Plan Nacional frente a la Resistencia a los Antibióticos PRAN

What Plan Nacional frente a la Resistencia a los Antibióticos PRAN does

Plan Nacional frente a la Resistencia a los Antibióticos (PRAN) is Spain's national strategic action plan to reduce the risk of selection and dissemination of antibiotic resistance, established in 2014 and coordinated by the Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). It operates under a One Health framework spanning human health, animal health, and the environment, with cross-ministerial support from Spain's Ministry of Health and Ministry of Agriculture. PRAN coordinates surveillance (antibiotic consumption maps, AWaRe classification tracking, ESUAvet veterinary surveillance), control (PROA programs in hospitals and community settings, REDUCE programs across livestock sectors), prevention, research, training, and public communication initiatives.

The program delivers a portfolio of digital platforms and educational products including a central website portal (resistenciaantibioticos.es), the Microcombat mobile card game app available in 19 languages, the PRANteca educational platform for university students, the PRANet collaboration workspace, and interactive surveillance dashboards. It runs annual public awareness campaigns, the Premios PRAN awards program (9 categories, €4,000 per winner), and the '¡Corre sin resistencias!' running event attracting approximately 5,000 participants in 2025. Outcomes reported include a 13.8% reduction in human health antibiotic consumption and a 60.15% reduction in animal health consumption since inception, placing Spain 1st in the EU for veterinary antibiotic reduction and 3rd for human health reduction.

PRAN is a government public health program with no commercial revenue, no equity ownership, and no investment capital. It is funded through Spanish public administration budgets, operates with approximately 8 core personnel based in Madrid, and is integrated into the European coordination framework through EU-JAMRAI 2 (120+ institutions across 30 countries) alongside formal partnerships with WHO, ECDC, EMA, EFSA, WOAH, and ISGlobal.

Name

Plan Nacional frente a la Resistencia a los Antibióticos PRAN

Legal name

Plan Nacional frente a la Resistencia a los Antibióticos (PRAN) — coordinated by Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)

Website

https://resistenciaantibioticos.es

Company type

Private

Founded year

2014

Operating status

Operating

Short description

PRAN is Spain's national strategic plan against antibiotic resistance, coordinated by AEMPS under a One Health approach spanning human health, animal health, and the environment, serving the Spanish National Health System, veterinary sector, universities, and the general public.

Ownership category

akta.pro rank

Headquarters

HQ city

Madrid

HQ country

Spain

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B and B2C

Offering type

Services

Cost components

Personnel, Operations, Marketing or Sales, Technology or R&D, Infrastructure

Revenue model

1. Government Funding: PRAN is a government initiative coordinated by the Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), funded through public administration budgets. No commercial revenue generation.

Go-to-market motion1 record

Distribution channels4 records

Marketing channels7 records

Core offering

PRAN is Spain's national strategic plan coordinated by AEMPS to reduce antibiotic resistance selection and dissemination. It operates a One Health framework spanning human health, animal health, and the environment, providing surveillance systems (consumption maps, AWaRe tracking, ESUAvet), PROA optimization programs, REDUCE livestock programs, therapeutic guidelines, public awareness campaigns, and educational platforms for professionals and citizens.

Product overview

The Plan Nacional frente a la Resistencia a los Antibióticos (PRAN) is Spain's national strategic action plan coordinated by the Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). It operates a central website portal as its primary digital offering, supplemented by educational applications and materials. The portfolio includes the Microcombat educational app, the PRANteca platform for university students and faculty, the PRANet internal collaboration portal for authorized partners, antibiotic consumption surveillance maps, and various awareness campaigns (including the 2025 'Usar bien los antibióticos es vital' campaign featuring Alexander Fleming). Additional resources include debate kits for schools, the antibiotic resistance symbol toolkit, and knowledge quizzes. All activities follow a One Health approach addressing human health, animal health, and environmental dimensions.

Differentiator

Problem solved

Functional benefit

Brands

• Microcombat: A card game and mobile app (available in 19 languages on Android and iOS) for educating citizens about antibiotic resistance. Players take on roles of doctors, researchers, and health workers to protect citizens from pathogens. Originally created by ISGlobal in collaboration with Laboratori de Jocs, produced with funding from the European Health Gastein Forum and ECDC, and further developed and funded by EU-JAMRAI.
• PRANteca
• PRANet
• Campaña PRAN 2025: Usar bien los antibióticos es vital
• Premios PRAN

Products and services

• PRAN Website Portal The central digital platform for Spain's National Plan Against Antibiotic Resistance, providing access to surveillance data, consumption maps, guidelines, educational materials, news, and publications across human health, animal health, and environmental sectors under a One Health approach.
• Microcombat App A mobile card game application based on an original game created by ISGlobal, designed to educate citizens about pathogen threats and antibiotic resistance through collaborative gameplay. Available in 19 languages on Android and iOS.
• PRANteca An educational platform for students and teachers in bioscience faculties at collaborating universities, providing specialized resources on antibiotic resistance and antimicrobial topics with faculty-specific access codes.
• PRANet An internal workspace portal for PRAN collaborators, providing secure access to working documents and coordination tools for participating organizations.
• Kit de Debate para Colegios e Institutos A didactic card game kit for students aged 11-18 featuring 8 characters representing different perspectives on antibiotic resistance, designed to teach debate skills and understanding of the prescription deferral system.
• Antibiotic Consumption Maps Interactive maps displaying antibiotic consumption data across human health (primary care, hospitals) and veterinary sectors, including AWaRe category breakdowns and regional comparisons by autonomous communities.
• Antibiotic Format Adjustment Initiative A program coordinated by AEMPS to adjust antibiotic packaging sizes to align with standard treatment guidelines, reducing household surpluses and self-medication risks.
• PROA Programs (Antibiotic Optimization Programs) Antibiotic Optimization Programs (Programas de Optimización de Uso de los Antibióticos) for hospital and community settings with certification systems for PROA teams, providing guidelines and quality assurance.
• REDUCE Programs (Animal Health) Programs for reducing antibiotic use in livestock across multiple categories including porcine, poultry, aquaculture, ovino/caprino, bovine, rabbits, and small animals.

Quantifiable outcome

• 13.8% reduction in human health antibiotic consumption since PRAN inception
• +4 more outcomes

Named customers3 records

Segments4 records

Ideal customer profiles5 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

Twelve partnerships are on record, tiered core and minor.

• EU-JAMRAI 2 (European Joint Action on Antimicrobial Resistance and Healthcare-Associated Infections)coreStrategic or Co-development Partner · 1 January 2024European joint action involving more than 120 institutions from 30 countries working to reinforce coordination in Europe against antimicrobial resistance and healthcare-associated infections. AEMPS leads the communication and awareness area.
• ISGlobal (Barcelona Institute for Global Health)coreStrategic or Co-development PartnerCollaboration on educational materials including Microcombat game app and original card game concept. ISGlobal collaborated with Laboratori de Jocs to create the original game idea.
• Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)coreStrategic or Co-development PartnerAEMPS is the coordinating body of PRAN, providing institutional support, regulatory authority, and operational resources for all PRAN activities.
• Spanish Universities NetworkcoreStrategic or Co-development PartnerCollaboration with universities including Universidad Complutense de Madrid, Universidad de Córdoba, Universidad de Murcia, Universidad del País Vasco, Universidad de Salamanca, Universidad de Sevilla, and Universidad de Valencia for educational programs, PRANteca platform, and awareness events.
• SEFAC (Sociedad Española de Farmacia Familiar y Comunitaria)minorStrategic or Co-development PartnerCollaboration on research study to understand perception of pharmacists and patients regarding causes of antibiotic resistance.
• SEFH (Sociedad Española de Farmacia Hospitalaria)minorStrategic or Co-development PartnerCollaboration on Platform for Monitoring Antibiotic Consumption in Hospital Settings in Spain.
• CSIC (Consejo Superior de Investigaciones Científicas)minorStrategic or Co-development PartnerCSIC invited PRAN team to learn about antibiotic resistance research through their Cicerón program, visiting CNB-CSIC and meeting with researchers working on resistance from different perspectives.
• EFSA (European Food Safety Authority)coreStrategic or Co-development PartnerEuropean authority collaborating on integrated surveillance systems and One Health approach to antimicrobial resistance.
• ECDC (European Centre for Disease Prevention and Control)coreStrategic or Co-development PartnerEuropean center for disease prevention collaborating on surveillance, awareness campaigns, and European Antibiotic Awareness Day activities.
• EMA (European Medicines Agency)coreStrategic or Co-development PartnerEuropean Medicines Agency collaborating on veterinary and human medicine aspects of antimicrobial resistance, joint strategies, and integrated surveillance.
• WHO (World Health Organization)coreStrategic or Co-development PartnerWHO collaborating on AWaRe classification system, global awareness campaigns including World Antimicrobial Awareness Week, and international coordination.
• WOAH (World Organisation for Animal Health)coreStrategic or Co-development PartnerInternational animal health organization collaborating on One Health approach and veterinary aspects of antimicrobial resistance.

Scale indicators8 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• UK Health Security Agency (UKHSA) AMR Programme: UK's national AMR coordination programme with comparable mandate in surveillance, antimicrobial stewardship, and public awareness campaigns. Operates as a government-led One Health programme addressing human and animal antibiotic resistance, making it the closest direct peer to PRAN.
• Santé Publique France: France's national public health agency with parallel functions in antimicrobial resistance surveillance, prevention, and public awareness campaigns. Operates a comparable national AMR strategy with similar One Health scope.
• Robert Koch Institute (RKI): Germany's federal public health institute coordinating the national AMR strategy (DART) with comparable surveillance, stewardship, and One Health functions. Provides a directly comparable model of government-led AMR coordination.
• ReAct: International independent AMR action network working globally on antibiotic resistance with parallel advocacy, awareness, and policy influence goals. Functions as a non-governmental counterpart with comparable mission focus on AMR reduction.

Broad incumbents

• European Centre for Disease Prevention and Control (ECDC): EU-level agency coordinating AMR surveillance across member states, European Antibiotic Awareness Day, and joint stewardship initiatives. Operates a broader EU-wide scope than PRAN but shares the same fundamental mission and partners with PRAN through EU-JAMRAI.
• Centers for Disease Control and Prevention (CDC) AMR Programs: US federal agency with broader public health scope but significant AMR programmes including AR Lab Network, stewardship initiatives, and public awareness. Provides a comparable but much larger-scale model of government-led AMR coordination.
• World Health Organization (WHO) AMR: Global coordinator for AMR strategy through the AWaRe classification, Tripartite Joint Secretariat with WOAH and FAO, and World Antimicrobial Awareness Week. Operates a broader global mandate and sets the frameworks PRAN implements nationally.
• WOAH (World Organisation for Animal Health): Global intergovernmental animal health organization coordinating AMR response in veterinary sectors under the One Health approach. Addresses the animal health component that PRAN manages nationally, with a much broader global scope.

Others

• ISGlobal (Barcelona Institute for Global Health): Key PRAN partner that co-developed the Microcombat educational app and contributes research expertise on AMR. Functions as an enabling research and policy partner rather than a direct competitor, but works on closely related AMR themes.
• EU-JAMRAI: European Joint Action on Antimicrobial Resistance and Healthcare-Associated Infections involving 120+ institutions from 30 countries. A core partner of PRAN with broader EU-wide coordination mandate, providing the platform through which PRAN's methodology scales.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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Frequently asked questions about Plan Nacional frente a la Resistencia a los Antibióticos PRAN