Bisy
- Company typePrivate
- Founded2014
- HeadquartersHofstätten an der Raab, Austria
- Headcount11–50
- GTM typeB2B
- OfferingServices
Bisy firmographics
Firmographics- Name
- Bisy
- Legal name
- bisy GmbH
- Website
- https://bisy.at
- Company type
- Private
- Founded year
- 2014
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Ownership category
- akta.pro rank
Bisy industry classification
Industry- Product category
- Biotechnology Services
- akta.pro primary industry
- Protein Engineering & Directed Evolution Platforms (enzyme/therapeutic protein optimization) (HLAAAIAC)
- akta.pro secondary industries
- Bioprocess Consumables & Reagents (resins, membranes, media components, buffers) (HLAAAJAI), Bispecific & Multispecific Antibodies (HLAAAAAF)
Keywords
Where Bisy is headquartered
LocationHeadquarters
- HQ city
- Hofstätten an der Raab
- HQ country
- Austria
- HQ region
- Europe
Offices2 records
Markets served
Bisy business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Operations, Technology or R&D, Infrastructure, Marketing or Sales
Revenue model
- Recombinant Protein Production Services: B2B services including vector design and construction, protein design and engineering, strain design and engineering, and lab- and pilot scale production. Projects guided from feasibility studies to commercial-scale production with milestone-based approach.
- Biocatalyst Products: Sale of recombinant biocatalysts including lipases, Cytochrome P450s, UPOs, and HRP variants. World's largest UPO collection commercialized with partner Aminoverse B.V.
- Scientific Training: Individualized scientific trainings for practitioners and researchers on Pichia pastoris expression and production system, including practical and theoretical sessions on expression strategies, laboratory procedures, bioprocess design and data evaluation.
- Bioinformatics Services: Standalone bioinformatics services for species and strain identification via phylogenetic and phylogenomic analysis, genome sequencing, RNA-seq analysis, and detection of transposable elements and antibiotic resistance genes.
- Expression Vectors and Kits: Sale of expression vectors, expression kits, and Komagataella phaffii strains including various platform strains tailored to diverse applications.
Go-to-market motion1 record
Distribution channels1 record
Marketing channels5 records
Bisy product offering
Product offeringCore offering
Bisy provides customized recombinant protein production services using the Pichia pastoris (Komagataella phaffii) yeast expression platform. The company delivers end-to-end project support spanning vector design and construction, protein engineering, strain design, lab- and pilot-scale production, and bioinformatics. In parallel, Bisy sells proprietary Komagataella phaffii platform strains, expression vectors, and a biocatalyst collection that includes the world's largest unspecific peroxygenase (UPO) library commercialized with Aminoverse B.V.
Product overview
Bisy is a biotechnology company offering a comprehensive suite of recombinant protein production services centered on the Pichia pastoris/Komagataella phaffii expression platform. The core offering consists of seven integrated services: Vector Design & Construction (expression vector toolbox with various promoters), Protein Design & Engineering (customized expression solutions), Strain Design & Engineering (platform strains), Lab- & Pilot Scale Production, Bioinformatics (WGS, RNA-seq), Organic Food Biotech (GMO-free fermentation), and Training. Supporting products include Komagataella phaffii strains (Mut+, Mutˢ, protease-deficient, glyco-engineered), expression Vectors (integrative/episomal, constitutive/inducible), and Biocatalysts (lipases, P450s, UPOs, HRP). The portfolio is unified by the company's proprietary expression technologies and expertise in strain engineering.
Differentiator
Problem solved
Functional benefit
Products and services
- Vector Design & Construction Expression vector toolbox service including constitutive, methanol-inducible and de-repressible (methanol-independent) promoters. Delivered as integrative or episomal systems for intracellular or secreted protein production, with multiple secretion signals, antibiotic and auxotrophic selection markers, and bidirectional promoter libraries for co-expression. Targeted at biotech and pharmaceutical R&D teams needing tailored expression constructs.
- Protein Design & Engineering Customized protein design and engineering service for Pichia pastoris/Komagataella phaffii expression, covering enzymes, structural proteins, biopharmaceuticals and biocatalysts. Includes codon optimization, directed evolution and rational protein design. Aimed at researchers and companies developing functional proteins for therapeutic, industrial or food applications.
- Strain Design & Engineering Strain design and engineering service providing Komagataella phaffii platform strains with methanol-dependent and methanol-free expression systems, diverse secretion signals, bidirectional expression for titer enhancement, co-expression solutions, and extrachromosomal plasmids for library screenings. Serves industrial biotech and pharma clients needing optimized production hosts.
- Lab- & Pilot Scale Production Scaled protein production service from microtiter plates and shake flasks through pilot fermentation trials, managed on a milestone-based project basis from feasibility study to commercial-scale production. Built for companies that need to translate laboratory protein expression into industrially relevant output.
- Bioinformatics Services Standalone bioinformatics services leveraging an in-house Illumina Whole Genome Sequencing pipeline, RNA-seq analysis for cultivation bottleneck identification, manually curated genome annotations, and species/strain identification via phylogenetic and phylogenomic analysis. Also covers detection of transposable elements and antibiotic resistance genes. Used by researchers and companies needing genomic and transcriptomic characterization of microbial strains.
- Organic Food Biotech Food biotechnology service delivered from a separate GMO-free organic lab, providing natural fermentation and enzymatic food processing under strict organic standards. Includes small-scale brewery operations and food-grade protein/enzyme development. Targeted at food technology companies pursuing organic and GMO-free products.
- Scientific Training Individualized scientific trainings for practitioners and researchers on the Pichia pastoris expression and production system, including practical and theoretical sessions on expression strategies, laboratory procedures, bioprocess design and data evaluation. Serves biotech professionals seeking hands-on expertise in yeast-based protein production.
- Komagataella phaffii Strains Sale of Komagataella phaffii platform strains including Mut+ and Mut[s] wild-type, protease-deficient, antibiotic-free selection, enhanced targeted integration, and glyco-engineered strains. Used by research labs and biotech companies as production hosts for recombinant protein expression.
- Expression Vectors Sale of expression vectors with constitutive, methanol-inducible or de-repressible promoters, available as integrative or episomal systems for intracellular or secreted production. Includes various antibiotic and auxotrophic selection markers. Designed for research groups and biotech companies building tailored yeast expression systems.
- Biocatalysts Sale of recombinant biocatalysts including lipases, fungal and human Cytochrome P450s, the world's largest unspecific peroxygenase (UPO) collection commercialized with partner Aminoverse B.V., and horse radish peroxidase (HRP) variants. Sold to chemical, pharmaceutical and industrial biotech customers needing regio- and enantioselective enzymes for production processes.
Quantifiable outcome
- Next-generation stress-inducible Komagataella phaffii promoter variants published in Microbial Cell Factories (2025) expanding promoter toolbox for methanol-free production
Companies that use Bisy
Customer profileSegments3 records
Ideal customer profiles3 records
Bisy technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature5 records
Bisy partnerships and signals
Strategic signalPartnerships
Seven partnerships are on record, tiered core and minor.
- ROBUSTOO Project (EU-funded)coreEU-funded project in which bisy hosted UPO Minisymposium showcasing unspecific peroxygenases as powerful tools in industrial biocatalysis.
- Aminoverse B.V.corePartnership for commercialization of the world's largest unspecific peroxygenase (UPO) collection. Aminoverse B.V. co-commercializes UPO biocatalysts with bisy.
- NovasigncoreCollaboration on AI-supported experimental planning for smarter, data-driven bioprocess development. Joint strategy to accelerate digitalization in biomanufacturing.
- TU WienminorCollaboration on hands-on DoE (Design of Experiments) workshop as part of DigiLab SFG project, focusing on digitalization in bioprocess development.
- Universitat Autònoma de BarcelonaminorCollaboration on hands-on DoE workshop as part of DigiLab SFG project, bringing academic insights and industrial translation for bioprocess innovation.
- Human.technology StyriaminorCluster organization supporting bisy's digital innovation transformation in biomanufacturing.
- SGI-DNAcoreImplementation of BioXp 3200 System by SGI-DNA for automated gene and DNA tool production directly from digital sequence data.
Scale indicators5 records
Recent moves8 records
Expansion highlights5 records
Bisy competitors and assessment
Company assessmentBroad incumbents
- Novozymes (Novonesis): Global leader in industrial enzymes and microbial protein production. Operates in adjacent territory to Bisy's industrial enzyme and food-applications stack, with overlapping end customers (food, beverage, industrial biotech).
- Lonza Group AG: Global CDMO leader offering mammalian and microbial biologics manufacturing. Competes with Bisy at the commercial-scale end of recombinant protein production, often as the transfer partner for Bisy's lab/pilot-scale projects.
- GenScript Biotech: Global life science services company offering gene synthesis, protein production, and bio-pharma CDMO services. Overlaps with Bisy in recombinant protein services and strain/vector products, but at much larger scale and broader portfolio.
- Codexis, Inc. US-based protein engineering company developing engineered enzymes and biocatalysts for pharma and industrial markets. Comparable to Bisy's protein engineering and biocatalyst (lipases, P450s, UPOs) offerings, with similar science but larger commercial scale.
Direct peers
- Enzymicals AG: Germany-based enzyme specialist offering custom enzyme development, production, and biocatalysis services. Closely comparable in custom protein/enzyme services and customer base (industrial biotech, food, pharma). Similar scale to Bisy.
- Celonic Group: Germany/Switzerland-based CDMO offering recombinant protein and cell line development services. Overlaps with Bisy in strain engineering and protein production services, with a comparable B2B custom services model.
- c-LEcta (Kerry Group): Germany-based specialist in engineered enzymes and biocatalysts for food and pharma applications. Comparable to Bisy's Biocatalyst Collection (lipases, P450s, UPOs) and analogous customer base in industrial biocatalysis.
- Biovian Oy: Finland-based contract manufacturer offering microbial (yeast/bacterial) biologics development and GMP manufacturing. Highly comparable to Bisy's lab-to-pilot scale services for microbial recombinant proteins, with a similar B2B custom-services model.
- BRAIN Biotech AG: Germany-based biotech specializing in microbial strain engineering and biocatalysis for industrial customers. Directly comparable to Bisy in technology (microbial protein expression), customer base (industrial biotech, food, pharma), and revenue model (services + products).
Others
- Eurofins BioPharma Product Testing: Global contract testing and bioanalytical services provider. Comparable to Bisy's bioinformatics/analytical capabilities for biologics clients, primarily as a service partner rather than direct competitor.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat4 records
Key risks6 records
Key highlights7 records
Customer concentration
Bisy social profiles
Digital presenceBisy financial estimates
Financial estimateRevenue estimate
Valuation estimate
Bisy leadership team
Management profileNumber of profiles
Profiles14 records
Bisy funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Bisy M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Bisy
What does Bisy do?
Bisy provides customized recombinant protein production services using the Pichia pastoris (Komagataella phaffii) yeast expression platform. The company delivers end-to-end project support spanning vector design and construction, protein engineering, strain design, lab- and pilot-scale production, and bioinformatics. In parallel, Bisy sells proprietary Komagataella phaffii platform strains, expression vectors, and a biocatalyst collection that includes the world's largest unspecific peroxygenase (UPO) library commercialized with Aminoverse B.V.
Is Bisy a public or private company?
Bisy is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was Bisy founded?
Bisy was founded in 2014. It employs 11 to 50 people.
Where is Bisy based?
Bisy is headquartered in Hofstätten an der Raab, Austria, in the Europe region.
How does Bisy make money?
Five revenue lines are on record. Recombinant Protein Production Services are the primary driver. The others are biocatalyst Products, scientific Training, bioinformatics Services and expression Vectors and Kits.
Who are Bisy's main competitors?
Broad incumbents on record are Novozymes (Novonesis), Lonza Group AG, GenScript Biotech and Codexis, Inc.. Direct peers are Enzymicals AG, Celonic Group, c-LEcta (Kerry Group), Biovian Oy and BRAIN Biotech AG. Eurofins BioPharma Product Testing is listed as an others.
Does Bisy have an API?
No public API is recorded for Bisy.
What industry is Bisy in?
Bisy's product category is Biotechnology Services. Its primary akta.pro industry code is HLAAAIAC, Protein Engineering & Directed Evolution Platforms (enzyme/therapeutic protein optimization), with a secondary code of HLAAAJAI, Bioprocess Consumables & Reagents (resins, membranes, media components, buffers).