What sync2brain GmbH does

sync2brain GmbH is a Tübingen, Germany-based neurotechnology company founded in 2019 as a spin-out from the University of Tübingen, supported by the German Ministry of Economic Affairs' EXIST Transfer of Research program and the European Social Fund. The company develops real-time EEG-synchronized Transcranial Magnetic Stimulation (TMS) technology, combining proprietary hardware (the bossdevice) with software (bossapp RESEARCH) to deliver brain-state dependent stimulation with millisecond-accuracy pattern detection and trigger generation. The core architecture consists of a real-time digital signal processor that reads raw EEG data streams from bio-signal amplifiers, continuously analyzes the data, detects oscillatory patterns in theta, alpha, and beta frequency bands, and triggers connected TMS devices when pre-defined brain states are detected. The system supports up to 128 EEG channels at 5 kHz sample rate and is compatible with Brain Products actiCHamp (with TurboLink) and Bittium NeurOne EEG amplifiers.

The company's product portfolio spans two distinct lines. The bossdevice RESEARCH is CE-marked for research use only and is sold directly to neuroscience research laboratories worldwide, paired with the MATLAB-based bossapp RESEARCH control software that requires a purchased license. The bossdevice MEDICAL, currently undergoing CE certification, targets the clinical and therapeutic market with planned deployment in hospitals and TMS clinics for EEG-synchronized TMS therapy in stroke neurorehabilitation and depression treatment. An open-source MATLAB API is also available on GitHub to enable custom research integrations. The company holds EN ISO 13485:2026 and MDSAP (Medical Device Single Audit Program) certifications, with MDSAP and MP2021 certificates obtained in November 2025 for the development, production, and trading of software-based devices for brain-state dependent stimulation.

sync2brain operates a sales-led, direct go-to-market targeting clinical research institutions, TMS clinics, and neuroscience research laboratories. Revenue is generated through one-time hardware sales (bossdevice RESEARCH), recurring software licensing (bossapp RESEARCH), and future medical device sales once the bossdevice MEDICAL obtains CE certification. Pricing is quote-based and not publicly disclosed. Key commercial and technology partners include Brain Products and Bittium (EEG amplifier integration), MathWorks (MATLAB/Simulink Real-Time platform), and the University of Tübingen (founding partner and ongoing clinical collaborator). The company is an associated partner of the EU-funded FRESCO4NoPain Marie Sklodowska-Curie Action Doctoral Network and was selected in 2026 for the EU Women TechEU program supporting high-potential women-led deep-tech startups.

Name

sync2brain GmbH

Legal name

sync2brain GmbH

Website

https://sync2brain.com

Company type

Private

Operating status

Operating

Headcount range

1–10 employees

Short description

sync2brain GmbH develops real-time EEG-synchronized Transcranial Magnetic Stimulation (TMS) hardware and software for brain-state dependent stimulation. The Tübingen-based company sells research equipment to neuroscience laboratories and is pursuing CE certification of its bossdevice MEDICAL for clinical TMS therapy applications.

Ownership category

akta.pro rank

Product category

Neuromodulation Medical Devices

NAICS

Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)

SIC

Electromedical & Electrotherapeutic Apparatus (3845)

akta.pro primary industry

Implantable Neuromodulation & Neurostimulation (SCS/DBS/VNS/PNS) (HLAHAEAK)

akta.pro secondary industry

Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables) (HLAHACAE)

Keywords

• Brain stimulation devices
• Neuromodulation technology
• TMS therapy systems
• EEG signal processing
• Medical device hardware

Headquarters

HQ city

Tübingen

HQ country

Germany

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Supply Chain

Revenue model

1. bossdevice RESEARCH Hardware Sales: Sale of the bossdevice RESEARCH hardware unit, a real-time digital signal processor for research use. The device requires a MathWorks MATLAB license (with Simulink Real-Time) and a separate control PC, and is compatible with specific EEG amplifiers from Brain Products and Bittium.
2. bossapp RESEARCH Software Licensing: The bossapp RESEARCH requires purchase of a license to use. Licenses are automatically verified when connected to the bossdevice via internet. Offline local license files are available for computers without internet connectivity. The company also offers demo licenses.
3. bossdevice MEDICAL (post-CE certification): Once CE certified, the bossdevice MEDICAL will be available as a medical device for clinical use with compatible EEG amplifiers and TMS stimulators, generating revenue from hospitals and TMS clinics.
4. bossdevice API - Open Source: An open-source MATLAB API is available for the bossdevice RESEARCH, provided free of charge to enable custom use cases and integration.

Go-to-market motion1 record

Distribution channels4 records

Marketing channels7 records

Core offering

sync2brain develops and sells a hardware-software platform for EEG-synchronized Transcranial Magnetic Stimulation (TMS) therapy. The core products are the bossdevice hardware (available as a CE-marked RESEARCH version and a MEDICAL version under CE certification) and the bossapp RESEARCH MATLAB-based control software, which together detect specific oscillatory brain states in real time from EEG data and trigger TMS stimulation with millisecond accuracy for personalized brain-state dependent therapy.

Product overview

sync2brain develops a hardware-software platform for personalized brain-stimulation therapy using Transcranial Magnetic Stimulation (TMS). The core offering consists of the bossdevice hardware (available in RESEARCH and MEDICAL versions) combined with bossapp RESEARCH software for device control. The bossdevice is a real-time digital signal processor that reads EEG data, predicts oscillatory brain states using autoregressive algorithms, and triggers TMS stimulation at precise moments. The RESEARCH version is CE-marked for research use, while the MEDICAL version is undergoing CE certification for clinical therapy applications.

Differentiator

Problem solved

Functional benefit

Brands

• bossdevice MEDICAL: Medical device for EEG-synchronized TMS experiments and therapy - CE certification in preparation, available as investigational device for approved clinical studies
• bossdevice RESEARCH
• bossapp RESEARCH

Products and services

• bossdevice RESEARCH Real-time digital signal processor (hardware plus software algorithms) that reads raw EEG data streams from bio-signal amplifiers, continuously analyzes the data, detects oscillatory patterns in theta, alpha, and beta frequency bands, and triggers connected devices with millisecond accuracy when pre-defined brain states are detected. CE marked for research use only; not a medical device. Sold to neuroscience research laboratories globally.
• bossdevice MEDICAL Medical device version of the bossdevice intended for use with compatible EEG amplifiers and TMS stimulators for EEG-synchronized TMS experiments and therapy. Once CE certified, will be available for clinical use with hospitals and TMS clinics; in the meantime available as an investigational device for approved clinical studies.
• bossapp RESEARCH MATLAB-based application software providing the graphical user interface for configuring and controlling the bossdevice RESEARCH. Enables EEG channel configuration, protocol setup, real-time visualization of EEG data, spatial filtering, oscillation metrics, artifact monitoring, phase estimation accuracy, and recording management. Requires a MathWorks MATLAB license with Simulink Real-Time.

Quantifiable outcome

• millisecond accuracy in detecting and responding to target oscillatory brain states
• +2 more outcomes

Named customers2 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

AI capability3 records

Feature6 records

Partnerships

Six partnerships are on record, tiered core.

• Women TechEU (EU Commission)coreGTM or Marketing Partner · 1 January 2025sync2brain was selected for the Women TechEU program, an EU initiative supporting high-potential women-led deep-tech startups. The program selected 40 companies out of more than 1,100 applicants. sync2brain participates as a cohort member, benefiting from visibility, networking, and support for scaling deep-tech technology. CEO Dr. Ramona Samba represents the company in this initiative.
• FRESCO4NoPain NetworkcoreStrategic or Co-development Partner · 1 January 2025sync2brain is an associated partner of the FRESCO4NoPain EU-funded Marie Sklodowska-Curie Action Doctoral Network. The network provides world-class interdisciplinary training to 17 Doctoral Candidates in non-pharmacological chronic pain treatment based on pain-related brain oscillations and neuromodulation. sync2brain contributes expertise in brain-state dependent stimulation technology to this training network.
• Brain Products (actiCHamp + TurboLink)coreTechnology or Integration · 1 January 2020Real-time brain-state dependent research collaboration between Brain Products and sync2brain. The bossdevice RESEARCH is compatible with Brain Products actiCHamp EEG amplifiers with TurboLink real-time digital output. TurboLink sends real-time EEG data to the bossdevice at 1000Hz via UDP to 192.168.200.255. Joint webinar and GoToStage recordings demonstrate collaborative solutions. Brain Products serves as a key technology integration partner and channel for sync2brain's research market.
• Bittium (NeurOne)coreTechnology or Integration · 1 January 2020The bossdevice RESEARCH is compatible with Bittium NeurOne EEG amplifiers with real-time digital output. The NeurOne system sends real-time EEG data to the bossdevice via its Digital OUT Ethernet port using specific UDP configuration (Target IP 192.168.200.255, Packet Frequency 1000, UDP Port 25000). This partnership enables sync2brain to serve the Bittium user base in neuroscience research.
• University of TübingencoreStrategic or Co-development Partnersync2brain was founded out of a technology transfer research project at the University of Tübingen. The TMS clinic at the University Neurology Hospital of Tübingen conducts TMS therapy and clinical trials using sync2brain technology (www.tms-nach-schlaganfall.de). The university is a key founding partner and ongoing research collaborator.
• MathWorks (MATLAB/Simulink)coreTechnology or IntegrationThe bossapp RESEARCH is developed using MathWorks MATLAB with Simulink Real-Time. sync2brain is featured on the MathWorks Startups blog as a startup using MATLAB/Simulink for developing personalized brain stimulation therapy. The bossdevice API is available as an open-source MATLAB toolkit on GitHub (sync2brain/bossdevice-api-matlab).

Scale indicators3 records

Expansion highlights6 records

Broad incumbents

• Magstim: Established UK-based manufacturer of Transcranial Magnetic Stimulation (TMS) systems widely used in research and clinical practice. Comparable as the dominant incumbent supplier of TMS stimulators that sync2brain's bossdevice pairs with, and a potential integrator of closed-loop functionality.
• Brain Products: Germany-based leading manufacturer of EEG amplifier systems and accessories (actiCHamp, LiveAmp) used widely in neuroscience research. Comparable as both a partner and an adjacent incumbent in the EEG signal chain that sync2brain's bossdevice integrates with.
• Bittium: Finland-based vendor of the NeurOne EEG amplifier system with real-time digital output used in clinical and research neurophysiology. Comparable as a technology integration partner whose EEG platform underpins sync2brain's bossdevice workflows.
• ANT Neuro: Netherlands-based provider of EEG, MEG, and TMS-neuronavigation solutions for neuroscience research and clinical applications. Comparable as a multi-modality neurotechnology vendor serving the same research-laboratory customers.

Direct peers

• Neuroelectrics: Barcelona-based company developing EEG-triggered transcranial electrical stimulation (tES) systems with closed-loop capabilities for clinical and research use. Directly comparable as a competitor building EEG-driven brain stimulation hardware/software platforms.
• Soterix Medical: US-based neuromodulation technology company specializing in non-invasive brain stimulation devices including tDCS, tACS, and HD-tES with research and clinical offerings. Comparable as a direct competitor in the personalized/non-invasive neurostimulation category.
• Nexstim: Finland-based company providing navigated TMS systems for both clinical depression therapy and presurgical mapping. Comparable as a TMS device company pursuing the same neurostimulation therapy market with regulatory-cleared devices.
• Brainsway: Israel-based medical device company commercializing deep TMS systems for clinical indications including depression and OCD. Directly comparable as a clinical TMS therapy company targeting the same hospital and clinic customer base that bossdevice MEDICAL would address.

Emerging players

• eNeura: US-based neuromodulation company developing non-invasive devices for migraine and other neurological conditions. Comparable as a non-invasive neuromodulation company pursuing regulated clinical indications with hardware-software therapy platforms.
• Rogue Research: Canada-based company producing BrainSight neuronavigation systems commonly paired with TMS in research and clinical workflows. Comparable as a TMS-adjacent hardware/software provider targeting the same research clinics.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks7 records

Key highlights7 records

Customer concentration

• GitHubgithub.com/sync2brain
• LinkedInlinkedin.com/company/sync2brain

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles11 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about sync2brain GmbH