The North American 3Rs Collaborative
The North American 3Rs Collaborative is a Denver-based 501(c)(3) nonprofit that advances Replacement, Reduction, and Refinement (3Rs) practices in animal research through certification courses, translational initiatives, and resource programs serving academic researchers, institutions, and pharmaceutical organizations across North America.
- Company typePrivate
- Founded-
- HeadquartersDenver, United States
- Headcount—
- GTM typeB2B
- OfferingServices
What The North American 3Rs Collaborative does
The North American 3Rs Collaborative is a 501(c)(3) nonprofit public charity (EIN 81-5084899) headquartered in Denver, Colorado, dedicated to advancing the 3Rs framework — Replacement, Reduction, and Refinement — in animal-based research across North America. The organization serves a broad stakeholder base that includes academic researchers, institutional animal care and use committees (IACUCs), veterinarians, pharmaceutical and biotechnology R&D teams, contract research organizations, and governmental research facilities.
The Collaborative operates a diversified portfolio of educational, certification, and translational programs. Its flagship product is the 3Rs Certification Course, delivered through a partnership with the CITI Program, which provides formal credentialing to research personnel. Additional initiatives include the Rodent Health Monitoring Initiative, Microphysiological Systems program, Translational Digital Biomarkers initiative, AI Initiative, Culture of Care program, Compassion Fatigue Resiliency resources, and species-specific refinement resources covering 9+ species. The organization also publishes a co-branded podcast (3-Minute 3Rs Podcast) with the Lab Animal journal and operates named awards in partnership with corporate sponsors.
The Collaborative's business model combines membership dues, course and subscription fees, corporate sponsorships (notably Charles River and Biomere), and individual donations. Pricing signals include institutional course fees of approximately $675-$1,000/site annually and CITI base subscriptions of $4,000-$5,500. The organization reports 3,500+ professional subscribers and a community of 35+ institutional members, and operates under a published Strategic Plan covering 2023-2027.
The North American 3Rs Collaborative firmographics
Firmographics- Name
- The North American 3Rs Collaborative
- Legal name
- North American 3Rs Collaborative, Inc.
- Website
- https://na3rsc.org
- Company type
- Private
- Operating status
- Operating
- Short description
- The North American 3Rs Collaborative is a Denver-based 501(c)(3) nonprofit that advances Replacement, Reduction, and Refinement (3Rs) practices in animal research through certification courses, translational initiatives, and resource programs serving academic researchers, institutions, and pharmaceutical organizations across North America.
- Ownership category
- akta.pro rank
The North American 3Rs Collaborative industry classification
Industry- Product category
- Nonprofit Research Education and Training
- NAICS
- Veterinary Services (54194), Veterinary Services (541940)
- SIC
- Services-Commercial Physical & Biological Research (8731)
- akta.pro primary industry
- One Health & Zoonotic Disease Partnerships (Human–Animal–Environment) (HLAJAOAJ)
Keywords
Where The North American 3Rs Collaborative is headquartered
LocationHeadquarters
- HQ city
- Denver
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
The North American 3Rs Collaborative business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Operations, Marketing or Sales, Technology or R&D, Others
Revenue model
- Membership Dues: The organization operates as a registered 501(c)(3) nonprofit accepting membership dues and donations to fund resources, outreach, and impact initiatives.
- 3Rs Certificate Course: Annual subscription fees for the 3Rs Certificate Course hosted on CITI Program platform, with tiered pricing for different organizational types (CITI subscribers, 3RsC members, non-members).
- Corporate Sponsorships: Corporate sponsors fund specific awards: Charles River sponsors the 3Rs Implementation Award, and Biomere sponsors the Building Bridges Award.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Annual | For CITI subscribers - for-profit institutions |
| Subscription | Annual | For CITI subscribers - non-profit institutions |
| Subscription | Annual | 3RsC members without CITI subscription - for-profit |
| Subscription | Annual | 3RsC members without CITI subscription - non-profit |
| Unit Pricing | Pay-as-you-go | Group Independent Learners (organizations not subscribed to CITI or 3RsC members) |
| Subscription | Annual | Institutional Subscription with CITI base |
Go-to-market motion1 record
Distribution channels2 records
Marketing channels6 records
The North American 3Rs Collaborative product offering
Product offeringCore offering
The North American 3Rs Collaborative is a nonprofit organization that provides educational programs, certification courses, species-specific refinement guides, and community resources to help the research community implement the 3Rs (Refinement, Reduction, Replacement) in animal research. Its core offerings include the 3Rs Certification Course delivered via CITI Program, the Rodent Health Monitoring Initiative, Microphysiological Systems Initiative, and the Culture of Care framework, targeted at laboratory animal professionals, research institutions, and pharmaceutical companies.
Product overview
The North American 3Rs Collaborative (3RsC) is a nonprofit organization offering a portfolio of educational programs, initiatives, and resources focused on advancing the 3Rs (Replacement, Reduction, Refinement) in animal research. The core offerings include the 3Rs Certification Course (hosted via CITI Program), the Rodent Health Monitoring Initiative, Microphysiological Systems (MPS) Initiative, Translational Digital Biomarkers Initiative, and Artificial Intelligence Initiative. The organization also provides comprehensive Culture of Care resources with four pillars (Scientific Integrity, Animal Welfare, Human Well-Being, Openness & Transparency) and Compassion Fatigue Resiliency programs. Species-specific refinement resources cover chinchillas, dogs, hamsters, mice, non-human primates, pigs, rabbits, rats, and zebrafish. Additional offerings include the 3Rs Tech Hub (member company directory), 3Rs Sharing Conference, 3-Minute 3Rs Podcast, and the 3RsC Awards Program. The 3RsC operates as a platform of interconnected educational resources rather than a single software product.
Differentiator
Problem solved
Functional benefit
Products and services
- 3Rs Certification Course A fully virtual, self-paced training program hosted by CITI Program designed to elevate understanding and application of the 3Rs (Replacement, Reduction, and Refinement). The course consists of 5 one-hour modules covering Introduction & History of the 3Rs, Replacement, Reduction, Refinement, and Applications & Related Topics. Targeted at anyone working with research animals.
- Rodent Health Monitoring Initiative An initiative promoting replacement of soiled bedding sentinel rodents with environmental health monitoring. Includes resources, SOPs, benchmarking surveys, mentorship program, and a community of 35+ institutions that have switched to environmental health monitoring.
- Microphysiological Systems (MPS) Initiative An initiative focused on organ-on-a-chip and tissue-chip technologies that replace or reduce animal testing. Includes MPS Tech Hub, MPS Publication Hub, MPS for Regulatory Applications, and MPS Conferences.
- Translational Digital Biomarkers Initiative An initiative leveraging digital technologies to collect objective, non-invasive data from research animals, supporting the Replacement and Reduction principles. Includes TDB Tech Hub and webinars.
- Artificial Intelligence Initiative An initiative exploring the application of AI and machine learning to advance the 3Rs in animal research.
- Culture of Care Framework A comprehensive framework consisting of four pillars: Scientific Integrity, Animal Welfare, Human Well-Being, and Openness & Transparency. Supports both scientific excellence and compassionate, responsible research.
- Compassion Fatigue Resiliency Program A program providing free resources to help institutions establish compassion fatigue resiliency programs. Includes webinars, self-assessment tools, self-care resources, classes, consultants, and institutional resources.
- Refined Mouse Handling Program A comprehensive program promoting refined handling methods for mice using tunnels, huts, or cup handling instead of tail handling. Includes how-to guides, operations resources, E-learning course (in partnership with NC3Rs), mentorship program, and workshops.
- 3RsC Awards Program Annual awards including The 3Rs Implementation Award (funded by Charles River, $2,500 personal award) and The Building Bridges Award (funded by Biomere, $1,000 personal award) recognizing outstanding work to implement the 3Rs.
- 3-Minute 3Rs Podcast A podcast providing quick 3-minute summaries of notable 3Rs research papers, created in partnership with Lab Animal and the NC3Rs. Features archived episodes of digestible 3Rs innovations.
- 3Rs Tech Hub A directory featuring 3Rs Collaborative member companies offering technologies and services that support Replacement, Reduction, and Refinement in research. Includes filtering by 3Rs impact, application area, and model type.
- 3Rs Sharing Conference Annual conference for sharing 3Rs knowledge, resources, and innovations with the research community.
Quantifiable outcome
- Over 9,000 animals replaced in research in one year
- +2 more outcomes
Companies that use The North American 3Rs Collaborative
Customer profileNamed customers2 records
Segments3 records
Ideal customer profiles1 record
The North American 3Rs Collaborative technology and API
TechnologyTechnology focussed No
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
The North American 3Rs Collaborative partnerships and signals
Strategic signalPartnerships
Three partnerships are on record, tiered core and minor.
- CITI ProgramcoreCITI Program hosts the 3Rs Certificate Course, providing the trusted platform for delivering online training on the 3Rs (Replacement, Reduction, Refinement). The course consists of 5 one-hour modules with quizzes, targeting anyone working with research animals.
- NC3Rs (UK National Centre for the 3Rs)coreThe 3Rs Collaborative partnered with NC3Rs to create an e-learning course on refined mouse handling. The course is accessible through NC3Rs platform and includes evidence-based training modules.
- Lab Animal JournalminorPartnership to produce the 3-Minute 3Rs Podcast featuring quick, digestible summaries of notable 3Rs papers.
Scale indicators5 records
Recent moves6 records
Expansion highlights5 records
The North American 3Rs Collaborative competitors and assessment
Company assessmentOthers
- Americans for Medical Progress: A nonprofit advocacy organization supporting the use of animals in biomedical research; comparable to the Collaborative in serving laboratory animal professionals and institutions, though with a different mission emphasis on public communication.
- Animal Welfare Institute: A nonprofit that promotes animal welfare through policy, research, and grants, including advocacy for refinement and reduction in laboratory animal settings; overlaps with the Collaborative on welfare policy engagement.
- Lab Animal (Nature Portfolio journal): The leading trade publication for laboratory animal professionals; an existing content partner with the Collaborative on the 3-Minute 3Rs Podcast and a complementary channel serving the same audience.
- PETA International Science Consortium: A science-focused nonprofit funding the development of non-animal test methods and training researchers in their use; comparable in its focus on Replacement but with a more activist posture.
- Foundation for Biomedical Research: An education and advocacy nonprofit that communicates the role of animal research to policymakers and the public, operating in the same animal-research stakeholder ecosystem as the 3Rs Collaborative.
- International Society for Applied Ethology (ISAE): ISAE is a scientific society advancing applied animal behavior science, including refinement of animal handling and welfare—closely related to the Collaborative's Refinement initiatives such as refined mouse handling and rat tickling.
Direct peers
- AAALAC International: AAALAC accredits laboratory animal care and use programs and is a core institution serving the same laboratory animal professional community, with overlapping focus on welfare standards and refinement practices in research facilities.
- NC3Rs (National Centre for the 3Rs): The UK-based National Centre for the 3Rs is the most direct peer: both organizations advance Replacement, Reduction, and Refinement in animal research through resources, training, and awards, and they explicitly partner on e-learning (refined mouse handling) and the 3-Minute 3Rs Podcast.
- Alternatives Research & Development Foundation (ARDF): ARDF funds and promotes development of alternatives to animal testing, sharing the Collaborative's Replacement agenda and serving as another US-based nonprofit convening point for animal welfare advocacy in research.
- Johns Hopkins Center for Alternatives to Animal Testing (CAAT): CAAT promotes alternatives to animal testing through research, education, and policy work, overlapping closely with the Collaborative's Replacement-focused mission and resources on microphysiological systems and in vitro methods.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat4 records
Key risks5 records
Key highlights7 records
Customer concentration
The North American 3Rs Collaborative social profiles
Digital presenceThe North American 3Rs Collaborative financial estimates
Financial estimateRevenue estimate
Valuation estimate
The North American 3Rs Collaborative leadership team
Management profileNumber of profiles
Profiles1 record
The North American 3Rs Collaborative funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
The North American 3Rs Collaborative M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about The North American 3Rs Collaborative
What does The North American 3Rs Collaborative do?
The North American 3Rs Collaborative is a nonprofit organization that provides educational programs, certification courses, species-specific refinement guides, and community resources to help the research community implement the 3Rs (Refinement, Reduction, Replacement) in animal research. Its core offerings include the 3Rs Certification Course delivered via CITI Program, the Rodent Health Monitoring Initiative, Microphysiological Systems Initiative, and the Culture of Care framework, targeted at laboratory animal professionals, research institutions, and pharmaceutical companies.
Is The North American 3Rs Collaborative a public or private company?
The North American 3Rs Collaborative is a private company. It is classified as nonprofit foundation owned and is currently operating.
When was The North American 3Rs Collaborative founded?
The North American 3Rs Collaborative was founded in -1.
Where is The North American 3Rs Collaborative based?
The North American 3Rs Collaborative is headquartered in Denver, United States, in the North America region.
How does The North American 3Rs Collaborative make money?
Three revenue lines are on record. Membership Dues are the primary driver. The others are 3Rs Certificate Course and corporate Sponsorships.
Who are The North American 3Rs Collaborative's main competitors?
Others on record are Americans for Medical Progress, Animal Welfare Institute, Lab Animal (Nature Portfolio journal), PETA International Science Consortium, Foundation for Biomedical Research and International Society for Applied Ethology (ISAE). Direct peers are AAALAC International, NC3Rs (National Centre for the 3Rs), Alternatives Research & Development Foundation (ARDF) and Johns Hopkins Center for Alternatives to Animal Testing (CAAT).
Does The North American 3Rs Collaborative have an API?
No public API is recorded for The North American 3Rs Collaborative.
What industry is The North American 3Rs Collaborative in?
The North American 3Rs Collaborative's product category is Nonprofit Research Education and Training. Its primary akta.pro industry code is HLAJAOAJ, One Health & Zoonotic Disease Partnerships (Human–Animal–Environment). Its NAICS code is 54194 and its SIC code is 8731.