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Immune Boost Capital

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uuid00q61jp

Namestring
Immune Boost Capital
Legal namestring
Immune Boost Capital
Company typeenum
Private
Founded yearint
2026
Descriptiontext

Immune Boost Capital (IBC) is a 501(c)(3) philanthropic venture fund that provides catalytic capital to founders and academic investigators developing early-stage autoimmune therapeutics, diagnostics, and enabling technologies. Founded in April 2026 as the venture investment arm of the Arthritis National Research Foundation (ANRF, established 1970), IBC targets the funding gap between academic discovery and venture-ready commercial development, writing exploratory seed checks of $100,000–$250,000, initial lead or co-investments up to $500,000, and selective follow-on catalytic top-ups intended to bridge teams to traditional Seed or Series A rounds.

IBC operates an evergreen fund structure that reinvests 100% of returns into the mission and charges no management fees or carried interest. Donations are processed under the parent ANRF's 501(c)(3) status and are explicitly charitable contributions with no financial return to donors. The fund's customers are early-stage founders, academic investigators and spinouts, and mission-aligned individual and organizational donors; deal sourcing is community-led, relying on ANRF's scientific network, word-of-mouth referrals, and inbound inquiries through a website pitch form, dedicated email, and phone line. There are no software products, platforms, or technology services — IBC's "product" is capital deployment and scientific partnership.

Leadership is centered on Fund Principal Dr. Sai Nandi (D.Phil. Biochemistry, Oxford; formerly managed $1B+ healthcare portfolios at AIG Investments; board roles at more than 10 biotech companies), supported by Board Chair Jeff Greenberg (Thermo Fisher Scientific affiliation), Venture Partner Schalon Newton, and Director of Operations Emily Stormoen (also CEO of parent ANRF). The organization is registered in California with a Los Angeles mailing address, employs 1–10 staff, and markets itself through its website, newsroom, and X (Twitter) presence.

Short descriptiontext

Immune Boost Capital is a 501(c)(3) philanthropic venture fund that provides $100K–$500K catalytic seed capital to early-stage founders and academic investigators developing autoimmune therapeutics, diagnostics, and enabling technologies, recycling 100% of returns into the mission.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
1–10
akta.pro rankint
HeadquartersIrvine, United States
HQ citystring
Irvine
HQ countrystring
United States
HQ regionstring
North America
Markets served

Serves global market

Offices1 record

Each record includes

City, Country, Type, Description, Source

Keyword5 values
venture philanthropy, autoimmune research funding, catalytic capital, nonprofit venture fund, early-stage biotech investment
Industry2 codes
PRIMARYBPAGAKAO
Capacity Building & Nonprofit Infrastructure Funders
Business & Public Services/Nonprofit, NGO & Social Services/Philanthropy, Foundations & Grantmaking
SECONDARYHLAIACAB
Immunology & Autoimmune Specialty Pharmaceuticals
NAICS code2 codes
  • Voluntary Health Organizations813212
  • Grantmaking Foundations813211
SIC code1 code
  • Services-Social Services8300
Product category
Venture Capital / Impact Investing
Social media profiles1 record
GTM motion1 record

Each record includes

Type, Description, Source

Revenue model1 record
1Charitable Donations
TypeGrants Donations
Description

IBC operates as a 501(c)(3) nonprofit philanthropic venture fund. Contributions from donors provide immediate tax benefits and are recycled into investment returns for autoimmune research. Donations do not constitute securities or investment interests.

immuneboostcapital.org
Marketing channels4 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels3 records

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components4 values
Personnel, Operations, Marketing or Sales, Others
Pricing details3 tiers
1Exploratory seed capital for hypothesis validation
ModelOtherBilling cadenceOne time/ perpetual license
Notes

$100K – $250K for earliest catalytic capital to validate hypotheses and generate decisive data

immuneboostcapital.org
2Initial investment for lead or co-invest opportunities
ModelOtherBilling cadenceOne time/ perpetual license
Notes

Up to $500K, lead or co-invest with flexibility to syndicate alongside aligned VCs and strategics

immuneboostcapital.org
3Selective follow-on catalytic top-ups
ModelOtherBilling cadenceMulti-year contract
Notes

Reserved capital to bridge teams to a traditional Seed or Series A round

immuneboostcapital.org
GTM typeB2B
B2B
Offering typeServices
Services
Core offering1 text field

Immune Boost Capital is a 501(c)(3) philanthropic venture fund that provides catalytic investment capital ($100K-$500K) to early-stage companies developing autoimmune therapeutics, diagnostics, and enabling technologies. Operating as an evergreen fund, it reinvests 100% of returns into autoimmune research and accepts charitable donations from mission-aligned individuals and organizations.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 of 2 values shown
  • Initial and co-investments up to $500K; pre-clinical to IND-enabling stage
+1 more record
Product overview1 text field

Immune Boost Capital (IBC) is a philanthropic venture fund, not a technology product company. It operates as an evergreen impact investment fund established by the Arthritis National Research Foundation, investing catalytic capital into early-stage autoimmune diagnostics and therapeutics. The fund recycles 100% of returns to accelerate innovation in immune-related diseases. No software products, platforms, or technology services are offered.

Product and service4 records
1Exploratory Seed Capital
CategoryVenture Investment
Description

Catalytic seed investment of $100K-$250K for the earliest validation of hypotheses and generation of decisive data, targeting founders of early-stage autoimmune diagnostics and therapeutics.

2Initial Investment Capital
CategoryVenture Investment
Description

Lead or co-investment of up to $500K for early-stage autoimmune companies, with the flexibility to syndicate alongside aligned venture capital and strategic investors.

3Selective Follow-on Capital
CategoryVenture Investment
Description

Reserved catalytic top-up capital designed to bridge portfolio teams to a traditional Seed or Series A financing round.

4Charitable Donation Program
CategoryPhilanthropy / Donations
Description

Tax-deductible charitable giving program that funds IBC's catalytic investments; donations are processed under ANRF's 501(c)(3) nonprofit status and are not securities or investment interests.

Scale indicator4 records

Each record includes

Type, Value, Description, Source

Partnership1 partner
Strategic tierCoreTypeStrategic or Co-development Partner
Description

ANRF is IBC's parent 501(c)(3) organization and financial/scientific partner. IBC is operationally independent but guided by ANRF's experienced investors, scientists, and healthcare leaders. ANRF has been funding autoimmune research cures since 1970.

Recent move6 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight6 records

Each record includes

Type, Description

Peers10 records
TypeRegional player
Description

UK-based medical research charity with a venture philanthropy arm making equity investments in early-stage therapeutics and spinning out companies from academic research. Comparable to IBC's mission-driven translational funding model, but operates primarily in the UK and is significantly larger.

TypeBroad incumbent
Description

The largest nonprofit funder of Parkinson's disease research, including substantial investments in biotech companies and translational programs. Operates a similar disease-focused mission-aligned funding model but at much greater scale and broader scope than IBC.

TypeBroad incumbent
Description

Nonprofit product development partnership funding development of new tuberculosis treatments with philanthropic and public capital. Comparable to IBC in mission-driven, returns-recycled funding of therapeutic development, though TB Alliance operates more as a PDP than a venture fund.

TypeDirect peer
Description

Nonprofit focused on Alpha-1 antitrypsin deficiency that funds research and has invested in therapeutic companies developing treatments for the disease. Comparable to IBC as a disease-specific nonprofit with research-funding and investment activities, though smaller and more narrowly focused than IBC.

TypeDirect peer
Description

Funds academic physician-scientists developing novel therapeutics, with an accompanying investment arm supporting commercialization. Comparable to IBC's mission of bridging academic discovery to venture-ready innovation in therapeutics.

TypeDirect peer
Description

Funds early-stage drug discovery for Alzheimer's and related dementias through grants and venture-style investments, with a focus on bridging academic discoveries to commercial development. Directly comparable to IBC's catalytic-capital-for-translational-science model in a single disease area.

TypeBroad incumbent
Description

The pioneer of venture philanthropy in disease-focused drug development, having funded CF therapeutic breakthroughs and reinvesting returns into further research. Significantly larger and more established than IBC, but operates on a structurally similar catalytic-capital, returns-recycled model for a single disease area.

TypeBroad incumbent
Description

Product development partnership that funds and develops new antimalarial treatments using mission-aligned capital from public and philanthropic sources. Operates a comparable catalytic-capital-for-therapeutics model, though focused on neglected tropical diseases and structured as a PDP rather than a venture fund.

TypeDirect peer
Description

The venture philanthropy fund of JDRF, investing catalytic capital in early-stage Type 1 Diabetes therapeutics. Operates on a near-identical model to IBC—mission-aligned, evergreen-style, recycling returns into further research—making it the closest comparable peer.

TypeDirect peer
Description

The venture philanthropy arm of the International Myeloma Foundation, investing in early-stage multiple myeloma therapeutics and recycling returns into further research. Highly comparable as a disease-focused, returns-recycled philanthropic venture fund serving founders of early-stage biotech.

Market position
Strengths5 records

Each record includes

Headline, Details, Source

Weaknesses5 records

Each record includes

Headline, Details, Source

Competitive moat4 records

Each record includes

Type, Details

Key risks6 records

Each record includes

Headline, Details, Source

Key highlights7 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Segment3 records

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile3 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
No
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles4 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

No data
No data
Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Immune Boost Capital

Venture Capital / Impact Investingimmuneboostcapital.org

Immune Boost Capital is a 501(c)(3) philanthropic venture fund that provides $100K–$500K catalytic seed capital to early-stage founders and academic investigators developing autoimmune therapeutics, diagnostics, and enabling technologies, recycling 100% of returns into the mission.

What Immune Boost Capital does

Immune Boost Capital (IBC) is a 501(c)(3) philanthropic venture fund that provides catalytic capital to founders and academic investigators developing early-stage autoimmune therapeutics, diagnostics, and enabling technologies. Founded in April 2026 as the venture investment arm of the Arthritis National Research Foundation (ANRF, established 1970), IBC targets the funding gap between academic discovery and venture-ready commercial development, writing exploratory seed checks of $100,000–$250,000, initial lead or co-investments up to $500,000, and selective follow-on catalytic top-ups intended to bridge teams to traditional Seed or Series A rounds.

IBC operates an evergreen fund structure that reinvests 100% of returns into the mission and charges no management fees or carried interest. Donations are processed under the parent ANRF's 501(c)(3) status and are explicitly charitable contributions with no financial return to donors. The fund's customers are early-stage founders, academic investigators and spinouts, and mission-aligned individual and organizational donors; deal sourcing is community-led, relying on ANRF's scientific network, word-of-mouth referrals, and inbound inquiries through a website pitch form, dedicated email, and phone line. There are no software products, platforms, or technology services — IBC's "product" is capital deployment and scientific partnership.

Leadership is centered on Fund Principal Dr. Sai Nandi (D.Phil. Biochemistry, Oxford; formerly managed $1B+ healthcare portfolios at AIG Investments; board roles at more than 10 biotech companies), supported by Board Chair Jeff Greenberg (Thermo Fisher Scientific affiliation), Venture Partner Schalon Newton, and Director of Operations Emily Stormoen (also CEO of parent ANRF). The organization is registered in California with a Los Angeles mailing address, employs 1–10 staff, and markets itself through its website, newsroom, and X (Twitter) presence.

Immune Boost Capital firmographics

Firmographics
Name
Immune Boost Capital
Legal name
Immune Boost Capital
Website
https://immuneboostcapital.org
Company type
Private
Founded year
2026
Operating status
Operating
Headcount range
1–10 employees
Short description
Immune Boost Capital is a 501(c)(3) philanthropic venture fund that provides $100K–$500K catalytic seed capital to early-stage founders and academic investigators developing autoimmune therapeutics, diagnostics, and enabling technologies, recycling 100% of returns into the mission.
Ownership category
akta.pro rank

Immune Boost Capital industry classification

Industry
Product category
Venture Capital / Impact Investing
NAICS
Voluntary Health Organizations (813212), Grantmaking Foundations (813211)
SIC
Services-Social Services (8300)
akta.pro industry
PRIMARYBPAGAKAO
Capacity Building & Nonprofit Infrastructure Funders
Business & Public Services/Nonprofit, NGO & Social Services/Philanthropy, Foundations & Grantmaking
SECONDARYHLAIACAB
Immunology & Autoimmune Specialty Pharmaceuticals

Keywords

  • Venture philanthropy
  • Autoimmune research funding
  • Catalytic capital
  • Nonprofit venture fund
  • Early-stage biotech investment

Where Immune Boost Capital is headquartered

Location

Headquarters

HQ city
Irvine
HQ country
United States
HQ region
North America

Offices1 record

Markets served

Immune Boost Capital business model

Business model
GTM type
B2B
Offering type
Services
Cost components
Personnel, Operations, Marketing or Sales, Others

Revenue model

  1. Charitable Donations: IBC operates as a 501(c)(3) nonprofit philanthropic venture fund. Contributions from donors provide immediate tax benefits and are recycled into investment returns for autoimmune research. Donations do not constitute securities or investment interests.

Pricing tiers

ModelBillingPrice
OtherOne time/ perpetual licenseExploratory seed capital for hypothesis validation
OtherOne time/ perpetual licenseInitial investment for lead or co-invest opportunities
OtherMulti-year contractSelective follow-on catalytic top-ups

Go-to-market motion1 record

Distribution channels3 records

Marketing channels4 records

Immune Boost Capital product offering

Product offering

Core offering

Immune Boost Capital is a 501(c)(3) philanthropic venture fund that provides catalytic investment capital ($100K-$500K) to early-stage companies developing autoimmune therapeutics, diagnostics, and enabling technologies. Operating as an evergreen fund, it reinvests 100% of returns into autoimmune research and accepts charitable donations from mission-aligned individuals and organizations.

Product overview

Immune Boost Capital (IBC) is a philanthropic venture fund, not a technology product company. It operates as an evergreen impact investment fund established by the Arthritis National Research Foundation, investing catalytic capital into early-stage autoimmune diagnostics and therapeutics. The fund recycles 100% of returns to accelerate innovation in immune-related diseases. No software products, platforms, or technology services are offered.

Differentiator

Problem solved

Functional benefit

Products and services

  • Exploratory Seed Capital Catalytic seed investment of $100K-$250K for the earliest validation of hypotheses and generation of decisive data, targeting founders of early-stage autoimmune diagnostics and therapeutics.
  • Initial Investment Capital Lead or co-investment of up to $500K for early-stage autoimmune companies, with the flexibility to syndicate alongside aligned venture capital and strategic investors.
  • Selective Follow-on Capital Reserved catalytic top-up capital designed to bridge portfolio teams to a traditional Seed or Series A financing round.
  • Charitable Donation Program Tax-deductible charitable giving program that funds IBC's catalytic investments; donations are processed under ANRF's 501(c)(3) nonprofit status and are not securities or investment interests.

Quantifiable outcome

  • Initial and co-investments up to $500K; pre-clinical to IND-enabling stage
  • +1 more outcomes

Companies that use Immune Boost Capital

Customer profile

Segments3 records

Ideal customer profiles3 records

Immune Boost Capital technology and API

Technology

Technology focussed No

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Immune Boost Capital partnerships and signals

Strategic signal

Partnerships

One partnership is on record.

  • Arthritis National Research Foundation (ANRF)coreStrategic or Co-development PartnerANRF is IBC's parent 501(c)(3) organization and financial/scientific partner. IBC is operationally independent but guided by ANRF's experienced investors, scientists, and healthcare leaders. ANRF has been funding autoimmune research cures since 1970.

Scale indicators4 records

Recent moves6 records

Expansion highlights6 records

Immune Boost Capital competitors and assessment

Company assessment

Regional players

  • LifeArc: UK-based medical research charity with a venture philanthropy arm making equity investments in early-stage therapeutics and spinning out companies from academic research. Comparable to IBC's mission-driven translational funding model, but operates primarily in the UK and is significantly larger.

Broad incumbents

  • Michael J. Fox Foundation: The largest nonprofit funder of Parkinson's disease research, including substantial investments in biotech companies and translational programs. Operates a similar disease-focused mission-aligned funding model but at much greater scale and broader scope than IBC.
  • TB Alliance: Nonprofit product development partnership funding development of new tuberculosis treatments with philanthropic and public capital. Comparable to IBC in mission-driven, returns-recycled funding of therapeutic development, though TB Alliance operates more as a PDP than a venture fund.
  • Cystic Fibrosis Foundation: The pioneer of venture philanthropy in disease-focused drug development, having funded CF therapeutic breakthroughs and reinvesting returns into further research. Significantly larger and more established than IBC, but operates on a structurally similar catalytic-capital, returns-recycled model for a single disease area.
  • Medicines for Malaria Venture: Product development partnership that funds and develops new antimalarial treatments using mission-aligned capital from public and philanthropic sources. Operates a comparable catalytic-capital-for-therapeutics model, though focused on neglected tropical diseases and structured as a PDP rather than a venture fund.

Direct peers

  • Alpha-1 Foundation: Nonprofit focused on Alpha-1 antitrypsin deficiency that funds research and has invested in therapeutic companies developing treatments for the disease. Comparable to IBC as a disease-specific nonprofit with research-funding and investment activities, though smaller and more narrowly focused than IBC.
  • Harrington Discovery Institute: Funds academic physician-scientists developing novel therapeutics, with an accompanying investment arm supporting commercialization. Comparable to IBC's mission of bridging academic discovery to venture-ready innovation in therapeutics.
  • Alzheimer's Drug Discovery Foundation: Funds early-stage drug discovery for Alzheimer's and related dementias through grants and venture-style investments, with a focus on bridging academic discoveries to commercial development. Directly comparable to IBC's catalytic-capital-for-translational-science model in a single disease area.
  • JDRF T1D Fund: The venture philanthropy fund of JDRF, investing catalytic capital in early-stage Type 1 Diabetes therapeutics. Operates on a near-identical model to IBC—mission-aligned, evergreen-style, recycling returns into further research—making it the closest comparable peer.
  • Myeloma Investment Fund: The venture philanthropy arm of the International Myeloma Foundation, investing in early-stage multiple myeloma therapeutics and recycling returns into further research. Highly comparable as a disease-focused, returns-recycled philanthropic venture fund serving founders of early-stage biotech.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

Immune Boost Capital social profiles

Digital presence

Immune Boost Capital financial estimates

Financial estimate

Revenue estimate

Valuation estimate

Immune Boost Capital leadership team

Management profile

Number of profiles

Profiles4 records

Immune Boost Capital funding detail

Funding detail

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

Immune Boost Capital M&A and investment

M&A and investment

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Immune Boost Capital

What does Immune Boost Capital do?

Immune Boost Capital is a 501(c)(3) philanthropic venture fund that provides catalytic investment capital ($100K-$500K) to early-stage companies developing autoimmune therapeutics, diagnostics, and enabling technologies. Operating as an evergreen fund, it reinvests 100% of returns into autoimmune research and accepts charitable donations from mission-aligned individuals and organizations.

Is Immune Boost Capital a public or private company?

Immune Boost Capital is a private company. It is classified as nonprofit foundation owned and is currently operating.

When was Immune Boost Capital founded?

Immune Boost Capital was founded in 2026. It employs 1 to 10 people.

Where is Immune Boost Capital based?

Immune Boost Capital is headquartered in Irvine, United States, in the North America region.

How does Immune Boost Capital make money?

One revenue line is on record: charitable Donations.

Who are Immune Boost Capital's main competitors?

LifeArc is listed as a regional player. Broad incumbents are Michael J. Fox Foundation, TB Alliance, Cystic Fibrosis Foundation and Medicines for Malaria Venture. Direct peers are Alpha-1 Foundation, Harrington Discovery Institute, Alzheimer's Drug Discovery Foundation, JDRF T1D Fund and Myeloma Investment Fund.

Does Immune Boost Capital have an API?

No public API is recorded for Immune Boost Capital.

What industry is Immune Boost Capital in?

Immune Boost Capital's product category is Venture Capital / Impact Investing. Its primary akta.pro industry code is BPAGAKAO, Capacity Building & Nonprofit Infrastructure Funders, with a secondary code of HLAIACAB, Immunology & Autoimmune Specialty Pharmaceuticals. Its NAICS code is 813212 and its SIC code is 8300.

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Live signals
EIN PresswireImmune Boost Capital backs Orthrus Therapeutics in autoimmune disease pushImmune Boost Capital invested in Orthrus Therapeutics, a Boston Children's Hospital spinout developing antigen-specific immune tolerance therapies for autoimmune disease, with a focus on rheumatoid arthritis. The deal adds a board observer and scientific adviser from IBC, and the company aims to move beyond broad immunosuppression toward durable remission.EIN PresswireImmune Boost Capital Invests in Orthrus Therapeutics to Advance Antigen-Specific Immune Tolerance for Autoimmune DiseaseImmune Boost Capital invested in Orthrus Therapeutics, a spinout from Boston Children's Hospital, to advance its antigen-specific immune tolerance platform. The platform uses VHH-conjugates to selectively suppress disease-driving T cells and expand regulatory T cells, aiming for durable remission without broad immunosuppression. Dr. Sai Nandi will join Orthrus's board as an observer.FierceBiotechImmune Boost Capital Invests in Orthrus Therapeutics to Advance Antigen-Specific Immune Tolerance for Autoimmune DiseaseImmune Boost Capital invested in Orthrus Therapeutics, a company developing VHH-conjugate therapies for autoimmune disease. The platform selectively suppresses disease-driving T cells and expands regulatory T cells, aiming for durable remission without broad immunosuppression. Dr. Sai Nandi will join Orthrus's board as an observer.EIN PresswireImmune Boost Capital Appoints Dr. Sai Nandi to Head Impact Investment Fund Targeting Immune-Mediated DiseasesImmune Boost Capital (IBC), the evergreen venture fund established by the Arthritis National Research Foundation, announced the appointment of Dr. Sai Nandi as Fund Principal to lead its impact investment fund targeting early-stage therapies, diagnostics, and technologies for immune-mediated diseases. Dr. Nandi brings more than two decades of life sciences investment experience, having previously managed public and private healthcare portfolios exceeding $1 billion at AIG Investments, and has served on boards of more than 10 biotech and healthcare technology companies. As an evergreen fund, IBC reinvests 100% of returns to accelerate innovation in immune-related diseases, with Dr. Nandi tasked with scaling the fund and expanding its investment strategy.EIN PresswireArthritis National Research Foundation Appoints Schalon Newton, DBA, as Principal of Immune Boost CapitalThe Arthritis National Research Foundation appointed Schalon Newton, DBA as Principal of Immune Boost Capital, a newly established philanthropic evergreen venture fund targeting early-stage autoimmune disease research. IBC was created to bridge the funding gap between academic discovery and commercial development by providing up to $500,000 in proof-of-concept capital per company, with a unique model that reinvests 100% of returns to sustain innovation. Dr. Newton brings over 30 years of life sciences leadership experience from Trefoil Therapeutics, Santen Inc., and Allergan Pharmaceuticals to guide this initiative addressing a critical translational funding gap that has stalled promising therapeutic approaches.