinical human genetics and genomics research core anchored by the SomaScan & Biomarker Core Services (powered by SomaLogic's SomaScan 7k and 11k Proteomic Platforms) and the Genomic Medicine Institute Biorepository, combined with the Center for Personalized Genetic Healthcare clinical program and a portfolio of thematic research programs (Brain, Cancer, Heart & Blood Vessels, Inflammation, and Systems Biology & Bioinformatics) delivered through individual labs such as the Feixiong Cheng Lab, Ignacio Mata Lab, and Mihriban Karaayvaz Lab.

Differentiator

Problem solved

Functional benefit

Brands

• Center for Personalized Genetic Healthcare: Clinical care arm affiliated with the Genomic Medicine Institute that centers treatment around each patient's unique genetic profile and its impact on them and their family.
• Genomic Medicine Institute Biorepository

Products and services

• SomaScan & Biomarker Core Services

Quantifiable outcome

• Only facility in Northeast offering SomaScan 7k and 11k Proteomic Platforms
• +3 more outcomes

Named customers8 records

Segments6 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability4 records

Feature8 records

Partnerships

15 partnerships are on record, tiered core, flagship and moderate.

• SomaLogiccoreTechnology or IntegrationProvider of the advanced SomaScan 7k and 11k Proteomic Platforms operated by the Genomic Medicine Institute. The Institute is the only facility in Northeast offering these targeted proteomics assays for biomarker discovery. Service access is via the SomaScan & Biomarker Core (lerner.ccf.org/cores/somascan-biomarker/).
• Center for Personalized Genetic Healthcare (Cleveland Clinic)flagshipStrategic or Co-development PartnerCleveland Clinic's clinical counterpart that delivers treatment centered around each patient's unique genetic profile. The Genomic Medicine Institute's translational research directly informs the Center's clinical genetic services and patient care.
• Kent State UniversitymoderateStrategic or Co-development PartnerCo-developed a quantum-computing-based drug design method with Cleveland Clinic researchers that outperforms classical computing methods for drug design, leveraging Kent State's computational students and faculty.
• Cleveland Clinic Genome CenterflagshipStrategic or Co-development PartnerConnects Cleveland Clinic experts from multiple fields to develop advanced genomic technologies and computational tools. Projects span global collaborations to study interconnected ways genomes determine human health and disease.
• Memorial Sloan Kettering Cancer CentercoreTechnology or IntegrationCo-developed cBioPortal, the open-source interactive cancer genomics web app used at Cleveland Clinic (CCF cBioPortal) and other major cancer centers. The platform supports genomics reporting for ordering clinicians and scalable genomics research.
• Case Western Reserve UniversityflagshipStrategic or Co-development PartnerLong-standing academic partner in the Clinical & Translational Science Collaborative of Cleveland (CTSC), the Molecular Medicine PhD Program, and the Case Comprehensive Cancer Center (NIH P30 CA43703 shared resources).
• MetroHealthmoderateStrategic or Co-development PartnerPartner in the Clinical & Translational Science Collaborative of Cleveland (CTSC), a catalyst for high-quality clinical and translational research locally and nationally.
• University HospitalsmoderateStrategic or Co-development PartnerPartner in the Clinical & Translational Science Collaborative of Cleveland (CTSC), supporting joint clinical and translational research.
• Louis Stokes Veterans Administration Medical CentermoderateStrategic or Co-development PartnerPartner in the Clinical & Translational Science Collaborative of Cleveland (CTSC), enabling joint clinical and translational research with the VA system.
• Case Comprehensive Cancer CentercoreStrategic or Co-development PartnerNIH-funded cancer center partnership (P30 CA43703) whose Shared Laboratory Resources complement Cleveland Clinic Research's Genomics, Imaging, and Proteomics & Metabolomics Cores, offering technologies and services beyond those available at Cleveland Clinic.
• IBMcoreTechnology or IntegrationCollaborated with Cleveland Clinic to develop an AI-powered solution that improves reproducibility in cell culturing, and provides access to the IBM Quantum System One for Cleveland Clinic's quantum computing research relevant to genomics and drug design.
• St. Jude Children's Research HospitalmoderateStrategic or Co-development PartnerResearch collaboration that identified SMARCAL1 as a risk gene for childhood osteosarcoma, by looking beyond known cancer genes.
• Taussig Cancer Institute (Cleveland Clinic)coreStrategic or Co-development PartnerInternal Cleveland Clinic partner that collaborates with the CITI Computational Oncology Platform to operate the Precision Oncology Program and integrate clinical-genomic data into MaGiC.
• Pathology & Laboratory Medicine Institute (PLMI)coreStrategic or Co-development PartnerInternal Cleveland Clinic partner collaborating with CITI on the Precision Oncology Program, integrating molecular sequencing results and clinical data into MaGiC.
• Cleveland Clinic Quantum Innovation Catalyzer ProgrammoderateStrategic or Co-development PartnerProgram empowering start-ups to conduct breakthrough quantum computing research with access to the IBM Quantum System One, supporting genomics-related drug design and computational biology applications.

Scale indicators10 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• HudsonAlpha Institute for Biotechnology: A nonprofit genomics and clinical sequencing institute offering fee-for-service genomic analysis and translational research. Comparable in providing clinical genomic services, conducting translational research, and operating as a hybrid academic-commercial genomics center.
• Mayo Clinic Center for Individualized Medicine: The genomics and precision medicine arm of a peer top-tier U.S. nonprofit hospital system. Directly comparable as an academic medical center's translational genomics and individualized medicine program with clinical care integration.
• St. Jude Children's Research Hospital: A pediatric-focused research hospital with substantial translational genomics, including recent GMI collaborations (SMARCAL1 osteosarcoma gene). Comparable in nonprofit research-hospital genomics, biobanking, and disease-focused genetic discovery programs.
• Baylor College of Medicine Human Genome Sequencing Center: A major academic genomic medicine and sequencing center embedded in a large U.S. medical school. Comparable to GMI in translational genomics research, sequencing/proteomics cores, and NIH-funded program portfolio.
• New York Genome Center: A nonprofit translational genomics collaborative serving academic and industry partners in the New York region. Directly comparable to GMI in its academic-industry hybrid model, sequencing cores, and translational research mandate.
• Jackson Laboratory for Genomic Medicine: An independent nonprofit genomics research institute focused on translational and clinical genomics, mouse models, and precision medicine. Closely comparable to GMI in mission, model (nonprofit genomics institute), and service offerings.
• Vanderbilt Genetics Institute: A genetics and genomics research institute within Vanderbilt University Medical Center with biobanking, translational programs, and AI-driven genomics. Comparable to GMI in academic medical center genomic medicine scope and infrastructure.
• Icahn Institute for Genomics and Multiscale Biology (Mount Sinai): A genomics and systems biology institute within a major U.S. academic medical center. Comparable in integrating network medicine, computational biology, and clinical-genomic data within a hospital-based research enterprise.

Broad incumbents

• NIH National Human Genome Research Institute (NHGRI): The federal government's lead agency for genomics research. Comparable in translational genomics mandate but operates as a much larger federally funded national-scale institute rather than a hospital-embedded department.
• Broad Institute of MIT and Harvard: A leading genomics and biomedical research institute with extensive translational programs, large-scale sequencing, and a genome center. Comparable in translational genomics focus but operates at a significantly larger scale and with broader disease-area coverage.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks4 records

Key highlights7 records

Customer concentration

• Xx.com/CCLRI
• Facebookfacebook.com/ClevelandClinicResearch
• LinkedInlinkedin.com/company/lerner-research-institute

Revenue estimate

Valuation estimate

Number of profiles

Subsidiaries3 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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