The 3Rs Collaborative (3RsC)
The 3Rs Collaborative (3RsC) is a US 501(c)(3) nonprofit that convenes 100+ academic, pharmaceutical, regulatory, and MPS technology-provider institutions to advance Refinement, Reduction, and Replacement in animal research through evidence-based resources, Tech Hubs, certification, and regulatory partnerships including FDA-CDER.
- Company typePrivate
- Founded2017
- HeadquartersDenver, United States
- Headcount11–50
- GTM typeB2B
- OfferingServices
What The 3Rs Collaborative (3RsC) does
The 3Rs Collaborative (3RsC) is a US 501(c)(3) nonprofit, founded in 2017 and headquartered in Denver, Colorado, that coordinates evidence-based implementation of the 3Rs (Refinement, Reduction, Replacement) of animal research across academic institutions, pharmaceutical and biotechnology companies, regulatory agencies, and MPS technology providers. Its core offerings are organized into flagship initiatives rather than discrete software products: Rodent Health Monitoring (a resource suite promoting Environmental Health Monitoring as a replacement for soiled bedding sentinels, with SOPs, publications, and cost analyses), the Microphysiological Systems (MPS) Initiative (a Tech Hub of 40+ commercial providers, a Publication Hub, a regulatory-applications track, and a quarterly webinar series co-run with IQ-MPS), the Refinement Initiative (including the Refined Mouse Handling Hub), Translational Digital Biomarkers, Culture of Care, Compassion Fatigue Resiliency, an AI Initiative, and the 3Rs Certification Course delivered through the CITI Program platform. These are supported by 100+ evidence-based resources, a 3,500+ subscriber newsletter, and an annual 3Rs Sharing Conference.
3RsC operates a nonprofit membership model with institutional tiers ranging from Bronze ($1,000+/year) to Platinum ($20,000+/year), supplemented by individual donations, conference registration and sponsorship fees, and partner revenue. Platinum members include Charles River and the University of Washington; Gold members include Novartis, BMS, Takeda, GSK, and AltaSciences; Silver members include AbbVie, AstraZeneca, Genentech, BioMere, and the FDA. Go-to-market combines direct institutional outreach, content marketing via the 3rc.org website, quarterly webinars, annual events, and a podcast. A December 2024 FDA-CDER Private Public Partnership and a DILI cross-platform project under FDA ISTAND qualification formalize 3RsC's role as a regulatory-relevant convener for alternative methods.
The 3Rs Collaborative (3RsC) firmographics
Firmographics- Name
- The 3Rs Collaborative (3RsC)
- Legal name
- North American 3Rs Collaborative, Inc.
- Website
- https://3rc.org
- Company type
- Private
- Founded year
- 2017
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- The 3Rs Collaborative (3RsC) is a US 501(c)(3) nonprofit that convenes 100+ academic, pharmaceutical, regulatory, and MPS technology-provider institutions to advance Refinement, Reduction, and Replacement in animal research through evidence-based resources, Tech Hubs, certification, and regulatory partnerships including FDA-CDER.
- Ownership category
- akta.pro rank
The 3Rs Collaborative (3RsC) industry classification
Industry- Product category
- Animal Research Welfare Services
- NAICS
- Support Activities for Animal Production (115210)
- SIC
- Services-Management Consulting Services (8742)
- akta.pro primary industry
- Referral, Collaboration & Care Coordination Networks (Specialist Referrals, Record Sharing) (HLAMAGAJ)
Keywords
Where The 3Rs Collaborative (3RsC) is headquartered
LocationHeadquarters
- HQ city
- Denver
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
The 3Rs Collaborative (3RsC) business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Operations, Technology or R&D, Marketing or Sales
Revenue model
- Institutional Membership Fees: Annual membership fees at four tiers: Bronze ($1,000+), Silver ($5,000+), Gold ($10,000+), and Platinum ($20,000+). Membership provides logo placement, discounted certificate courses, consulting hours, newsletter features, and year-round advertising. Over 100 member institutions including industry leaders and top universities.
- Individual Donations: Individual membership via donation with tax-creditable receipts. Donors may be listed by name on the membership page and/or annual report. The organization is a registered 501(c)(3) nonprofit.
- Conference Revenue: Registration fees for the annual 3Rs Sharing Conference. Individual member registration at $300, group of 4 at $1,100; non-member individual at $325, group at $1,200. Sponsorships (presenting sponsor, lunch sponsor, breakfast sponsor, reception sponsor) and exhibitor fees ($850) also generate revenue.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Annual | Bronze Institutional Membership — $1,000+/year |
| Subscription | Annual | Silver Institutional Membership — $5,000+/year |
| Subscription | Annual | Gold Institutional Membership — $10,000+/year |
| Subscription | Annual | Platinum Institutional Membership — $20,000+/year |
| Subscription | One time/ perpetual license | Conference Registration — Individual Member |
| Subscription | One time/ perpetual license | Conference Registration — Group of 4 Member |
Go-to-market motion3 records
Distribution channels5 records
Marketing channels9 records
The 3Rs Collaborative (3RsC) product offering
Product offeringCore offering
The 3Rs Collaborative (3RsC) is a 501(c)(3) nonprofit that delivers evidence-based resources, collaborative initiatives, training programs, and resource hubs to help research institutions, pharmaceutical and biotechnology companies, and regulators implement the 3Rs of animal research (Refinement, Reduction, Replacement). Its core offerings include the Rodent Health Monitoring (Environmental Health Monitoring) initiative, the Microphysiological Systems (MPS) Initiative, the Refinement Initiative, the Translational Digital Biomarkers Initiative, the 3Rs Certification Course, the Culture of Care Initiative, the Artificial Intelligence Initiative, and the Compassion Fatigue Resiliency program, supported by an annual conference, quarterly webinars, and a network of 100+ member institutions.
Product overview
The 3Rs Collaborative (3RsC) is a nonprofit organization offering a platform of interconnected programs, resources, and initiatives focused on advancing the 3Rs of animal research: Refinement, Reduction, and Replacement. The organization operates multiple flagship initiatives including Rodent Health Monitoring (replacing sentinel animals with Environmental Health Monitoring), the Microphysiological Systems Initiative (promoting organ-on-chip technologies), the Refinement Initiative, Translational Digital Biomarkers, 3Rs Certification Course, Culture of Care, Artificial Intelligence Initiative, and Compassion Fatigue Resiliency. These initiatives are supported by various resource hubs (MPS Tech Hub, TDB Tech Hub, 3Rs Tech Hub), educational content (publications, presentations, SOPs, webinars), events (3Rs Sharing Conference, MPS Webinar Series), and the 3Rs Certification Course delivered via CITI Program. The organization serves a network of 100+ member institutions including industry leaders and universities, providing resources, training, and collaborative opportunities to help researchers and institutions implement the 3Rs.
Differentiator
Problem solved
Functional benefit
Products and services
- Rodent Health Monitoring (Environmental Health Monitoring) Comprehensive initiative and resource program replacing traditional soiled bedding sentinel rodent health monitoring with Environmental Health Monitoring methods (EDT, SFSB, DCS, REM); for academic and pharmaceutical research institutions seeking improved pathogen detection and cost savings.
- Microphysiological Systems (MPS) Initiative Collaborative initiative working with 40+ commercial technology providers, end-users, regulators, and consultants to drive industry adoption and regulatory acceptance of microphysiological systems (organ-on-chip, organoid, spheroid) as replacements for animals in research.
- Refinement Initiative Initiative focused on increasing implementation of evidence-based refinement techniques, including species-specific housing/husbandry resources and the Refined Mouse Handling hub for mice, rats, NHPs, dogs, pigs, rabbits, zebrafish, chinchillas, hamsters, and wildlife.
- Translational Digital Biomarkers (TDB) Initiative Initiative engaging end-users and technology providers to drive adoption of translational digital biomarkers - objective, quantifiable physiological and behavioral data collected via digital technologies in home cage settings.
- 3Rs Certification Course Virtual, interactive, self-paced certification program of 5 one-hour modules covering Introduction and History of the 3Rs (Refinement, Reduction, Replacement), delivered via the CITI Program course platform at a discounted rate for institutional members.
- Culture of Care Initiative Initiative promoting culture of care in animal research, encompassing scientific integrity, animal welfare, human well-being, and openness & transparency resources.
- Artificial Intelligence Initiative Collaboration between technology developers, end-users, regulators, academics, and other stakeholders to advance implementation and qualification of AI methods in animal research.
- Compassion Fatigue Resiliency Initiative creating materials to promote compassion fatigue resiliency among animal research professionals, including a resource hub with publications, self-care and self-assessment tools, classes & consultants listings, and an institutional starter pack for building resiliency programs.
- 3Rs Sharing Conference Annual in-person conference bringing together 3Rs experts for discussion-focused content on emerging technologies across all 3Rs, with registration fees (individual member $300, group of 4 members $1,100; non-member rates $325 and $1,200), sponsorships, and exhibitor fees ($850).
Quantifiable outcome
- Replaced over 9,000 animals in research in the past year (membership page states >11,000 animals replaced)
- +5 more outcomes
Companies that use The 3Rs Collaborative (3RsC)
Customer profileNamed customers21 records
Segments5 records
Ideal customer profiles5 records
The 3Rs Collaborative (3RsC) technology and API
TechnologyTechnology focussed No
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature4 records
The 3Rs Collaborative (3RsC) partnerships and signals
Strategic signalPartnerships
Twelve partnerships are on record, tiered core, minor and major.
- New Jersey Association for Biomedical Research (NJABR)core3RsC co-hosts the annual 3Rs Sharing Conference with NJABR and the Pennsylvania Society for Biomedical Research. The 2026 conference features expert speakers on AI, NAMs, Reduction, Digital Measures, and Refinement. NJABR handles registration and venue coordination at University of Pennsylvania.
- Pennsylvania Society for Biomedical ResearchcoreCo-host of the 2026 3Rs Sharing Conference alongside NJABR and 3RsC at University of Pennsylvania.
- Charles River LaboratoriescoreServed as Presenting Sponsor of the 2026 3Rs Sharing Conference. Platinum-level institutional member. Alan Hoberman (Executive Director at Charles River) serves as 3RsC Treasurer on the Board of Directors.
- TecniplastminorServed as Lunch Sponsor of the 2026 3Rs Sharing Conference.
- AllentownminorServed as Breakfast Sponsor of the 2026 3Rs Sharing Conference. Allentown provides IVC caging equipment with Sentinel and Sentinel2 systems for Environmental Health Monitoring.
- SartoriusminorServed as Reception Sponsor of the 2026 3Rs Sharing Conference.
- C-Path (Critical Path Institute)majorCollaborates with 3RsC on the DILI Project alongside FDA, NIH-NIEHS, and 9 MPS developers. The project aims to establish confidence in and validation metrics for MPS for regulatory applications.
- NIH-NIEHSmajorNIH-NIEHS participates in the 3RsC DILI Project alongside FDA, C-Path, and 9 MPS developers to advance the use of MPS in regulatory applications.
- FDA Center for Drug Evaluation & Research (FDA-CDER)corePrivate-public partnership (PPP) between 3RsC-MPS Initiative and FDA-CDER approved in December 2024. FDA representatives attend quarterly 3RsC-MPS meetings and semi-monthly regulatory subgroup meetings. Collaboration includes a cross-platform Drug-Induced Liver Injury (DILI) project with multiple platform manufacturers, working toward qualification under FDA's ISTAND program.
- International Consortium for Innovation & Quality (IQ) Microphysiological Systemscore3RsC and IQ-MPS established a joint webinar series beginning December 2021. Webinars occur quarterly and are composed of 15-minute company presentations followed by 30-minute Q&A. The collaboration includes joint publications, projects, and stakeholder engagement. IQ-MPS includes 20+ pharmaceutical companies committed to addressing MPS.
- CITI ProgramcoreThe 3Rs Certification Course (5 one-hour modules on the 3Rs) is delivered via the CITI Program platform as of January 2025. CITI Program provides the online learning infrastructure for the certification.
- Over 40 Commercial MPS Technology ProviderscoreMPS Initiative members include commercial MPS providers, enabling technology providers, end-users, and consultants. Featured in the MPS Tech Hub with company descriptions, tissue types, and applications. Companies include Emulate, CN Bio, Hesperos, Mimetas, InSphero, and many others.
Scale indicators8 records
Recent moves7 records
Expansion highlights6 records
The 3Rs Collaborative (3RsC) competitors and assessment
Company assessmentDirect peers
- Animal Welfare Information Center (AWIC): USDA-NAL information center providing resources on animal welfare in research. Jessie Carder (Supervisory Technical Information Specialist at AWIC) serves as Ad Hoc Advisor to 3RsC, indicating close collaboration in the research animal welfare space.
- Foundation for Biomedical Research: Nonprofit advocacy organization promoting public understanding and support for humane and responsible animal research. Operates in overlapping institutional networks with similar education and outreach missions, though focused more on advocacy than 3Rs implementation.
- Americans for Medical Progress: Nonprofit advocacy group protecting society's investment in human and animal health research. Partners with 3RsC (Naomi Charalambakis serves as Ad Hoc Advisor) and operates in similar institutional networks focused on supporting biomedical research.
- NC3Rs (National Centre for the 3Rs): UK-based government-funded nonprofit with the same mission of advancing the 3Rs (Replacement, Reduction, Refinement) in animal research. Operates the largest international 3Rs research funding program and CRACK IT challenges. Direct peer with overlapping membership pools across pharma.
- International Consortium for Innovation & Quality (IQ) - MPS Affiliate: Pharmaceutical industry consortium with 20+ member companies working on MPS regulatory applications. Direct partner in the MPS Webinar Series (since Dec 2021) and the cross-platform DILI project. Overlapping membership across major pharma (Pfizer, Novartis, BMS, etc.).
Broad incumbents
- Institute for Laboratory Animal Research (ILAR): National Academies-based organization that develops guidelines and resources for the care and use of laboratory animals. Operates as a more authoritative/incumbent standards body in the same ecosystem, with overlap in serving academic and pharma research institutions.
- Charles River Laboratories: Major CRO and Platinum-level institutional member of 3RsC. Alan Hoberman (Executive Director) serves as 3RsC Treasurer and Charles River sponsors the annual 3Rs Sharing Conference. Comparable as a key institutional stakeholder and customer.
- AAALAC International: Private, nonprofit international accreditation body for animal care and use programs. While 3RsC focuses on advancing 3Rs practices, AAALAC sets accreditation standards referenced across the same research institutions and pharmaceutical companies.
Emerging players
- Emulate, Inc. Commercial MPS technology provider featured in 3RsC's MPS Tech Hub. Develops organ-on-chip platforms that align directly with 3RsC's Replacement mission. Comparable as a member of the MPS Initiative ecosystem with shared regulatory adoption goals.
- CN Bio: Commercial MPS technology provider developing organ-on-chip systems for drug discovery. Member of 3RsC's MPS Initiative (40+ commercial providers) and participates in the cross-platform DILI project with FDA-CDER.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
The 3Rs Collaborative (3RsC) social profiles
Digital presenceThe 3Rs Collaborative (3RsC) financial estimates
Financial estimateRevenue estimate
Valuation estimate
The 3Rs Collaborative (3RsC) leadership team
Management profileNumber of profiles
Profiles20 records
The 3Rs Collaborative (3RsC) funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
The 3Rs Collaborative (3RsC) M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about The 3Rs Collaborative (3RsC)
What does The 3Rs Collaborative (3RsC) do?
The 3Rs Collaborative (3RsC) is a 501(c)(3) nonprofit that delivers evidence-based resources, collaborative initiatives, training programs, and resource hubs to help research institutions, pharmaceutical and biotechnology companies, and regulators implement the 3Rs of animal research (Refinement, Reduction, Replacement). Its core offerings include the Rodent Health Monitoring (Environmental Health Monitoring) initiative, the Microphysiological Systems (MPS) Initiative, the Refinement Initiative, the Translational Digital Biomarkers Initiative, the 3Rs Certification Course, the Culture of Care Initiative, the Artificial Intelligence Initiative, and the Compassion Fatigue Resiliency program, supported by an annual conference, quarterly webinars, and a network of 100+ member institutions.
Is The 3Rs Collaborative (3RsC) a public or private company?
The 3Rs Collaborative (3RsC) is a private company. It is classified as nonprofit foundation owned and is currently operating.
When was The 3Rs Collaborative (3RsC) founded?
The 3Rs Collaborative (3RsC) was founded in 2017. It employs 11 to 50 people.
Where is The 3Rs Collaborative (3RsC) based?
The 3Rs Collaborative (3RsC) is headquartered in Denver, United States, in the North America region.
How does The 3Rs Collaborative (3RsC) make money?
Three revenue lines are on record. Institutional Membership Fees are the primary driver. The others are individual Donations and conference Revenue.
Who are The 3Rs Collaborative (3RsC)'s main competitors?
Direct peers on record are Animal Welfare Information Center (AWIC), Foundation for Biomedical Research, Americans for Medical Progress, NC3Rs (National Centre for the 3Rs) and International Consortium for Innovation & Quality (IQ) - MPS Affiliate. Broad incumbents are Institute for Laboratory Animal Research (ILAR), Charles River Laboratories and AAALAC International. Emerging players are Emulate, Inc. and CN Bio.
Does The 3Rs Collaborative (3RsC) have an API?
No public API is recorded for The 3Rs Collaborative (3RsC).
What industry is The 3Rs Collaborative (3RsC) in?
The 3Rs Collaborative (3RsC)'s product category is Animal Research Welfare Services. Its primary akta.pro industry code is HLAMAGAJ, Referral, Collaboration & Care Coordination Networks (Specialist Referrals, Record Sharing). Its NAICS code is 115210 and its SIC code is 8742.