Transplant Advocates LLC

What Transplant Advocates LLC does

Paragonix Technologies (operating entity referenced as Transplant Advocates LLC) is a Massachusetts-incorporated medical device company, founded in 2015 and headquartered in Waltham, MA, that develops FDA-cleared and CE-marked advanced organ preservation systems for heart, lung, liver, kidney, and pancreas transplantation. The company's core technology combines controlled hypothermic preservation (maintaining consistent 4-8°C thermal environments to prevent freezing injury) with a digital monitoring layer — the Paragonix App, VantagePoint GPS tracking, and the Paragonix Web Portal — that provides real-time temperature readings, location visibility, and HIPAA-compliant team coordination. Its portfolio includes six FDA 510(k)-cleared devices (SherpaPak, LUNGguard, BAROguard, LIVERguard, PancreasPak, KidneyVault), five of which also hold EU MDR approval, with several being the first FDA-cleared devices for their respective organ types (heart, liver, pancreas).

The company operates a dual revenue model combining hardware sales of preservation devices with clinical procurement services that supply skilled surgeons, preservationists, surgical assistance, and 24/7 logistical coordination to transplant programs and Organ Procurement Organizations (OPOs). Distribution is direct-to-enterprise, supported by seven US procurement hubs, a dedicated nationwide Paragonix Distribution Fleet (launched November 2025), and over 50 procurement professionals. As of the most recent data, the company reports over 20,000 donor organs preserved across 250+ transplant centers globally and over 35 peer-reviewed clinical studies, anchored by the GUARDIAN-Heart, GUARDIAN-Lung, and GUARDIAN-Liver registries — the largest observational database studying post-transplant impact of organ preservation.

In March 2023, Paragonix raised a $24 million Series B led by Signet Healthcare Partners, and in August 2024 the company signed a definitive agreement to be acquired by Getinge, a global MedTech company. Post-acquisition, Paragonix operates as a Getinge subsidiary while maintaining its brand identity and leadership in advanced organ preservation. The company also pursues strategic partnerships with OPOs (Donor Network West, HonorBridge, Sierra Donor Services, Mid-America Transplant) and runs clinical trials such as CONCERT-DCD with UW Medicine aimed at expanding utilization of donation-after-circulatory-death donor hearts.

Name

Transplant Advocates LLC

Legal name

Paragonix Technologies, Inc.

Website

https://transplantadvocates.com

Company type

Private

Founded year

2015

Operating status

Operating

Headcount range

11–50 employees

Short description

Paragonix Technologies (operating via Transplant Advocates LLC) develops FDA-cleared hypothermic organ preservation devices and real-time digital monitoring platforms for heart, lung, liver, kidney, and pancreas transplants, serving 250+ transplant centers and federally designated OPOs globally. Now a Getinge subsidiary following its August 2024 acquisition.

Ownership category

akta.pro rank

Product category

Organ Preservation Medical Devices

NAICS

Surgical Appliance and Supplies Manufacturing (339113), Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)

SIC

Surgical & Medical Instruments & Apparatus (3841), Electromedical & Electrotherapeutic Apparatus (3845)

akta.pro primary industry

Transplantation & Advanced Therapies Pharmaceuticals (incl. Cell & Gene Therapies) (HLAIAAAO)

Keywords

• Organ preservation devices
• Transplant logistics services
• Clinical procurement services
• Hypothermic transport technology
• Organ transplant monitoring

Headquarters

HQ city

Waltham

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Operations, Supply Chain, Marketing or Sales, Infrastructure

Revenue model

1. Organ Preservation Device Sales: Sale of FDA-cleared and CE-marked advanced organ preservation devices (SherpaPak, LUNGguard, BAROguard, LIVERguard, PancreasPak, KidneyVault) to transplant centers and OPOs.
2. Clinical Procurement Services: 24/7 on-call procurement services providing skilled procurement surgeons, preservationists, surgical assistance, logistical support, air and ground transportation coordination to transplant centers. Customized to fit specific needs of each center.

Pricing tiers

Go-to-market motion3 records

Distribution channels4 records

Marketing channels6 records

Core offering

Transplant Advocates LLC, operating as Paragonix Technologies, designs, manufactures, and sells FDA-cleared and CE-marked advanced hypothermic organ preservation devices (SherpaPak for heart, LUNGguard and BAROguard for lung, LIVERguard for liver, PancreasPak for pancreas, KidneyVault for kidney) that maintain donor organs at controlled temperatures during transport. The hardware is paired with the Paragonix App and VantagePoint GPS-based digital monitoring platform for real-time temperature, location, and case coordination, and complemented by 24/7 nationwide clinical procurement and logistics services delivered through a network of 50+ certified surgeons and preservationists across seven U.S. procurement hubs.

Product overview

Paragonix Technologies offers a comprehensive organ transplant preservation portfolio comprising six FDA-cleared and five CE-marked medical devices. The core product line includes SherpaPak (cardiac transport), LUNGguard and BAROguard (lung preservation), LIVERguard (liver preservation), PancreasPak (pancreas preservation), and KidneyVault (renal perfusion). These devices are complemented by the Paragonix App and VantagePoint digital tracking platform for real-time monitoring, GPS location tracking, and HIPAA-compliant coordination. Clinical support services provide 24/7 procurement teams and surgical assistance. The GUARDIAN clinical registries collect post-transplant outcome data. All devices maintain controlled hypothermic temperatures to prevent freezing damage during organ transport.

Differentiator

Problem solved

Functional benefit

Brands

• SherpaPak: Cardiac Transport System for heart preservation and transport
• LUNGguard
• BAROguard
• LIVERguard
• PancreasPak
• KidneyVault
• VantagePoint
• Every Possible Angle
• GUARDIAN Registries

Products and services

• SherpaPak Cardiac Transport System FDA-cleared and CE-marked heart preservation device that securely transports donor hearts at controlled hypothermic temperatures (4-8°C) to prevent freezing damage, replacing traditional ice storage with up to 4 hours of preservation. Used by hospital cardiac transplant programs and OPOs.
• LUNGguard Donor Lung Preservation System

Quantifiable outcome

• 67% reduction in Severe Primary Graft Dysfunction (p=0.011) in heart transplant patients using SherpaPak vs conventional ice storage
• +9 more outcomes

Named customers12 records

Segments6 records

Ideal customer profiles6 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature12 records

Partnerships

Nine partnerships are on record, tiered core and minor.

• UW Medicine (University of Washington)coreStrategic or Co-development Partner · 27 May 2026Collaboration with UW Medicine to launch the CONCERT-DCD clinical trial, aiming to maximize heart transplant utilization using Paragonix preservation technology for donation after circulatory death (DCD) donors.
• Gravitas SurgicalcoreStrategic or Co-development Partner · 18 November 2025Strategic partnership with Gravitas Surgical to improve donor lung viability and availability on the US West Coast. Combines Paragonix's organ preservation technology with Gravitas Surgical's medical technology services.
• HonorBridgecoreStrategic or Co-development Partner · 29 October 2025HonorBridge, North Carolina's largest organ donation and tissue recovery organization, partnered with Paragonix for first successful liver transplant using LIVERguard technology, transporting donor liver from North Carolina to Tampa General Hospital.
• Donor Network WestcoreStrategic or Co-development Partner · 17 September 2025Strategic partnership with Donor Network West, a federally designated OPO, to enhance clinical utilization of complex donor kidneys via the KidneyVault Portable Renal Perfusion System.
• UC HealthcoreStrategic or Co-development Partner · 19 May 2025UC Health utilizes the Paragonix LIVERguard Donor Liver Preservation System to support its growing liver transplant program and help expand access to transplantation for more patients.
• Sierra Donor ServicescoreStrategic or Co-development Partner · 13 May 2025Partnership with Sierra Donor Services and UCI Health to place high-risk donor kidneys, expanding transplant opportunities for patients in need through KidneyVault preservation technology.
• Dr. Kiran Dhanireddy / Tampa General Hospital Transplant InstitutecoreStrategic or Co-development Partner · 3 October 2024Dr. Kiran Dhanireddy, VP and Chief of Tampa General Hospital Transplant Institute, appointed as principal investigator of the GUARDIAN-Liver clinical registry which has surpassed 500 enrollments.
• NORA (Nationwide Organ Recovery Transport Alliance)coreStrategic or Co-development Partner · 29 August 2024Paragonix led a new donor organ courier service initiative in partnership with NORA to establish a cost-effective transport alternative. NORA provides transport logistics for organ recovery.
• Enduring HeartsminorGTM or Marketing Partner · 1 June 2023Paragonix sponsors Enduring Hearts' Road to Recovery family program, which provides gas gift cards to pediatric heart transplant families to help subsidize costs of frequent travel to medical appointments. Collaboration includes podcast participation and awareness building.

Scale indicators14 records

Recent moves10 records

Expansion highlights5 records

Broad incumbents

• Getinge: Parent company of Paragonix following the August 2024 acquisition; broader MedTech incumbent with adjacent surgical, perfusion, and ICU product lines that overlap with transplant center purchasing.

Direct peers

• OrganOx: Maker of the metra normothermic liver perfusion device, competing with Paragonix's LIVERguard for liver transplant programs. Comparable customer base of transplant centers and OPOs in the same organ preservation category.
• Institut Georges Lopez (IGL): Manufacturer of organ preservation solutions (e.g., IGL-1, SCOT, UW solution variants). Competes with Paragonix at the preservation chemistry/consumables layer of the transplant workflow.
• XVIVO Perfusion: Public Swedish company providing machine perfusion and preservation technologies for lungs, livers, and kidneys. Competes with Paragonix's LUNGguard, LIVERguard, and KidneyVault products in European and U.S. transplant markets.
• BioLife Solutions: Provider of biopreservation media and storage/protection products for cells, tissues, and organs. Adjacent competitor in the preservation consumables and solutions category serving transplant and cell therapy workflows.
• Bridge to Life: Supplier of organ preservation solutions and devices used in transplantation logistics. Comparable offering in the preservation workflow sold to transplant centers and OPOs.
• TransMedics: Developer of the Organ Care System (OCS), a normothermic perfusion platform for heart, lung, and liver preservation and transport. Most direct head-to-head competitor to Paragonix across overlapping organ categories and transplant center customers.
• Organ Recovery Systems: Manufacturer of the LifePort Kidney Transporter and other static cold storage/perfusion devices. Direct competitor in hypothermic kidney perfusion, the same category as Paragonix's KidneyVault.
• Waters Medical Systems: Developer of hypothermic perfusion devices for kidney preservation. Direct competitor in renal machine perfusion alongside Paragonix's KidneyVault.

Emerging players

• Preservation Solutions: Specialty manufacturer of organ and tissue preservation solutions for transplantation. Smaller-scale competitor with overlap in static cold storage chemistries used by transplant centers.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/paragonixsherpa
• YouTubeyoutube.com/channel/UCcSIumk2Sncu0RpzmT1mwnA
• Facebookfacebook.com/paragonixsherpa
• LinkedInlinkedin.com/company/transplant-advocates-llc

Compliance5 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles8 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Transplant Advocates LLC