Orsini

What Orsini does

Orsini is a privately held, independent U.S. specialty pharmacy founded in 1987, headquartered in Elk Grove Village, Illinois, with a second fully redundant facility in Columbus, Ohio launched in October 2025. The company focuses exclusively on rare disease and gene therapy pharmacy solutions, organizing its operations around 15 Therapeutic Centers of Excellence (including Cell & Gene Therapy, Allergy & Immunology, Cardiology, Genetics, Neurology, Hematology, and Pulmonology) and dedicated Therapy Care Teams. Orsini's product surface spans specialty pharmacy dispensing, a Patient Services Hub, Third-Party Logistics (3PL, operated in partnership with Presa Solutions), and a nationwide Home Infusion & Nursing network. The differentiator is ORBIT (Orsini Rare Business Intelligence Technology), an AI-enabled, API-first analytics and real-world data platform that exchanges data with manufacturers, patient engagement systems, and partners such as PicnicHealth.

The business is enterprise-anchored: Orsini signs exclusive or limited-distribution agreements with biopharma manufacturers for high-cost, complex specialty drugs and gene therapies (12+ FDA-approved gene therapies, including Zolgensma, Elevidys, Casgevy, Hemgenix, LYFGENIA, ZYNTEGLO, and SKYSONA) and earns revenue from dispensing fees/margins, managed-services fees for hub/3PL, and home infusion nursing services. Go-to-market is sales-led, targeting biopharma manufacturers for commercialization partnerships, prescribers for referrals, and payors for access. The customer base includes major manufacturers such as Gilead, Roche/Genentech, Ionis, KalVista, Crinetics, Cytokinetics, Zevra, Glaukos, Immedica, Genetix, and Denali. Orsini is licensed and accredited across URAC (including Rare Disease Pharmacy Center of Excellence), ACHC (with Distinction in Rare Diseases and Orphan Drugs), NABP, the Joint Commission, and Legitscript, and serves patients in all 50 states and Puerto Rico.

Name

Orsini

Legal name

Orsini

Website

https://orsini.com

Company type

Private

Founded year

1987

Operating status

Operating

Short description

Orsini is a privately held, independent U.S. specialty pharmacy founded in 1987 providing rare disease and gene therapy pharmacy solutions. It serves biopharma manufacturers, prescribers, payors, and patients across all 50 states via specialty dispensing, a patient services hub, 3PL logistics, home infusion, and the ORBIT analytics platform.

Ownership category

akta.pro rank

Product category

Specialty Pharmacy Services

NAICS

Ambulatory Health Care Services (621), Other Ambulatory Health Care Services (6219)

SIC

Wholesale-Medical, Dental & Hospital Equipment & Supplies (5047), Services-Nursing & Personal Care Facilities (8050)

akta.pro primary industry

Specialty Pharmacy & Complex Therapy Management Platforms (HLACAKAG)

akta.pro secondary industry

Medication Pricing, Copay Assistance & Patient Financial Support Tools (HLACAKAN)

Keywords

• Specialty pharmacy services
• Rare disease pharmacy
• Gene therapy distribution
• Patient support services
• Home infusion services

Headquarters

HQ city

Elk Grove Village

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B and B2C

Offering type

Services

Cost components

Personnel, Operations, Supply Chain, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. Specialty Pharmacy Dispensing: Orsini dispenses high-cost, high-complexity specialty pharmaceuticals for rare disease patients. Services include pharmacy distribution, clinical management, reimbursement support, and direct delivery to home or site of administration. Revenue is generated through dispensing fees and margins on specialty medications.
2. Patient Services Hub: Integrated hub services for biopharma manufacturers including patient services, benefits verification, financial assistance enrollment, clinical education, nurse coordination, and data services. Provides a single point of contact between manufacturers and patients.
3. Third-Party Logistics (3PL): 3PL services to biopharma manufacturers as part of full-service commercialization solutions. Includes supply chain management, inventory control, and logistics coordination from facilities in Illinois and Ohio.
4. Home Infusion & Nursing Services: Home infusion services through a nationwide nursing network, with nurse managers overseeing the network. Revenue generated through nursing visit fees and infusion service coordination.

Go-to-market motion3 records

Distribution channels5 records

Marketing channels5 records

Core offering

Orsini is a nationwide specialty pharmacy that dispenses high-cost, high-complexity medications for rare disease and gene therapy patients, with direct-to-patient delivery, home infusion nursing, and patient support services. It also provides biopharma manufacturers with Patient Services Hub, third-party logistics (3PL), and the ORBIT AI-enabled analytics platform for real-world data and program management.

Product overview

Orsini is a nationwide specialty pharmacy providing integrated rare disease pharmacy solutions with a high-touch care model centered on experienced Therapy Care Teams. The core offering combines specialty pharmacy services with a Patient Services Hub, Third-Party Logistics (3PL), and Home Infusion & Nursing. Central to the platform is ORBIT (Orsini Rare Business Intelligence Technology), an AI-enabled analytics platform that uses an API-forward approach for real-time data exchange with manufacturers and partners. The company organizes services through Therapeutic Centers of Excellence across 15+ specialty areas including Allergy & Immunology, Cardiology, Cell & Gene Therapy, Endocrinology, Genetics, Hematology, Neurology, and Pulmonology. Services are delivered from headquarters in Elk Grove Village, IL and a fully redundant Columbus, OH facility.

Differentiator

Problem solved

Functional benefit

Products and services

• Specialty Pharmacy Services Nationwide specialty pharmacy focused on rare disease patients, providing high-touch, customized dispensing and clinical management from dedicated Therapy Care Teams throughout the treatment journey. Services include prescription processing, benefits investigation, prior authorization support, free overnight delivery, and 24/7 pharmacist access across all 50 states and Puerto Rico.
• Patient Services Hub Integrated patient services hub acting as single point of contact between biopharma manufacturers and patients. Offers benefits verification, patient education, clinical education, adherence calls, financial assistance enrollment, and customized data and insights for manufacturer clients.
• Third-Party Logistics (3PL) 3PL services for biopharma manufacturers with a single point of contact and dedicated subject matter experts, providing supply chain management, inventory control, and logistics. Managed from the Illinois headquarters and the fully redundant Columbus, Ohio facility, powered by Presa Solutions, and includes ultra-cold storage capabilities for gene therapies.
• Home Infusion and Nursing Nationwide home infusion services through a comprehensive nursing network of highly skilled RNs providing disease- and therapy-specific training, in-home infusions, therapy self-administration training, and nurse support hotline. Coordinated through Orsini nurse managers for seamless care delivery.
• ORBIT Technology Platform AI-enabled reporting and analytics platform that leverages real-world data collection with robust analytics to help pharmaceutical manufacturers better understand and address the unique needs of rare disease patients. Uses an API-forward approach for real-time data exchange with pharmacies, patient engagement platforms, and manufacturers' systems, and includes the ORBIT Track feature for partner collaboration and patient case management.

Quantifiable outcome

• Average time to fill: 4 days for pharmacy benefit dispenses, 10 days for medical benefit dispenses
• +3 more outcomes

Named customers11 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

AI capability3 records

Feature3 records

Scale indicators7 records

Recent moves7 records

Expansion highlights5 records

Direct peers

• Amber Specialty Pharmacy: Amber Specialty Pharmacy (Hy-Vee subsidiary) operates a specialty pharmacy focused on complex patient populations including rare diseases, transplants, and oncology with embedded hub services. Closely aligned with Orsini on specialty dispensing plus integrated hub model.
• Soleo Health: Soleo Health provides specialty home infusion and pharmacy services for patients with complex chronic and rare conditions, including gene therapies. Closely comparable to Orsini's home infusion & nursing network for high-cost specialty biologics.
• PantherRx Rare: PantherRx Rare is a specialty pharmacy dedicated to rare and orphan disease therapies, providing dispensing, hub, and clinical management. A direct competitor to Orsini in rare disease specialty distribution with similar independence positioning.
• Biologics by McKesson: Biologics by McKesson is an independently operated specialty pharmacy focused on oncology, rare disease, and chronic complex conditions, providing dispensing and patient support services. Closely comparable to Orsini in business model, though Biologics leans more oncology, while Orsini leans rare/gene therapy.

Regional players

• Onco360 Oncology Pharmacy: Onco360 is one of the largest independent specialty pharmacies focused on oncology, with select rare disease coverage. Indirect peer to Orsini due to overlapping specialty drug distribution and hub services, but more concentrated in oncology rather than rare/gene therapy.

Broad incumbents

• US Bioservices (AmerisourceBergen): US Bioservices, part of AmerisourceBergen / Cencora, provides specialty pharmacy and patient support services for chronic and rare conditions. Comparable to Orsini's hub and specialty dispensing for rare disease therapies, with broader distribution scale.
• Diplomat Specialty Pharmacy (now Optum): Diplomat was an independent specialty pharmacy leader in rare disease before being acquired by UnitedHealth/Optum. Provides relevant historical and structural comparability for Orsini's rare disease niche, even as it has been folded into a payor-aligned platform.
• CVS Specialty: CVS Specialty, part of CVS Health/Caremark, dispenses high-cost specialty and rare disease therapies and provides patient hub services. Operates as a direct competitor to Orsini in rare disease distribution and hub services, with stronger payor integration but less focus as an independent specialist.
• Accredo (Express Scripts specialty pharmacy): Accredo is one of the largest specialty pharmacies in the US, dispatching high-cost and rare disease therapies via its Evernorth-backed distribution network. Directly comparable to Orsini on specialty distribution and hub services for rare disease, though at meaningfully greater scale and with a payor-aligned ownership structure.
• Walgreens Specialty Pharmacy: Walgreens Specialty Pharmacy (now part of Shields Health Solutions under Walgreens-owned specialty strategy) dispenses specialty and rare disease therapies and offers hub/adherence support. A direct broad peer to Orsini with national reach and access to specialty infusion.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/orsiniRDPS
• LinkedInlinkedin.com/company/orsini-rdps

Compliance4 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles9 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Orsini