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ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante

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uuid004o19q

Namestring
ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante
Legal namestring
FUNDACIÓN DE LA COMUNITAT VALENCIANA PARA LA GESTIÓN DEL INSTITUTO DE INVESTIGACIÓN SANITARIA Y BIOMÉDICA DE ALICANTE (ISABIAL)
Websiteurl
isabial.es
Company typeenum
Private
Founded yearint
2020
Descriptiontext

ISABIAL (Instituto de Investigación Sanitaria y Biomédica de Alicante) is a public, non-profit health research institute (foundation CIF G42641308) based at Hospital General Universitario Dr. Balmis in Alicante, Valencian Community, Spain. It was initially accredited by the Instituto de Salud Carlos III in February 2020 and reaccredited in February 2025. The institute operates as a tripartite collaboration among the Departamento de Salud Alicante-Hospital General (Conselleria de Sanitat), Universidad de Alicante (UA), and Universidad Miguel Hernández (UMH), and is governed under the Valencian Community's regional authority.

ISABIAL conducts multidisciplinary, translational biomedical research organized into five strategic areas — neurosciences, endocrinology/metabolism, translational medicine, digestive pathology, and cancer — supported by 48 research groups and more than 670 affiliated researchers. The institute operates 15 specialized research platforms including the Biobank, Bioinformatics, Clinical Analysis and Genetics, Pharmacogenetics, Phase I Clinical Trials Unit (UECA), Clinical Research Unit (UIC), SimIA Simulation Laboratory, and the BioFab joint 3D biomanufacturing unit (the first in the Valencian Community authorized to manufacture custom medical devices). It integrates the TriNetX global real-world data network (220+ organizations, 30 countries, 275M+ patients) and uses REDCap, iFundanet, Microsoft Outlook 365, and Acumbamail as core operational systems. Outputs to date include over 2,200 scientific publications, 115+ competitive research projects, and 353 active clinical trials.

The institute does not operate a commercial revenue model. Funding flows from three streams: (1) competitive public grants from national (ISCIII, Ministerio de Ciencia, Innovación y Universidades), regional (Generalitat Valenciana), and European (ERDF) sources; (2) institutional partnership agreements with UA, UMH, and the Alicante Health Department; and (3) voluntary donations processed via REDSYS. External participants pay €600 for instructor training courses, while internal Alicante Department of Health staff access training for free. ISABIAL is pursuing technology transfer via its Innovation department (CPI), has filed at least one patent application on epigenetic antifibrotic compounds, and was awarded the 2024 FECYT national award for Responsible Research and Innovation for its OPEN DAYS citizen engagement program.

Short descriptiontext

ISABIAL is a public, non-profit biomedical research institute in Alicante, Spain, accredited by ISCIII and jointly operated with two universities and the Alicante Health Department. It runs 48 research groups across five therapeutic areas, 353 clinical trials, and 15 specialized research platforms including a region-first 3D biomanufacturing unit.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
51–100
akta.pro rankint
HeadquartersAlicante, Spain
HQ citystring
Alicante
HQ countrystring
Spain
HQ regionstring
Europe
Markets served

Serves global market

Offices2 records

Each record includes

City, Country, Type, Description, Source

Keyword5 values
biomedical research, clinical trials, translational medicine, health research, scientific innovation
Industry2 codes
PRIMARYHLAGAJAM
Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF)
Healthcare & Life Sciences/Life Science Tools & Services (CRO/CDMO/Lab Services)/Life Science Software & Informatics (LIMS/ELN/Bioinformatics)
SECONDARYHLAKAEAL
Liver & GI Clinical Research (Trials Centers)
NAICS code2 codes
  • Scientific Research and Development Services5417
  • Research and Development in Biotechnology (except Nanobiotechnology)541714
SIC code2 codes
  • Services-Commercial Physical & Biological Research8731
  • Services-Medical Laboratories8071
Product category
Biomedical Research Services
GTM motion1 record

Each record includes

Type, Description, Source

Revenue model3 records
1Competitive Research Funding
TypeProfessional Services
Description

Public funding from national (Instituto de Salud Carlos III), regional (Generalitat Valenciana), and European sources for competitive research projects

isabial.es
2Institutional Partnerships
TypeProfessional Services
Description

Collaboration agreements with Universidad de Alicante, Universidad Miguel Hernández, and the Alicante Health Department

isabial.es
3Donations
TypeGrants Donations
Description

Voluntary contributions from individuals and organizations to support specific research projects

isabial.es
Marketing channels8 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels1 record

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components5 values
Personnel, Technology or R&D, Operations, Infrastructure, Marketing or Sales
Pricing details1 tier
1Free training for internal staff
ModelSubscriptionBilling cadenceOne time
Notes

Free for Department of Health Alicante personnel; €600 for external participants for instructor training courses

isabial.es
GTM typeB2B
B2B
Offering typeServices
Services
Core offering1 text field

ISABIAL is a multidisciplinary translational biomedical research institute that integrates basic, clinical, epidemiological, and health services research across five strategic areas (neurosciences, endocrinology/metabolism, translational medicine, digestive pathology, and cancer). It operates 48 research groups and provides specialized research platforms (biobank, bioinformatics, 3D biomanufacturing, clinical trials units, simulation laboratory, and pharmacogenetics) along with training programs and technology transfer services to improve clinical care quality.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 of 3 values shown
  • Reduced hypoglycemia risk by 50% through ENDOCARE protocol for hospitalized diabetes type 2 patients
+2 more records
Product and service4 records
1BioFab - Joint Unit in Biomedical Design and 3D Printing (Unidad Mixta de Investigación en Diseño y Fabricación Biomédica)
CategoryBiomedical Manufacturing Platform
2UECA - Alicante Phase I Clinical Trials Unit (Unidad de Ensayos Clínicos de Alicante Fase I)
CategoryClinical Research Platform
3UIC - Clinical Research Unit (Unidad de Investigación Clínica)
CategoryClinical Research Platform
4SimIA - Simulation and Innovation Laboratory of Alicante (Laboratorio de Simulación e Innovación de Alicante)
Scale indicator7 records

Each record includes

Type, Value, Description, Source

Partnership7 partners
Strategic tierCoreTypeStrategic or Co-development PartnerAnnounced on2024-11-11
Description

UCC+I Network membership strengthening scientific outreach and citizen engagement in health research.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

University partner contributing academic research expertise to ISABIAL. UA collaborates on joint research units including the BioFab 3D printing unit and various biomedical research projects.

3Universidad Miguel Hernández (UMH)
Strategic tierCoreTypeStrategic or Co-development Partner
Description

University partner providing research expertise in areas including hepatology, immunology, and epigenetics. UMH researchers collaborate on various ISABIAL research projects and co-lead studies.

isabial.es
Strategic tierCoreTypeStrategic or Co-development Partner
Description

Healthcare provider and primary clinical research partner. The Hospital General Universitario Dr. Balmis serves as the main clinical setting for ISABIAL research activities.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

Regional government providing institutional support and funding through the Consellería de Sanitat. Key funder of research activities and infrastructure.

6Instituto de Salud Carlos III (ISCIII)
Strategic tierCoreTypeStrategic or Co-development Partner
Description

National health research institute providing official accreditation as Health Research Institute and funding for competitive research projects through national calls.

isabial.es
Strategic tierCoreTypeStrategic or Co-development Partner
Description

Collaborative research through various CIBER thematic areas including CIBERehd (Hepatic and Digestive Diseases), contributing researchers and resources to national research networks.

Recent move8 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight5 records

Each record includes

Type, Description

Peers10 records
TypeDirect peer
Description

One of Spain's leading ISCIII-accredited biomedical research institutes, affiliated with Hospital Clínic Barcelona. Comparable structure (university + hospital + regional government), broad thematic coverage, and active clinical trial operations make it a benchmark peer.

TypeDirect peer
Description

ISCIII-accredited biomedical research institute in Málaga integrating hospital, university, and regional government. Comparable multi-thematic structure with a strong clinical trials operation.

TypeBroad incumbent
Description

Spain's national oncology research centre; larger and much better funded than ISABIAL with a focused mandate in cancer (one of ISABIAL's 5 areas). Offers a reference point for scale and depth rather than direct competition.

TypeDirect peer
Description

ISCIII-accredited Spanish health research institute affiliated with Hospital Universitario Marqués de Valdecilla in Santander. Similar mid-tier regional scale, structure (university + regional health authority), and translational mandate.

TypeDirect peer
Description

Catalan biomedical research institute with similar institutional architecture (university + regional health service) and ISCIII recognition. Comparable mid-size scope and clinical research focus.

TypeDirect peer
Description

The largest health research institute in the Valencian Community, also ISCIII-accredited and covering multiple research areas with strong clinical trial activity. Most direct geographic and structural comparable to ISABIAL within the same regional health system.

TypeDirect peer
Description

Valencia-based biomedical research centre and an existing ISABIAL partner (joint Electron Microscopy unit). Locally adjacent, multi-area biomedical focus, and a structural operational comparable.

TypeDirect peer
Description

ISCIII-accredited health research institute in Galicia affiliated with complex hospital and university partners. Similar translational/biomedical research mandate and regional focus.

TypeDirect peer
Description

ISCIII-accredited regional health research institute coordinating hospital, university, and regional government activity in Aragón. Comparable governance and translational research mandate.

TypeDirect peer
Description

ISCIII-accredited regional biomedical research institute in Murcia, covering multiple clinical research areas with a similar governance model involving regional government and universities. Comparable scale and operating model.

Market position
Strengths5 records

Each record includes

Headline, Details, Source

Weaknesses5 records

Each record includes

Headline, Details, Source

Competitive moat5 records

Each record includes

Type, Details

Key risks6 records

Each record includes

Headline, Details, Source

Key highlights7 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Named customers3 records

Each record includes

Name, Industry, Type, Use case, Source, UUID

Segment3 records

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile4 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
No
API detail
Has APIbool
No

Docs URL, Description

Integration9 records

Each record includes

Title, Type, Description, Source

AI capability8 records

Each record includes

Type, Description, Source

AI maturity
App detail

Has app

Feature9 records

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles9 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

No data
No data
Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante

Biomedical Research Servicesisabial.es

ISABIAL is a public, non-profit biomedical research institute in Alicante, Spain, accredited by ISCIII and jointly operated with two universities and the Alicante Health Department. It runs 48 research groups across five therapeutic areas, 353 clinical trials, and 15 specialized research platforms including a region-first 3D biomanufacturing unit.

What ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante does

ISABIAL (Instituto de Investigación Sanitaria y Biomédica de Alicante) is a public, non-profit health research institute (foundation CIF G42641308) based at Hospital General Universitario Dr. Balmis in Alicante, Valencian Community, Spain. It was initially accredited by the Instituto de Salud Carlos III in February 2020 and reaccredited in February 2025. The institute operates as a tripartite collaboration among the Departamento de Salud Alicante-Hospital General (Conselleria de Sanitat), Universidad de Alicante (UA), and Universidad Miguel Hernández (UMH), and is governed under the Valencian Community's regional authority.

ISABIAL conducts multidisciplinary, translational biomedical research organized into five strategic areas — neurosciences, endocrinology/metabolism, translational medicine, digestive pathology, and cancer — supported by 48 research groups and more than 670 affiliated researchers. The institute operates 15 specialized research platforms including the Biobank, Bioinformatics, Clinical Analysis and Genetics, Pharmacogenetics, Phase I Clinical Trials Unit (UECA), Clinical Research Unit (UIC), SimIA Simulation Laboratory, and the BioFab joint 3D biomanufacturing unit (the first in the Valencian Community authorized to manufacture custom medical devices). It integrates the TriNetX global real-world data network (220+ organizations, 30 countries, 275M+ patients) and uses REDCap, iFundanet, Microsoft Outlook 365, and Acumbamail as core operational systems. Outputs to date include over 2,200 scientific publications, 115+ competitive research projects, and 353 active clinical trials.

The institute does not operate a commercial revenue model. Funding flows from three streams: (1) competitive public grants from national (ISCIII, Ministerio de Ciencia, Innovación y Universidades), regional (Generalitat Valenciana), and European (ERDF) sources; (2) institutional partnership agreements with UA, UMH, and the Alicante Health Department; and (3) voluntary donations processed via REDSYS. External participants pay €600 for instructor training courses, while internal Alicante Department of Health staff access training for free. ISABIAL is pursuing technology transfer via its Innovation department (CPI), has filed at least one patent application on epigenetic antifibrotic compounds, and was awarded the 2024 FECYT national award for Responsible Research and Innovation for its OPEN DAYS citizen engagement program.

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante firmographics

Firmographics
Name
ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante
Legal name
FUNDACIÓN DE LA COMUNITAT VALENCIANA PARA LA GESTIÓN DEL INSTITUTO DE INVESTIGACIÓN SANITARIA Y BIOMÉDICA DE ALICANTE (ISABIAL)
Website
https://isabial.es
Company type
Private
Founded year
2020
Operating status
Operating
Headcount range
51–100 employees
Short description
ISABIAL is a public, non-profit biomedical research institute in Alicante, Spain, accredited by ISCIII and jointly operated with two universities and the Alicante Health Department. It runs 48 research groups across five therapeutic areas, 353 clinical trials, and 15 specialized research platforms including a region-first 3D biomanufacturing unit.
Ownership category
akta.pro rank

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante industry classification

Industry
Product category
Biomedical Research Services
NAICS
Scientific Research and Development Services (5417), Research and Development in Biotechnology (except Nanobiotechnology) (541714)
SIC
Services-Commercial Physical & Biological Research (8731), Services-Medical Laboratories (8071)
akta.pro industry
PRIMARYHLAGAJAM
Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF)
Healthcare & Life Sciences/Life Science Tools & Services (CRO/CDMO/Lab Services)/Life Science Software & Informatics (LIMS/ELN/Bioinformatics)
SECONDARYHLAKAEAL
Liver & GI Clinical Research (Trials Centers)

Keywords

  • Biomedical research
  • Clinical trials
  • Translational medicine
  • Health research
  • Scientific innovation

Where ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante is headquartered

Location

Headquarters

HQ city
Alicante
HQ country
Spain
HQ region
Europe

Offices2 records

Markets served

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante business model

Business model
GTM type
B2B
Offering type
Services
Cost components
Personnel, Technology or R&D, Operations, Infrastructure, Marketing or Sales

Revenue model

  1. Competitive Research Funding: Public funding from national (Instituto de Salud Carlos III), regional (Generalitat Valenciana), and European sources for competitive research projects
  2. Institutional Partnerships: Collaboration agreements with Universidad de Alicante, Universidad Miguel Hernández, and the Alicante Health Department
  3. Donations: Voluntary contributions from individuals and organizations to support specific research projects

Pricing tiers

ModelBillingPrice
SubscriptionOne timeFree training for internal staff

Go-to-market motion1 record

Distribution channels1 record

Marketing channels8 records

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante product offering

Product offering

Core offering

ISABIAL is a multidisciplinary translational biomedical research institute that integrates basic, clinical, epidemiological, and health services research across five strategic areas (neurosciences, endocrinology/metabolism, translational medicine, digestive pathology, and cancer). It operates 48 research groups and provides specialized research platforms (biobank, bioinformatics, 3D biomanufacturing, clinical trials units, simulation laboratory, and pharmacogenetics) along with training programs and technology transfer services to improve clinical care quality.

Differentiator

Problem solved

Functional benefit

Products and services

  • BioFab - Joint Unit in Biomedical Design and 3D Printing (Unidad Mixta de Investigación en Diseño y Fabricación Biomédica)
  • UECA - Alicante Phase I Clinical Trials Unit (Unidad de Ensayos Clínicos de Alicante Fase I)
  • UIC - Clinical Research Unit (Unidad de Investigación Clínica)
  • SimIA - Simulation and Innovation Laboratory of Alicante (Laboratorio de Simulación e Innovación de Alicante)

Quantifiable outcome

  • Reduced hypoglycemia risk by 50% through ENDOCARE protocol for hospitalized diabetes type 2 patients
  • +2 more outcomes

Companies that use ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante

Customer profile

Named customers3 records

Segments3 records

Ideal customer profiles4 records

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante technology and API

Technology

Technology focussed No

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Integration9 records

AI capability8 records

Feature9 records

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante partnerships and signals

Strategic signal

Partnerships

Seven partnerships are on record, tiered core.

  • FECYT (Spanish Foundation for Science and Technology)coreStrategic or Co-development Partner · 11 November 2024UCC+I Network membership strengthening scientific outreach and citizen engagement in health research.
  • Universidad de Alicante (UA)coreStrategic or Co-development PartnerUniversity partner contributing academic research expertise to ISABIAL. UA collaborates on joint research units including the BioFab 3D printing unit and various biomedical research projects.
  • Universidad Miguel Hernández (UMH)coreStrategic or Co-development PartnerUniversity partner providing research expertise in areas including hepatology, immunology, and epigenetics. UMH researchers collaborate on various ISABIAL research projects and co-lead studies.
  • Departamento de Salud Alicante-Hospital GeneralcoreStrategic or Co-development PartnerHealthcare provider and primary clinical research partner. The Hospital General Universitario Dr. Balmis serves as the main clinical setting for ISABIAL research activities.
  • Generalitat ValencianacoreStrategic or Co-development PartnerRegional government providing institutional support and funding through the Consellería de Sanitat. Key funder of research activities and infrastructure.
  • Instituto de Salud Carlos III (ISCIII)coreStrategic or Co-development PartnerNational health research institute providing official accreditation as Health Research Institute and funding for competitive research projects through national calls.
  • CIBER (Biomedical Research Networks)coreStrategic or Co-development PartnerCollaborative research through various CIBER thematic areas including CIBERehd (Hepatic and Digestive Diseases), contributing researchers and resources to national research networks.

Scale indicators7 records

Recent moves8 records

Expansion highlights5 records

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante competitors and assessment

Company assessment

Direct peers

Broad incumbents

  • CNIO (Centro Nacional de Investigaciones Oncológicas): Spain's national oncology research centre; larger and much better funded than ISABIAL with a focused mandate in cancer (one of ISABIAL's 5 areas). Offers a reference point for scale and depth rather than direct competition.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante social profiles

Digital presence

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante financial estimates

Financial estimate

Revenue estimate

Valuation estimate

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante leadership team

Management profile

Number of profiles

Profiles9 records

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante funding detail

Funding detail

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante M&A and investment

M&A and investment

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante

What does ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante do?

ISABIAL is a multidisciplinary translational biomedical research institute that integrates basic, clinical, epidemiological, and health services research across five strategic areas (neurosciences, endocrinology/metabolism, translational medicine, digestive pathology, and cancer). It operates 48 research groups and provides specialized research platforms (biobank, bioinformatics, 3D biomanufacturing, clinical trials units, simulation laboratory, and pharmacogenetics) along with training programs and technology transfer services to improve clinical care quality.

Is ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante a public or private company?

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante is a private company. It is classified as state government owned and is currently operating.

When was ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante founded?

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante was founded in 2020. It employs 51 to 100 people.

Where is ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante based?

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante is headquartered in Alicante, Spain, in the Europe region.

How does ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante make money?

Three revenue lines are on record. Competitive Research Funding is the primary driver. The others are institutional Partnerships and donations.

Who are ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante's main competitors?

Direct peers on record are IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), IBIMA Plataforma BIONAND, IDIVAL (Instituto de Investigación Sanitaria Valdecilla), IRBLleida (Institut de Recerca Biomèdica de Lleida), IIS La Fe (Instituto de Investigación Sanitaria La Fe), CIPF (Centro de Investigación Príncipe Felipe), IDIS (Instituto de Investigación Sanitaria de Santiago de Compostela), IIS Aragón (Instituto de Investigación Sanitaria Aragón) and IMIB (Instituto Murciano de Investigación Biosanitaria). CNIO (Centro Nacional de Investigaciones Oncológicas) is listed as a broad incumbent.

Does ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante have an API?

No public API is recorded for ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante.

What industry is ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante in?

ISABIAL, Instituto de Investigación Sanitaria y Biomédica de Alicante's product category is Biomedical Research Services. Its primary akta.pro industry code is HLAGAJAM, Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF), with a secondary code of HLAKAEAL, Liver & GI Clinical Research (Trials Centers). Its NAICS code is 5417 and its SIC code is 8731.

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