Kreatis
Kreatis (KREATiS SAS) is a French computational (eco)toxicology company developing High Accuracy QSAR (HA-QSAR) models, mechanistic profilers (MechoA/MechoA+), and regulatory consulting services that help chemical, cosmetics, pharmaceutical, and regulator clients replace animal testing in dossiers.
- Company typePrivate
- Founded2014
- HeadquartersL'isle-d'abeau, France
- Headcount1–10
- GTM typeB2B
- OfferingSoftware
What Kreatis does
KREATiS (KREATiS SAS) is a French computational (eco)toxicology R&D company founded in 2014 and headquartered in L'Isle-d'Abeau (Auvergne-Rhône-Alpes). The company develops and operates the iSafeRat® High Accuracy QSAR (HA-QSAR) platform, a suite of in-house computational models that predict physicochemical endpoints (log Kow, water solubility, vapor pressure, Henry's law constant), ecotoxicological endpoints (acute and chronic fish, daphnid, algae, and mixture toxicity), and toxicological endpoints (skin/eye irritation, skin sensitisation, dermal absorption, endocrine disruption potential). Alongside the core platform, KREATiS maintains the MechoA/MechoA+ mechanistic profiler — a structural-alert-based decision tree co-developed with Unilever and Liverpool John Moores University, with 152 alerts covering approximately 80% of 70,000+ substances — plus the CLASS skin sensitisation model (updated to meet QSAR Assessment Framework requirements), the free MechoApedia educational tool, and the in-development SafePAC application for cosmetic packaging ecotoxicity. Adjacent capabilities include in-situ 3D molecular modeling (docking, molecular dynamics, free-energy calculation). KREATiS monetises through three streams: iSafeRat Online (web-based SaaS) and iSafeRat Desktop software subscriptions, in silico consulting services for regulatory dossier submissions (REACH, CPSR, ICH M7, Medical Devices, Plant Protection Products, Biocides, Pharmaceuticals), and QUALIOPI-certified training programs on QSARs and the OECD QSAR Toolbox. The company sells primarily via direct sales to chemical, cosmetics, pharmaceutical, medical-device, and consumer-goods enterprises and to regulatory authorities, with named customers including ECHA, Environment and Climate Change Canada, Mane, FoBiG, and LPL. Operationally, KREATiS is a privately owned, founder-led micro-organisation with approximately 11–12 staff, €150,000 of share capital, no disclosed external funding, and presence in France, Germany, the United Kingdom, and Canada.
Kreatis firmographics
Firmographics- Name
- Kreatis
- Legal name
- KREATiS SAS
- Website
- https://kreatis.eu
- Company type
- Private
- Founded year
- 2014
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Short description
- Kreatis (KREATiS SAS) is a French computational (eco)toxicology company developing High Accuracy QSAR (HA-QSAR) models, mechanistic profilers (MechoA/MechoA+), and regulatory consulting services that help chemical, cosmetics, pharmaceutical, and regulator clients replace animal testing in dossiers.
- Ownership category
- akta.pro rank
Kreatis industry classification
Industry- Product category
- Computational Toxicology Software
- NAICS
- Testing Laboratories and Services (54138)
- SIC
- Services-Testing Laboratories (8734), Services-Commercial Physical & Biological Research (8731)
- akta.pro primary industry
- In Silico / Computational Toxicology & PK/PD Modeling (HLAGAFAM)
- akta.pro secondary industries
- Regulatory Compliance Testing (Microbiological, Chemical, Allergen) (AFALADAA), Method Development & Validation (ICH/USP) (HLAGADAB)
Keywords
Where Kreatis is headquartered
LocationHeadquarters
- HQ city
- L'isle-d'abeau
- HQ country
- France
- HQ region
- Europe
Offices1 record
Markets served
Kreatis business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Marketing or Sales, Operations
Revenue model
- iSafeRat® Software Licenses/Subscriptions: Access to iSafeRat® Online and Desktop platforms for QSAR predictions - High Accuracy QSAR models for regulatory submissions
- In Silico Consulting Services: Expert consulting services for regulatory documents, dossier submissions, and third-party tool recommendations for endpoints required in regulatory submissions (REACH, CPSR, ICH M7, Medical Devices, Plant Protection Products, Biocides, Pharmaceuticals)
- Training Services: QUALIOPI certified training on QSARs, OECD QSAR Toolbox, third party models, and in silico ecotoxicology and toxicology methods
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Annual | Quote-based pricing tailored to client needs |
Go-to-market motion1 record
Distribution channels5 records
Marketing channels8 records
Kreatis product offering
Product offeringCore offering
KREATiS develops and sells proprietary in silico (eco)toxicology tools based on High Accuracy QSAR (HA-QSAR) models, centered on the iSafeRat® platform (available as iSafeRat Online SaaS and iSafeRat Desktop). The platform predicts physicochemical, ecotoxicological, and toxicological endpoints for chemical substances to replace animal testing. The company also provides in silico regulatory consulting services for dossier submissions (REACH, CPSR, ICH M7, Medical Devices, Plant Protection Products, Biocides, Pharmaceuticals) and QUALIOPI-certified training programs.
Product overview
KREATiS is a computational (eco)toxicology R&D company offering a suite of in silico tools centred on the iSafeRat High Accuracy QSAR platform. The platform consists of iSafeRat Desktop (v1.0, with v4.3 upcoming) and iSafeRat Online for on-demand predictions across physicochemical, ecotoxicological, and toxicological endpoints. Complementary modules include MechoA/MechoA+ for mechanistic profiling of toxic action (with MechoA+ available as a free add-in to the OECD QSAR Toolbox) and the CLASS model for skin sensitisation. The portfolio also includes free tools (MechoApedia), regulatory consulting services, and QUALIOPI-certified training programmes.
Differentiator
Problem solved
Functional benefit
Brands
- iSafeRat®: In-house validated High Accuracy QSAR (HA-QSAR) platform to replace experimental studies for predicting toxicology, ecotoxicology and physical chemistry endpoints for regulatory and R&D needs.
- MechoA
- MechoA+
- MechoApedia
Products and services
- iSafeRat Toolbox Core High Accuracy QSAR (HA-QSAR) platform offering predictions of physicochemical endpoints (log Kow, water solubility, vapour pressure, Henry's law constant), ecotoxicological endpoints (acute/chronic fish and daphnid toxicity, algae toxicity, aquatic toxicity for mixtures, toxicity to microorganisms), and toxicological endpoints (skin/eye irritation, skin sensitisation, dermal absorption, endocrine disruption). Designed for regulatory dossier submissions (REACH, CPSR, ICH M7, Medical Devices, Plant Protection Products, Biocides, Pharmaceuticals) and R&D hazard screening.
- MechoA+ profiler Enhanced structure-based profiler designed to predict Molecular Initiating Events (MIEs) by combining and refining existing mechanistic schemes. Contains 152 structural alerts and covers approximately 80% of chemicals from a database of 70,000+ substances. Distributed as a free downloadable add-in to the OECD QSAR Toolbox for use by regulatory and R&D professionals globally.
- MechoApedia
Quantifiable outcome
- 42 vertebrate animals (acute fish) + 80 fish eggs (chronic fish) saved using in silico methods instead of animal testing
- +1 more outcomes
Companies that use Kreatis
Customer profileNamed customers5 records
Segments5 records
Ideal customer profiles4 records
Kreatis technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration1 record
AI capability2 records
Feature6 records
Kreatis partnerships and signals
Strategic signalPartnerships
Nine partnerships are on record, tiered core and minor.
- OECD (Organisation for Economic Co-operation and Development)coreMechoA+ profiler now available as free add-in to OECD QSAR Toolbox. Recognition from OECD for the MechoA profiler being included in official Toolbox. Collaboration with ECHA on Toolbox development.
- BayercorePartnership for Advanced Toxicology Testing Software using iSafeRat technology. Provides in silico ecotoxicology predictions based on MechoA decision tree to boost R&D.
- UnilevercoreCollaboration to update the MechoA (Mechanisms of toxic Action) scheme with Unilever and Liverpool John Moores University. Joint research to align and combine findings for enhanced MechoA scheme availability in OECD Toolbox and other platforms.
- Liverpool John Moores UniversitycoreCollaboration with Unilever and KREATiS to develop MechoA+ profiler. Academic partner with Prof. Mark Cronin contributing to mechanistic Mode of Action classification scheme. KREATiS team member Dr. Franklin Bauer completed PhD fellowship in collaboration with university.
- ECHA (European Chemicals Agency)coreEuropean Chemicals Agency working with OECD on QSAR Toolbox development. ECHA Computational Unit provided feedback on iSafeRat Desktop software interface and report functionality.
- 2RcubeminorPartnership with shared vision to implement the 3Rs (Replace, Reduce, Refine) in animal testing. Complementary approach - KREATiS provides in silico predictions while 2Rcube continues laboratory work where needed.
- LPL (Laboratoire de Recherche en Sciences de l'Environnement)minorRegular collaboration on R&D projects and as complement to empirical ecotoxicity studies especially for mixtures (WAF tests). Combined laboratory and in silico approaches.
- COSMETOX ConsortiumminorEuropean research project with LIEC (Laboratoire interdisciplinaire des environnements continentaux) from Université de Lorraine. KREATiS leads modeling unit developing predictive calculation methods for cosmetic product toxicity.
- Université Côte d'AzurminorAcademic partner through logo association. Dr. Franklin Bauer completed PhD fellowship in collaboration with University of Haute-Alsace.
Scale indicators4 records
Recent moves8 records
Expansion highlights6 records
Kreatis competitors and assessment
Company assessmentDirect peers
- Cyprotex (Evotec): Cyprotex, part of Evotec, offers in silico ADME and toxicity prediction services alongside in vitro assays. Comparable in offering combined in silico toxicology with experimental support, similar to KREATiS+2Rcube positioning.
- Leadscope (Instem): Leadscope, now part of Instem, offers QSAR and expert alert software for genetic toxicology, carcinogenicity, and reproductive toxicology. Competes with KREATiS in QSAR-based regulatory dossiers (ICH M7, REACH).
- MultiCase: MultiCase provides QSAR software and expert systems for toxicity and property prediction used by regulators and industry. Direct competitor to KREATiS's iSafeRat HA-QSAR offering in the QSAR predictions market.
- Simulations Plus: Simulations Plus provides ADMET and quantitative modeling software (including QSAR tools). Competes with KREATiS in computational toxicology predictions for pharma and chemical industry clients.
- Lhasa Limited: Lhasa is a UK-based not-for-profit specializing in in silico toxicology and chemical safety tools (Derek, Sarah, Mirabilis). Closest direct competitor to KREATiS in computational (eco)toxicology for regulatory submissions.
Emerging players
- Scitovation: Scitovation (formerly ILSI Health and Environmental Sciences Institute spin-out activity) develops computational toxicology frameworks. Adjacent player in NAMs and QSAR development for regulatory use.
- MolPort: MolPort operates a chemical informatics and sourcing platform with overlapping cheminformatics capabilities. Adjacent player in chemical safety screening workflows used by KREATiS's buyer base.
- Toxys: Toxys is a Dutch biotech offering in vitro toxicity testing (ToxTracker, ReproTracker). Competes in the broader alternatives-to-animal-testing space with KREATiS though on the experimental rather than computational side.
Others
- CEHTRA: CEHTRA is the parent company from which KREATiS spun out in 2014 and now operates as a regulatory consulting firm for REACH, biocides, and plant protection products. Historical parent and overlapping consulting customer base in regulatory dossier work.
Broad incumbents
- Dassault Systèmes BIOVIA: BIOVIA provides broad computational chemistry, toxicology, and regulatory workflow software suites used by large chemical/pharma enterprises. A broad incumbent whose cheminformatics and predictive toxicology capabilities overlap with KREATiS's HA-QSAR platform.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
Kreatis social profiles
Digital presenceKreatis compliance and trust
Trust signalCompliance2 records
Kreatis financial estimates
Financial estimateRevenue estimate
Valuation estimate
Kreatis leadership team
Management profileNumber of profiles
Profiles9 records
Kreatis funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Kreatis M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Kreatis
What does Kreatis do?
KREATiS develops and sells proprietary in silico (eco)toxicology tools based on High Accuracy QSAR (HA-QSAR) models, centered on the iSafeRat® platform (available as iSafeRat Online SaaS and iSafeRat Desktop). The platform predicts physicochemical, ecotoxicological, and toxicological endpoints for chemical substances to replace animal testing. The company also provides in silico regulatory consulting services for dossier submissions (REACH, CPSR, ICH M7, Medical Devices, Plant Protection Products, Biocides, Pharmaceuticals) and QUALIOPI-certified training programs.
Is Kreatis a public or private company?
Kreatis is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was Kreatis founded?
Kreatis was founded in 2014. It employs 1 to 10 people.
Where is Kreatis based?
Kreatis is headquartered in L'isle-d'abeau, France, in the Europe region.
How does Kreatis make money?
Three revenue lines are on record. iSafeRat® Software Licenses/Subscriptions are the primary driver. The others are in Silico Consulting Services and training Services.
Who are Kreatis's main competitors?
Direct peers on record are Cyprotex (Evotec), Leadscope (Instem), MultiCase, Simulations Plus and Lhasa Limited. Emerging players are Scitovation, MolPort and Toxys. CEHTRA is listed as an others. Dassault Systèmes BIOVIA is listed as a broad incumbent.
Does Kreatis have an API?
No public API is recorded for Kreatis.
What industry is Kreatis in?
Kreatis's product category is Computational Toxicology Software. Its primary akta.pro industry code is HLAGAFAM, In Silico / Computational Toxicology & PK/PD Modeling, with a secondary code of AFALADAA, Regulatory Compliance Testing (Microbiological, Chemical, Allergen). Its NAICS code is 54138 and its SIC code is 8734.