NPIS - Non-Pharmacological Intervention Society

What NPIS - Non-Pharmacological Intervention Society does

NPIS (Non-Pharmacological Intervention Society), founded in 2021 and headquartered in Paris, is an international non-profit scientific society that develops, evaluates, and promotes non-pharmacological interventions (NPIs) in healthcare. Its core offering is the NPIS Model, a standardized scientific framework specifying methodological and ethical requirements for five study types — prototypical, mechanistic, observational, interventional, and implementation — that an NPI must satisfy to be validated. Validation requires a minimum of five peer-reviewed studies (1 prototypical, 1 mechanistic, 2 interventional, 1 implementation) and anonymous expert voting with at least 80% agreement, after which an NPI receives the NPIS© label and is published in the Référentiel des INM (NPI Registry).

The NPI Registry is a centralized, multilingual (French/English) platform cataloging validated NPI protocol cards across three categories — psychosocial, bodily, and nutritional — covering health problems such as Alzheimer's, cancer, chronic pain, mental health, sleep disorders, and pediatric oncology. The registry is supported by NPIS Guidelines (a three-language methodological guide), NPIS Open Badge Science (training program for NPI card writing), and a series of webinars. The society also operates the annual NPIS Summit in October, NPIS Forum regional events since 2024, and NPIS Satellite gatherings, plus a partnership presence at WONCA Europe 2026.

NPIS serves three primary user tiers: citizens, patients, and caregivers (basic information access); healthcare professionals including physicians, nurses, psychologists, physiotherapists, and dietitians (full NPI card access); and health authorities, institutions, and organizations (complete registry data and functionality). Its revenue model is membership and subscription-based access differentiated by user category, supplemented by NPIS funding from institutions such as INSERM and European project grants. The organization is GDPR-compliant, WCAG 2.2 AAA-certified, and endorsed by WHO, French Haute Autorité de Santé, French Ministry of Health, INSERM, INCa, UNESCO, UNICEF, and 30 French scientific societies.

Name

NPIS - Non-Pharmacological Intervention Society

Legal name

NPIS

Website

https://referentielinm.org

Company type

Private

Founded year

2021

Operating status

Operating

Headcount range

11–50 employees

Short description

NPIS is a Paris-based international non-profit scientific society, founded in 2021, that operates the NPIS Model framework and the multilingual Référentiel des INM (NPI Registry) to identify, validate, and distribute evidence-based non-pharmacological interventions to healthcare professionals, institutions, and the public.

Ownership category

akta.pro rank

Product category

Healthcare Research and Clinical Evidence Registry

NAICS

Other Scientific and Technical Consulting Services (54169)

SIC

Services-Membership Organizations (8600)

akta.pro primary industry

Chronic Disease & NCD Program Evaluation (e.g., diabetes/CVD/cancer) (HLAJANAG)

Keywords

• Non-pharmacological interventions
• Clinical evidence registry
• Healthcare validation services
• Scientific society membership
• Medical research standards

Headquarters

HQ city

Paris

HQ country

France

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B and B2C

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Others

Revenue model

1. Registry Access and Membership: NPIS operates as a scientific society offering registry access to different user categories: citizens and patients (basic access to NPI information), healthcare professionals (full NPI card access), and institutional partners (complete data and functionality access). The society maintains a 'Members' newsletter sharing funding opportunities for NPI research.

Go-to-market motion2 records

Distribution channels5 records

Marketing channels7 records

Core offering

NPIS operates a centralized, multilingual scientific registry (Référentiel des INM) that catalogs and validates non-pharmacological interventions (NPIs) using its proprietary NPIS Model evaluation framework. Each NPI is documented in a standardized protocol card covering target audience, health benefits and risks, mechanisms of action, professional requirements, and implementation conditions. The society supports the full NPI value chain from research to clinical practice through expert validation procedures, training programs (Open Badge Science), methodological guidelines, and recurring international events (NPIS Summit, NPIS Forum).

Product overview

NPIS (Non-Pharmacological Intervention Society) operates a unified platform centered on the Référentiel des INM (NPI Registry), a centralized database of validated non-pharmacological intervention cards. The ecosystem includes the NPIS Model as the scientific evaluation framework, the NPIS Guidelines as the methodological guide, and NPIS Open Badge Science as the training program. Supporting these core offerings are recurring events including the annual NPIS Summit international conference and regional NPIS Forum gatherings. The registry systematically catalogs NPI protocols across three domains—psychosocial, bodily, and nutritional—with standardized cards validated through independent expert review.

Differentiator

Problem solved

Functional benefit

Brands

• Référentiel des INM: The NPI Registry - a centralized, multilingual database cataloging validated non-pharmacological intervention protocols for prevention, care, and autonomy support.
• NPIS Model
• NPIS Registry

Products and services

• Référentiel des INM / NPI Registry A centralized, multilingual, shared repository cataloging validated non-pharmacological intervention (NPI) protocol cards for prevention, care, and autonomy support. Each NPI is codified, applicable, traceable, and fundable, with standardized content covering target audience, health benefits and risks, mechanisms of action, professional requirements, implementation conditions, and user information notices. Publicly accessible in French and English.
• NPIS Model A standardized scientific framework for identifying non-pharmacological interventions that are explainable, effective, safe, and reproducible based on published studies. Provides methodological and ethical recommendations for prototypical studies (describing the intervention), mechanistic studies (explaining mechanisms of action), observational studies (tracking evolution), interventional studies (demonstrating benefits and risks), and implementation studies (application and personalization).
• NPIS Guidelines A comprehensive guide in three languages (French, English, and one additional) providing structured guidance on writing and submitting NPI cards, detailing the validation process, methodological expectations, and ethical requirements for non-pharmacological interventions. Available as a downloadable PDF.
• NPIS Open Badge Science A training program dedicated to NPI card writing, validating competencies in NPIS Model methodology and scientific standards for non-pharmacological intervention research and practice. Provides participants with the knowledge and tools necessary for submitting validated NPI documentation to the registry.
• NPIS Summit Annual international scientific summit dedicated to non-pharmacological interventions, held each October in Paris in presential and hybrid formats. Brings together researchers, health professionals, practitioners, decision-makers, institutions, students, and partners around research, evaluation, dissemination, and integration of NPIs in health systems.
• NPIS Forum Regional forums organized since 2024 in France and Europe, gathering professionals and users around specific health themes to share experiences and build the NPI value chain ecosystem.
• Registry Webinars Freely accessible webinar series providing structured guidance on the NPIS Registry, including presentations on the registry overview, writing and submitting NPI cards, expert assessment procedures, and upgrading NPI cards. 2026 replays available on YouTube.

Quantifiable outcome

• 80% minimum agreement required for NPI expert validation
• +1 more outcomes

Segments5 records

Ideal customer profiles5 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

16 partnerships are on record, tiered core and moderate.

• WHO (World Health Organization)coreStrategic or Co-development PartnerWHO has advocated for 'self-care interventions' since 2022 and included NPIs in its Global Action Plan for Mental Health (2022). WHO identifies 'most effective and feasible interventions in national context' (2021). NPIS aligns its 2021-2030 roadmap with WHO strategies and exchanges on NPI frameworks.
• WHO EuropecoreStrategic or Co-development PartnerWHO Europe declared intent to identify 'most effective health interventions' by 2030. NPIS has initiated discussions with WHO Europe on NPI validation and registry development aligned with European health innovation strategies.
• European Public Health Association (EUPHA)coreStrategic or Co-development PartnerEUPHA is involved in health service innovation. NPIS has initiated discussions with EUPHA regarding NPI framework alignment with European public health strategies.
• European Centre for Disease Prevention and Control (ECDC)coreStrategic or Co-development PartnerECDC is projecting to create a registry, similar to NPIS Registry. NPIS has initiated discussions with ECDC regarding potential alignment and NPI validation frameworks.
• European CommissioncoreStrategic or Co-development PartnerEuropean Commission aims to promote 'health, nutrition, mental health, and psychosocial support to communities.' NPIS submitted several European projects in 2024 aligned with Commission priorities.
• UNESCOmoderateStrategic or Co-development PartnerUNESCO has promoted 'specific health and well-being education interventions' since 2016. NPIS exchanges with UNESCO on NPI frameworks for health education and well-being.
• UNICEFmoderateStrategic or Co-development PartnerUNICEF advocates for sharing 'effective health interventions' since 2016 and developing 'primary healthcare' since 2018. NPIS engages with UNICEF on NPI frameworks for early intervention and primary care contexts.
• UN (United Nations)moderateStrategic or Co-development PartnerUN has called for 'accelerating essential health services' since 2023. NPIS contributes to UN health objectives through NPI ecosystem development supporting universal health coverage.
• Coalition of Partnerships for Universal Health Coverage and Global HealthmoderateStrategic or Co-development PartnerCoalition advocates for 'people-centered, comprehensive, and integrated services' since 2021. NPIS participates in coalition efforts to advance integrated NPI approaches within universal health coverage frameworks.
• INSERMcoreStrategic or Co-development PartnerINSERM provided seed funding for participatory research supporting NPIS Model development. Over 1,000 participants engaged under 22-expert committee guidance in co-construction process.
• 30 French Scientific SocietiescoreStrategic or Co-development PartnerThirty French scientific societies support the NPIS Model transdisciplinary innovation. These societies participate in validation processes and endorse NPI framework for their respective domains.
• National Center for Palliative Care and End of Life (CNSPFV)coreStrategic or Co-development PartnerCNSPFV supports NPIS Model innovation and participates in NPI validation ecosystem for palliative and end-of-life care interventions.
• INCa (National Cancer Institute, France)coreStrategic or Co-development PartnerINCa supports NPIS Model and participates in NPI validation framework for oncology-related non-pharmacological interventions.
• French Platform for Clinical Research NetworkscoreStrategic or Co-development PartnerPlatform supports NPIS Model and provides infrastructure for multi-center NPI validation studies and implementation research across clinical networks.
• Haute Autorité de Santé (HAS)coreStrategic or Co-development PartnerFrench National Authority for Health has encouraged use of term 'INM' (NPI) since 2011 and publishes relevant recommendations. NPIS Registry complements HAS recommendations with operational implementation tools.
• WONCA EuropemoderateGTM or Marketing PartnerWONCA Europe 2026 Congress in Paris features NPIs in one of five keynote sessions (July 3 morning), demonstrating growing recognition of non-pharmacological interventions among general practitioners.

Scale indicators7 records

Recent moves6 records

Expansion highlights5 records

Emerging players

• Mapi Research Trust: Non-profit organization curating patient-reported outcome measures and clinical registries. Comparable to NPIS as a registry operator enabling traceability and codification across healthcare systems.

Direct peers

• CAMbrella: European research network on complementary and alternative medicine. Comparable to NPIS as a European-level consortium focused on NPI/complementary intervention evaluation and harmonization.
• Research Council for Complementary Medicine: UK charitable organization promoting research and evidence-based understanding of complementary medicine. Comparable to NPIS in mission to validate non-pharmacological health interventions through scientific rigor.
• Cochrane: International not-for-profit organization producing systematic reviews of healthcare interventions. Directly comparable as an evidence-synthesis and methodological-standards body that, like NPIS, defines what counts as a validated intervention.
• NCCIH (National Center for Complementary and Integrative Health): US NIH center dedicated to research on complementary and integrative health interventions. Comparable to NPIS as a scientific body that evaluates non-conventional health interventions and funds research in the NPI space.

Broad incumbents

• Haute Autorité de Santé (HAS): French national health authority that publishes clinical recommendations and evaluates health interventions. Comparable to NPIS as a reference-setting body in the French health ecosystem, with which NPIS already partners.
• NICE (National Institute for Health and Care Excellence): UK health technology assessment body producing clinical guidelines and evaluating interventions for the NHS. Comparable to NPIS as a framework-setter for intervention evaluation and integration into healthcare systems.
• WHO (World Health Organization): Global health authority that develops guidelines and frameworks for health interventions. Directly comparable as NPIS's strategic partner and the highest-level reference body for NPI-relevant global action plans.

Others

• EUPHA (European Public Health Association): European public health association engaged in health service innovation. Comparable to NPIS as an institutional partner and ecosystem participant in European public health policy.
• WONCA: World Organization of National Colleges of General Practitioners. Comparable to NPIS as a clinical-community partner featuring NPI content in keynote programming (WONCA Europe 2026).

Market position

Strengths4 records

Weaknesses4 records

Competitive moat6 records

Key risks6 records

Key highlights6 records

Customer concentration

• YouTubeyoutube.com/playlist?list=PLLjA66e5RkaJTY5FFPG73Ysn_ou4INJvF
• LinkedInlinkedin.com/company/npisociety

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about NPIS - Non-Pharmacological Intervention Society