LIS Technologies Inc.

What LIS Technologies Inc. does

LIS Technologies Inc. (LIST) is a privately held, U.S.-origin developer of patented laser isotope separation technology for uranium enrichment and adjacent isotope production. The company was formed in August 2023 through the acquisition of CRISLA, Inc. — founded in 2020 by physicist Dr. Jeff Eerkens, the inventor of the CRISLA process — and is headquartered at the historic K-25 site in Oak Ridge, Tennessee. Its core technology, CRISLA (Condensation Repression Isotope Selective Laser Activation), uses infrared lasers at 5.3μm wavelength to selectively excite the 3ν3 vibrational mode of 235UF6 molecules, enabling separation factors reportedly 2–20x higher than conventional centrifuge methods with significantly lower energy consumption. The CRISLA-3G technology has been independently evaluated at TRL-4 with 60% of TRL-5 elements met per DOE guide DOE G 413.3-4A, and the company holds a USPTO patent on the process.

The company's intended product portfolio spans Low-Enriched Uranium (LEU) for the existing U.S. fleet of 94 nuclear reactors, High-Assay Low-Enriched Uranium (HALEU) for next-generation SMRs and microreactors, and stable and medical isotopes under Project SMILE (including silicon-28 for semiconductors and quantum computing applications). A Test Demonstration Facility operates at the K-1330 building on the K-25 site, and the company acquired the 206-acre LIST Island (formerly Duct Island) for $8 million in January 2026 to site the planned LEU-3 commercial enrichment facility under Project F.U.E.L., targeted to produce up to 5.5 million SWUs annually with construction starting in 2026 and completion in the early 2030s. Planned investment is $1.38 billion and 203 new jobs.

LIST's revenue model is multiplayer: long-term utility offtake agreements for LEU and HALEU, IDIQ contract participation under the DOE's $3.4 billion LEU Enrichment Acquisition Program (10-year ceiling, $2 million minimum per awardee), potential U.S. Navy and defense fuel supply, and direct sales of stable and medical isotopes to semiconductor, quantum, and healthcare buyers. The company is currently pre-revenue, having raised over $71 million across five consecutive oversubscribed funding rounds, and is in the NRC licensing process for its commercial facility. Go-to-market is enterprise field sales anchored by Platinum-tier industry conference participation, strategic partnerships (e.g., NANO Nuclear Energy), and policy advocacy through NEI, WNA, and ANS memberships.

Name

LIS Technologies Inc.

Legal name

LIS Technologies Inc.

Website

https://laseristech.com

Company type

Private

Founded year

2023

Operating status

Operating

Short description

LIS Technologies Inc. is a privately held U.S. developer of patented CRISLA laser uranium enrichment technology, producing Low-Enriched Uranium and High-Assay Low-Enriched Uranium for nuclear utilities, advanced reactor developers, and U.S. defense, with planned operations from Oak Ridge, Tennessee.

Ownership category

akta.pro rank

Product category

Uranium Enrichment Services

akta.pro primary industry

Uranium Enrichment Services (Centrifuge/Laser, SWU Supply) (EUAKACAD)

akta.pro secondary industries

HALEU Production & Supply Chain (Feedstock, Enrichment, Downblending) (EUAKACAH), Fuel Cycle Support Services (Engineering, licensing support, conversion/enrichment contracting) (EUAKACAL)

Keywords

• Laser uranium enrichment
• Nuclear fuel production
• HALEU enrichment services
• Stable isotope production
• Medical isotope manufacturing

Headquarters

HQ city

Oak Ridge North

HQ country

United States

HQ region

North America

Offices3 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Infrastructure, Operations, Supply Chain, Marketing or Sales

Revenue model

1. Uranium Enrichment Services: Commercial laser uranium enrichment services producing Low-Enriched Uranium (LEU) and High-Assay Low-Enriched Uranium (HALEU) for nuclear power plants and advanced reactors under long-term supply contracts
2. DOE LEU Enrichment Acquisition Program: IDIQ contract participation under the up to $3.4 billion Department of Energy program, with minimum $2 million per awardee and contracts lasting up to 10 years
3. Medical and Stable Isotope Production: Production of stable isotopes for semiconductor, quantum computing, and medical applications using CRISLA laser enrichment technology
4. Strategic Government Contracts: National defense and government nuclear fuel supply contracts, including potential fuel supply for U.S. Navy fleet

Pricing tiers

Go-to-market motion2 records

Distribution channels4 records

Marketing channels8 records

Core offering

LIS Technologies Inc. develops and commercializes patented CRISLA (Condensation Repression Isotope Selective Laser Activation) laser uranium enrichment technology, providing uranium enrichment services producing Low-Enriched Uranium (LEU) for existing U.S. nuclear power plants and High-Assay Low-Enriched Uranium (HALEU) for next-generation Small Modular Reactors (SMRs) and microreactors. The company also produces stable and medical isotopes for semiconductor, quantum computing, and healthcare applications through its Project SMILE program.

Product overview

LIS Technologies Inc. is a USA-based proprietary developer of advanced laser technology and the only US-origin and patented laser uranium enrichment company. The company's core offering is the CRISLA (Condensation Repression Isotope Selective Laser Activation) technology - a patented laser enrichment process using infrared lasers to selectively excite UF6 molecules for isotope separation. The technology portfolio includes the LEU-3 commercial enrichment facility planned for LIST Island as part of Project F.U.E.L. (Future Uranium Enrichment with Lasers), a Test Demonstration Facility at the K-25 site, and the Stable and Medical Isotope Laser Enrichment Program (Project SMILE) for producing isotopes for medical, quantum computing, and semiconductor applications. The company is targeting production of Low Enriched Uranium (LEU) for existing nuclear reactors and High-Assay Low-Enriched Uranium (HALEU) for next-generation SMRs and microreactors.

Differentiator

Problem solved

Functional benefit

Brands

• Project F.U.E.L. Future Uranium Enrichment with Lasers - the company's initiative to develop the first commercial laser uranium enrichment facility in the United States
• LIST Island
• LEU-3 Facility
• Project SMILE

Products and services

• CRISLA Laser Enrichment Technology CRISLA (Condensation Repression Isotope Selective Laser Activation) is a U.S.-origin patented laser uranium enrichment technology using infrared lasers at 5.3µm wavelength to selectively excite UF6 molecules for isotope separation. Optimized for both LEU production for existing nuclear reactors and HALEU for next-generation SMRs and microreactors.
• Low-Enriched Uranium (LEU) Enrichment Services Commercial laser uranium enrichment services producing Low-Enriched Uranium (LEU) for the United States' current fleet of 94 nuclear reactors under long-term supply contracts.
• High-Assay Low-Enriched Uranium (HALEU) Enrichment Services High-Assay Low-Enriched Uranium (HALEU) production using CRISLA technology for next-generation Small Modular Reactors (SMRs) and microreactors, addressing the global HALEU supply shortage.
• Stable and Medical Isotope Production (Project SMILE) Production of stable isotopes (including silicon-28 for enhanced thermal conductivity in advanced semiconductor chips) and medical isotopes for detection and treatment applications, including theranostic systems, using CRISLA laser enrichment technology.
• DOE LEU Enrichment Acquisition Program Services U.S. government procurement of Low-Enriched Uranium enrichment services under the Department of Energy's LEU Enrichment Acquisition Program, with IDIQ contracts up to 10 years and allocations up to $3.4 billion overall.

Quantifiable outcome

• 5.5 million Separative Work Units (SWUs) annual capacity planned for LEU-3 Facility
• +3 more outcomes

Named customers5 records

Segments5 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

Seven partnerships are on record, tiered minor and core.

• American Museum of Science and Energy FoundationminorGTM or Marketing Partner · 19 March 2026Sponsorship of the 4th Annual Energy & Elements Gala supporting STEAM education outreach programs throughout the Tennessee Valley region. Supports K-12 students and families through critical educational resources.
• Los Alamos National LaboratorycoreTechnology or Integration · 1 January 2026Dr. Kirk D. Rector joins from LANL where he served as Program Director for the US DOE Isotope Program, overseeing Mission Essential radioisotope production. His expertise in actinide chemistry and nuclear materials brings direct technical capability to LIS Technologies.
• NANO Nuclear Energy Inc.coreStrategic or Co-development Partner · 23 December 2025Strategic commercial partnership for laser uranium enrichment collaboration. NANO Nuclear holds a collaboration agreement with LIS Technologies to develop supportive fuel cycle capabilities as part of its vertically integrated fuel pipeline strategy. NANO Nuclear is a publicly listed company (NASDAQ) developing portable micoreactors.
• Nuclear Energy Institute (NEI)coreGTM or Marketing Partner · 1 March 2025Corporate membership joining the leading U.S. nuclear policy organization representing hundreds of companies worldwide. NEI works with policymakers, industry stakeholders, and the public to advocate for safe, reliable, and efficient nuclear technologies.
• World Nuclear AssociationcoreGTM or Marketing Partner · 1 April 2024Corporate membership in the international organization that promotes nuclear power and supports companies across the global nuclear fuel cycle including uranium mining, conversion, enrichment, and electricity generation.
• Nuclear Institute (UK)minorGTM or Marketing Partner · 1 April 2024Corporate affiliation with the professional body representing nuclear professionals in the UK, supporting knowledge of nuclear energy among members and the public, and offering professional qualification routes.
• American Nuclear Society (ANS)coreGTM or Marketing Partner · 1 March 2024Corporate membership in the premier organization for those embracing nuclear sciences and technologies, with products and services including meetings, publications, standards, outreach, honors and awards, scholarships, and Washington D.C. representation.

Scale indicators11 records

Recent moves7 records

Expansion highlights6 records

Emerging players

• General Matter: Well-funded private U.S. uranium enrichment startup explicitly named alongside LIS Technologies as a beneficiary of U.S. executive orders rebuilding the domestic nuclear fuel ecosystem. Directly competing for the same DOE and utility enrichment contracts.
• Silex Systems: Australian-listed developer of the SILEX laser isotope separation technology, majority owner of Global Laser Enrichment. Closely comparable as another laser-enrichment platform pursuing commercial uranium enrichment and stable isotope markets.
• TerraPower: Bill Gates-backed advanced reactor developer pursuing the Natrium sodium-cooled fast reactor, which requires HALEU fuel. A potential large-volume customer for LIS Technologies' HALEU production alongside other Gen IV developers.
• NANO Nuclear Energy: NANO Nuclear is both a strategic customer/partner and an indirect peer; the publicly listed NASDAQ company develops portable microreactors and holds a collaboration agreement with LIS Technologies for vertically integrated HALEU fuel. Shared founder Jay Yu makes this both a partner and a related business in the U.S. nuclear fuel ecosystem.

Broad incumbents

• Urenco: European centrifuge-based uranium enrichment consortium (UK/Germany/Netherlands) and one of the principal incumbent suppliers of LEU globally. Competes with LIS Technologies for utility offtakes and is the parent-linked owner of GLE's centrifuge heritage.
• Westinghouse Electric Company: Major nuclear reactor vendor and fuel cycle services provider offering enrichment, fabrication, and related fuel services. Adjacent competitor and partner ecosystem participant across the U.S. nuclear fuel cycle that LIS Technologies is seeking to enter.
• Orano: French state-owned nuclear fuel cycle company operating the Georges Besse II centrifuge enrichment plant. One of the foreign incumbents LIS Technologies is positioning to displace in the U.S. domestic market.

Direct peers

• Global Laser Enrichment (GLE): Laser-based uranium enrichment venture owned by Silex Systems and Cameco, pursuing SILEX third-generation laser enrichment at a licensed test loop in North Carolina. Direct technology and customer competitor to LIS Technologies' CRISLA in the U.S. domestic enrichment race.
• Centrus Energy: U.S.-listed uranium enrichment company and the only currently operating HALEU producer in the United States. Competes head-to-head with LIS Technologies in the DOE LEU Enrichment Acquisition Program (also one of the six selected companies) and supplies LEU to the same U.S. utility customer base.

Others

• BWX Technologies: U.S. supplier of naval nuclear reactor fuel and components, including HALEU-related capabilities for defense and national security applications. Comparable as a domestic nuclear fuel supplier serving the U.S. Navy and DOE, which are both target customer segments for LIS Technologies.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xtwitter.com/LaserisTech
• Facebookfacebook.com/profile.php?id=100094867642073
• Instagraminstagram.com/laseristech

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about LIS Technologies Inc.