SIGNAGEN LABORATORIES LLC

What SIGNAGEN LABORATORIES LLC does

SignaGen Laboratories LLC is a privately-held life sciences company headquartered in Frederick, Maryland that develops, manufactures, and sells gene delivery reagents and viral vector products used in research laboratories. Its core product portfolio is organized around three pillars: (1) transfection reagents — proprietary polymer- and lipid-based DNA and siRNA delivery reagents including GenJet™, LipoJet™, PolyJet™, LipoD293™, CalFectin™, GenMute™, PepMute™, and PowerFect™ product lines, many built on the company's PDCC (pH-dependent conformational change) polymer chemistry platform, with both in vitro and in vivo (GenJet™ Plus, PepJet™) variants; (2) pre-made viral vectors — an in-stock catalog of 580+ AAV, 110+ lentivirus, and 360+ adenovirus vectors produced using the proprietary Lenti.MAX™ lentiviral packaging system and Ad.MAX™ helper-virus-free adenoviral expression system; and (3) custom production services — end-to-end AAV, lentivirus, and adenovirus packaging plus Stable Cell Line Development using lentiviral vectors.

The business operates a hybrid go-to-market: a self-serve e-commerce platform (signagen.com) for catalog items priced at $39-$488 per unit with same-day shipping on in-stock vectors, supplemented by phone/email/fax order intake and a quote-based model for custom services where PhD scientists scope projects before pricing (e.g., ~$3,569 for an entry-level stable cell line project). The company maintains an international distributor network, offers OEM white-label manufacturing to qualified life science reagent companies, and actively publishes scientific content, technical guides, and a searchable citation library of 7,000+ peer-reviewed publications citing its products. Customer mix spans academic research institutions (primary segment) and pharmaceutical/biotechnology companies, with displayed enterprise logos including AstraZeneca, Pfizer, Novartis, Merck, Roche, Sanofi, Eli Lilly, Amgen, Regeneron, Gilead, and others. No funding rounds, parent company, or external investors are disclosed, consistent with a founder or management-owned operator.

Name

SIGNAGEN LABORATORIES LLC

Legal name

SignaGen Laboratories LLC

Website

https://signagen.com

Company type

Private

Operating status

Operating

Headcount range

1–10 employees

Short description

SignaGen Laboratories LLC, a privately-held Frederick, Maryland life sciences company, develops and manufactures proprietary transfection reagents and pre-made viral vectors (AAV, lentivirus, adenovirus) plus custom viral vector and stable cell line services for academic and pharmaceutical research laboratories worldwide.

Ownership category

akta.pro rank

Product category

Life Sciences Reagents

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714)

SIC

Biological Products, (No Disgnostic Substances) (2836), Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Gene Therapy (Viral Vector/Plasmid) CDMO (HLAGABAE)

akta.pro secondary industries

Viral Vector Manufacturing Services (AAV, lentiviral, adenoviral) (HLAAAKAD), Gene Therapy CMC/Process Development Platforms (capsid engineering, producer cell lines, plasmids, upstream/downstream) (HLAAACAN)

Keywords

• Transfection reagents
• Viral vector production
• Gene delivery products
• AAV lentivirus adenovirus
• Stable cell line development

Headquarters

HQ city

Frederick

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Operations, Technology or R&D, Marketing or Sales, Supply Chain, Infrastructure

Revenue model

1. Transfection Reagent Sales: Direct sales of in vitro and in vivo transfection reagents including GenJet™, LipoJet™, PolyJet™, LipoD293™, CalFectin™, GenMute™, PepMute™, and PowerFect™ product lines. Products sold in multiple unit sizes (0.1 mL to 5 x 1.0 mL).
2. Pre-made Viral Vector Products: Sales of catalog AAV (580+ vectors), lentivirus (110+ vectors), and adenovirus (360+ vectors) products. All pre-made viral vectors are in stock and ship same day upon order confirmation.
3. Custom Viral Vector Production Services: Full-service custom production of AAV, lentivirus, and adenovirus vectors including end-to-end services from construct design to delivery. Services include plasmid packaging, amplification, and quality control.
4. Stable Cell Line Development: Custom stable cell line generation service delivering high-quality customized stable cell lines using lentiviral vector systems. Delivers 3×10^6 to 3×10^8 stable cells in stable pool or single-cell clone format.
5. OEM Manufacturing Services: OEM manufacturing services for transfection reagents offered to qualified life science reagent companies for resale under their own brand names.

Pricing tiers

Go-to-market motion3 records

Distribution channels4 records

Marketing channels5 records

Core offering

SignaGen Laboratories develops, manufactures, and sells transfection reagents (DNA, siRNA, mRNA, in vivo) and pre-made viral vectors (AAV, Lentivirus, Adenovirus) used by research laboratories for gene delivery. The company also provides full-service custom viral vector production, plasmid packaging, adenovirus amplification, and stable cell line development for academic and pharmaceutical/biotech customers. Products are built on proprietary polymer chemistry (PDCC) and high-titer packaging systems (Lenti.MAX™, Ad.MAX™).

Product overview

SignaGen Laboratories is a life sciences company offering a comprehensive portfolio of transfection reagents and viral vector products/services for gene delivery applications. The core product lines include: (1) Transfection Reagents — polymer and lipid-based DNA/siRNA transfection reagents for in vitro and in vivo use, including the LipoJet™, CalFectin™, GenJet™, PolyJet™, LipoD293™, PepMute™, GenMute™, PowerFect™, and PepJet™ branded products, many utilizing proprietary PDCC (pH-dependent conformational change) technology; (2) Pre-made Viral Vectors — catalog of 580+ AAV, 110+ lentivirus, and 360+ adenovirus products in stock; (3) Custom Production Services — end-to-end AAV, lentivirus, and adenovirus production services using proprietary Lenti.MAX™ (lentivirus) and Ad.MAX™ (adenovirus) packaging systems; (4) Stable Cell Line Development — custom stable cell line generation service. The company also offers pre-optimized transfection reagents for specific cell lines and OEM manufacturing partnerships for reagent resale.

Differentiator

Problem solved

Functional benefit

Brands

• Lenti.MAX™: Proprietary lentivirus packaging system optimized for high-titer production
• Ad.MAX™
• GenJet™
• LipoJet™
• PolyJet™
• LipoD293™
• CalFectin™
• GenMute™
• PepMute™
• PowerFect™

Products and services

• GenJet™ In Vitro DNA Transfection Reagent (Ver. II) General-purpose in vitro DNA transfection reagent for a wide range of adherent and suspension mammalian cell lines, used by researchers for plasmid DNA delivery into cultured cells.
• LipoJet™ In Vitro Transfection Kit (Ver. II) Lipid-based in vitro DNA transfection reagent kit, designed for routine transfection of commonly used mammalian cell lines.
• PolyJet™ In Vitro DNA Transfection Reagent Polymer-based in vitro DNA transfection reagent used as a cost-effective alternative to lipid reagents for routine mammalian cell line transfection.
• CalFectin™ Mammalian Cell Transfection Reagent

Quantifiable outcome

• 7,000+ scientific citations in peer-reviewed publications
• +3 more outcomes

Named customers2 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

One partnership is on record.

• International DistributorsstandardChannel Partner/ Reseller/ DistributorSignaGen maintains a network of international distributors to serve customers outside the United States. Distributor information is available by contacting [email protected] or visiting the distributors page on the website.

Scale indicators12 records

Recent moves6 records

Expansion highlights5 records

Broad incumbents

• Aldevron: Aldevron is a major CDMO producing plasmids, viral vectors, and proteins for gene therapy applications, now part of Danaher. Overlaps with SignaGen in viral vector manufacturing but serves clinical-stage and commercial customers with GMP capacity SignaGen lacks.
• GenScript: GenScript is a diversified life sciences services company offering gene synthesis, viral vector services, transfection reagents, and cell line development. Overlaps with SignaGen's transfection reagents and custom viral vector production but operates at much larger scale across broader service lines.

Direct peers

• VectorBuilder: VectorBuilder is a global leader in custom viral vector design and manufacturing services (AAV, lentivirus, adenovirus, MMLV), with similar catalog offerings and CDMO services to SignaGen. Highly comparable as a one-stop viral vector platform for research and preclinical applications.
• Mirus Bio: Mirus Bio is a specialized transfection reagent manufacturer (TransIT® product line) with deep expertise in nucleic acid delivery for research applications. Directly comparable to SignaGen's GenJet™, LipoJet™, and PolyJet™ reagent portfolio, including both DNA and siRNA delivery.
• Cell Biolabs: Cell Biolabs manufactures viral vectors (lentivirus, AAV, adenovirus) and transfection reagents for research applications with similar e-commerce distribution and academic/pharma customer base. Direct competitor in the research-grade viral vector and reagent space.
• Polyplus (Sartorius): Polyplus (acquired by Sartorius) provides PEI-based transfection reagents (jetPEI®, jetPRIME®) and develops plasmid/saRNA delivery technologies for gene therapy. Direct competitor in transfection reagent space serving similar academic and biotech customers.
• Vigene Biosciences: Vigene provides viral vector production services (AAV, lentivirus, adenovirus) including both research-grade and GMP-grade manufacturing. Comparable custom viral vector production services targeting gene therapy research and preclinical development customers.
• PackGene Biotech: PackGene is a CRO/CDMO specializing in AAV vector design and manufacturing for gene therapy research and preclinical applications. Comparable custom viral vector production services with focus on AAV, similar catalog and custom service mix.
• Applied Biological Materials (abm): abm offers transfection reagents, pre-made viral vectors (AAV, lentivirus, adenovirus), and custom viral vector production services. Highly comparable product mix and target customer base, with similar pricing tiers and e-commerce-led distribution.
• System Biosciences (SBI): SBI provides pre-made lentivirus, AAV, and adenovirus products plus custom viral vector services for gene delivery research. Direct peer in catalog viral vector sales and custom production services targeting similar academic and biotech customers.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat4 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/signagen-laboratories-llc

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about SIGNAGEN LABORATORIES LLC